-
1
-
-
0142166328
-
Cancer chemoprevention with dietary phytochemicals
-
Surh, Y.J. 2003. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 3: 768-780.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 768-780
-
-
Surh, Y.J.1
-
2
-
-
0032813348
-
Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances
-
Surh, Y. 1999. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 428: 305-327.
-
(1999)
Mutat. Res.
, vol.428
, pp. 305-327
-
-
Surh, Y.1
-
3
-
-
0026577605
-
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure
-
Zhang, Y. et al 1992. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc. Natl. Acad. Sci. USA 89: 2399-2403.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 2399-2403
-
-
Zhang, Y.1
-
4
-
-
0034928041
-
Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans
-
Shapiro, T.A. et al 2001. Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiol. Biomarkers Prev. 10: 501-508.
-
(2001)
Cancer Epidemiol. Biomarkers Prev.
, vol.10
, pp. 501-508
-
-
Shapiro, T.A.1
-
5
-
-
33749581701
-
Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
-
Hu, R. et al 2006. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27: 2038-2046.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2038-2046
-
-
Hu, R.1
-
6
-
-
33748089664
-
Inhibition of 7,12-dimethylbenz(a) anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2
-
Xu, C. et al 2006. Inhibition of 7, 12-dimethylbenz(a) anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. Cancer Res. 66: 8293-8296.
-
(2006)
Cancer Res.
, vol.66
, pp. 8293-8296
-
-
Xu, C.1
-
7
-
-
69949157311
-
Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway
-
Keum, Y.S. et al 2009. Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. Pharm Res. 26: 2324-2331.
-
(2009)
Pharm Res.
, vol.26
, pp. 2324-2331
-
-
Keum, Y.S.1
-
8
-
-
5144230473
-
Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action
-
Zhang, Y. 2004. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat. Res. 555: 173-190.
-
(2004)
Mutat. Res.
, vol.555
, pp. 173-190
-
-
Zhang, Y.1
-
9
-
-
28644450910
-
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China
-
Kensler, T.W. et al 2005. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol. Biomarkers Prev. 14: 2605-2613.
-
(2005)
Cancer Epidemiol. Biomarkers Prev.
, vol.14
, pp. 2605-2613
-
-
Kensler, T.W.1
-
10
-
-
0031711928
-
Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes
-
Seow, A. et al 1998. Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypes. Cancer Epidemiol. Biomarkers Prev. 7: 775-781.
-
(1998)
Cancer Epidemiol. Biomarkers Prev.
, vol.7
, pp. 775-781
-
-
Seow, A.1
-
11
-
-
0036949607
-
Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study
-
Seow, A. et al 2002. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23: 2055-2061.
-
(2002)
Carcinogenesis
, vol.23
, pp. 2055-2061
-
-
Seow, A.1
-
12
-
-
51349088974
-
Multi-targeted prevention of cancer by sulforaphane
-
Clarke, J.D., R.H. Dashwood & E. Ho 2008. Multi-targeted prevention of cancer by sulforaphane. Cancer Lett. 269: 291-304.
-
(2008)
Cancer Lett.
, vol.269
, pp. 291-304
-
-
Clarke, J.D.1
Dashwood, R.H.2
Ho, E.3
-
13
-
-
0037106099
-
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
-
Thimmulappa, R.K. et al 2002. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62: 5196-5203.
-
(2002)
Cancer Res.
, vol.62
, pp. 5196-5203
-
-
Thimmulappa, R.K.1
-
14
-
-
0037821802
-
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
-
McMahon, M. et al 2003. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J. Biol. Chem. 278: 21592-21600.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21592-21600
-
-
McMahon, M.1
-
15
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
Itoh, K. et al 1997. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236: 313-322.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 313-322
-
-
Itoh, K.1
-
16
-
-
78751703950
-
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution
-
Taguchi, K., H. Motohashi & M. Yamamoto 2011. Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution. Genes. Cells 16: 123-140.
