-
1
-
-
84907259851
-
-
Centers for Disease Control and Prevention: About Arthritis Disabilities and Limitations.. ]., http://www.cdc.gov/arthritis/data_statistics/disabilities-limitations.htm
-
About Arthritis Disabilities and Limitations
-
-
-
2
-
-
54149090275
-
-
update
-
World Health Organization: The global burden of disease. 2004. update []., http://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/
-
(2004)
The global burden of disease
-
-
-
3
-
-
77649110175
-
The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis
-
20187160
-
Bondeson J, Blom AB, Wainwright S, Hughes C, Caterson B, van den Berg WB. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum 2010, 62:647-657. 10.1002/art.27290, 20187160.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 647-657
-
-
Bondeson, J.1
Blom, A.B.2
Wainwright, S.3
Hughes, C.4
Caterson, B.5
van den Berg, W.B.6
-
4
-
-
84857057096
-
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis
-
22324945
-
Mimata Y, Kamataki A, Oikawa S, Murakami K, Uzuki M, Shimamura T, Sawai T. Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Int J Rheum Dis 2012, 15:36-44. 10.1111/j.1756-185X.2011.01656.x, 22324945.
-
(2012)
Int J Rheum Dis
, vol.15
, pp. 36-44
-
-
Mimata, Y.1
Kamataki, A.2
Oikawa, S.3
Murakami, K.4
Uzuki, M.5
Shimamura, T.6
Sawai, T.7
-
5
-
-
0029993571
-
Matrix metalloproteinases in the formation of human synovial joint cavities
-
8621334
-
Edwards JC, Wilkinson LS, Soothill P, Hembry RM, Murphy G, Reynolds JJ. Matrix metalloproteinases in the formation of human synovial joint cavities. J Anat 1996, 188:355-360. 8621334.
-
(1996)
J Anat
, vol.188
, pp. 355-360
-
-
Edwards, J.C.1
Wilkinson, L.S.2
Soothill, P.3
Hembry, R.M.4
Murphy, G.5
Reynolds, J.J.6
-
6
-
-
0346963598
-
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
-
9590175
-
Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell 1998, 93:411-422. 10.1016/S0092-8674(00)81169-1, 9590175.
-
(1998)
Cell
, vol.93
, pp. 411-422
-
-
Vu, T.H.1
Shipley, J.M.2
Bergers, G.3
Berger, J.E.4
Helms, J.A.5
Hanahan, D.6
Shapiro, S.D.7
Senior, R.M.8
Werb, Z.9
-
7
-
-
10344245561
-
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
-
15563592
-
Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, Krane SM. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A 2004, 101:17192-17197. 10.1073/pnas.0407788101, 15563592.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17192-17197
-
-
Inada, M.1
Wang, Y.2
Byrne, M.H.3
Rahman, M.U.4
Miyaura, C.5
Lopez-Otin, C.6
Krane, S.M.7
-
8
-
-
19944426775
-
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice
-
15539485
-
Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development 2004, 131:5883-5895. 10.1242/dev.01461, 15539485.
-
(2004)
Development
, vol.131
, pp. 5883-5895
-
-
Stickens, D.1
Behonick, D.J.2
Ortega, N.3
Heyer, B.4
Hartenstein, B.5
Yu, Y.6
Fosang, A.J.7
Schorpp-Kistner, M.8
Angel, P.9
Werb, Z.10
-
9
-
-
26444528459
-
MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO)
-
Kennedy AM, Inada M, Krane SM, Christie PT, Harding B, Lopez-Otin C, Sanchez LM, Pannett AAJ, Dearlove A, Hartley C, Byrne MH, Reed AAC, Nesbit A, Whyte MP, Thakker RV: MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO).J Clin Invest 2005, 115:2832-2842..
-
(2005)
J Clin Invest
, vol.115
, pp. 2832-2842
-
-
Kennedy, A.M.1
Inada, M.2
Krane, S.M.3
Christie, P.T.4
Harding, B.5
Lopez-Otin, C.6
Sanchez, L.M.7
Pannett, A.A.J.8
Dearlove, A.9
Hartley, C.10
Byrne, M.H.11
Reed, A.A.C.12
Nesbit, A.13
Whyte, M.P.14
Thakker, R.V.15
-
10
-
-
68249126851
-
Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia
-
19615667
-
Lausch E, Keppler R, Hilbert K, Cormier-Daire V, Nikkel S, Nishimura G, Unger S, Spranger J, Superti-Furga A, Zabel B. Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia. Am J Hum Genet 2009, 85:168-178. 10.1016/j.ajhg.2009.06.014, 19615667.
-
(2009)
Am J Hum Genet
, vol.85
, pp. 168-178
-
-
Lausch, E.1
Keppler, R.2
Hilbert, K.3
Cormier-Daire, V.4
Nikkel, S.5
Nishimura, G.6
Unger, S.7
Spranger, J.8
Superti-Furga, A.9
Zabel, B.10
-
11
-
-
0034635966
-
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
-
10737763
-
Zhou Z, Apte SS, Soininen R, Cao R, Baaklini GY, Rauser RW, Wang J, Cao Y, Tryggvason K. Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A 2000, 97:4052-4057. 10.1073/pnas.060037197, 10737763.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 4052-4057
-
-
Zhou, Z.1
Apte, S.S.2
Soininen, R.3
Cao, R.4
Baaklini, G.Y.5
Rauser, R.W.6
Wang, J.7
Cao, Y.8
Tryggvason, K.9
-
12
-
-
84866128740
-
Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome
-
22922033
-
Evans BR, Mosig RA, Lobl M, Martignetti CR, Camacho C, Grum-Tokars V, Glucksman MJ, Martignetti JA. Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. Am J Hum Genet 2012, 91:572-576. 10.1016/j.ajhg.2012.07.022, 22922033.
-
(2012)
Am J Hum Genet
, vol.91
, pp. 572-576
-
-
Evans, B.R.1
Mosig, R.A.2
Lobl, M.3
Martignetti, C.R.4
Camacho, C.5
Grum-Tokars, V.6
Glucksman, M.J.7
Martignetti, J.A.8
-
13
-
-
18644369778
-
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo
-
15880348
-
Little CB, Mittaz L, Belluoccio D, Rogerson FM, Campbell IK, Meeker CT, Bateman JF, Pritchard MA, Fosang AJ. ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis Rheum 2005, 52:1461-1472. 10.1002/art.21022, 15880348.
-
(2005)
Arthritis Rheum
, vol.52
, pp. 1461-1472
-
-
Little, C.B.1
Mittaz, L.2
Belluoccio, D.3
Rogerson, F.M.4
Campbell, I.K.5
Meeker, C.T.6
Bateman, J.F.7
Pritchard, M.A.8
Fosang, A.J.9
-
14
-
-
20444394733
-
Adamts9 is widely expressed during mouse embryo development
-
15939373
-
Jungers KA, Le Goff C, Somerville RP, Apte SS. Adamts9 is widely expressed during mouse embryo development. Gene Expr Patterns 2005, 5:609-617. 10.1016/j.modgep.2005.03.004, 15939373.
