메뉴 건너뛰기




Volumn 25, Issue 3, 2014, Pages 417-427

5-HT6receptor antagonists as treatment for age-related cognitive decline

Author keywords

Ageing; Alzheimer's; Clinical trials; Memory; Plasticity; Serotonin

Indexed keywords

3 PHENYLSULFONYL 8 (1 PIPERAZINYL)QUINOLINE; AVN 322; BAPINEUZUMAB; BEXAROTENE; DIMEBON; DONEPEZIL; GALANTAMINE; MEMANTINE; PF 05212337; RIVASTIGMINE; SEROTONIN 6 ANTAGONIST; TACRINE; UNCLASSIFIED DRUG; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

EID: 84907172251     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/revneuro-2014-0013     Document Type: Review
Times cited : (26)

References (80)
  • 1
    • 0344517088 scopus 로고    scopus 로고
    • A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat
    • Ahlander M. Misane I. Sch ött P.A. and Ogren S.O. (1999). A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (dizocilpine) in the rat. Neuropsychopharmacology 21 414-426
    • (1999) Neuropsychopharmacology , vol.21 , pp. 414-426
    • Ahlander, M.1    Misane, I.2    Schött, P.A.3    Ogren, S.O.4
  • 3
    • 60849112820 scopus 로고    scopus 로고
    • Tumour cell survival signalling by the ERK1/2 pathway
    • Balmanno K. and Cook S.J. (2009). Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ. 16 368-377
    • (2009) Cell Death Differ , vol.16 , pp. 368-377
    • Balmanno, K.1    Cook, S.J.2
  • 4
    • 0034125843 scopus 로고    scopus 로고
    • On neurodegenerative diseases models and treatment strategies: Lessons learned and lessons forgotten a generation following the cholinergic hypothesis
    • Bartus R.T. (2000). On neurodegenerative diseases models and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163 495-529
    • (2000) Exp. Neurol , vol.163 , pp. 495-529
    • Bartus, R.T.1
  • 5
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R.T. Dean R.L. 3rd Beer B. and Lippa A.S. (1982). The cholinergic hypothesis of geriatric memory dysfunction. Science 217 408-414
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 7
    • 77957138323 scopus 로고    scopus 로고
    • The rise and fall of dimebon
    • Bezprozvanny I . (2010). The rise and fall of Dimebon. Drug News Perspect. 23 518-523
    • (2010) Drug News Perspect , vol.23 , pp. 518-523
    • Bezprozvanny, I.1
  • 8
    • 27444437758 scopus 로고    scopus 로고
    • Disease-related modifications in tau affect the interaction between Fyn and Tau
    • Bhaskar K. Yen S.-H. and Lee G. (2005). Disease-related modifications in tau affect the interaction between Fyn and Tau. J. Biol. Chem. 280 35119-35125.
    • (2005) J. Biol. Chem , vol.280 , pp. 35119-35125
    • Bhaskar, K.1    Yen, S.-H.2    Lee, G.3
  • 9
    • 42749100518 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease
    • Birks J., 2006, Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst. Rev.,(1) Art.No.: CD005593.,doi:10.1002/14651858.CD005593.
