메뉴 건너뛰기




Volumn 10, Issue 2, 2011, Pages 253-263

Oxidative stress as a mechanism underlying sulfasalazine-induced toxicity

Author keywords

hepatotoxicity; infertility; lipid peroxidation; nephrotoxicity; oxidative stress; sulfasalazine

Indexed keywords

MESALAZINE; REACTIVE OXYGEN METABOLITE; SALAZOSULFAPYRIDINE; SULFAPYRIDINE;

EID: 79952350508     PISSN: 14740338     EISSN: None     Source Type: Journal    
DOI: 10.1517/14740338.2011.529898     Document Type: Review
Times cited : (88)

References (123)
  • 1
    • 34249100276 scopus 로고    scopus 로고
    • 5-Aminosalicylates and renal function in inflammatory bowel disease: A systematic review
    • DOI 10.1002/ibd.20099
    • Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis 2007;13:629-38 (Pubitemid 46799647)
    • (2007) Inflammatory Bowel Diseases , vol.13 , Issue.5 , pp. 629-638
    • Gisbert, J.P.1    Gonzalez-Lama, Y.2    Mate, J.3
  • 2
    • 24344457766 scopus 로고    scopus 로고
    • Sulfasalazine: A review of its use in the management of rheumatoid arthritis
    • DOI 10.2165/00003495-200565130-00008
    • Plosker GL, Croom KF. Sulfasalazine: a review of its use in the management of rheumatoid arthritis. Drugs 2005;65:1825-49 (Pubitemid 41258139)
    • (2005) Drugs , vol.65 , Issue.13 , pp. 1825-1849
    • Plosker, G.L.1    Croom, K.F.2
  • 3
    • 84920223116 scopus 로고
    • An experiment to determine the active therapeutic moiety of sulphasalazine
    • Azad Khan AK, Piris J, Truelove SC. An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet 1977;2:892-5
    • (1977) Lancet , vol.2 , pp. 892-895
    • Azad Khan, A.K.1    Piris, J.2    Truelove, S.C.3
  • 4
    • 0029051820 scopus 로고
    • Use of old and new oral 5-aminosalicylic acid formulations in inflammatory bowel disease
    • Brzezinski A, Rankin GB, Seidner DL, Lshner BA. Use of old and new oral 5-aminosalicylic acid formulations in inflammatory bowel disease. Cleve Clin J Med 1995;62:317-19
    • (1995) Cleve Clin J Med , vol.62 , pp. 317-319
    • Brzezinski, A.1    Rankin, G.B.2    Seidner, D.L.3    Lshner, B.A.4
  • 6
    • 0036786888 scopus 로고    scopus 로고
    • Sulphasalazine and mesalazine: Serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines
    • Ransford RA, Langman MJ. Sulphasalazine and mesalazine: serious adverse reactions re-evaluated on the basis of suspected adverse reaction reports to the Committee on Safety of Medicines. Gut 2002;51:536-9
    • (2002) Gut , vol.51 , pp. 536-539
    • Ransford, R.A.1    Langman, M.J.2
  • 7
    • 0033981670 scopus 로고    scopus 로고
    • Therapy of inflammatory bowel disease
    • Sands BE. Therapy of inflammatory bowel disease. Gastroenterology 2000;118:S68-82
    • (2000) Gastroenterology , vol.118
    • Sands, B.E.1
  • 8
    • 0015348162 scopus 로고
    • The role of intestinal bacteria in the metabolism of salicylazosulfapyridine
    • Peppercorn MA, Goldman P. The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther 1972;181:555-62
    • (1972) J Pharmacol Exp Ther , vol.181 , pp. 555-562
    • Peppercorn, M.A.1    Goldman, P.2
  • 9
    • 3042662702 scopus 로고    scopus 로고
    • N-acelyltransferase 2 genotyping: An accurate and feasible approach for simultaneous detection of the most common NAT2 alleles
    • DOI 10.1373/clinchem.2003.027748
    • Brans R, Laizane D, Khan A, Blomeke B. N-Acetyltransferase 2 genotyping: an acccurate and feasible approach for simultaneous detection of the most common NAT2 alleles. Clin Chem 2004;50:1264-6 (Pubitemid 38824245)
    • (2004) Clinical Chemistry , vol.50 , Issue.7 , pp. 1264-1266
    • Brans, R.1    Laizane, D.2    Khan, A.3    Blomeke, B.4
  • 10
    • 0015374469 scopus 로고
    • Absorption, metabolism, and excretion of salicylazosulfapyridine in man
    • Schroder H, Campbell DE. Absorption, metabolism, and excretion of salicylazosulfapyridine in man. Clin Pharmacol Ther 1972;13:539-51
    • (1972) Clin Pharmacol Ther , vol.13 , pp. 539-551
    • Schroder, H.1    Campbell, D.E.2
  • 11
    • 0015916139 scopus 로고
    • Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype
    • Das KM, Eastwood MA, McManus PA, Sircus W. Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype. N Engl J Med 1973;289:491-5
    • (1973) N Engl J Med , vol.289 , pp. 491-495
    • Das, K.M.1    Eastwood, M.A.2    McManus, P.A.3    Sircus, W.4
  • 12
    • 84982333870 scopus 로고
    • Salazopyrin, a new sulfanilamide preparation
    • Svartz N. Salazopyrin, a new sulfanilamide preparation. Acta Med Scand 1942;110:577-98
    • (1942) Acta Med Scand , vol.110 , pp. 577-598
    • Svartz, N.1
  • 13
    • 79952340753 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of salycilazosulphapyridine in F344/N Rats and B6C3F1 mice
    • National Toxicology Program (NTP)