-
(2005)
Gene Expr Patterns
, vol.5
, pp. 609-617
-
-
Jungers, K.A.1
Le Goff, C.2
Somerville, R.P.3
Apte, S.S.4
-
15
-
-
84891479862
-
Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase
-
24220035
-
Dancevic CM, Fraser FW, Smith AD, Stupka N, Ward AC, McCulloch DR. Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase. J Biol Chem 2013, 288:37267-37276. 10.1074/jbc.M112.418624, 24220035.
-
(2013)
J Biol Chem
, vol.288
, pp. 37267-37276
-
-
Dancevic, C.M.1
Fraser, F.W.2
Smith, A.D.3
Stupka, N.4
Ward, A.C.5
McCulloch, D.R.6
-
16
-
-
18744437369
-
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints
-
9202061
-
Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J Clin Invest 1997, 100:93-106. 10.1172/JCI119526, 9202061.
-
(1997)
J Clin Invest
, vol.100
, pp. 93-106
-
-
Lark, M.W.1
Bayne, E.K.2
Flanagan, J.3
Harper, C.F.4
Hoerrner, L.A.5
Hutchinson, N.I.6
Singer, I.I.7
Donatelli, S.A.8
Weidner, J.R.9
Williams, H.R.10
Mumford, R.A.11
Lohmander, L.S.12
-
17
-
-
0034854048
-
Distribution of aggrecanase (ADAMts 4/5) cleavage products in normal and osteoarthritic human articular cartilage: the influence of age, topography and zone of tissue
-
11520169
-
Bayliss MT, Hutton S, Hayward J, Maciewicz RA. Distribution of aggrecanase (ADAMts 4/5) cleavage products in normal and osteoarthritic human articular cartilage: the influence of age, topography and zone of tissue. Osteoarthritis Cartilage 2001, 9:553-560. 10.1053/joca.2001.0425, 11520169.
-
(2001)
Osteoarthritis Cartilage
, vol.9
, pp. 553-560
-
-
Bayliss, M.T.1
Hutton, S.2
Hayward, J.3
Maciewicz, R.A.4
-
18
-
-
0024549792
-
Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1
-
2783591
-
Dodge GR, Poole AR. Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1. J Clin Invest 1989, 83:647-661. 10.1172/JCI113929, 2783591.
-
(1989)
J Clin Invest
, vol.83
, pp. 647-661
-
-
Dodge, G.R.1
Poole, A.R.2
-
19
-
-
0024367522
-
Immunohistologic demonstration of type II collagen in synovial fluid phagocytes of osteoarthritis and rheumatoid arthritis patients
-
2684170
-
Moreland LW, Stewart T, Gay RE, Huang GQ, McGee N, Gay S. Immunohistologic demonstration of type II collagen in synovial fluid phagocytes of osteoarthritis and rheumatoid arthritis patients. Arthritis Rheum 1989, 32:1458-1464. 10.1002/anr.1780321116, 2684170.
-
(1989)
Arthritis Rheum
, vol.32
, pp. 1458-1464
-
-
Moreland, L.W.1
Stewart, T.2
Gay, R.E.3
Huang, G.Q.4
McGee, N.5
Gay, S.6
-
20
-
-
1842365544
-
Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures
-
9008612
-
Kozaci LD, Buttle DJ, Hollander AP. Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures. Arthritis Rheum 1997, 40:164-174. 10.1002/art.1780400121, 9008612.
-
(1997)
Arthritis Rheum
, vol.40
, pp. 164-174
-
-
Kozaci, L.D.1
Buttle, D.J.2
Hollander, A.P.3
-
21
-
-
84864387009
-
Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage
-
22507082
-
Takahashi T, Naito S, Onoda J, Yamauchi A, Nakamura E, Kishino J, Kawai T, Matsukawa S, Toyosaki-Maeda T, Tanimura M, Fukui N, Numata Y, Yamane S. Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage. Clin Chim Acta 2012, 413:1591-1599. 10.1016/j.cca.2012.03.022, 22507082.
-
(2012)
Clin Chim Acta
, vol.413
, pp. 1591-1599
-
-
Takahashi, T.1
Naito, S.2
Onoda, J.3
Yamauchi, A.4
Nakamura, E.5
Kishino, J.6
Kawai, T.7
Matsukawa, S.8
Toyosaki-Maeda, T.9
Tanimura, M.10
Fukui, N.11
Numata, Y.12
Yamane, S.13
-
22
-
-
0027316964
-
Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1
-
8325982
-
Mohtai M, Smith RL, Schurman DJ, Tsuji Y, Torti FM, Hutchinson NI, Stetler-Stevenson WG, Goldberg GI. Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1. J Clin Invest 1993, 92:179-185. 10.1172/JCI116547, 8325982.
-
(1993)
J Clin Invest
, vol.92
, pp. 179-185
-
-
Mohtai, M.1
Smith, R.L.2
Schurman, D.J.3
Tsuji, Y.4
Torti, F.M.5
Hutchinson, N.I.6
Stetler-Stevenson, W.G.7
Goldberg, G.I.8
-
23
-
-
0024603047
-
Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3
-
2930500
-
Gunja-Smith Z, Nagase H, Woessner JF. Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3. Biochem J 1989, 258:115-119. 2930500.
-
(1989)
Biochem J
, vol.258
, pp. 115-119
-
-
Gunja-Smith, Z.1
Nagase, H.2
Woessner, J.F.3
-
24
-
-
0026040194
-
Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
-
1874716
-
Fosang AJ, Neame PJ, Hardingham TE, Murphy G, Hamilton JA. Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins. J Biol Chem 1991, 266:15579-15582. 1874716.
-
(1991)
J Biol Chem
, vol.266
, pp. 15579-15582
-
-
Fosang, A.J.1
Neame, P.J.2
Hardingham, T.E.3
Murphy, G.4
Hamilton, J.A.5
-
25
-
-
84865165620
-
MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover
-
22670872
-
Struglics A, Hansson M. MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover. Biochem J 2012, 446:213-223. 10.1042/BJ20120274, 22670872.
-
(2012)
Biochem J
, vol.446
, pp. 213-223
-
-
Struglics, A.1
Hansson, M.2
-
26
-
-
45249093673
-
Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity
-
18513402
-
Karsdal MA, Madsen SH, Christiansen C, Henriksen K, Fosang AJ, Sondergaard BC. Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther 2008, 10:R63. 10.1186/ar2434, 18513402.
-
(2008)
Arthritis Res Ther
, vol.10
, pp. R63
-
-
Karsdal, M.A.1
Madsen, S.H.2
Christiansen, C.3
Henriksen, K.4
Fosang, A.J.5
Sondergaard, B.C.6
-
27
-
-
0242580819
-
Aggrecan protects cartilage collagen from proteolytic cleavage
-
12890681
-
Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 2003, 278:45539-45545. 10.1074/jbc.M303737200, 12890681.