    • (2006) Cochrane Database Syst. Rev , vol.1
    • Birks, J.1
  • 10
    • 0035246514 scopus 로고    scopus 로고
    • 5-HT(6) receptor antagonists: Lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
    • Bö s M. Sleight A.J. Godel T. Martin J.R. Riemer C. and Stadler H. (2001). 5-HT(6) receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides. Eur. J. Med. Chem. 36 165-178
    • (2001) Eur. J. Med. Chem , vol.36 , pp. 165-178
    • Bös, M.1    Sleight, A.J.2    Godel, T.3    Martin, J.R.4    Riemer, C.5    Stadler, H.6
  • 11
    • 0028981113 scopus 로고
    • Determination of the role of the 5-HT6 receptor in the rat brain: A study using antisense oligo nucleotides
    • Bourson A. Borroni E. Austin R.H. Monsma F.J. Jr and Sleight A.J. (1995). Determination of the role of the 5-HT6 receptor in the rat brain: a study using antisense oligo nucleotides. J. Pharmacol. Exp. Ther. 274 173-180
    • (1995) J. Pharmacol. Exp. Ther , vol.274 , pp. 173-180
    • Bourson, A.1    Borroni, E.2    Austin, R.H.3    Monsma, F.J.4    Sleight, A.J.5
  • 12
    • 84864486360 scopus 로고    scopus 로고
    • Age-related declines in delayed non-match-to-sample perfo rmance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457
    • Callaghan C.K. Hok V. Della-Chiesa A. Virley D.J. Upton N. and O'Mara S.M. (2012). Age-related declines in delayed non-match-to-sample perfo rmance (DNMS) are reversed by the novel 5HT6 receptor antagonist SB742457. Neuropharmacology 63 890-897
    • (2012) Neuropharmacology , vol.63 , pp. 890-897
    • Callaghan, C.K.1    Hok, V.2    Della-Chiesa, A.3    Virley, D.J.4    Upton, N.5    O'Mara, S.M.6
  • 15
    • 57849111780 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficit s in spatial recognition memory in the mouse
    • Da Silva Costa V. Duchatelle P. Boulouard M. and Dauphin F. (2009). Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficit s in spatial recognition memory in the mouse. Neuropsychopharmacology 34 488-500
    • (2009) Neuropsychopharmacology , vol.34 , pp. 488-500
    • Da Silva Costa, V.1    Duchatelle, P.2    Boulouard, M.3    Dauphin, F.4
  • 16
    • 79955764929 scopus 로고    scopus 로고
    • Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice
    • Da Silva Costa-Aze V. Dauphin F. and Boulouard M. (2011). Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. Behav. Brain Res. 222 134-140
    • (2011) Behav. Brain Res , vol.222 , pp. 134-140
    • Da Silva Costa-Aze, V.1    Dauphin, F.2    Boulouard, M.3
  • 17
    • 84861855874 scopus 로고    scopus 로고
    • 5-HT6 receptor blockade differentially affect s scopolamine-induced deficits of working memory recognition memory and aversive learning in mice
    • Da Silva Costa-Aze V. Quiedeville A. Boulouard M. and Dauphin F. (2012). 5-HT6 receptor blockade differentially affect s scopolamine-induced deficits of working memory recognition memory and aversive learning in mice. Psychopharmacology 222 99-115
    • (2012) Psychopharmacology , vol.222 , pp. 99-115
    • Da Silva Costa-Aze, V.1    Quiedeville, A.2    Boulouard, M.3    Dauphin, F.4
  • 18
    • 0034098959 scopus 로고    scopus 로고
    • In vivo effects of the 5-HT (6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline dopamine 5-HT glutamate and aspartate
    • Dawson L.A. Nguyen H.Q. and Li P. (2000). In vivo effects of the 5-HT (6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline dopamine 5-HT glutamate and aspartate. Br. J. Pharmacol. 130 23-26
    • (2000) Br. J. Pharmacol , vol.130 , pp. 23-26
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 19
    • 0034782825 scopus 로고    scopus 로고
    • The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
    • Dawson L.A. Nguyen H.Q. and Li P. (2001). The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 25 662-668
    • (2001) Neuropsychopharmacology , vol.25 , pp. 662-668
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 21
    • 84884362398 scopus 로고    scopus 로고
    • Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival
    • De Foubert G. Khundakar A.A. and Zetterströ m T.S. (2013). Effects of repeated 5-HT6 receptor stimulation on BDNF gene expression and cell survival. Neurosci. Lett. 553 211-215
    • (2013) Neurosci. Lett , vol.553 , pp. 211-215
