N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6454-6457

  Gilbert, Adam M ^a   Bursavich, Matthew G ^a   Lombardi, Sabrina ^a   Georgiadis, Katy E ^b   Reifenberg, Erica ^b   Flannery, Carl R ^b   Morris, Elisabeth A ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

ADAMTS 4; ADAMTS 5; Aggrecanase 1; Aggrecanase 2; Metalloproteases; Osteoarthritis

Indexed keywords

ACETAMIDE DERIVATIVE; AGGRECANASE; AMINE; BENZENE DERIVATIVE; COLLAGENASE 3; CYTOCHROME P450 3A4; DISEASE MODIFYING ANTIRHEUMATIC DRUG; MACROPHAGE ELASTASE; PROTEIN ADAMTS 4; PROTEIN ADAMTS 5; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ADAM PROTEINS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; MODELS, CHEMICAL; OSTEOARTHRITIS; PROCOLLAGEN N-ENDOPEPTIDASE; RATS;

RATTUS;

EID: 56249124956     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.065     Document Type: Article

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