-
(2003)
J Biol Chem
, vol.278
, pp. 45539-45545
-
-
Pratta, M.A.1
Yao, W.2
Decicco, C.3
Tortorella, M.D.4
Liu, R.Q.5
Copeland, R.A.6
Magolda, R.7
Newton, R.C.8
Trzaskos, J.M.9
Arner, E.C.10
-
28
-
-
34249897267
-
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair
-
17510707
-
Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, Fosang AJ. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest 2007, 117:1627-1636. 10.1172/JCI30765, 17510707.
-
(2007)
J Clin Invest
, vol.117
, pp. 1627-1636
-
-
Little, C.B.1
Meeker, C.T.2
Golub, S.B.3
Lawlor, K.E.4
Farmer, P.J.5
Smith, S.M.6
Fosang, A.J.7
-
29
-
-
0345211445
-
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins
-
10356395
-
Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R, Rockwell A, Yang F, Duke JL, Solomon K, George H, Bruckner R, Nagase H, Itoh Y, Ellis DM, Ross H, Wiswall BH, Murphy K, Hillman MC, Hollis GF, Newton RC, Magolda RL, Trzaskos JM, Arner EC. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 1999, 284:1664-1666. 10.1126/science.284.5420.1664, 10356395.
-
(1999)
Science
, vol.284
, pp. 1664-1666
-
-
Tortorella, M.D.1
Burn, T.C.2
Pratta, M.A.3
Abbaszade, I.4
Hollis, J.M.5
Liu, R.6
Rosenfeld, S.A.7
Copeland, R.A.8
Decicco, C.P.9
Wynn, R.10
Rockwell, A.11
Yang, F.12
Duke, J.L.13
Solomon, K.14
George, H.15
Bruckner, R.16
Nagase, H.17
Itoh, Y.18
Ellis, D.M.19
Ross, H.20
Wiswall, B.H.21
Murphy, K.22
Hillman, M.C.23
Hollis, G.F.24
Newton, R.C.25
Magolda, R.L.26
Trzaskos, J.M.27
Arner, E.C.28
more..
-
30
-
-
0033551844
-
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family
-
10438522
-
Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, Ellis DM, Tortorella MD, Pratta MA, Hollis JM, Wynn R, Duke JL, George HJ, Hillman MC, Murphy K, Wiswall BH, Copeland RA, Decicco CP, Bruckner R, Nagase H, Itoh Y, Newton RC, Magolda RL, Trzaskos JM, Hollis GF, Arner EC, Burn TC. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem 1999, 274:23443-23450. 10.1074/jbc.274.33.23443, 10438522.
-
(1999)
J Biol Chem
, vol.274
, pp. 23443-23450
-
-
Abbaszade, I.1
Liu, R.Q.2
Yang, F.3
Rosenfeld, S.A.4
Ross, O.H.5
Link, J.R.6
Ellis, D.M.7
Tortorella, M.D.8
Pratta, M.A.9
Hollis, J.M.10
Wynn, R.11
Duke, J.L.12
George, H.J.13
Hillman, M.C.14
Murphy, K.15
Wiswall, B.H.16
Copeland, R.A.17
Decicco, C.P.18
Bruckner, R.19
Nagase, H.20
Itoh, Y.21
Newton, R.C.22
Magolda, R.L.23
Trzaskos, J.M.24
Hollis, G.F.25
Arner, E.C.26
Burn, T.C.27
more..
-
31
-
-
0033520318
-
ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family
-
10464288
-
Hurskainen TL, Hirohata S, Seldin MF, Apte SS. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem 1999, 274:25555-25563. 10.1074/jbc.274.36.25555, 10464288.
-
(1999)
J Biol Chem
, vol.274
, pp. 25555-25563
-
-
Hurskainen, T.L.1
Hirohata, S.2
Seldin, M.F.3
Apte, S.S.4
-
32
-
-
41949131462
-
ADAMTS-5: the story so far
-
18247274
-
Fosang AJ, Rogerson FM, East CJ, Stanton H. ADAMTS-5: the story so far. Eur Cell Mater 2008, 15:11-26. 18247274.
-
(2008)
Eur Cell Mater
, vol.15
, pp. 11-26
-
-
Fosang, A.J.1
Rogerson, F.M.2
East, C.J.3
Stanton, H.4
-
33
-
-
15844384854
-
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro
-
15800625
-
Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 2005, 434:648-652. 10.1038/nature03417, 15800625.
-
(2005)
Nature
, vol.434
, pp. 648-652
-
-
Stanton, H.1
Rogerson, F.M.2
East, C.J.3
Golub, S.B.4
Lawlor, K.E.5
Meeker, C.T.6
Little, C.B.7
Last, K.8
Farmer, P.J.9
Campbell, I.K.10
Fourie, A.M.11
Fosang, A.J.12
-
34
-
-
15844413814
-
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
-
15800624
-
Glasson SS, Askew R, Sheppard B, Carito B, Blanchet T, Ma HL, Flannery CR, Peluso D, Kanki K, Yang Z, Majumdar MK, Morris EA. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005, 434:644-648. 10.1038/nature03369, 15800624.
-
(2005)
Nature
, vol.434
, pp. 644-648
-
-
Glasson, S.S.1
Askew, R.2
Sheppard, B.3
Carito, B.4
Blanchet, T.5
Ma, H.L.6
Flannery, C.R.7
Peluso, D.8
Kanki, K.9
Yang, Z.10
Majumdar, M.K.11
Morris, E.A.12
-
35
-
-
34249999133
-
Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages
-
17360199
-
Plaas A, Osborn B, Yoshihara Y, Bai Y, Bloom T, Nelson F, Mikecz K, Sandy JD. Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages. Osteoarthritis Cartilage 2007, 15:719-734. 10.1016/j.joca.2006.12.008, 17360199.
-
(2007)
Osteoarthritis Cartilage
, vol.15
, pp. 719-734
-
-
Plaas, A.1
Osborn, B.2
Yoshihara, Y.3
Bai, Y.4
Bloom, T.5
Nelson, F.6
Mikecz, K.7
Sandy, J.D.8
-
36
-
-
33847010576
-
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
-
17265492
-
Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW. Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5. Arthritis Rheum 2007, 56:575-585. 10.1002/art.22334, 17265492.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 575-585
-
-
Song, R.H.1
Tortorella, M.D.2
Malfait, A.M.3
Alston, J.T.4
Yang, Z.5
Arner, E.C.6
Griggs, D.W.7
-
37
-
-
83855165792
-
Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines
-
21800360
-
Wylie JD, Ho JC, Singh S, McCulloch DR, Apte SS. Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines. J Orthop Res 2012, 30:226-233. 10.1002/jor.21508, 21800360.
-
(2012)
J Orthop Res
, vol.30
, pp. 226-233
-
-
Wylie, J.D.1
Ho, J.C.2
Singh, S.3
McCulloch, D.R.4
Apte, S.S.5
-
38
-
-
84855445254
-
Zonal differences in meniscus matrix turnover and cytokine response
-
22062355
-
Fuller ES, Smith MM, Little CB, Melrose J. Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis Cartilage 2012, 20:49-59. 10.1016/j.joca.2011.10.002, 22062355.