    • De Foubert, G.1    Khundakar, A.A.2    Zetterström, T.S.3
  • 22
    • 0346057791 scopus 로고    scopus 로고
    • The 5-HT(6) receptor an tagonist SB-271046 reverses scopolaminedisrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats
    • Foley A.G. Murphy K.J. Hirst W.D. Gallagher H.C. Hagan J.J. Upton N. Walsh F.S. and Regan C.M. (2004). The 5-HT(6) receptor an tagonist SB-271046 reverses scopolaminedisrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 29 93-100
    • (2004) Neuropsychopharmacology , vol.29 , pp. 93-100
    • Foley, A.G.1    Murphy, K.J.2    Hirst, W.D.3    Gallagher, H.C.4    Hagan, J.J.5    Upton, N.6    Walsh, F.S.7    Regan, C.M.8
  • 23
    • 44149105604 scopus 로고    scopus 로고
    • The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate N CAM PSA immunolabeling of dentate granule cells but not neurogenesis in the hippocampal formation of mature Wistar rats
    • Foley A.G. Hirst W.D. Gallagher H.C. Barry C. Hagan J.J. Upton N. Walsh F.S. Hunter A.J. and Regan C.M. (2008). The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate N CAM PSA immunolabeling of dentate granule cells but not neurogenesis in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 1166-1174
    • (2008) Neuropharmacology , vol.54 , pp. 1166-1174
    • Foley, A.G.1    Hirst, W.D.2    Gallagher, H.C.3    Barry, C.4    Hagan, J.J.5    Upton, N.6    Walsh, F.S.7    Hunter, A.J.8    Regan, C.M.9
  • 24
    • 53449090731 scopus 로고    scopus 로고
    • An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function
    • Fone K.C.F. (2008). An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology 55 1015-1022
    • (2008) Neuropharmacology , vol.55 , pp. 1015-1022
    • Fone, K.C.F.1
  • 25
    • 79958056062 scopus 로고    scopus 로고
    • Mindspan: Lessons from rat models of neurocognitive aging
    • Gallagher M. Stocker A.M. and Koh M.T. (2011). Mindspan: lessons from rat models of neurocognitive aging. ILAR J. 52 32-40
    • (2011) ILAR J , vol.52 , pp. 32-40
    • Gallagher, M.1    Stocker, A.M.2    Koh, M.T.3
  • 26
    • 84873026509 scopus 로고    scopus 로고
    • Toward the treatment and prevention of Alzheimer's disease: Rational strategies and recent progress
    • Gandy S. and DeKosky S.T. (2013). Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress. Annu. Rev. Med. 64 367-383
    • (2013) Annu. Rev. Med , vol.64 , pp. 367-383
    • Gandy, S.1    De Kosky, S.T.2
  • 27
    • 0842308152 scopus 로고    scopus 로고
    • Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease
    • Garcia-Alloza M. Hirst W.D. Chen C.P.L.-H. Lasheras B. Francis P.T. and Ramírez M.J. (2004). Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology 29 410-416
    • (2004) Neuropsychopharmacology , vol.29 , pp. 410-416
    • Garcia-Alloza, M.1    Hirst, W.D.2    Chen, C.P.L.-H.3    Lasheras, B.4    Francis, P.T.5    Ramírez, M.J.6
  • 28
    • 0029987475 scopus 로고    scopus 로고
    • Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 57-dihydroxytryptaminetreated rats
    • Gé rard C. el Mestikawy S. Lebrand C. Adrien J. Ruat M. Traiffort E. Hamon M. and Martres M.P. (1996). Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 57-dihydroxytryptaminetreated rats. Synapse 23 164-173
    • (1996) Synapse , vol.23 , pp. 164-173
    • Gérard, C.1    El Mestikawy, S.2    Lebrand, C.3    Adrien, J.4    Ruat, M.5    Traiffort, E.6    Hamon, M.7    Martres, M.P.8
  • 29
    • 0027772145 scopus 로고
    • The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice
    • Gower A.J. and Lamberty Y. (1993). The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice. Behav. Brain Res. 57 163-173
    • (1993) Behav. Brain Res , vol.57 , pp. 163-173
    • Gower, A.J.1    Lamberty, Y.2
  • 31
    • 0141723971 scopus 로고    scopus 로고
    • High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation
    • Hasselmo M.E.,Mc Gaughy J., 2004, High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation, Prog. Brain Res., 145, 207-231
    • (2004) Prog. Brain Res , vol.145 , pp. 207-231
    • Hasselmo, M.E.1    Mc Gaughy, J.2
  • 32
    • 0347824360 scopus 로고    scopus 로고
    • Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors inves tigated by radioligand binding site-directed mutagenesis and molecular modeling