    • National Toxicology Program (NTP). Toxicology and carcinogenesis studies of salycilazosulphapyridine in F344/N Rats and B6C3F1 mice. National Toxicology Program Technical Report Series. 1997;457:15-21
    • (1997) National Toxicology Program Technical Report Series , vol.457 , pp. 15-21
  • 14
    • 0018084814 scopus 로고
    • Role of prostaglandins in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine
    • Sharon P, Ligumsky M, Rachmilewitz D, Zor U. Role of prostagandins in ulcerative colitis, enhanced production during active disease and inhibition by sulfasalazine. Gastroenterology 1978;75:638-40 (Pubitemid 9025499)
    • (1978) Gastroenterology , vol.75 , Issue.4 , pp. 638-640
    • Sharon, P.1    Ligumsky, M.2    Rachmilewitz, D.3    Zor, U.4
  • 15
    • 0031595210 scopus 로고    scopus 로고
    • Nuclear factor-kB is activated in macrophages and epithelial cells of inflamed intestinal mucosa
    • Rogler G, Brand K, Vogl D, et al. Nuclear factor-kB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology 1998;115:537-69
    • (1998) Gastroenterology , vol.115 , pp. 537-569
    • Rogler, G.1    Brand, K.2    Vogl, D.3
  • 16
    • 0033696206 scopus 로고    scopus 로고
    • The anti-inflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages inducing apoptosis
    • Robenbury RJ, Ganga A, Van Lent PL, et al. The anti-inflammatory drug sulfasalazine inhibits tumor necrosis factor alpha expression in macrophages inducing apoptosis. Arthritis Rheum 2000;43:1941-50
    • (2000) Arthritis Rheum , vol.43 , pp. 1941-1950
    • Robenbury, R.J.1    Ganga, A.2    Van Lent, P.L.3
  • 17
    • 0030786363 scopus 로고    scopus 로고
    • 2) by sulfasalazine: A novel mechanism of anti- Inflammatory activity
    • DOI 10.1016/S0006-2952(97)00137-8, PII S0006295297001378
    • Pruzauski W, Stefanski E, Vadas P, Ramamurthy NS. Inhibition of extracellular release of pro-inflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine: a novel mechanism of anti-inflammatory activity. Biochem Pharmacol 1997;53:1901-7 (Pubitemid 27356063)
    • (1997) Biochemical Pharmacology , vol.53 , Issue.12 , pp. 1901-1907
    • Pruzanski, W.1    Stefanski, E.2    Vadas, P.3    Ramamurthy, N.S.4
  • 19
    • 21844439776 scopus 로고    scopus 로고
    • Sulfasalazine inhibits activation of nuclear factor-kappa B in patients with ulcerative colitis
    • DOI 10.1111/j.1400-1746.2005.03862.x
    • Gan HT, Chen YQ, Ouyang Q. Sulfasalazine inhibits activation of nuclear factor-kappa B in patients with ulcerative colitis. J Gastroenterol Hepatol 2005;20:1016-24 (Pubitemid 40961223)
    • (2005) Journal of Gastroenterology and Hepatology , vol.20 , Issue.7 , pp. 1016-1024
    • Gan, H.-T.1    Chen, Y.-Q.2    Ouyang, Q.3
  • 21
    • 0032032469 scopus 로고    scopus 로고
    • Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
    • Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. J Clin Invest 1998;101:1163-74 (Pubitemid 28125296)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.5 , pp. 1163-1174
    • Wahl, C.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 22
    • 0036119573 scopus 로고    scopus 로고
    • Role of 5-aminosalicylic acid (5-ASA) in treatment of inflammatory bowel disease: A systematic review
    • DOI 10.1023/A:1017987229718
    • Gisbert JP, Gomollon F, Mate J, Pajares JM. Role of 5-aminosalicylic acid (5-ASA) in treatment of inflammatory bowel disease: a systematic review. Dig Dis Sci 2002;47:471-88 (Pubitemid 34218873)
    • (2002) Digestive Diseases and Sciences , vol.47 , Issue.3 , pp. 471-488
    • Gisbert, J.P.1    Gomollon, F.2    Mate, J.3    Pajares, J.M.4
  • 23
    • 0018647430 scopus 로고
    • Male infertility due to sulphasalazine
    • Levi AJ, Fisher AM, Hughes L, Henry WF. Male infertility due to sulphasalazine. Lancet 1979;314:276-8 (Pubitemid 9244105)
    • (1979) Lancet , vol.2 , Issue.8137 , pp. 276-278
    • Levi, A.J.1    Fischer, A.M.2    Hughes, L.3    Hendry, W.F.4
  • 24
    • 0018802928 scopus 로고
    • Male infertility due to sulphasalazine
    • Toth A. Male infertility due to sulphasalazine. Lancet 1979;2:904
    • (1979) Lancet , vol.2 , pp. 904
    • Toth, A.1
  • 25
    • 0021146285 scopus 로고
    • Reversible male infertility due to sulphasalazine: Studies in man and rat
    • O'Morain C, Smethurst P, Dore CJ, Levi AJ. Reversible male infertility due to sulfasalazine: studies in man and rat. Gut 1984;25:1078-84 (Pubitemid 14002122)
    • (1984) Gut , vol.25 , Issue.10 , pp. 1078-1084
    • O'Morain, C.1    Smethurst, P.2    Dore, C.J.3    Levi, A.J.4
  • 27
    • 0025185364 scopus 로고
    • Antifertility effect of the metabolites of sulfasalazine for male rats
    • Ueno T, Ishizu K, Baba Y, et al. Antifertility effect of the metabolites of sulfasalazine for male rats. Jpn J Fertil Steril 1990;35:715-20
    • (1990) Jpn J Fertil Steril , vol.35 , pp. 715-720