-
(2012)
Osteoarthritis Cartilage
, vol.20
, pp. 49-59
-
-
Fuller, E.S.1
Smith, M.M.2
Little, C.B.3
Melrose, J.4
-
39
-
-
84865605996
-
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance
-
22820172
-
Kim HY, Lee SW, Park SY, Baek SH, Lee CW, Hong KW, Kim CD. Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance. Life Sci 2012, 91:250-257. 10.1016/j.lfs.2012.07.003, 22820172.
-
(2012)
Life Sci
, vol.91
, pp. 250-257
-
-
Kim, H.Y.1
Lee, S.W.2
Park, S.Y.3
Baek, S.H.4
Lee, C.W.5
Hong, K.W.6
Kim, C.D.7
-
40
-
-
33644665938
-
Quinacrine but not chloroquine inhibits PMA induced upregulation of matrix metalloproteinases in leukocytes: quinacrine acts at the transcriptional level through a PLA2-independent mechanism
-
16511916
-
Stuhlmeier KM, Pollaschek C. Quinacrine but not chloroquine inhibits PMA induced upregulation of matrix metalloproteinases in leukocytes: quinacrine acts at the transcriptional level through a PLA2-independent mechanism. J Rheumatol 2006, 33:472-480. 16511916.
-
(2006)
J Rheumatol
, vol.33
, pp. 472-480
-
-
Stuhlmeier, K.M.1
Pollaschek, C.2
-
41
-
-
79952350508
-
Oxidative stress as a mechanism underlying sulfasalazine-induced toxicity
-
21219240
-
Linares V, Alonso V, Domingo JL. Oxidative stress as a mechanism underlying sulfasalazine-induced toxicity. Expert Opin Drug Saf 2011, 10:253-263. 10.1517/14740338.2011.529898, 21219240.
-
(2011)
Expert Opin Drug Saf
, vol.10
, pp. 253-263
-
-
Linares, V.1
Alonso, V.2
Domingo, J.L.3
-
42
-
-
0033053835
-
Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial
-
9929017
-
Smolen JS, Kalden JR, Scott DL, Rozman B, Kvien TK, Larsen A, Loew-Friedrich I, Oed C, Rosenburg R. Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a double-blind, randomised, multicentre trial. Lancet 1999, 353:259-266. 10.1016/S0140-6736(98)09403-3, 9929017.
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Smolen, J.S.1
Kalden, J.R.2
Scott, D.L.3
Rozman, B.4
Kvien, T.K.5
Larsen, A.6
Loew-Friedrich, I.7
Oed, C.8
Rosenburg, R.9
-
43
-
-
84876333416
-
Tocilizumab as monotherapy or in combination with nonbiologic disease-modifying antirheumatic drugs: twenty-four-week results of an open-label, clinical practice study (ACT-STAR)
-
Weinblatt ME, Kremer J, Cush J, Rigby W, Teng LL, Devenport J, Singh N, Lepley D, Genovese MC. Tocilizumab as monotherapy or in combination with nonbiologic disease-modifying antirheumatic drugs: twenty-four-week results of an open-label, clinical practice study (ACT-STAR). Arthritis Care Res 2013, 65:362-371. 10.1002/acr.21847.
-
(2013)
Arthritis Care Res
, vol.65
, pp. 362-371
-
-
Weinblatt, M.E.1
Kremer, J.2
Cush, J.3
Rigby, W.4
Teng, L.L.5
Devenport, J.6
Singh, N.7
Lepley, D.8
Genovese, M.C.9
-
44
-
-
67449133560
-
Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study
-
19066176
-
Keystone EC, Genovese MC, Klareskog L, Hsia EC, Hall ST, Miranda PC, Pazdur J, Bae S-C, Palmer W, Zrubek J, Wiekowski M, Visvanathan S, Wu Z, Rahman MU. Golimumab, a human antibody to tumour necrosis factor α given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study. Ann Rheum Dis 2009, 68:789-796. 10.1136/ard.2008.099010, 19066176.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 789-796
-
-
Keystone, E.C.1
Genovese, M.C.2
Klareskog, L.3
Hsia, E.C.4
Hall, S.T.5
Miranda, P.C.6
Pazdur, J.7
Bae, S.-C.8
Palmer, W.9
Zrubek, J.10
Wiekowski, M.11
Visvanathan, S.12
Wu, Z.13
Rahman, M.U.14
-
45
-
-
10744223002
-
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
-
15001324
-
Klareskog L, van der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M, Martín Mola E, Pavelka K, Sany J, Settas L, Wajdula J, Pederson R, Fatenejad S, Sanda M. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 2004, 363:675-681. 10.1016/S0140-6736(04)15640-7, 15001324.
-
(2004)
Lancet
, vol.363
, pp. 675-681
-
-
Klareskog, L.1
van der Heijde, D.2
de Jager, J.P.3
Gough, A.4
Kalden, J.5
Malaise, M.6
Martín Mola, E.7
Pavelka, K.8
Sany, J.9
Settas, L.10
Wajdula, J.11
Pederson, R.12
Fatenejad, S.13
Sanda, M.14
-
46
-
-
84869417617
-
Adalimumab in the treatment of rheumatoid arthritis
-
22954150
-
Voulgari PV, Kaltsonoudis E, Papagoras C, Drosos AA. Adalimumab in the treatment of rheumatoid arthritis. Expert Opin Biol Ther 2012, 12:1679-1686. 10.1517/14712598.2012.721771, 22954150.
-
(2012)
Expert Opin Biol Ther
, vol.12
, pp. 1679-1686
-
-
Voulgari, P.V.1
Kaltsonoudis, E.2
Papagoras, C.3
Drosos, A.A.4
-
47
-
-
84867398615
-
Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort study
-
22504561
-
van der Maas A, Kievit W, van den Bemt BJ, van den Hoogen FH, van Riel PL, den Broeder AA. Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort study. Ann Rheum Dis 2012, 71:1849-1854. 10.1136/annrheumdis-2011-200945, 22504561.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1849-1854
-
-
van der Maas, A.1
Kievit, W.2
van den Bemt, B.J.3
van den Hoogen, F.H.4
van Riel, P.L.5
den Broeder, A.A.6
-
48
-
-
84880797201
-
Therapeutic efficacy of tocilizumab in patients with rheumatoid arthritis refractory to anti-tumor-necrosis-factor inhibitors: 1 year follow-up with low-field extremity MRI
-
22975733
-
Suzuki T, Horikoshi M, Sugihara M, Hirota T, Ogishima H, Umeda N, Kondo Y, Tsuboi H, Hayashi T, Chino Y, Matsumoto I, Sumida T. Therapeutic efficacy of tocilizumab in patients with rheumatoid arthritis refractory to anti-tumor-necrosis-factor inhibitors: 1 year follow-up with low-field extremity MRI. Mod Rheumatol 2013, 23:782-787. 10.3109/s10165-012-0746-2, 22975733.
