New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 21, 2010, Pages 6213-6216

  Maingot, Lucie ^a,b,c   Leroux, Florence ^a,b,c,d   Landry, Valérie ^a,b,c   Dumont, Julie ^a,b,c   Nagase, Hideaki ^f   Villoutreix, Bruno ^d,e   Sperandio, Olivier ^d,e   Deprez Poulain, Rebecca ^a,b   Deprez, Benoit ^a,b,c,d  

^a UNIV LILLE   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c PRIM   (France)

^d CDithem Platform/IGM   (France)

^e INSERM   (France)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

1,2,4 Triazol 3 thiol; ADAMTS 5; Metalloprotease; Triazol 5 thiol

Indexed keywords

1,2,4 OXADIAZOLE DERIVATIVE; 1,2,4 TRIAZOLE 3 THIOL DERIVATIVE; 3 (N IMIDAZOLYL)PROPYL DERIVATIVE; AGGRECANASE 2; AGGRECANASE 2 INHIBITOR; IMIDAZOLE DERIVATIVE; METALLOPROTEINASE INHIBITOR; MOLECULAR SCAFFOLD; THIOL DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ZINC BINDING PROTEIN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIZATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN STRUCTURE;

ADAM PROTEINS; BINDING SITES; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; OSTEOARTHRITIS; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; X-RAY DIFFRACTION;

EID: 77957877525     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.108     Document Type: Article

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