Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: Role of Nrf2-dependent gene expression and antioxidant enzymes

Pharmacological Research

Volumn 78, Issue , 2013, Pages 28-40

  Kleszczyński, Konrad ^a   Ernst, Insa M A ^b   Wagner, Anika E ^b   Kruse, Nathalie ^a   Zillikens, Detlef ^a   Rimbach, Gerald ^b   Fischer, Tobias W ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Apoptosis; Nrf2; Oxidative stress; Phenylethyl isothiocyanate; Skin; Sulforaphane; UVR

Indexed keywords

ANTIOXIDANT; BIOLOGICAL MARKER; CASPASE 3; CATALASE; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; ISOTHIOCYANIC ACID DERIVATIVE; MESSENGER RNA; PHENYLETHYL ISOTHIOCYANATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVATION; EX VIVO STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION DOSE; SKIN PROTECTION; SUNBURN; ULTRAVIOLET RADIATION;

APOPTOSIS; CAT; CATALASE; CL. CASP-3; CLEAVED CASPASE-3; GLUTATHIONE; GSH; H&E; HEMATOXYLIN AND EOSIN; HEME OXYGENASE 1; HO-1; NAD(P)H QUINONE OXIDOREDUCTASE 1; NQO1; NRF2; NUCLEAR FACTOR ERYTHROID-2 RELATED FACTOR 2; OXIDATIVE STRESS; PEITC; PHENYLETHYL ISOTHIOCYANATE; SFN; SKIN; SULFORAPHANE; ULTRAVIOLET RADIATION; UVR; Γ-GLUTAMYLCYSTEINE-SYNTHETASE; ΓGCS;

ANTICARCINOGENIC AGENTS; APOPTOSIS; CASPASE 3; CATALASE; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; ISOTHIOCYANATES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; SKIN; ULTRAVIOLET RAYS;

EID: 84887101092     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2013.09.009     Document Type: Article

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