-
(2013)
Mod Rheumatol
, vol.23
, pp. 782-787
-
-
Suzuki, T.1
Horikoshi, M.2
Sugihara, M.3
Hirota, T.4
Ogishima, H.5
Umeda, N.6
Kondo, Y.7
Tsuboi, H.8
Hayashi, T.9
Chino, Y.10
Matsumoto, I.11
Sumida, T.12
-
49
-
-
84863857793
-
Optimizing outcomes in patients with rheumatoid arthritis and an inadequate response to anti-TNF treatment
-
22718923
-
Emery P. Optimizing outcomes in patients with rheumatoid arthritis and an inadequate response to anti-TNF treatment. Rheumatology 2012, 51:v22-v30. 10.1093/rheumatology/kes115, 22718923.
-
(2012)
Rheumatology
, vol.51
, pp. v22-v30
-
-
Emery, P.1
-
50
-
-
33746961890
-
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
-
16947627
-
Cohen SB, Emery P, Greenwald MW, Dougados M, Furie RA, Genovese MC, Keystone EC, Loveless JE, Burmester G-R, Cravets MW, Hessey EW, Shaw T, Totoritis MC. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006, 54:2793-2806. 10.1002/art.22025, 16947627.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 2793-2806
-
-
Cohen, S.B.1
Emery, P.2
Greenwald, M.W.3
Dougados, M.4
Furie, R.A.5
Genovese, M.C.6
Keystone, E.C.7
Loveless, J.E.8
Burmester, G.-R.9
Cravets, M.W.10
Hessey, E.W.11
Shaw, T.12
Totoritis, M.C.13
-
51
-
-
84871474793
-
Steroid modulation of cytokine release and desmosine levels in bilateral total knee replacement: a prospective, double-blind, randomized controlled trial
-
23097096
-
Jules-Elysee KM, Wilfred SE, Memtsoudis SG, Kim DH, YaDeau JT, Urban MK, Lichardi ML, McLawhorn AS, Sculco TP. Steroid modulation of cytokine release and desmosine levels in bilateral total knee replacement: a prospective, double-blind, randomized controlled trial. J Bone Joint Surg Am 2012, 94:2120-2127. 10.2106/JBJS.K.00995, 23097096.
-
(2012)
J Bone Joint Surg Am
, vol.94
, pp. 2120-2127
-
-
Jules-Elysee, K.M.1
Wilfred, S.E.2
Memtsoudis, S.G.3
Kim, D.H.4
YaDeau, J.T.5
Urban, M.K.6
Lichardi, M.L.7
McLawhorn, A.S.8
Sculco, T.P.9
-
52
-
-
72249122067
-
Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trials
-
19054817
-
Gaujoux-Viala C, Dougados M, Gossec L. Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trials. Ann Rheum Dis 2009, 68:1843-1849. 10.1136/ard.2008.099572, 19054817.
-
(2009)
Ann Rheum Dis
, vol.68
, pp. 1843-1849
-
-
Gaujoux-Viala, C.1
Dougados, M.2
Gossec, L.3
-
53
-
-
33744805780
-
The effect of corticosteroid on collagen expression in injured rotator cuff tendon
-
16757768
-
Wei AS, Callaci JJ, Juknelis D, Marra G, Tonino P, Freedman KB, Wezeman FH. The effect of corticosteroid on collagen expression in injured rotator cuff tendon. J Bone Joint Surg Am 2006, 88:1331-1338. 10.2106/JBJS.E.00806, 16757768.
-
(2006)
J Bone Joint Surg Am
, vol.88
, pp. 1331-1338
-
-
Wei, A.S.1
Callaci, J.J.2
Juknelis, D.3
Marra, G.4
Tonino, P.5
Freedman, K.B.6
Wezeman, F.H.7
-
54
-
-
33947716805
-
Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial
-
17371885
-
Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, van Zeben D, Kerstens PJ, Hazes JM, Zwinderman AH, Peeters AJ, de Jonge-Bok JM, Mallée C, de Beus WM, de Sonnaville PB, Ewals JA, Breedveld FC, Dijkmans BA. Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial. Ann Intern Med 2007, 146:406-415. 10.7326/0003-4819-146-6-200703200-00005, 17371885.
-
(2007)
Ann Intern Med
, vol.146
, pp. 406-415
-
-
Goekoop-Ruiterman, Y.P.1
de Vries-Bouwstra, J.K.2
Allaart, C.F.3
van Zeben, D.4
Kerstens, P.J.5
Hazes, J.M.6
Zwinderman, A.H.7
Peeters, A.J.8
de Jonge-Bok, J.M.9
Mallée, C.10
de Beus, W.M.11
de Sonnaville, P.B.12
Ewals, J.A.13
Breedveld, F.C.14
Dijkmans, B.A.15
-
55
-
-
84901839343
-
Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress
-
24721459
-
Su SC, Tanimoto K, Tanne Y, Kunimatsu R, Hirose N, Mitsuyoshi T, Okamoto Y. Celecoxib exerts protective effects on extracellular matrix metabolism of mandibular condylar chondrocytes under excessive mechanical stress. Osteoarthritis Cartilage 2014, 22:845-851. 10.1016/j.joca.2014.03.011, 24721459.
-
(2014)
Osteoarthritis Cartilage
, vol.22
, pp. 845-851
-
-
Su, S.C.1
Tanimoto, K.2
Tanne, Y.3
Kunimatsu, R.4
Hirose, N.5
Mitsuyoshi, T.6
Okamoto, Y.7
-
56
-
-
44949177577
-
Bone protective effect of simvastatin in experimental arthritis
-
18464303
-
Funk JL, Chen J, Downey KJ, Clark RA. Bone protective effect of simvastatin in experimental arthritis. J Rheumatol 2008, 35:1083-1091. 18464303.
-
(2008)
J Rheumatol
, vol.35
, pp. 1083-1091
-
-
Funk, J.L.1
Chen, J.2
Downey, K.J.3
Clark, R.A.4
-
57
-
-
84873989626
-
Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA
-
22451024
-
Xiao Y, Liang L, Pan Y, Lian F, Li L, Lin H, Fu D, Fan J, Yang X, Sun L, Xu H. Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA. Rheumatol Int 2013, 33:389-399. 10.1007/s00296-012-2383-7, 22451024.
-
(2013)
Rheumatol Int
, vol.33
, pp. 389-399
-
-
Xiao, Y.1
Liang, L.2
Pan, Y.3
Lian, F.4
Li, L.5
Lin, H.6
Fu, D.7
Fan, J.8
Yang, X.9
Sun, L.10
Xu, H.11
-
58
-
-
84880180990
-
The role of simvastatin in the therapeutic approach of rheumatoid arthritis
-
23840942
-
Cojocaru L, Rusali AC, Suta C, Radulescu AM, Suta M, Craiu E. The role of simvastatin in the therapeutic approach of rheumatoid arthritis. Autoimmune Dis 2013, 2013:326258. 23840942.