    • Ueno, T.1    Ishizu, K.2    Baba, Y.3
  • 29
    • 0029294675 scopus 로고
    • The effects of sulphasalazine on male fertility
    • review
    • Marmor D. The effects of sulphasalazine on male fertility [review]. Reprod Toxicol 1995;9:219-23
    • (1995) Reprod Toxicol , vol.9 , pp. 219-223
    • Marmor, D.1
  • 30
    • 0029294054 scopus 로고
    • Short-term male reproductive toxicity study with sulfasalazine in the rat
    • Hoyt JA, Fisher LF, Swisher DK. Short-term male reproductive toxicity study with sulfasalazine in the rat. Reprod Toxicol 1995;9:315-26
    • (1995) Reprod Toxicol , vol.9 , pp. 315-326
    • Hoyt, J.A.1    Fisher, L.F.2    Swisher, D.K.3
  • 31
    • 0018286205 scopus 로고
    • Male infertility due to sulphasalazine
    • Grieve J. Male infertility due to sulphasalazine. Lancet 1979;2:464 (Pubitemid 9250412)
    • (1979) Lancet , vol.2 , Issue.8140 , pp. 464
    • Grieve, J.1
  • 32
    • 0019413993 scopus 로고
    • Sulphasalazine and male infertility: Reversibility and possible mechanism
    • Toovey S, Hudson E, Hendry WF, Levi AJ. Sulphasalazine and male infertility: reversibility and possible mechanism. Gut 1981;22:445-51 (Pubitemid 11053277)
    • (1981) Gut , vol.22 , Issue.6 , pp. 445-451
    • Toovey, S.1    Hudson, E.2    Hendry, W.F.3    Levi, A.J.4
  • 35
    • 33846804463 scopus 로고    scopus 로고
    • Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine
    • DOI 10.1016/j.reprotox.2006.10.003, PII S0890623806002644
    • Fukushima T, Hamada Y, Komiyama M, et al. Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine. Reprod Toxicol 2007;23:153-7 (Pubitemid 46215992)
    • (2007) Reproductive Toxicology , vol.23 , Issue.2 , pp. 153-157
    • Fukushima, T.1    Hamada, Y.2    Komiyama, M.3    Matsuno, Y.4    Mori, C.5    Horii, I.6
  • 36
    • 58749113228 scopus 로고    scopus 로고
    • Sulfasalazine induced oxidative stress: A possible mechanism of male infertility
    • Alonso V, Linares V, Belles M, et al. Sulfasalazine induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol 2009;27:35-40
    • (2009) Reprod Toxicol , vol.27 , pp. 35-40
    • Alonso, V.1    Linares, V.2    Belles, M.3
  • 37
    • 34547406223 scopus 로고    scopus 로고
    • Review article: Reproduction in the patient with inflammatory bowel disease
    • DOI 10.1111/j.1365-2036.2007.03397.x
    • Heetun ZS, Byrnes C, Neary P, O'Morain C. Review article: reproduction in the patient with inflammatory bowel disease [review]. Aliment Pharmacol Ther 2007;26:513-33 (Pubitemid 47174282)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , Issue.4 , pp. 513-533
    • Heetun, Z.S.1    Byrnes, C.2    Neary, P.3    O'Morain, C.4
  • 38
    • 0024160802 scopus 로고
    • Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones
    • Zelissen PM, van Hattum J, Poen H, et al. Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones. Scand J Gastroenterol 1988;23:1100-4
    • (1988) Scand J Gastroenterol , vol.23 , pp. 1100-1104
    • Zelissen, P.M.1    Van Hattum, J.2    Poen, H.3
  • 39
    • 39749151003 scopus 로고    scopus 로고
    • Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: A meta-analysis
    • Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reprod Toxicol 2008;25:271-75
    • (2008) Reprod Toxicol , vol.25 , pp. 271-275
    • Rahimi, R.1    Nikfar, S.2    Rezaie, A.3    Abdollahi, M.4
  • 41
    • 0019352963 scopus 로고
    • Pregnancy in inflammatory bowel disease: Effect of sulfasalazine and corticosteroids on fetal outcome
    • Mogadam M, Dobbins WO, Korelitz BI, Ahmed SW. Pregnancy in inflammatory bowel disease: effect of sulfasalazine and corticosteroids on fetal outcome. Gastroenterology 1981;80:72-6 (Pubitemid 11213291)
    • (1981) Gastroenterology , vol.80 , Issue.1 , pp. 72-76
    • Mogadam, M.1    Dobbins III, W.O.2    Korelitz, B.I.3    Ahmed, S.W.4
  • 43
    • 0019788971 scopus 로고
    • Albumin reserve for binding of bilirubin in maternal and cord serum under treatment with sulphasalazine
    • Jarnerot G, Anderson S, Esbjorner E, Sandstrom B. Albumin reserve for binding of bilirubin in maternal and cord serum under treatment of sulfasalazine. Scand J Gastroenterol 1981;16:1049-55 (Pubitemid 12236125)
    • (1981) Scandinavian Journal of Gastroenterology , vol.16 , Issue.8 , pp. 1049-1055
    • Jarnerot, G.1    Andersen, S.2    Esbjorner, E.3
  • 44
    • 0023138311 scopus 로고
    • Sulphasalazine and sulphapyridine serum levels in children to mothers treated with sulphasalazine during pregnancy and lactation
    • Esbjorner E, Jarnerot G, Wranne L. Sulphasalazine and sulphapyridine serum levels in children to mothers treated with sulfasalazine during pregnancy and lactation. Acta Paediatr Scand 1987;76:137-42 (Pubitemid 17020978)
    • (1987) Acta Paediatrica Scandinavica , vol.76 , Issue.1 , pp. 137-142