    • Hirst W.D. Abrahamsen B. Blaney F.E. Calver A.R. Aloj L. Price G.W. and Medhurst A.D. (2003). Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors inves tigated by radioligand binding site-directed mutagenesis and molecular modeling. Mol. Pharmacol. 64 1295-1308
    • (2003) Mol. Pharmacol , vol.64 , pp. 1295-1308
    • Hirst, W.D.1    Abrahamsen, B.2    Blaney, F.E.3    Calver, A.R.4    Aloj, L.5    Price, G.W.6    Medhurst, A.D.7
  • 33
    • 33751162382 scopus 로고    scopus 로고
    • SB-399885 is a potent selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models
    • Hirst W.D. Stean T.O. Rogers D.C. Sunter D. Pugh P. Moss S.F. Bromidge S.M. Riley G. Smith D.R. Bartlett S. et al. (2006). SB-399885 is a potent selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur. J. Pharmacol. 553 109-119
    • (2006) Eur. J. Pharmacol. , vol.553 , pp. 109-119
    • Hirst, W.D.1    Stean, T.O.2    Rogers, D.C.3    Sunter, D.4    Pugh, P.5    Moss, S.F.6    Bromidge, S.M.7    Riley, G.8    Smith, D.R.9    Bartlett, S.10
  • 34
    • 84864242444 scopus 로고    scopus 로고
    • 5HT(6) receptor antagonists: A patent update. Part 1. Sulfonyl derivatives
    • Ivachtchenko A.V. and Ivanenkov Y.A. (2012). 5HT(6) receptor antagonists: a patent update. Part 1. Sulfonyl derivatives. Expert Opin. Ther. Pat. 22 917-964
    • (2012) Expert Opin. Ther. Pat , vol.22 , pp. 917-964
    • Ivachtchenko, A.V.1    Ivanenkov, Y.A.2
  • 35
    • 79952485799 scopus 로고    scopus 로고
    • E-6801 a 5-HT6 receptor agonist improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission i n the rat
    • Kendall I. Slotten H.A. Codony X. Burgueño J. Pauwels P.J. Vela J.M. and Fone K.C.F. (2011). E-6801 a 5-HT6 receptor agonist improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission i n the rat. Psychopharmacology (Berl.) 213 413-430
    • (2011) Psychopharmacology (Berl.) , vol.213 , pp. 413-430
    • Kendall, I.1    Slotten, H.A.2    Codony, X.3    Burgueño, J.4    Pauwels, P.J.5    Vela, J.M.6    Fone, K.C.F.7
  • 36
    • 3042561627 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation-an effect sensitive to NMDA receptor antagonism
    • King M.V. Sleight A.J. Woolley M.L. Topham I.A. Marsden C.A. and Fone K.C.F. (2004). 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation-an effect sensitive to NMDA receptor antagonism. Neuropharmacology 47 195-204
    • (2004) Neuropharmacology , vol.47 , pp. 195-204
    • King, M.V.1    Sleight, A.J.2    Woolley, M.L.3    Topham, I.A.4    Marsden, C.A.5    Fone, K.C.F.6
  • 38
    • 77954086949 scopus 로고    scopus 로고
    • The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
    • Klinkenberg I. and Blokland A. (2010). The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci. Biobehav. Rev. 34 1307-1350
    • (2010) Neurosci. Biobehav. Rev , vol.34 , pp. 1307-1350
    • Klinkenberg, I.1    Blokland, A.2
  • 41
    • 0037244358 scopus 로고    scopus 로고
    • The serotonin 5-HT4 receptor and the amyloid precursor protein processing
    • Lezoualc'h F. and Robert S.J. (2003). The serotonin 5-HT4 receptor and the amyloid precursor protein processing. Exp. Gerontol. 38 159-166
    • (2003) Exp. Gerontol , vol.38 , pp. 159-166
    • Le Zoualc'h, F.1    Robert, S.J.2
  • 42
    • 27844475728 scopus 로고    scopus 로고
    • The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotoner gic models of memory deficiency in the rat
    • Lieben C.K.J. Blokland A. Sik A. Sung E. van Nieuwenhuizen P. and Schreiber R. (2005). The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotoner gic models of memory deficiency in the rat. Neuropsychopharmacology 30 2169-2179
    • (2005) Neuropsychopharmacology , vol.30 , pp. 2169-2179
    • Lieben, C.K.J.1    Blokland, A.2    Sik, A.3    Sung, E.4    Van Nieuwenhuizen, P.5    Schreiber, R.6
  • 44
    • 38149054026 scopus 로고    scopus 로고
    • Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: Implication of the frontal cortex
    • Loiseau F. Deke yne A. and Millan M.J. (2008). Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. Psychopharmacology (Berl.) 196 93-104
    • (2008) Psychopharmacology (Berl.) , vol.196 , pp. 93-104
