Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

Free Radical Biology and Medicine

Volumn 52, Issue 3, 2012, Pages 671-682

  Oh, Chang Joo ^a   Kim, Joon Young ^a   Min, Ae Kyung ^a   Park, Keun Gyu ^a   Harris, Robert A ^a,b   Kim, Han Jong ^a   Lee, In Kyu ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidant genes; Free radicals; Hepatic fibrosis; Nrf2; Sulforaphane; TGF Smad signaling pathway

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; FIBRONECTIN; HEME OXYGENASE 1; INTERSTITIAL COLLAGENASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD PROTEIN; SMAD3 PROTEIN; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BILE DUCT LIGATION; CELL ACTIVATION; CONTROLLED STUDY; DISEASE COURSE; GENE SILENCING; IN VIVO STUDY; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERIAL ANALYSIS OF GENE EXPRESSION; SIGNAL TRANSDUCTION; STELLATE CELL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; ENZYME INDUCTION; EXTRACELLULAR MATRIX PROTEINS; FIBROSIS; GENE EXPRESSION; GENES, REPORTER; HUMANS; LIVER DISEASES; LUCIFERASES; MALE; MICE; MICE, INBRED C57BL; NF-E2-RELATED FACTOR 2; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SERPIN E2; SIGNAL TRANSDUCTION; SMAD PROTEINS; THIOCYANATES; TRANSFORMING GROWTH FACTOR BETA;

MUS;

EID: 84856302591     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.11.012     Document Type: Article

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