    • Esbjorner, E.1    Jarnerot, G.2    Wranne, L.3
  • 45
    • 1842367916 scopus 로고    scopus 로고
    • 5-Aminosalicylic acid-associated renal tubular acidosis with decreased renal function in Crohn's disease
    • Hamling J, Raedler A, Helmchen U, Schreiber S. 5-Aminosalicylic acid associated renal tubular acidosis with decreased renal function in Crohn's disease. Digestion 1997;58:304-7 (Pubitemid 27270198)
    • (1997) Digestion , vol.58 , Issue.3 , pp. 304-307
    • Hamling, J.1    Raedler, A.2    Helmchen, U.3    Schreiber, S.4
  • 46
    • 0026735018 scopus 로고
    • Sulphasalazine induced renal failure
    • Dwarakanath AD, Michael J, Allan RN. Sulphasalazine induced renal failure. Gut 1992;33:1006-1007
    • (1992) Gut , vol.33 , pp. 1006-1007
    • Dwarakanath, A.D.1    Michael, J.2    Allan, R.N.3
  • 47
    • 0030847141 scopus 로고    scopus 로고
    • Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate
    • Schreiber S, Hamling J, Zehnter E, et al. Renal tubular dysfunction in patients with inflammatory bowel disease treated with aminosalicylate. Gut 1997;40:761-6 (Pubitemid 27305469)
    • (1997) Gut , vol.40 , Issue.6 , pp. 761-766
    • Schreiber, S.1    Hamling, J.2    Zehnter, E.3    Howaldt, S.4    Daerr, W.5    Raedler, A.6    Kruis, W.7
  • 48
    • 77949523128 scopus 로고    scopus 로고
    • Sulfasalazine-induced nephrotic syndrome in a patient with ulcerative colitis
    • Molnar T, Farkas K, Nagy F, et al. Sulfasalazine-induced nephrotic syndrome in a patient with ulcerative colitis. Inflamm Bowel Dis 2009;16:552-3
    • (2009) Inflamm Bowel Dis , vol.16 , pp. 552-553
    • Molnar, T.1    Farkas, K.2    Nagy, F.3
  • 49
    • 65549108991 scopus 로고    scopus 로고
    • Renal effects of long-term treatment with 5-aminosalicylic acid
    • Patel H, Barr A, Jeejeebhoy KN. Renal effects of long-term treatment with 5-aminosalicylic acid. Can J Gastroenterol 2009;23:170-6
    • (2009) Can J Gastroenterol , vol.23 , pp. 170-176
    • Patel, H.1    Barr, A.2    Jeejeebhoy, K.N.3
  • 50
    • 0034326746 scopus 로고    scopus 로고
    • Glomerular and tubular renal functions after long-term medication of sulphasalazine, olsalazine, and mesalazine in patients with ulcerative colitis
    • Birketvedt GS, Berg KJ, Fausa O, Florholmen J. Glomerular and tubular renal functions after long-term medication of sulphasalazine, olsalazine, and mesalazine in patients with ulcerative colitis. Inflamm Bowel Dis 2000;6:275-9
    • (2000) Inflamm Bowel Dis , vol.6 , pp. 275-279
    • Birketvedt, G.S.1    Berg, K.J.2    Fausa, O.3    Florholmen, J.4
  • 51
    • 69249127424 scopus 로고    scopus 로고
    • A case of sulphasalazine-induced DRESS syndrome with delayed acute interstitial nephritis
    • Augusto JF, Sayegh J, Simon A, et al. A case of sulphasalazine-induced DRESS syndrome with delayed acute interstitial nephritis. Nephrol Dial Transplant 2009;24:2940-2
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2940-2942
    • Augusto, J.F.1    Sayegh, J.2    Simon, A.3
  • 52
    • 63249107612 scopus 로고    scopus 로고
    • Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment
    • Miura N, Aoyama R, Kitagawa W, et al. Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment. Clin Nephrol 2009;71:74-9
    • (2009) Clin Nephrol , vol.71 , pp. 74-79
    • Miura, N.1    Aoyama, R.2    Kitagawa, W.3
  • 53
    • 0025044118 scopus 로고
    • Nephrotic syndrome associated with sulphasalazine
    • Barbour VM, Williams PF. Nephrotic syndrome associated with sulphasalazine. BMJ 1990;301:818 (Pubitemid 20352604)
    • (1990) British Medical Journal , vol.301 , Issue.6755 , pp. 818
    • Barbour, V.M.1    Williams, P.F.2
  • 54
    • 2942559886 scopus 로고
    • Sulphasalazine and nephritic syndrome
    • Sharma AK. Sulphasalazine and nephritic syndrome. Am J Gastroenterol 1993;88:1584
    • (1993) Am J Gastroenterol , vol.88 , pp. 1584
    • Sharma, A.K.1
  • 55
    • 2942587176 scopus 로고    scopus 로고
    • 5-Aminosalicylic acids and the risk of renal disease: A large British epidemiologic study
    • DOI 10.1053/j.gastro.2004.03.016
    • Van Staa TP, Travis S, Leufkens HG, Logan RF. 5-Aminosalicylic acids and the risk of renal disease: a large British epidemiologic study. Gastroenterology 2004;126:1733-9 (Pubitemid 38736338)
    • (2004) Gastroenterology , vol.126 , Issue.7 , pp. 1733-1739
    • Van, S.T.P.1    Travis, S.2    Leufkens, H.G.M.3    Logan, R.F.4
  • 56
    • 0035981660 scopus 로고    scopus 로고
    • Role of mesalazine in acute and long-term treatment of ulceratice colitis and its complications
    • review
    • Schroeder KM. Role of mesalazine in acute and long-term treatment of ulceratice colitis and its complications [review]. Scand J Gastroenterol Suppl 2002;236:42-7
    • (2002) Scand J Gastroenterol Suppl , vol.236 , pp. 42-47