    • Loiseau, F.1    Deke Yne, A.2    Millan, M.J.3
  • 45
    • 33847135229 scopus 로고    scopus 로고
    • Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients
    • Lork e D.E. Lu G. Cho E. and Yew D.T. (2006). Serotonin 5-HT2A and 5-HT6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC Neurosci. 7 36
    • (2006) BMC Neurosci , vol.7 , pp. 36
    • Lorke, D.E.1    Lu, G.2    Cho, E.3    Yew, D.T.4
  • 47
    • 33748751956 scopus 로고    scopus 로고
    • Lack of localization of 5-HT6 receptors on cholinergic neurons: Implication of multiple neurotransmitter systems in 5-HT6 receptor-me diated acetylcholine release
    • Maher-Edwards G. Dixon R . Hunter J. Gold M. Hopton G. Jacobs G. Hunter J. and Williams P. (2011). SB-742457 and donepezil in Alzheimer disease: a randomized placebocontrolled study. Int. J. Geriatr. Psychiatry 26 536-544. Marcos B. Gil-Bea F.J. Hirst W.D. García-Alloza M. and Ramírez M.J. (2006). Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-me diated acetylcholine release. Eur. J. Neurosci. 24 1299-1306
    • (2006) Eur. J. Neurosci , vol.24 , pp. 1299-1306
    • Marcos, B.1    Gil-Bea, F.J.2    Hirst, W.D.3    García-Alloza, M.4    Ramírez, M.J.5
  • 48
    • 52949099850 scopus 로고    scopus 로고
    • Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat
    • Marcos B. Chuang T.T. Gil-Bea F.J. and Ramirez M.J. (2008a ). Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br. J. Pharmacol. 155 434-440
    • (2008) Br. J. Pharmacol , vol.155 , pp. 434-440
    • Marcos, B.1    Chuang, T.T.2    Gil-Bea, F.J.3    Ramirez, M.J.4
  • 50
    • 0034042406 scopus 로고    scopus 로고
    • Synaptic plasticity and memory: An evaluation of the hypothesis
    • Martin S.J. Grimwood P.D. and Morris R.G. (2000) . Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23 649-711
    • (2000) Annu. Rev. Neurosci , vol.23 , pp. 649-711
    • Martin, S.J.1    Grimwood, P.D.2    Morris, R.G.3
  • 52
    • 65949119310 scopus 로고    scopus 로고
    • How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer
    • Mebratu Y.,Tesfaigzi Y., 2009, How ERK1/2 activation controls cell proliferation and cell death: is subcellular localization the answer? Cell Cycle, 8, 1168-1175.
    • (2009) Cell Cycle , vol.8 , pp. 1168-1175
    • Mebratu, Y.1    Tesfaigzi, Y.2
  • 54
    • 0035825243 scopus 로고    scopus 로고
    • Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation
    • Meneses A. (20 01). Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation. Behav. Brain Res. 118 107-110
    • (2001) Behav. Brain Res , vol.118 , pp. 107-110
    • Meneses, A.1
  • 55
    • 33846994072 scopus 로고    scopus 로고
    • Memory consolidation and amnesia modify 5-HT6 receptors expression in rat brain: An autoradiographic study
    • Meneses A. Manuel-Apolinar L. Castillo C. and Castillo E. (2007). Memory consolidation and amnesia modify 5-HT6 receptors expression in rat brain: an autoradiographic study. Behav. Brain Res. 178 53-61
    • (2007) Behav. Brain Res , vol.178 , pp. 53-61
    • Meneses, A.1    Manuel-Apolinar, L.2    Castillo, C.3    Castillo, E.4
  • 56
    • 32144460821 scopus 로고    scopus 로고
    • BGC2 0-761 a novel tryptamine analog enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism
    • Mitchell E.S. Hoplight B.J. Lear S.P. and Neumaier J.F. (2006). BGC2 0-761 a novel tryptamine analog enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 412-420
    • (2006) Neuropharmacology , vol.50 , pp. 412-420
    • Mitchell, E.S.1    Hoplight, B.J.2    Lear, S.P.3    Neumaier, J.F.4
  • 57
    • 70449467081 scopus 로고    scopus 로고
    • Adaptations in 5-HT receptor expression and function: Implications for treatment of cognitive impairment in aging
    • Mitchell E.S. McDevitt R.A. and Neumaier J.F. (2009). Adaptations in 5-HT receptor expression and function: implications for treatment of cognitive impairment in aging. J. Neurosci. Res. 87 2803-2811
    • (2009) J. Neurosci. Res , vol.87 , pp. 2803-2811
    • Mitchell, E.S.1    Mc Devitt, R.A.2    Neumaier, J.F.3
  • 58
    • 0027481384 scopus 로고
    • Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
    • Monsma F.J. Jr Shen Y. Ward R.P. Hamblin M.W. and Sibley D.R. (1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43 320-327
