The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat

Neuropsychopharmacology

Volumn 30, Issue 12, 2005, Pages 2169-2179

  Lieben, Cindy K J ^a   Blokland, Arjan ^b   Şik, Ayhan ^a   Sung, Eric ^c   Van Nieuwenhuizen, Petra ^b   Schreiber, Rudy ^c  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c ROCHE BIOSCIENCE   (United States)

Author keywords

5 HT; ACh; Acute tryptophan depletion; Memory; Metrifonate; Object recognition task; Scopolamine

Indexed keywords

3 BENZENESULFONYL 7 (4 METHYLPIPERAZIN 1 YL) 1H INDOLE; CHOLINESTERASE INHIBITOR; METRIFONATE; RO 4368554; SCOPOLAMINE; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; TRYPTOPHAN; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; MUSCARINIC RECEPTOR BLOCKING AGENT; PIPERAZINE DERIVATIVE; RO4368554; SEROTONIN; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLINERGIC SYSTEM; COGNITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; MALE; MEMORY DISORDER; NONHUMAN; PRIORITY JOURNAL; RAT; RECOGNITION; SEROTONINERGIC SYSTEM; TASK PERFORMANCE; ANIMAL; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; METABOLISM; PATHOPHYSIOLOGY; PERCEPTIVE DISCRIMINATION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; CHOLINESTERASE INHIBITORS; COGNITION; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; MALE; MEMORY DISORDERS; MUSCARINIC ANTAGONISTS; PARASYMPATHETIC NERVOUS SYSTEM; PIPERAZINES; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; RECOGNITION (PSYCHOLOGY); SCOPOLAMINE; SEROTONIN; SEROTONIN ANTAGONISTS; TRICHLORFON; TRYPTOPHAN;

EID: 27844475728     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300777     Document Type: Article

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