    • Schroeder, K.M.1
  • 57
    • 0033976913 scopus 로고    scopus 로고
    • Review article: Interstitial nephritis associated with the use of mesalazine in inflammatory bowel disease
    • Corrigan G, Stevens PE. Review article: interstitial nephritis associated with the use of mesalazine in inflammatory bowel disease. Aliment Pharmacol Ther 2000;14:1-6 (Pubitemid 30058154)
    • (2000) Alimentary Pharmacology and Therapeutics , vol.14 , Issue.1 , pp. 1-6
    • Corrigan, G.1    Stevens, P.E.2
  • 59
    • 0018208376 scopus 로고
    • Hypersensitivity to salicylazosulfapyridine. Renal and hepatic toxic reactions
    • DOI 10.1001/archinte.138.7.1138
    • Chester AC, Diamond LH, Schreiner GE. Hypersensitivity to salicylazosulfapyridine: renal and hepatic toxic reactions. Arch Intern Med 1978;138:1138-9 (Pubitemid 10220767)
    • (1978) Archives of Internal Medicine , vol.138 , Issue.7 , pp. 1138-1139
    • Chester, A.C.1    Diamond, L.H.2    Schreiner, G.E.3
  • 61
    • 0032547470 scopus 로고    scopus 로고
    • Late onset interstitial nephritis
    • Popoola J, Muller AF, Pollock L, et al. Late onset interstitial nephritis. Br Med J 1998;317:795-7
    • (1998) Br Med J , vol.317 , pp. 795-797
    • Popoola, J.1    Muller, A.F.2    Pollock, L.3
  • 63
    • 2342462248 scopus 로고    scopus 로고
    • Interstitial nephritis from mesalazine: Case report and literature review
    • DOI 10.1007/s00467-004-1411-6
    • Arend LJ, Springate JE. Interstitial nephritis from mesalazine: case report and literature review. Pediatr Nephrol 2004;19:550-3 (Pubitemid 38594297)
    • (2004) Pediatric Nephrology , vol.19 , Issue.5 , pp. 550-553
    • Arend, L.J.1    Springate, J.E.2
  • 64
    • 84970828934 scopus 로고
    • Nephrotoxic lesions from 5-aminosalicylic acid
    • Calder IC, Funder CC, Green CR, et al. Nephrotoxic lesions from 5-aminosalicylic acid. BMJ 1972;1:52-4
    • (1972) BMJ , vol.1 , pp. 52-54
    • Calder, I.C.1    Funder, C.C.2    Green, C.R.3
  • 66
    • 0021234509 scopus 로고
    • Renal function was not impaired by treatment with 5-aminosalicylic acid in rats and man
    • Diener U, Tuczek HV, Fischer C, et al. Renal function was not impaired by treatment with 5-aminosalicylic acid in rats and man. Naunyn Schmiedebergs Arch Pharmacol 1984;326:278-82
    • (1984) Naunyn Schmiedebergs Arch Pharmacol , vol.326 , pp. 278-282
    • Diener, U.1    Tuczek, H.V.2    Fischer, C.3
  • 67
    • 0026671294 scopus 로고
    • Short report: Comparison of two doses of balsalazide in maintaining ulcerative colitis in remission over 12 months
    • Green JR, Swan CH, Rowlinson A, et al. Short report: comparison of two doses of balsalazide in maintaining ulcerative colitis in remission over 12 months. Aliment Pharmacol Ther 1992;6:647-52
    • (1992) Aliment Pharmacol Ther , vol.6 , pp. 647-652
    • Green, J.R.1    Swan, C.H.2    Rowlinson, A.3
  • 69
    • 0025728830 scopus 로고
    • Sulphasalazine in ulcerative colitis: In memoriam?
    • Hayllar J, Bjarnason I. Sulphasalazine in ulcerative colitis: in memoriam? Gut 1991;32:462-3
    • (1991) Gut , vol.32 , pp. 462-463
    • Hayllar, J.1    Bjarnason, I.2
  • 70
    • 0028825885 scopus 로고
    • Adverse effects of sulfasalazine and treatment of ulcerative colitis with mesalazine
    • Nakajima H, Munakata A, Yoshida Y. Adverse effects of sulfasalazine and treatment of ulcerative colitis with mesalazine. J Gastroenterol 1995;30:115-17
    • (1995) J Gastroenterol , vol.30 , pp. 115-117
    • Nakajima, H.1    Munakata, A.2    Yoshida, Y.3
  • 71
    • 0028323287 scopus 로고
    • Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis
    • Rubin R. Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis. Am J Gastroenterol 1994;89:789-91 (Pubitemid 24132068)
    • (1994) American Journal of Gastroenterology , vol.89 , Issue.5 , pp. 789-791
    • Rubin, R.1
  • 74
    • 0030789930 scopus 로고    scopus 로고
    • Seizures and hepatotoxicity following sulphasalazine administration
    • DOI 10.1007/s002960050012
    • Senturk T, Aydintug AO, Duzgun N, Tokgoz G. Seizures and hepatotoxicity following sulphasalazine administration. Rheumatol Int 1997;17:75-7 (Pubitemid 27364012)
    • (1997) Rheumatology International , vol.17 , Issue.2 , pp. 75-77
    • Senturk, T.1    Aydintug, A.O.2    Duzgun, N.3    Tokgoz, G.4
  • 75
    • 42549153989 scopus 로고    scopus 로고
    • Hepatotoxicity associated with Sulfasalazine in inflammatory arthritis: A case series from a local surveillance of serious adverse events
    • Jobanputra P, Amarasena R, Maggs F, et al. Hepatotoxicity associated with Sulfasalazine in inflammatory arthritis: a case series from a local surveillance of serious adverse events. BMC Musculoskelet Disord 2008;9:48
    • (2008) BMC Musculoskelet Disord , vol.9 , pp. 48