    • (1993) Mol. Pharmacol , vol.43 , pp. 320-327
    • Monsma, F.J.1    Shen, Y.2    Ward, R.P.3    Hamblin, M.W.4    Sibley, D.R.5
  • 59
    • 84876789760 scopus 로고    scopus 로고
    • Successful brain aging: Plasticity environmental enrichment and lifestyle
    • Mora F. (2013). Successful brain aging: plasticity environmental enrichment and lifestyle. Dialogues Clin. Neurosci. 15 45-52
    • (2013) Dialogues Clin. Neurosci , vol.15 , pp. 45-52
    • Mora, F.1
  • 60
    • 75649105019 scopus 로고    scopus 로고
    • Current treatment and recent clinical research in Alzheimer's disease
    • Neugroschl J. Sano M. (2010). Current treatment and recent clinical research in Alzheimer's disease. MT Sinai J. Med. 77 3-16
    • (2010) MT Sinai J. Med , vol.77 , pp. 3-16
    • Neugroschl, J.1    Sano, M.2
  • 62
    • 22044457309 scopus 로고    scopus 로고
    • Oral administration of the 5-HT 6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task
    • Perez-García G. and Meneses A. (2005). Oral administration of the 5-HT 6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol. Biochem. Behav. 81 673-682
    • (2005) Pharmacol. Biochem. Behav , vol.81 , pp. 673-682
    • Perez-García, G.1    Meneses, A.2
  • 63
    • 0037468873 scopus 로고    scopus 로고
    • Influence of the 5-HT6 receptor on acetylcholine release in the cortex: Pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine a potent and selective 5-HT6 rece ptor antagonist
    • Riemer C. Borroni E. Levet-Trafit B. Martin J.R. Poli S. Porter R.H.P. and Bö s M. (2003). Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine a potent and selective 5-HT6 rece ptor antagonist. J. Med. Chem. 46 1273-1276
    • (2003) J. Med. Chem , vol.46 , pp. 1273-1276
    • Riemer, C.1    Borroni, E.2    Levet-Trafit, B.3    Martin, J.R.4    Poli, S.5    Porter, R.H.P.6    Bös, M.7
  • 64
    • 78651506630 scopus 로고    scopus 로고
    • Amyloid-?/Fyn-induced synaptic network and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
    • Roberson E.D. Halabisky B. Yoo J.W. Yao J. Chin J. Yan F. Wu T. Hamto P. Devidze N. Yu G.-Q. et al. (2011). Amyloid-?/Fyn-induced synaptic network and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J. Neurosci. 31 700-711
    • (2011) J. Neurosci , vol.31 , pp. 700-711
    • Roberson, E.D.1    Halabisky, B.2    Yoo, J.W.3    Yao, J.4    Chin, J.5    Yan, F.6    Wu, T.7    Hamto, P.8    Devidze, N.9    Yu, G.-Q.10
  • 67
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimerń s disease is a synaptic failure
    • Selkoe D.J. (2002). Alzheimerń s disease is a synaptic failure. Science 298 789-791
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 68
    • 0036201186 scopus 로고    scopus 로고
    • Effects of typical and atypical antipsychotics and receptor selective compounds on ace tylcholine efflux in the hippocampus of the rat
    • Shirazi-Southall S. Rodriguez D.E. and Nomikos G.G. (2002). Effects of typical and atypical antipsychotics and receptor selective compounds on ace tylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology 26 583-594
    • (2002) Neuropsychopharmacology , vol.26 , pp. 583-594
    • Shirazi-Southall, S.1    Rodriguez, D.E.2    Nomikos, G.G.3
  • 69
    • 33645109827 scopus 로고    scopus 로고
    • Normal aging and cognition
    • Ska B. and Joanette Y. (2006). Normal aging and cognition. Med. Sci. (Paris) 22 284-287
    • (2006) Med. Sci. (Paris) , vol.22 , pp. 284-287
    • Ska, B.1    Joanette, Y.2
  • 71
    • 33746103661 scopus 로고    scopus 로고
    • Animal models of behavioral dysfunctions: Basic concepts and classifications and an evaluation strategy
    • Van der Staay F.J. (2006). Animal models of behavioral dysfunctions: basic concepts and classifications and an evaluation strategy. Brain Res. Rev. 52 131-159
    • (2006) Brain Res. Rev , vol.52 , pp. 131-159
    • Van Der Staay, F.J.1
  • 72
    • 0030018405 scopus 로고    scopus 로고
    • Colocalization of serotonin receptor subtypes 5-HT2A 5-HT2C and 5-HT6 with neuropeptides in rat striatum
    • Ward R.P. and Dorsa D.M. (1996). Colocalization of serotonin receptor subtypes 5-HT2A 5-HT2C and 5-HT6 with neuropeptides in rat striatum. J. Comp. Neurol. 370 405-414.
