Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines

Journal of Orthopaedic Research

Volumn 30, Issue 2, 2012, Pages 226-233

  Wylie, James D ^a   Ho, Jason C ^a   Singh, Shweta ^a   McCulloch, Daniel R ^b,c   Apte, Suneel S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b DEAKIN UNIVERSITY   (Australia)

^c Molecular and Medical Research Strategic Research Center   (Australia)

Author keywords

ADAMTS; aggrecanase; arthritis; cartilage; metalloprotease

Indexed keywords

AGGRECAN; AGGRECANASE 2; BETA GALACTOSIDASE; BINDING PROTEIN; CYTOKINE; FURIN; INTERLEUKIN 1ALPHA; MESSENGER RNA; PROTEIN PACE4; PROTEOGLYCAN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VERSICAN;

ADAMTS5 GENE; ALLELE; ANIMAL TISSUE; ARTHRITIS; ARTICLE; ARTICULAR CARTILAGE; BONE MARROW; CARTILAGE DEGENERATION; CELL TYPE; CONTROLLED STUDY; EX VIVO STUDY; EXPLANT; FEMUR; GENE; GENE EXPRESSION; GENE INDUCTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KNEE; LACZ GENE; LIGAMENT; MALE; MOUSE; MUSCULOSKELETAL SYSTEM; NONHUMAN; PATELLA; PATHOPHYSIOLOGY; PERIOSTEUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CLEAVAGE; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; SYNOVIUM; TENDON; TIBIA; VALIDATION PROCESS; WILD TYPE;

ADAM PROTEINS; ANIMALS; ARTHRITIS; BONE AND BONES; FURIN; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1ALPHA; KNEE JOINT; MALE; MICE; MICE, INBRED C57BL; PROPROTEIN CONVERTASES; PROTEOGLYCANS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 83855165792     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21508     Document Type: Article

References (33)

1. Abbaszade I, Liu RQ, Yang F, et al. 1999. Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem 274: 23443-23450.
2. Longpre JM, McCulloch DR, Koo BH, et al. 2009. Characterization of proADAMTS5 processing by proprotein convertases. Int J Biochem Cell Biol 41: 1116-1126.
3. Kiani C, Chen L, Wu YJ, et al. 2002. Structure and function of aggrecan. Cell Res 12: 19-32. (Pubitemid 135708300)
4. Hall BK, Miyake T,. 1995. Divide, accumulate, differentiate: Cell condensation in skeletal development revisited. Int J Dev Biol 39: 881-893. (Pubitemid 26097613)
5. Glasson SS, Askew R, Sheppard B, et al. 2005. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434: 644-648. (Pubitemid 40488556)
6. Stanton H, Rogerson FM, East CJ, et al. 2005. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434: 648-652. (Pubitemid 40488557)
7. Little CB, Meeker CT, Golub SB, et al. 2007. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest 117: 1627-1636. (Pubitemid 46871347)
8. Malfait AM, Arner EC, Song RH, et al. 2008. Proprotein convertase activation of aggrecanases in cartilage in situ. Arch Biochem Biophys 478: 43-51.
9. Gendron C, Kashiwagi M, Lim NH, et al. 2007. Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4. J Biol Chem 282: 18294-18306. (Pubitemid 47100219)
10. Li J, Anemaet W, Diaz MA, et al. 2011. Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthopaed Res 29: 516-522.
11. Flannery CR, Little CB, Hughes CE, et al. 1999. Expression of ADAMTS homologues in articular cartilage. Biochem Biophys Res Commun 260: 318-322. (Pubitemid 29353255)
12. -/- mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes. Osteoarthritis Cartilage 17: 636-645.
13. McCulloch DR, Le Goff C, Bhatt S, et al. 2009. Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues. Gene Expr Patterns 9: 314-323.
14. Livak KJ, Schmittgen TD,. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25: 402-408. (Pubitemid 34164012)
15. Kopp HG, Hooper AT, Shmelkov SV, et al. 2007. Beta-galactosidase staining on bone marrow. The osteoclast pitfall. Histol Histopathol 22: 971-976. (Pubitemid 47034162)
16. Brachtendorf G, Kuhn A, Samulowitz U, et al. 2001. Early expression of endomucin on endothelium of the mouse embryo and on putative hematopoietic clusters in the dorsal aorta. Dev Dyn 222: 410-419. (Pubitemid 33042140)
17. Plaas A, Sandy JD, Liu H, et al. 2011. Biochemical identification and immunolocalizaton of aggrecan, ADAMTS5 and inter-alpha-trypsin-inhibitor in equine degenerative suspensory ligament desmitis. J Orthopaed Res 29: 900-906.
18. Rees SG, Dent CM, Caterson B,. 2009. Metabolism of proteoglycans in tendon. Scand J Med Sci Sports 19: 470-478.
19. Rees SG, Flannery CR, Little CB, et al. 2000. Catabolism of aggrecan, decorin and biglycan in tendon. Biochem J 350 (Pt 1): 181-188.
20. Samiric T, Ilic MZ, Handley CJ,. 2004. Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon. Matrix Biol 23: 127-140. (Pubitemid 38891526)
21. Froimson MI, Ratcliffe A, Gardner TR, et al. 1997. Differences in patellofemoral joint cartilage material properties and their significance to the etiology of cartilage surface fibrillation. Osteoarthritis Cartilage 5: 377-386. (Pubitemid 27522757)
22. Kamm JL, Nixon AJ, Witte TH,. 2010. Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi. Equine Vet J 42: 693-699.
23. Lee JH, Fitzgerald JB, DiMicco MA, et al. 2009. Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. Arch Biochem Biophys 489: 118-126.
24. Vankemmelbeke MN, Holen I, Wilson AG, et al. 2001. Expression and activity of ADAMTS-5 in synovium. Eur J Biochem 268: 1259-1268. (Pubitemid 32231878)
25. Dodge GR, Diaz A, Sanz-Rodriguez C, et al. 1998. Effects of interferon-gamma and tumor necrosis factor alpha on the expression of the genes encoding aggrecan, biglycan, and decorin core proteins in cultured human chondrocytes. Arthritis Rheum 41: 274-283. (Pubitemid 28087695)
26. Sun L, Wang X, Kaplan DL,. 2011. A 3D cartilage-inflammatory cell culture system for the modeling of human osteoarthritis. Biomaterials 32: 5581-5589.
27. Plaimauer B, Mohr G, Wernhart W, et al. 2001. 'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus. Biochem J 354: 689-695. (Pubitemid 32269733)
28. Mains RE, Berard CA, Denault JB, et al. 1997. PACE4: a subtilisin-like endoprotease with unique properties. Biochem J 321 (Pt 3): 587-593. (Pubitemid 27084863)
29. Longpre JM, Leduc R,. 2004. Identification of prodomain determinants involved in ADAMTS-1 biosynthesis. J Biol Chem 279: 33237-33245. (Pubitemid 39062970)
30. Somerville RP, Longpre JM, Jungers KA, et al. 2003. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem 278: 9503-9513. (Pubitemid 36800443)
31. Tortorella MD, Arner EC, Hills R, et al. 2005. ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms. Arch Biochem Biophys 444: 34-44. (Pubitemid 41642983)
32. Little CB, Mittaz L, Belluoccio D, et al. 2005. ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis Rheum 52: 1461-1472. (Pubitemid 40663938)
33. Glasson SS, Askew R, Sheppard B, et al. 2004. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Arthritis Rheum 50: 2547-2558. (Pubitemid 39062716)