    • Jobanputra, P.1    Amarasena, R.2    Maggs, F.3
  • 76
    • 0018141998 scopus 로고
    • Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity
    • Sotolongo RP, Neefe LI, Rudzki C, Ishak KG. Hypersensitivity reaction to sulfasalazine with severe hepatotoxicity. Gastroenterology 1978;75:95-9 (Pubitemid 8378778)
    • (1978) Gastroenterology , vol.75 , Issue.1 , pp. 95-99
    • Sotolongo, R.P.1    Neefe, L.I.2    Rudzki, C.3    Ishak, K.G.4
  • 77
    • 0018643141 scopus 로고
    • Hepatotoxicity of salicylazosulfapyridine. A case report and review of the literature
    • Gulley RM, Mirza A, Kelly CE. Hepatotoxicity of salicylazosulfapyridine: a case report and review of the literature. Am J Gastroenterol 1979;72:561-4 (Pubitemid 10146385)
    • (1979) American Journal of Gastroenterology , vol.72 , Issue.5 , pp. 561-564
    • Gulley, R.M.1    Mirza, A.2    Kelly, C.E.3
  • 79
    • 69149097823 scopus 로고    scopus 로고
    • Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: Fatal recurrence after liver transplantation
    • Mennicke M, Zawodniak A, Keller M, et al. Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: fatal recurrence after liver transplantation. Am J Transplant 2009;9:2197-202
    • (2009) Am J Transplant , vol.9 , pp. 2197-2202
    • Mennicke, M.1    Zawodniak, A.2    Keller, M.3
  • 80
    • 12844264897 scopus 로고    scopus 로고
    • DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis
    • DOI 10.1016/j.jbspin.2004.06.002, PII S1297319X04001228
    • Michel F, Navellou JC, Ferraud D, et al. DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis [review]. Joint Bone Spine 2005;72:82-5 (Pubitemid 40169972)
    • (2005) Joint Bone Spine , vol.72 , Issue.1 , pp. 82-85
    • Michel, F.1    Navellou, J.-C.2    Ferraud, D.3    Toussirot, E.4    Wendling, D.5
  • 82
    • 33644907464 scopus 로고    scopus 로고
    • Sulphasalazine-induced DRESS
    • Teo L, Tan E. Sulphasalazine-induced DRESS. Singapore Med J 2006;47:237-9
    • (2006) Singapore Med J , vol.47 , pp. 237-239
    • Teo, L.1    Tan, E.2
  • 83
    • 58149466610 scopus 로고    scopus 로고
    • Sulfasalazine-induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms)
    • Aquino RT, Vergueiro CS, Magliari ME, de Freitas TH. Sulfasalazine- induced DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms). Sao Paulo Med J 2008;126:225-6
    • (2008) Sao Paulo Med J , vol.126 , pp. 225-226
    • Aquino, R.T.1    Vergueiro, C.S.2    Magliari, M.E.3    De Freitas, T.H.4
  • 84
    • 0026463006 scopus 로고
    • Influence of acetylator status on sulphasalazine efficacy and toxicity in patients with rheumatoid arthritis
    • Kitas G, Farr M, Waterhouse L, Bacon PA. Influence of acetylator status on sulphasalazine efficacy and toxicity in patients with rheumatoid arthritis. Scand J Rheumatol 1992;21:220-5
    • (1992) Scand J Rheumatol , vol.21 , pp. 220-225
    • Kitas, G.1    Farr, M.2    Waterhouse, L.3    Bacon, P.A.4
  • 87
    • 34249946316 scopus 로고    scopus 로고
    • N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulfasalazine in the treatment of inflammatory bowel disease
    • Chen M, Xia B, Chen B, et al. N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease. Can J Gastroenterol 2007;21:155-8 (Pubitemid 47061612)
    • (2007) Canadian Journal of Gastroenterology , vol.21 , Issue.3 , pp. 155-158
    • Chen, M.1    Xia, B.2    Chen, B.3    Guo, Q.4    Li, J.5    Ye, M.6    Hu, Z.7
  • 90
    • 0024439958 scopus 로고
    • Elevated superoxide dismutase in Bloom's syndrome: A genetic condition of oxidative stress
    • Nicotera TM, Notaro J, Notaro S. Elevated superoxide dismutase in Bloom's syndrome, a genetic condition of oxidative stress. Cancer Res 1989;49:5239-43 (Pubitemid 19240453)
    • (1989) Cancer Research , vol.49 , Issue.19 , pp. 5239-5243
    • Nicotera, T.M.1    Notaro, J.2    Notaro, S.3    Schumer, J.4    Sandberg, A.A.5
  • 92
    • 33645285308 scopus 로고    scopus 로고
    • Sperm function tests and fertility
    • Aitken RJ. Sperm function tests and fertility. Int J Androl 2006;29:69-75
    • (2006) Int J Androl , vol.29 , pp. 69-75
    • Aitken, R.J.1
  • 93
    • 0028834966 scopus 로고
    • Impact of reactive oxygen species on spermatozoa: A balancing act between beneficial and detrimental effects
    • De Lamirande E, Gagnon C. Impact of reactive oxygen species on spermatozoa: a balancing act between beneficial and detrimental effects. Hum Reprod 1995;10:15-21
    • (1995) Hum Reprod , vol.10 , pp. 15-21
    • De Lamirande, E.1    Gagnon, C.2
  • 94
    • 0033954920 scopus 로고    scopus 로고
    • Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation
    • DOI 10.1016/S0015-0282(99)00567-1, PII S0015028299005671
    • Pasqualotto FF, Sharma RK, Nelson DR, et al. Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 2000;73:459-64 (Pubitemid 30109638)
