Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: Pharmacologic and clinical significance

Life Sciences

Volumn 91, Issue 7-8, 2012, Pages 250-257

  Kim, Hye Young ^a   Lee, Sung Won ^c   Park, So Youn ^a   Baek, Seung Hoon ^b   Lee, Choong Won ^d   Hong, Ki Whan ^a   Kim, Chi Dae ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

^c Dong A University   (South Korea)

^d Wallace Memorial Baptist Hospital   (South Korea)

Author keywords

Cilostazol; Collagen induced arthritis; Cytokine; Methotrexate; NURR1; PKA

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; CD68 ANTIGEN; CILOSTAZOL; INTERLEUKIN 1BETA; INTERLEUKIN 6; KT 5720; METHOTREXATE; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR RECEPTOR RELATED FACTOR 1; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEOGLYCAN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; FIBROBLAST; HUMAN; MALE; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM;

ANIMALS; ANTIRHEUMATIC AGENTS; APOPTOSIS; ARTHRITIS, RHEUMATOID; BASE SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DNA PRIMERS; DRUG THERAPY, COMBINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METHOTREXATE; MICE; MICE, INBRED DBA; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLES;

MUS;

EID: 84865605996     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.07.003     Document Type: Article

References (23)

1. G.S. Alarcon, I.C. Tracy, and W.D. Blackburn Jr. Methotrexate in rheumatoid arthritis: toxic effects as the major factor in limiting long-term treatment Arthritis Rheum 32 1989 671 676 (Pubitemid 19179245)
2. E.S. Chan, and B.N. Cronstein Methotrexate-how does it really work? Nat Rev Rheumatol 6 2010 175 178
3. B.N. Cronstein, D. Naime, and E. Ostad The antiinflammatory mechanism of methotrexate increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation J Clin Invest 92 1993 2675 2682 (Pubitemid 24006532)
4. M. Cutolo, A. Sulli, C. Pizzorni, B. Seriolo, and R.H. Straub Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis Ann Rheum Dis 60 2001 729 735 (Pubitemid 32685871)
5. M.R. Davies, C.J. Harding, S. Raines, K. Tolley, A.E. Parker, and M. Downey-Jones NURR1-dependent regulation of pro-inflammatory mediators in immortalized synovial fibroblasts J Inflamm 2 2005 15 23
6. M. Feldmann, F.M. Brennan, and R.N. Maini Role of cytokines in rheumatoid arthritis Annu Rev Immunol 14 1996 397 440 (Pubitemid 26130190)
7. G. Haskó, and B.N. Cronstein Adenosine: an endogenous regulator of innate immunity Trends Immunol 25 2004 33 39 (Pubitemid 38032805)
8. B. Le Goff, E. Soltner, C. Charrier, Y. Maugars, F. Rédini, and D. Heymann A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritis Arthritis Res Ther 11 2009 1R185-195
9. C.K. Lee, E.Y. Lee, S.M. Chung, S.H. Mun, B. Yoo, and H.B. Moon Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor κB, osteoprotegerin, and receptor activator of nuclear factor κB ligand Arthritis Rheum 50 2004 3831 3843 (Pubitemid 39643930)
10. A.N. McEvoy, E.P. Murphy, T. Ponnio, O.M. Conneely, B. Bresnihan, and O. FitzGerald Activation of nuclear orphan receptor NURR1 transcription by NF-κB and cyclic adenosine 5′-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue J Immunol 168 2002 2979 2987 (Pubitemid 34211679)
11. 3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68 Arthritis Rheum 48 2003 240 247 (Pubitemid 36091669)
12. L. Morabito, M.C. Montesinos, D.M. Schreibman, L. Balter, L.F. Thompson, and R. Resta Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5′-nucleotidase-mediated conversion of adenine nucleotides J Clin Invest 101 1998 295 300 (Pubitemid 28067325)
13. L.W. Moreland, L.W. Heck Jr., and W.J. Koopman Biologic agents for treating rheumatoid arthritis: concepts and progress Arthritis Rheum 40 1997 397 409
14. M. Neidhart, C.A. Seemayer, K.M. Hummel, B.A. Michel, R.E. Gay, and S. Gay Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo Arthritis Rheum 48 2003 1873 1880 (Pubitemid 36828682)
15. S.Y. Park, S.W. Lee, H.K. Shin, W.S. Lee, B.Y. Rhim, and K.W. Hong Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction Arthritis Rheum 62 2010 732 741
16. R.M. Pope Apoptosis as a therapeutic tool in rheumatoid arthritis Nat Rev Immunol 2 2002 527 535 (Pubitemid 37328744)
17. 2A receptor-mediated responses J Immunol 175 2005 555 565 (Pubitemid 40884362)
18. K. Redlich, S. Hayer, R. Ricci, J.P. David, M. Tohidast-Akrad, and G. Kollias Osteoclasts are essential for TNF-alpha-mediated joint destruction J Clin Invest 110 2002 1419 1427 (Pubitemid 35396913)
19. E. Romas, M.T. Gillespie, and T.J. Martin Involvement of receptor activator of NF-kappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis Bone 30 2002 340 346 (Pubitemid 34154863)
20. G. Schett, C. Stach, J. Zwerina, R. Voll, and B. Manger How antirheumatic drugs protect joints from damage in rheumatoid arthritis Arthritis Rheum 58 2008 2936 2948
21. P.P. TAK, and B. Bresnihan The pathogenesis and prevention of joint damage in rheumatoid arthritis. Advances from synovial biopsy and tissue analysis Arthritis Rheum 43 2000 2619 2633 (Pubitemid 32001727)
22. W.B. van den Berg Anti-cytokine therapy in chronic destructive arthritis Arthritis Res 3 2001 18 26
23. J. Zwerina, S. Hayer, M. Tohidast-Akrad, H. Bergmeister, K. Redlich, and U. Feige Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction Arthritis Rheum 50 2004 277 290 (Pubitemid 38084313)