    • (1996) J. Comp. Neurol , vol.370 , pp. 405-414
    • Ward, R.P.1    Dorsa, D.M.2
  • 73
    • 70349734329 scopus 로고    scopus 로고
    • Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus
    • West P.J.,Marcy V.R.,Marino M.J.,Schaffhauser H., 2009, Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus, Neuroscience, 164, 692-701.
    • (2009) Neuroscience , vol.164 , pp. 692-701
    • West, P.J.1    Marcy, V.R.2    Marino, M.J.3    Schaffhauser, H.4
  • 74
    • 84865425244 scopus 로고    scopus 로고
    • 5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms
    • Woods S. Clarke N.N. Layfield R. and Fone K.C.F. (2012). 5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms. Br. J. Pharmacol. 167 436-449
    • (2012) Br. J. Pharmacol , vol.167 , pp. 436-449
    • Woods, S.1    Clarke, N.N.2    Layfield, R.3    Fone, K.C.F.4
  • 75
    • 0346973946 scopus 로고    scopus 로고
    • Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist Ro 04-6790
    • Woolley M.L. Marsden C.A. Sleight A.J. and Fone K.C.F. (2003). Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist Ro 04-6790. Psychopharmacology (Berl. ) 170 358-367
    • (2003) Psychopharmacology (Berl.) , vol.170 , pp. 358-367
    • Woolley, M.L.1    Marsden, C.A.2    Sleight, A.J.3    Fone, K.C.F.4
  • 76
    • 0032445751 scopus 로고    scopus 로고
    • Central distribution and function of 5-HT6 receptor subtype in the rat brain
    • Yoshioka M. Matsumoto M. Togashi H. and Mori K. (1998). Central distribution and function of 5-HT6 receptor subtype in the rat brain. Ann. NY Acad. Sci. 861 244
    • (1998) Ann. NY Acad. Sci , vol.861 , pp. 244
    • Yoshioka, M.1    Matsumoto, M.2    Togashi, H.3    Mori, K.4
  • 77
    • 84862856870 scopus 로고    scopus 로고
    • The serotonin-6 receptor as a novel therapeutic target
    • Yun H.-M. and Rhim H. (2011). The serotonin-6 receptor as a novel therapeutic target. Exp. Neurobiol. 20 159-168
    • (2011) Exp. Neurobiol , vol.20 , pp. 159-168
    • Yun, H.-M.1    Rhim, H.2
  • 79
    • 77951226972 scopus 로고    scopus 로고
    • Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival
    • Yun H.-M. Baik J.-H. Kang I. Jin C. and Rhim H. (2010). Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. J. Biol. Chem. 285 10016-10029
    • (2010) J. Biol. Chem , vol.285 , pp. 10016-10029
    • Yun, H.-M.1    Baik, J.-H.2    Kang, I.3    Jin, C.4    Rhim, H.5
  • 80
    • 34249931450 scopus 로고    scopus 로고
    • Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples
    • Zhang M.-Y. Hughes Z.A. Kerns E.H . Lin Q. and Beyer C.E. (2007). Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples. J. Pharm. Biomed. Anal. 44 586-593
    • (2007) J. Pharm. Biomed. Anal , vol.44 , pp. 586-593
    • Zhang, M.-Y.1    Hughes, Z.A.2    Kerns, E.H.3    Lin, Q.4    Beyer, C.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.