-
(2013)
Autoimmune Dis
, vol.2013
, pp. 326258
-
-
Cojocaru, L.1
Rusali, A.C.2
Suta, C.3
Radulescu, A.M.4
Suta, M.5
Craiu, E.6
-
59
-
-
79551708938
-
Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis
-
21041278
-
El-Barbary AM, Hussein MS, Rageh EM, Hamouda HE, Wagih AA, Ismail RG. Effect of atorvastatin on inflammation and modification of vascular risk factors in rheumatoid arthritis. J Rheumatol 2011, 38:229-235. 10.3899/jrheum.100582, 21041278.
-
(2011)
J Rheumatol
, vol.38
, pp. 229-235
-
-
El-Barbary, A.M.1
Hussein, M.S.2
Rageh, E.M.3
Hamouda, H.E.4
Wagih, A.A.5
Ismail, R.G.6
-
60
-
-
2942670131
-
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
-
15207950
-
McCarey DW, McInnes IB, Madhok R, Hampson R, Scherbakov O, Ford I, Capell HA, Sattar N. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial. Lancet 2004, 363:2015-2021. 10.1016/S0140-6736(04)16449-0, 15207950.
-
(2004)
Lancet
, vol.363
, pp. 2015-2021
-
-
McCarey, D.W.1
McInnes, I.B.2
Madhok, R.3
Hampson, R.4
Scherbakov, O.5
Ford, I.6
Capell, H.A.7
Sattar, N.8
-
61
-
-
84860116947
-
Statins accelerate the onset of collagen type II-induced arthritis in mice
-
22537858
-
Vandebriel RJ, De Jong HJ, Gremmer ER, Klungel OH, Tervaert JW, Slob W, Van Der Laan JW, Van Loveren H. Statins accelerate the onset of collagen type II-induced arthritis in mice. Arthritis Res Ther 2012, 14:R90. 10.1186/ar3814, 22537858.
-
(2012)
Arthritis Res Ther
, vol.14
, pp. R90
-
-
Vandebriel, R.J.1
De Jong, H.J.2
Gremmer, E.R.3
Klungel, O.H.4
Tervaert, J.W.5
Slob, W.6
Van Der Laan, J.W.7
Van Loveren, H.8
-
62
-
-
33646016282
-
Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes
-
16621994
-
Coward WR, Marei A, Yang A, Vasa-Nicotera MM, Chow SC. Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes. J Immunol 2006, 176:5284-5292. 10.4049/jimmunol.176.9.5284, 16621994.
-
(2006)
J Immunol
, vol.176
, pp. 5284-5292
-
-
Coward, W.R.1
Marei, A.2
Yang, A.3
Vasa-Nicotera, M.M.4
Chow, S.C.5
-
63
-
-
84860546691
-
Rosuvastatin might have an effect on C-reactive protein but not on rheumatoid disease activity: Tayside randomized controlled study
-
22555227
-
Kumar P, Kennedy G, Khan F, Pullar T, Belch JJ. Rosuvastatin might have an effect on C-reactive protein but not on rheumatoid disease activity: Tayside randomized controlled study. Scott Med J 2012, 57:80-83. 10.1258/smj.2012.012004, 22555227.
-
(2012)
Scott Med J
, vol.57
, pp. 80-83
-
-
Kumar, P.1
Kennedy, G.2
Khan, F.3
Pullar, T.4
Belch, J.J.5
-
64
-
-
73249146659
-
Protective effect of atorvastatin in cultured osteoarthritic chondrocytes
-
19623662
-
Simopoulou T, Malizos KN, Poultsides L, Tsezou A. Protective effect of atorvastatin in cultured osteoarthritic chondrocytes. J Orthop Res 2010, 28:110-115. 19623662.
-
(2010)
J Orthop Res
, vol.28
, pp. 110-115
-
-
Simopoulou, T.1
Malizos, K.N.2
Poultsides, L.3
Tsezou, A.4
-
65
-
-
59249095198
-
Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation
-
18672387
-
Akasaki Y, Matsuda S, Nakayama K, Fukagawa S, Miura H, Iwamoto Y. Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation. Osteoarthritis Cartilage 2009, 17:235-243. 10.1016/j.joca.2008.06.012, 18672387.
-
(2009)
Osteoarthritis Cartilage
, vol.17
, pp. 235-243
-
-
Akasaki, Y.1
Matsuda, S.2
Nakayama, K.3
Fukagawa, S.4
Miura, H.5
Iwamoto, Y.6
-
66
-
-
84860389970
-
Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3
-
21863259
-
Aktas E, Sener E, Gocun PU. Mechanically induced experimental knee osteoarthritis benefits from anti-inflammatory and immunomodulatory properties of simvastatin via inhibition of matrix metalloproteinase-3. J Orthop Traumatol 2011, 12:145-151. 10.1007/s10195-011-0154-y, 21863259.
-
(2011)
J Orthop Traumatol
, vol.12
, pp. 145-151
-
-
Aktas, E.1
Sener, E.2
Gocun, P.U.3
-
67
-
-
0027251836
-
A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
-
8347186
-
Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res 1993, 53:2087-2091. 8347186.
-
(1993)
Cancer Res
, vol.53
, pp. 2087-2091
-
-
Davies, B.1
Brown, P.D.2
East, N.3
Crimmin, M.J.4
Balkwill, F.R.5
-
68
-
-
0028124522
-
Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor
-
8077060
-
Naito K, Kanbayashi N, Nakajima S, Murai T, Arakawa K, Nishimura S, Okuyama A. Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor. Int J Cancer 1994, 58:730-735. 10.1002/ijc.2910580518, 8077060.
-
(1994)
Int J Cancer
, vol.58
, pp. 730-735
-
-
Naito, K.1
Kanbayashi, N.2
Nakajima, S.3
Murai, T.4
Arakawa, K.5
Nishimura, S.6
Okuyama, A.7
-
69
-
-
0028129494
-
Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth
-
8062280
-
Koop S, Khokha R, Schmidt EE, MacDonald IC, Morris VL, Chambers AF, Groom AC. Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. Cancer Res 1994, 54:4791-4797. 8062280.
-
(1994)
Cancer Res
, vol.54
, pp. 4791-4797
-
-
Koop, S.1
Khokha, R.2
Schmidt, E.E.3
MacDonald, I.C.4
Morris, V.L.5
Chambers, A.F.6
Groom, A.C.7
-
70
-
-
0027994031
-
Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice
-
8062271
-
Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM. Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 1994, 54:4726-4728. 8062271.
-
(1994)
Cancer Res
, vol.54
, pp. 4726-4728
-
-
Wang, X.1
Fu, X.2
Brown, P.D.3
Crimmin, M.J.4
Hoffman, R.M.5
-
71
-
-
0027956746
-
Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide
-
7520359
-
Galardy RE, Grobelny D, Foellmer HG, Fernandez LA. Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. Cancer Res 1994, 54:4715-4718. 7520359.
