Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1012-1022

  Alfieri, Alessio ^a   Srivastava, Salil ^a   Siow, Richard C M ^a   Cash, Diana ^a   Modo, Michel ^a   Duchen, Michael R ^b   Fraser, Paul A ^a   Williams, Steven C R ^a   Mann, Giovanni E ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Blood brain barrier; Gliovascular complex; Heme oxygenase; Nrf2; Preconditioning; Stroke; Sulforaphane

Indexed keywords

HEME OXYGENASE 1; PEROXYNITRITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; HMOX1 PROTEIN, MOUSE; ISOTHIOCYANIC ACID DERIVATIVE; MEMBRANE PROTEIN; NEUROPROTECTIVE AGENT; NFE2L2 PROTEIN, MOUSE; SULFORAFAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; MALE; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; ANIMAL; BRAIN ARTERY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; GENETICS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; PSYCHOMOTOR DISORDERS; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UPREGULATION;

RATTUS;

ANIMALS; BLOOD-BRAIN BARRIER; CEREBRAL ARTERIES; GENE EXPRESSION; HEME OXYGENASE-1; INFARCTION, MIDDLE CEREBRAL ARTERY; ISOTHIOCYANATES; MALE; MEMBRANE PROTEINS; MICROVESSELS; NEUROPROTECTIVE AGENTS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PSYCHOMOTOR DISORDERS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84884493497     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.08.190     Document Type: Article

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