-
(2011)
Genes. Cells
, vol.16
, pp. 123-140
-
-
Taguchi, K.1
Motohashi, H.2
Yamamoto, M.3
-
17
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
Itoh, K. et al 1999. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13: 76-86.
-
(1999)
Genes Dev.
, vol.13
, pp. 76-86
-
-
Itoh, K.1
-
18
-
-
0141493447
-
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
-
Xu, L. et al 2003. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425: 316-321.
-
(2003)
Nature
, vol.425
, pp. 316-321
-
-
Xu, L.1
-
19
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
Zhang, D.D. et al 2004. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol. Cell Biol. 24: 10941-10953.
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
-
20
-
-
33750613056
-
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
-
Tong, K.I. et al 2006. Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism. Biol. Chem. 387: 1311-1320.
-
(2006)
Biol. Chem.
, vol.387
, pp. 1311-1320
-
-
Tong, K.I.1
-
21
-
-
42649130014
-
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
-
Lo, S.C. & M. Hannink 2008. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp. Cell Res. 314: 1789-1803.
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 1789-1803
-
-
Lo, S.C.1
Hannink, M.2
-
22
-
-
58249117780
-
The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds
-
Kobayashi, M. et al 2009. The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds. Mol. Cell Biol. 29: 493-502.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 493-502
-
-
Kobayashi, M.1
-
23
-
-
0242580049
-
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
-
Zhang, D.D. & M. Hannink 2003. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol. Cell Biol. 23: 8137-8151.
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 8137-8151
-
-
Zhang, D.D.1
Hannink, M.2
-
24
-
-
29644443964
-
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane
-
Hong, F., M.L. Freeman & D.C. Liebler 2005. Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem. Res. Toxicol. 18: 1917-1926.
-
(2005)
Chem. Res. Toxicol.
, vol.18
, pp. 1917-1926
-
-
Hong, F.1
Freeman, M.L.2
Liebler, D.C.3
-
25
-
-
79954489673
-
Modification of keap1 cysteine residues by sulforaphane
-
Hu, C. et al 2011. Modification of keap1 cysteine residues by sulforaphane. Chem. Res. Toxicol. 24: 515-521.
-
(2011)
Chem. Res. Toxicol.
, vol.24
, pp. 515-521
-
-
Hu, C.1
-
26
-
-
33749019130
-
Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells
-
Keum, Y.S. et al 2006. Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells. Cancer Res. 66: 8804-8813.
-
(2006)
Cancer Res.
, vol.66
, pp. 8804-8813
-
-
Keum, Y.S.1
-
27
-
-
68749120854
-
Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response
-
Sun, Z., Z. Huang & D.D. Zhang 2009. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One 4: e6588.
-
(2009)
PLoS One
, vol.4
-
-
Sun, Z.1
Huang, Z.2
Zhang, D.D.3
-
28
-
-
77449106593
-
Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
-
Cheung, K.L. & A.N. Kong 2010. Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. AAPS J. 12: 87-97.
-
(2010)
AAPS J.
, vol.12
, pp. 87-97
-
-
Cheung, K.L.1
Kong, A.N.2
-
29
-
-
33744953050
-
Phosphorylation of tyrosine 568 controls nuclear export of Nrf2
-
Jain, A.K. & A.K. Jaiswal 2006. Phosphorylation of tyrosine 568 controls nuclear export of Nrf2. J. Biol. Chem. 281: 12132-12142.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12132-12142
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
30
-
-
34447526197
-
GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
-
Jain, A.K. & A.K. Jaiswal 2007. GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2. J. Biol. Chem. 282: 16502-16510.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16502-16510
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
31
-
-
79952256187
-
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
-
Rada, P. et al 2011. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol. Cell Biol. 31: 1121-1133.
-
(2011)
Mol. Cell Biol.
, vol.31
, pp. 1121-1133
-
-
Rada, P.1
-
32
-
-
49749117926
-
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death
-
Rojo, A.I. et al 2008. Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. Mol. Cell Neurosci. 39: 125-132.
-
(2008)
Mol. Cell Neurosci.
, vol.39
, pp. 125-132
-
-
Rojo, A.I.1
|