-
(1994)
Cancer Res
, vol.54
, pp. 4715-4718
-
-
Galardy, R.E.1
Grobelny, D.2
Foellmer, H.G.3
Fernandez, L.A.4
-
72
-
-
0028129059
-
Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor
-
8050828
-
Chirivi RG, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R. Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 1994, 58:460-464. 10.1002/ijc.2910580326, 8050828.
-
(1994)
Int J Cancer
, vol.58
, pp. 460-464
-
-
Chirivi, R.G.1
Garofalo, A.2
Crimmin, M.J.3
Bawden, L.J.4
Stoppacciaro, A.5
Brown, P.D.6
Giavazzi, R.7
-
73
-
-
33749189084
-
Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status
-
16639492
-
Groves MD, Puduvalli VK, Conrad CA, Gilbert MR, Yung WK, Jaeckle K, Liu V, Hess KR, Aldape KD, Levin VA. Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status. J Neurooncol 2006, 80:83-90. 10.1007/s11060-006-9160-y, 16639492.
-
(2006)
J Neurooncol
, vol.80
, pp. 83-90
-
-
Groves, M.D.1
Puduvalli, V.K.2
Conrad, C.A.3
Gilbert, M.R.4
Yung, W.K.5
Jaeckle, K.6
Liu, V.7
Hess, K.R.8
Aldape, K.D.9
Levin, V.A.10
-
74
-
-
0036668663
-
A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer
-
12181245
-
Miller KD, Gradishar W, Schuchter L, Sparano JA, Cobleigh M, Robert N, Rasmussen H, Sledge GW. A randomized phase II pilot trial of adjuvant marimastat in patients with early-stage breast cancer. Ann Oncol 2002, 13:1220-1224. 10.1093/annonc/mdf199, 12181245.
-
(2002)
Ann Oncol
, vol.13
, pp. 1220-1224
-
-
Miller, K.D.1
Gradishar, W.2
Schuchter, L.3
Sparano, J.A.4
Cobleigh, M.5
Robert, N.6
Rasmussen, H.7
Sledge, G.W.8
-
75
-
-
12144287866
-
A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancer
-
15041714
-
Miller KD, Saphner TJ, Waterhouse DM, Chen TT, Rush-Taylor A, Sparano JA, Wolff AC, Cobleigh MA, Galbraith S, Sledge GW. A randomized phase II feasibility trial of BMS-275291 in patients with early stage breast cancer. Clin Cancer Res 2004, 10:1971-1975. 10.1158/1078-0432.CCR-03-0968, 15041714.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1971-1975
-
-
Miller, K.D.1
Saphner, T.J.2
Waterhouse, D.M.3
Chen, T.T.4
Rush-Taylor, A.5
Sparano, J.A.6
Wolff, A.C.7
Cobleigh, M.A.8
Galbraith, S.9
Sledge, G.W.10
-
76
-
-
34250630512
-
A phase II and pharmacological study of the matrix metalloproteinase inhibitor (MMPI) COL-3 in patients with advanced soft tissue sarcomas
-
17237909
-
Chu QS, Forouzesh B, Syed S, Mita M, Schwartz G, Cooper J, Curtright J, Rowinsky EK. A phase II and pharmacological study of the matrix metalloproteinase inhibitor (MMPI) COL-3 in patients with advanced soft tissue sarcomas. Invest New Drugs 2007, 25:359-367. 10.1007/s10637-006-9031-6, 17237909.
-
(2007)
Invest New Drugs
, vol.25
, pp. 359-367
-
-
Chu, Q.S.1
Forouzesh, B.2
Syed, S.3
Mita, M.4
Schwartz, G.5
Cooper, J.6
Curtright, J.7
Rowinsky, E.K.8
-
77
-
-
30744471132
-
Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation
-
16393953
-
Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. J Immunol 2006, 176:721-725. 10.4049/jimmunol.176.2.721, 16393953.
-
(2006)
J Immunol
, vol.176
, pp. 721-725
-
-
Smookler, D.S.1
Mohammed, F.F.2
Kassiri, Z.3
Duncan, G.S.4
Mak, T.W.5
Khokha, R.6
-
78
-
-
19544382895
-
Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis
-
15920158
-
Mahmoodi M, Sahebjam S, Smookler D, Khokha R, Mort JS. Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis. Am J Pathol 2005, 166:1733-1740. 10.1016/S0002-9440(10)62483-2, 15920158.
-
(2005)
Am J Pathol
, vol.166
, pp. 1733-1740
-
-
Mahmoodi, M.1
Sahebjam, S.2
Smookler, D.3
Khokha, R.4
Mort, J.S.5
-
79
-
-
33947175117
-
Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice
-
17328064
-
Sahebjam S, Khokha R, Mort JS. Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice. Arthritis Rheum 2007, 56:905-909. 10.1002/art.22427, 17328064.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 905-909
-
-
Sahebjam, S.1
Khokha, R.2
Mort, J.S.3
-
80
-
-
0035918309
-
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)
-
11278243
-
Kashiwagi M, Tortorella M, Nagase H, Brew K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem 2001, 276:12501-12504. 10.1074/jbc.C000848200, 11278243.
-
(2001)
J Biol Chem
, vol.276
, pp. 12501-12504
-
-
Kashiwagi, M.1
Tortorella, M.2
Nagase, H.3
Brew, K.4
-
81
-
-
70449722891
-
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
-
19643179
-
Troeberg L, Fushimi K, Scilabra SD, Nakamura H, Dive V, Thogersen IB, Enghild JJ, Nagase H. The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Matrix Biol 2009, 28:463-469. 10.1016/j.matbio.2009.07.005, 19643179.
-
(2009)
Matrix Biol
, vol.28
, pp. 463-469
-
-
Troeberg, L.1
Fushimi, K.2
Scilabra, S.D.3
Nakamura, H.4
Dive, V.5
Thogersen, I.B.6
Enghild, J.J.7
Nagase, H.8
-
82
-
-
77956644315
-
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
-
20645923
-
Lim NH, Kashiwagi M, Visse R, Jones J, Enghild JJ, Brew K, Nagase H. Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications. Biochem J 2010, 431:113-122. 10.1042/BJ20100725, 20645923.
-
(2010)
Biochem J
, vol.431
, pp. 113-122
-
-
Lim, N.H.1
Kashiwagi, M.2
Visse, R.3
Jones, J.4
Enghild, J.J.5
Brew, K.6
Nagase, H.7
-
83
-
-
0035846124
-
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors
-
11585439
-
Yao W, Wasserman ZR, Chao M, Reddy G, Shi E, Liu RQ, Covington MB, Arner EC, Pratta MA, Tortorella M, Magolda RL, Newton R, Qian M, Ribadeneira MD, Christ D, Wexler RR, Decicco CP. Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors. J Med Chem 2001, 44:3347-3350. 10.1021/jm015533c, 11585439.