    • (2000) Fertility and Sterility , vol.73 , Issue.3 , pp. 459-464
    • Pasqualotto, F.F.1    Sharma, R.K.2    Nelson, D.R.3    Thomas Jr., A.J.4    Agarwal, A.5
  • 95
    • 0042280453 scopus 로고    scopus 로고
    • Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues
    • Fujii J, Iuchi Y, Matsuki S, Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J Androl 2003;5:231-42 (Pubitemid 37107312)
    • (2003) Asian Journal of Andrology , vol.5 , Issue.3 , pp. 231-242
    • Fujii, J.1    Iuchi, Y.2    Matsuki, S.3    Ishii, T.4
  • 96
    • 1842483365 scopus 로고    scopus 로고
    • Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility
    • Garrido N, Meseguer M, Simon C, et al. Pro-oxidative and antioxidative imbalance in human semen and its relation with male fertility. Asian J Androl 2004;6:59-65 (Pubitemid 38418340)
    • (2004) Asian Journal of Andrology , vol.6 , Issue.1 , pp. 59-65
    • Garrido, N.1    Meseguer, M.2    Simon, C.3    Pellicer, A.4    Remohi, J.5
  • 97
    • 0025951479 scopus 로고
    • Protective role of superoxide dismutase in human sperm motility: Superoxide dismutase activity and lipid peroxide in human seminal plasma and spermatozoa
    • Kobayashi T, Miyazaki T, Natori M, Nozawa S. Protective role of superoxide dismutase in human sperm motility: superoxide dismutase activity and lipid peroxide in human seminal plasma and spermatozoa. Hum Reprod 1991;6:987-91
    • (1991) Hum Reprod , vol.6 , pp. 987-991
    • Kobayashi, T.1    Miyazaki, T.2    Natori, M.3    Nozawa, S.4
  • 99
    • 34248648785 scopus 로고    scopus 로고
    • Pro-oxidant effects in the brain of rats concurrently exposed to uranium and stress
    • DOI 10.1016/j.tox.2007.04.001, PII S0300483X07002107
    • Linares MV, Sanchez DJ, Belles M, et al. Pro-oxidant effects in the brain of rats concurrently exposed to uranium and stress. Toxicology 2007;236:82-91 (Pubitemid 46777071)
    • (2007) Toxicology , vol.236 , Issue.1-2 , pp. 82-91
    • Linares, V.1    Sanchez, D.J.2    Belles, M.3    Albina, L.4    Gomez, M.5    Domingo, J.L.6
  • 102
    • 0035754146 scopus 로고    scopus 로고
    • Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: A review of the evidence
    • DOI 10.1385/CBB:34:2:237
    • Reiter RJ, Tan DX, Manchester LC, Tamura H. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. A review of the evidence. Cell Biochem Biophys 2001;34:237-56 (Pubitemid 33615836)
    • (2001) Cell Biochemistry and Biophysics , vol.34 , Issue.2 , pp. 237-256
    • Reiter, R.J.1    Tan, D.-X.2    Manchester, L.C.3    Qi, W.4
  • 103
    • 0347933048 scopus 로고    scopus 로고
    • Melatonin Protects Against Mercury(II)-Induced Oxidative Tissue Damage in Rats
    • DOI 10.1111/j.1600-0773.2003.pto930607.x
    • Sener G, Sehirli AO, Ayanoglu-Dulger G. Melatonin protects against mercury(II)-induced oxidative tissue damage in rats. Pharmacol Toxicol 2003;93:290-6 (Pubitemid 38096108)
    • (2003) Pharmacology and Toxicology , vol.93 , Issue.6 , pp. 290-296
    • Sener, G.1    Sehirli, A.O.2    Ayanoglu-Dulger, G.3
  • 106
    • 0035879827 scopus 로고    scopus 로고
    • Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death
    • DOI 10.1016/S0891-5849(01)00560-3, PII S0891584901005603
    • Hickey EJ, Raje RR, Reid VE, et al. Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. J Clin Endocrinol 2001;31:139-52 (Pubitemid 32607581)
    • (2001) Free Radical Biology and Medicine , vol.31 , Issue.2 , pp. 139-152
    • Hickey, E.J.1    Raje, R.R.2    Reid, V.E.3    Gross, S.M.4    Ray, S.D.5
  • 108
    • 0142219774 scopus 로고    scopus 로고
    • Diclofenac-induced liver injury: A paradigm of idiosyncratic drug toxicity
    • DOI 10.1016/S0041-008X(03)00368-5
    • Boelsterli UA. Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. Toxicol Appl Pharmacol 2003;192:307-22 (Pubitemid 37311346)
    • (2003) Toxicology and Applied Pharmacology , vol.192 , Issue.3 , pp. 307-322
    • Boelsterli, U.A.1
  • 109
    • 58349096891 scopus 로고    scopus 로고
    • Lipid peroxidation and antioxidant status in kidney and liver of rats treated with sulfasalazine
    • Linares V, Alonso V, Albina ML, et al. Lipid peroxidation and antioxidant status in kidney and liver of rats treated with sulfasalazine. Toxicology 2009;256:152-6
    • (2009) Toxicology , vol.256 , pp. 152-156
    • Linares, V.1    Alonso, V.2    Albina, M.L.3
  • 111
    • 36949026481 scopus 로고    scopus 로고
    • Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepato-nephro toxicity
    • Ghosh A, Sil PC. Anti-oxidative effect of a protein from Cajanus indicus L against acetaminophen-induced hepato-nephrotoxicity. J Biochem Mol Biol 2007;40:1039-49 (Pubitemid 350242292)
    • (2007) Journal of Biochemistry and Molecular Biology , vol.40 , Issue.6 , pp. 1039-1049
    • Ghosh, A.1    Sil, P.C.2
