ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

Arthritis and Rheumatism

Volumn 52, Issue 5, 2005, Pages 1461-1472

  Little, Chris B ^a,b   Mittaz, Laureane ^c   Belluoccio, Daniele ^b   Rogerson, Fraser M ^b   Campbell, Ian K ^d   Meeker, Clare T ^b   Bateman, John F ^b   Pritchard, Melanie A ^c   Fosang, Amanda J ^b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADAMTS 1 PROTEIN; AGGRECAN; AGGRECANASE; ANTIGEN; GLYCOSAMINOGLYCAN; INTERLEUKIN 1; PROTEINASE; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ADAMTS1 GENE; ADAMTS4 GENE; ADAMTS5 GENE; ADAMTS9 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN INDUCED ARTHRITIS; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; BINDING SITE; BONE DEVELOPMENT; BONE GROWTH; BONE MATURATION; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE MODEL; FEMUR HEAD; GENE; GENE EXPRESSION; GENOTYPE; GROWTH PLATE; HISTOLOGY; HYPERTROPHY; IMMUNOBLOTTING; IMMUNOHISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; QUANTITATIVE ANALYSIS; REAL TIME REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; STATISTICAL SIGNIFICANCE; SYNOVITIS; UPREGULATION; WESTERN BLOTTING;

ADAM PROTEINS; AGGRECANS; ANIMALS; ARTHRITIS; BONE DEVELOPMENT; CARTILAGE; DISINTEGRINS; EXTRACELLULAR MATRIX PROTEINS; GROWTH PLATE; JOINTS; LECTINS, C-TYPE; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; PROTEOGLYCANS;

EID: 18644369778     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21022     Document Type: Article

References (60)

1. Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, et al. Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 2003;278:45539-45.
2. Caterson B, Flannery CR, Hughes CE, Little CB. Mechanisms involved in cartilage proteoglycan catabolism [review]. Matrix Biol 2000;19:333-44.
3. Fosang AJ, Stanton H, Little CB, Alley LM. Neoepitopes as biomarkers of cartilage catabolism. Inflamm Res 2003;52:277-82.
4. Lee ER, Lamplugh L, Leblond CP, Mordier S, Magny MC, Mort JS. Immunolocalization of the cleavage of the aggrecan core protein at the Asn341-Phe342 bond, as an indicator of the location of the metalloproteinases active in the lysis of the rat growth plate. Anat Rec 1998;252:117-32.
5. Lee ER, Lamplugh L, Davoli MA, Beauchemin A, Chan K, Mort JS, et al. Enzymes active in the areas undergoing cartilage resorption during the development of the secondary ossification center in the tibiae of rats ages 0-21 days. I. Two groups of proteinases cleave the core protein of aggrecan. Dev Dyn 2001;222:52-70.
6. Mort JS, Flannery CR, Makkerh J, Krupa JC, Lee ER. Use of anti-neoepitope antibodies for the analysis of degradative events in cartilage and the molecular basis for neoepitope specificity [review]. Biochem Soc Symp 2003;70:107-14.
7. Rodriguez-Manzaneque JC, Westling J, Thai SN, Luque A, Knauper V, Murphy G, et al. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem Biophys Res Commun 2002;293:501-8.
8. Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, et al. Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 1999;284:1664-6.
9. Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, et al. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem 1999;274:23443-50.
10. Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko S, et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem 2003;278:9503-13.
11. Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, et al. Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum 2004;50:131-41.
12. Collins-Racie LA, Flannery CR, Zeng W, Corcoran C, Annis-Freeman B, Agostino MJ, et al. ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. Matrix Biol 2004;23:219-30.
13. Yamaji N, Nishimura K, Abe K, Ohara O, Nagase T, Nomura N, inventors. Novel metalloproteinase having aggrecanase activity. European Patent 00974894.8. 2000.
14. Flannery CR, Little CB, Hughes CE, Caterson B. Expression of ADAMTS homologues in articular cartilage. Biochem Biophys Res Commun 1999;260:318-22.
15. Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T. Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro. Arthritis Rheum 2002;46:2648-57.
16. Wachsmuth L, Bau B, Fan Z, Pecht A, Gerwin N, Aigner T. ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1β. J Rheumatol 2004;31:315-20.
17. Malfait AM, Liu RQ, Ijiri K, Komiya S, Tortorella MD. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem 2002;277:22201-8.
18. Gao G, Westling J, Thompson VP, Howell TD, Gottschall PE, Sandy JD. Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation. J Biol Chem 2002;277:11034-41.
19. Makihira S, Yan W, Murakami H, Furukawa M, Kawai T, Nikawa H, et al. Thyroid hormone enhances aggrecanase-2/ADAM-TS5 expression and proteoglycan degradation in growth plate cartilage. Endocrinology 2003;144:2480-8.
20. Thai SN, Iruela-Arispe ML. Expression of ADAMTS1 during murine development. Mech Dev 2002;115:181-5.
21. Miles RR, Sluka JP, Halladay DL, Santerre RF, Hale LV, Bloem L, et al. ADAMTS-1: a cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone. Endocrinology 2000;141:4533-42.
22. Glasson SS, Askew R, Sheppard B, Carito BA, Blanchet T, Ma HL, et al. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 2004;50:2547-58.
23. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, et al. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. J Clin Invest 2000;105:1345-52.
24. Yokoyama H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, et al. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. Nephrol Dial Transplant 2002;17 Suppl 9:39-41.
25. Mittaz L, Russell DL, Wilson T, Brasted M, Tkalcevic J, Salamonsen LA, et al. Adamts-1 is essential for the development and function of the urogenital system. Biol Reprod 2004;70:1096-105.
26. Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombarde M, et al. METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J Biol Chem 1999;274:23349-57.
27. Voros G, Maquoi E, Collen D, Lijnen HR. Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-α, TNF-α converting enzyme and ADAMTS family members in murine fat territories. Biochim Biophys Acta 2003;1625:36-42.
28. Robker RL, Russell DL, Espey LL, Lydon JP, O'Malley BW, Richards JS. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci USA 2000;97:4689-94.
29. Mendell JT, Sharifi NA, Meyers JL, Martinez-Murillo F, Dietz HC. Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise [published erratum appears in Nat Genet 2004;36:1238]. Nat Genet 2004;36:1073-8.
30. Pfaffl M. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:2002-7.
31. Little C, Smith S, Ghosh P, Bellenger C. Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep. J Rheumatol 1997;24:2199-209.
32. Brackertz D, Mitchell GF, Mackay IR. Antigen-induced arthritis in mice. I. Induction of arthritis in various strains of mice. Arthritis Rheum 1977;20:841-50.
33. Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, et al. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro. Biochem J 1999;344:61-8.
34. Mercuri FA, Doege KJ, Arner EC, Pratta MA, Last K, Fosang AJ. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase. J Biol Chem 1999;274:32387-95.
35. Christner JE, Caterson B, Baker JR. Immunological determinants of proteoglycans: antibodies against the unsaturated oligosaccharide products of chondroitinase ABC-digested cartilage proteoglycans. J Biol Chem 1980;255:7102-5.
36. Caterson B, Baker JR, Christner JE, Lee Y, Lentz M. Monoclonal antibodies as probes for determining the microheterogeneity of the link proteins of cartilage proteoglycan. J Biol Chem 1985;260:11348-56.
37. Otterness IG, Downs JT, Lane C, Bliven ML, Stukenbrok H, Scampoli DN, et al. Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody. Matrix Biol 1999;18:331-41.
38. Dew G, Murphy G, Stanton H, Vallon R, Angel P, Reynolds JJ, et al. Localisation of matrix metalloproteinases and TIMP-2 in resorbing mouse bone. Cell Tissue Res 2000;299:385-94.
39. Van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, van den Berg WB. Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis. Arthritis Rheum 1999;42:1128-39.
40. Mort JS, Magny MC, Lee ER. Cathepsin B: an alternative protease for the generation of an aggrecan 'metalloproteinase' cleavage neoepitope. Biochem J 1998;335:491-4.
41. Oshita H, Sandy JD, Suzuki K, Akaike A, Bai Y, Sasaki T, et al. Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain. Biochem J 2004;382:253-9.
42. Kronenberg HM. Developmental regulation of the growth plate [review]. Nature 2003;423:332-6.
43. Kuno K, Terashima Y, Matsushima K. ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix. J Biol Chem 1999;274:18821-6.
44. Kuno K, Okada Y, Kawashima H, Nakamura H, Miyasaka M, Ohno H, et al. ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS Lett 2000;478:241-5.
45. Luque A, Carpizo DR, Iruela-Arispe ML. ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem 2003;278:23656-65.
46. Iruela-Arispe ML, Carpizo D, Luque A. ADAMTS1: a matrix metalloprotease with angioinhibitory properties [review]. Ann N Y Acad Sci 2003;995:183-90.
47. Dickinson SC, Vankemmelbeke MN, Buttle DJ, Rosenberg K, Heinegard D, Hollander AP. Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs. Matrix Biol 2003;22:267-78.
48. Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, et al. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing [published erratum appears in J Biol Chem 2004;279:22786]. J Biol Chem 2004;279:10109-19.
49. Tortorella MD, Liu RQ, Burn T, Newton RC, Arner E. Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4). Matrix Biol 2002;21:499-511.
50. Tortorella MD, Pratta M, Liu RQ, Austin J, Ross OH, Abbaszade I, et al. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4). J Biol Chem 2000;275:18566-73.
51. Tortorella MD, Malfait AM, Deccico C, Arner E. The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation [published erratum appears in Osteoarthritis Cartilage 2002;10:82]. Osteoarthritis Cartilage 2001;9:539-52.
52. Fosang AJ, Tyler JA, Hardingham TE. Effect of interleukin-1 and insulin like growth factor-1 on the release of proteoglycan components and hyaluronan from pig articular cartilage in explant culture. Matrix 1991;11:17-24.
53. Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, et al. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biol 2002;21:271-88.
54. Sztrolovics R, White RJ, Roughley PJ, Mort JS. The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism. Biochem J 2002;362:465-72.
55. Sztrolovics R, Recklies AD, Roughley PJ, Mort JS. Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1β-stimulated catabolism. Biochem J 2002;362:473-9.
56. Hughes CE, Little CB, Buttner FH, Bartnik E, Caterson B. Differential expression of aggrecanase and matrix metalloproteinase activity in chondrocytes isolated from bovine and porcine articular cartilage. J Biol Chem 1998;273:30576-82.
57. Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, et al. Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids. Arthritis Rheum 2002;46:1544-53.
58. Fosang AJ, Last K, Stanton H, Weeks DB, Campbell IK, Hardingham TE, et al. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants. J Biol Chem 2000;275:33027-37.
59. Jimenez MJ, Balbin M, Alvarez J, Komori T, Bianco P, Holmbeck K, et al. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol 2001;155:1333-44.
60. Balbin M, Fueyo A, Knauper V, Lopez JM, Alvarez J, Sanchez LM, et al. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem 2001;276:10253-62.