-
(2001)
J Med Chem
, vol.44
, pp. 3347-3350
-
-
Yao, W.1
Wasserman, Z.R.2
Chao, M.3
Reddy, G.4
Shi, E.5
Liu, R.Q.6
Covington, M.B.7
Arner, E.C.8
Pratta, M.A.9
Tortorella, M.10
Magolda, R.L.11
Newton, R.12
Qian, M.13
Ribadeneira, M.D.14
Christ, D.15
Wexler, R.R.16
Decicco, C.P.17
-
84
-
-
69949136769
-
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
-
19586907
-
Tortorella MD, Tomasselli AG, Mathis KJ, Schnute ME, Woodard SS, Munie G, Williams JM, Caspers N, Wittwer AJ, Malfait A-M, Shieh H-S. Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors. J Biol Chem 2009, 284:24185-24191. 10.1074/jbc.M109.029116, 19586907.
-
(2009)
J Biol Chem
, vol.284
, pp. 24185-24191
-
-
Tortorella, M.D.1
Tomasselli, A.G.2
Mathis, K.J.3
Schnute, M.E.4
Woodard, S.S.5
Munie, G.6
Williams, J.M.7
Caspers, N.8
Wittwer, A.J.9
Malfait, A.-M.10
Shieh, H.-S.11
-
85
-
-
79956096421
-
Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis
-
21536437
-
De Savi C, Pape A, Sawyer Y, Milne D, Davies C, Cumming JG, Ting A, Lamont S, Smith PD, Tart J, Page K, Moore P. Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis. Bioorg Med Chem Lett 2011, 21:3301-3306. 10.1016/j.bmcl.2011.04.028, 21536437.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 3301-3306
-
-
De Savi, C.1
Pape, A.2
Sawyer, Y.3
Milne, D.4
Davies, C.5
Cumming, J.G.6
Ting, A.7
Lamont, S.8
Smith, P.D.9
Tart, J.10
Page, K.11
Moore, P.12
-
86
-
-
77957877525
-
New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold
-
20846863
-
Maingot L, Leroux F, Landry V, Dumont J, Nagase H, Villoutreix B, Sperandio O, Deprez-Poulain R, Deprez B. New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold. Bioorg Med Chem Lett 2010, 20:6213-6216. 10.1016/j.bmcl.2010.08.108, 20846863.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 6213-6216
-
-
Maingot, L.1
Leroux, F.2
Landry, V.3
Dumont, J.4
Nagase, H.5
Villoutreix, B.6
Sperandio, O.7
Deprez-Poulain, R.8
Deprez, B.9
-
87
-
-
56249124956
-
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)
-
18974001
-
Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg Med Chem Lett 2008, 18:6454-6457. 10.1016/j.bmcl.2008.10.065, 18974001.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 6454-6457
-
-
Gilbert, A.M.1
Bursavich, M.G.2
Lombardi, S.3
Georgiadis, K.E.4
Reifenberg, E.5
Flannery, C.R.6
Morris, E.A.7
-
88
-
-
33846896972
-
5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5
-
17210252
-
Gilbert AM, Bursavich MG, Lombardi S, Georgiadis KE, Reifenberg E, Flannery CR, Morris EA. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett 2007, 17:1189-1192. 10.1016/j.bmcl.2006.12.020, 17210252.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1189-1192
-
-
Gilbert, A.M.1
Bursavich, M.G.2
Lombardi, S.3
Georgiadis, K.E.4
Reifenberg, E.5
Flannery, C.R.6
Morris, E.A.7
-
89
-
-
79960371941
-
Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors
-
21733683
-
Peng L, Duan L, Liu X, Shen M, Li Y, Yan J, Li H, Ding K. Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors. Bioorg Med Chem Lett 2011, 21:4457-4461. 10.1016/j.bmcl.2011.06.009, 21733683.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 4457-4461
-
-
Peng, L.1
Duan, L.2
Liu, X.3
Shen, M.4
Li, Y.5
Yan, J.6
Li, H.7
Ding, K.8
-
90
-
-
71749093118
-
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors
-
19767207
-
Shiozaki M, Imai H, Maeda K, Miura T, Yasue K, Suma A, Yokota M, Ogoshi Y, Haas J, Fryer AM, Laird ER, Littman NM, Andrews SW, Josey JA, Mimura T, Shinozaki Y, Yoshiuchi H, Inaba T. Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors. Bioorg Med Chem Lett 2009, 19:6213-6217. 10.1016/j.bmcl.2009.08.093, 19767207.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 6213-6217
-
-
Shiozaki, M.1
Imai, H.2
Maeda, K.3
Miura, T.4
Yasue, K.5
Suma, A.6
Yokota, M.7
Ogoshi, Y.8
Haas, J.9
Fryer, A.M.10
Laird, E.R.11
Littman, N.M.12
Andrews, S.W.13
Josey, J.A.14
Mimura, T.15
Shinozaki, Y.16
Yoshiuchi, H.17
Inaba, T.18
-
91
-
-
84866910785
-
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT)
-
22891645
-
Deng H, O'Keefe H, Davie CP, Lind KE, Acharya RA, Franklin GJ, Larkin J, Matico R, Neeb M, Thompson MM, Lohr T, Gross JW, Centrella PA, O'Donovan GK, Bedard KL, van Vloten K, Mataruse S, Skinner SR, Belyanskaya SL, Carpenter TY, Shearer TW, Clark MA, Cuozzo JW, Arico-Muendel CC, Morgan BA. Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT). J Med Chem 2012, 55:7061-7079. 10.1021/jm300449x, 22891645.
-
(2012)
J Med Chem
, vol.55
, pp. 7061-7079
-
-
Deng, H.1
O'Keefe, H.2
Davie, C.P.3
Lind, K.E.4
Acharya, R.A.5
Franklin, G.J.6
Larkin, J.7
Matico, R.8
Neeb, M.9
Thompson, M.M.10
Lohr, T.11
Gross, J.W.12
Centrella, P.A.13
O'Donovan, G.K.14
Bedard, K.L.15
van Vloten, K.16
Mataruse, S.17
Skinner, S.R.18
Belyanskaya, S.L.19
Carpenter, T.Y.20
Shearer, T.W.21
Clark, M.A.22
Cuozzo, J.W.23
Arico-Muendel, C.C.24
Morgan, B.A.25
more..
-
92
-
-
84884975754
-
Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis
-
23954517
-
Chiusaroli R, Visentini M, Galimberti C, Casseler C, Mennuni L, Covaceuszach S, Lanza M, Ugolini G, Caselli G, Rovati LC, Visintin M. Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis. Osteoarthritis Cartilage 2013, 21:1807-1810. 10.1016/j.joca.2013.08.015, 23954517.
-
(2013)
Osteoarthritis Cartilage
, vol.21
, pp. 1807-1810
-
-
Chiusaroli, R.1
Visentini, M.2
Galimberti, C.3
Casseler, C.4
Mennuni, L.5
Covaceuszach, S.6
Lanza, M.7
Ugolini, G.8
Caselli, G.9
Rovati, L.C.10
Visintin, M.11
|