Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24185-24191

  Tortorella, Micky D ^a   Tomasselli, Alfredo G ^a   Mathis, Karl J ^a   Schnute, Mark E ^a   Woodard, Scott S ^a   Munie, Grace ^a   Williams, Jennifer M ^a   Caspers, Nicole ^a   Wittwer, Arthur J ^a   Malfait, Anne Marie ^a   Shieh, Huey Sheng ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROAD SPECTRUM; CATALYTIC DOMAINS; CHARGE INTERACTIONS; HYDROGEN BONDINGS; INDANOL; INDIRECT FACTORS; METALLOPROTEASE INHIBITORS; METALLOPROTEASES; PROTEIN CONFORMATION; SPECIFIC INTERACTION;

AMINES; HYDROGEN; ZINC;

HYDROGEN BONDS;

ADAM WITH THROMPOSPONDIN MOTIF 5; AGGRECANASE INHIBITOR; MARIMASTAT; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHELATION; CONTROLLED STUDY; COW; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; ANIMALS; CATTLE; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; PROCOLLAGEN N-ENDOPEPTIDASE; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN; ZINC;

EID: 69949136769     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.029116     Document Type: Article

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