  • 112
    • 29244456109 scopus 로고    scopus 로고
    • Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity
    • DOI 10.1016/j.tox.2005.10.015, PII S0300483X0500524X
    • Yilmaz S, Atessahin A, Sahna E, et al. Protective effect of lycopene on adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology 2006;218:164-71 (Pubitemid 41821347)
    • (2006) Toxicology , vol.218 , Issue.2-3 , pp. 164-171
    • Yilmaz, S.1    Atessahin, A.2    Sahna, E.3    Karahan, I.4    Ozer, S.5
  • 113
    • 7944234974 scopus 로고    scopus 로고
    • Iminium metabolite mechanism for nicotine toxicity and addiction: Oxidative stress and electron transfer
    • DOI 10.1016/j.mehy.2004.03.048, PII S0306987704003706
    • Kovacic P, Cooksy A. Iminium metabolite mechanism for nicotine toxicity and addiction: oxidative stress and electron transfer. Med Hypotheses 2005;64:104-11 (Pubitemid 39469246)
    • (2005) Medical Hypotheses , vol.64 , Issue.1 , pp. 104-111
    • Kovacic, P.1    Cooksy, A.2
  • 114
    • 33645933894 scopus 로고    scopus 로고
    • Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress
    • Luqman S, Rizvi SI. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res 2006;20:303-6
    • (2006) Phytother Res , vol.20 , pp. 303-306
    • Luqman, S.1    Rizvi, S.I.2
  • 115
    • 0031058356 scopus 로고    scopus 로고
    • Effect of selenium supplementation on the glutathione redox system in the kidney of mice after chronic cadmium exposures
    • DOI 10.1002/(SICI)1099-1263(199701)17:1<81::AID-JAT398>3.0.CO;2-K
    • Nehru LB, Bansal MP6. Effect of selenium supplementation on the glutathione redox system in the kidney of mice after chronic cadmium exposures. J Appl Toxicol 1996;17:81-4 (Pubitemid 27091402)
    • (1997) Journal of Applied Toxicology , vol.17 , Issue.1 , pp. 81-84
    • Nehru, L.B.1    Bansal, M.P.2
  • 117
    • 0027344154 scopus 로고
    • Glutathione S-transferases: Biomedical applications
    • Beckett GJ, Hayes JD. Glutathione S-transferases: biomedical applications. Adv Clin Chem 1993;30:281-380
    • (1993) Adv Clin Chem , vol.30 , pp. 281-380
    • Beckett, G.J.1    Hayes, J.D.2
  • 118
    • 0029561598 scopus 로고
    • The glutathione S-tranferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
    • Hayes JD, Pulford DJ. The glutathione S-tranferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 1995;30:445-600
    • (1995) Crit Rev Biochem Mol Biol , vol.30 , pp. 445-600
    • Hayes, J.D.1    Pulford, D.J.2
  • 119
    • 47149101936 scopus 로고    scopus 로고
    • Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells
    • Boesch-Saadatmandi C, Loboda A, Jozkowicz A, et al. Effect of ochratoxin A on redox-regulated transcription factors, antioxidant enzymes and glutathione-S-transferase in cultured kidney tubulus cells. Food Chem Toxicol 2008;46:2665-71
    • (2008) Food Chem Toxicol , vol.46 , pp. 2665-2671
    • Boesch-Saadatmandi, C.1    Loboda, A.2    Jozkowicz, A.3
  • 120
    • 0037100078 scopus 로고    scopus 로고
    • Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats
    • Muruganandan S, Gupta S, Kataria M, et al. Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats. Toxicology 2002;176:165-76
    • (2002) Toxicology , vol.176 , pp. 165-176
    • Muruganandan, S.1    Gupta, S.2    Kataria, M.3
  • 121
    • 2942516133 scopus 로고    scopus 로고
    • S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo
    • Pedraza-Chaverri J, Barrera D, Maldonado PD, et al. S- allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. BMC Clin Pharmacol 2004;4:5
    • (2004) BMC Clin Pharmacol , vol.4 , pp. 5
    • Pedraza-Chaverri, J.1    Barrera, D.2    Maldonado, P.D.3
  • 122
    • 41849109537 scopus 로고    scopus 로고
    • Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats
    • DOI 10.1248/bpb.31.602
    • Chiu PO, Leung HY, Ko KM. Schisandrin B enhances renal mitochondrial antioxidant status, functional and structural integrity, and protects against gentamicin-induced nephrotoxicity in rats. Biol Farm Bull 2008;31:602-5 (Pubitemid 351500488)
    • (2008) Biological and Pharmaceutical Bulletin , vol.31 , Issue.4 , pp. 602-605
    • Chiu, P.Y.1    Leung, H.Y.2    Ko, K.M.3
  • 123
    • 37048999963 scopus 로고    scopus 로고
    • Protective effect of quercetin on nicotine-induced prooxidant and antioxidant imbalance and DNA damage in Wistar rats
    • DOI 10.1016/j.tox.2007.10.006, PII S0300483X07007007
    • Muthukumaran S, Sudheer A, Menon VP, Nalini N. Protective effect of quercetin on nicotine-induced prooxidant and antioxidant imbalance and DNA damage in Wistar rats. Toxicology 2008;243:207-15 (Pubitemid 350250972)
    • (2008) Toxicology , vol.243 , Issue.1-2 , pp. 207-215
    • Muthukumaran, S.1    Sudheer, A.R.2    Menon, V.P.3    Nalini, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.