Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 21, 2009, Pages 6213-6217

  Shiozaki, Makoto ^a   Imai, Hiroto ^a   Maeda, Katsuya ^a   Miura, Tomoya ^a   Yasue, Katsutaka ^a   Suma, Akira ^a   Yokota, Masahiro ^a   Ogoshi, Yosuke ^a   Haas, Julia ^b   Fryer, Andrew M ^b   Laird, Ellen R ^b   Littmann, Nicole M ^b   Andrews, Steven W ^b   Josey, John A ^b   Mimura, Takayuki ^a   Shinozaki, Yuichi ^a   Yoshiuchi, Hiromi ^a   Inaba, Takashi ^a  

^a JAPAN TOBACCO INC   (Japan)

^b ARRAY BIOPHARMA INC   (United States)

Author keywords

2 Phenyl 1 sulfonylaminocyclopropanecarboxylates; ADAMTS 5 (Aggrecanase 2) inhibitors; SAR

Indexed keywords

2 PHENYL 1 SULFONYLAMINOCYCLOPROPANE CARBOXYLATE; AGGRECANASE INHIBITOR; ANTIINFLAMMATORY AGENT; CYCLOPROPANECARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADAM PROTEINS; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CYCLOPROPANES; DRUG DESIGN; HUMANS; PROTEASE INHIBITORS; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 71749093118     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.093     Document Type: Article

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