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Volumn 222, Issue 1, 2012, Pages 99-115

5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice

Author keywords

Aversive learning; Mouse; Passive avoidance; Place recognition; Recognition memory; SB 271046; Scopolamine; Spontaneous alternation; Working memory

Indexed keywords

5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; SCOPOLAMINE;

EID: 84861855874     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2627-3     Document Type: Article
Times cited : (49)

References (62)
  • 1
    • 69949153829 scopus 로고    scopus 로고
    • The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short termand long term memory in the mouse
    • Bazin MA, El Kihel L, Boulouard M, Bouet V, Rault S (2009) The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short termand long term memory in the mouse. Steroids 74:931-937
    • (2009) Steroids , vol.74 , pp. 931-937
    • Bazin, M.A.1    El Kihel, L.2    Boulouard, M.3    Bouet, V.4    Rault, S.5
  • 2
    • 0013811904 scopus 로고
    • Action of caffeine on the spontaneous motility of the mouse
    • Boissier JR, Simon P (1965) Action of caffeine on the spontaneous motility of the mouse. Arch Int Pharmacodyn Ther 158:212-221
    • (1965) Arch Int Pharmacodyn Ther , vol.158 , pp. 212-221
    • Boissier, J.R.1    Simon, P.2
  • 3
    • 0042924142 scopus 로고    scopus 로고
    • Cognitive enhancing properties and tolerability of cholinergic agents in mice: A comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors
    • DOI 10.1038/sj.npp.1300150
    • Bontempi B,Whelan KT, Risbrough VB, Lloyd GK,Menzaghi F (2003) Cognitive enhancing properties and tolerability of cholinergic agents inmice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors. Neuropsychopharmacology 28:1235-1246 (Pubitemid 41070893)
    • (2003) Neuropsychopharmacology , vol.28 , Issue.7 , pp. 1235-1246
    • Bontempi, B.1    Whelan, K.T.2    Risbrough, V.B.3    Lloyd, G.K.4    Menzaghi, F.5
  • 4
    • 0029080364 scopus 로고
    • Serotonergic modulation of cholinergic function in the central nervous system: Cognitive implications
    • Cassel JC, Jeltsch H (1995) Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience 69:1-41
    • (1995) Neuroscience , vol.69 , pp. 1-41
    • Cassel, J.C.1    Jeltsch, H.2
  • 6
    • 57849111780 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse
    • Da Silva Costa V, Duchatelle P, Boulouard M, Dauphin F (2009) Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse. Neuropsychopharmacology 34:488-500
    • (2009) Neuropsychopharmacology , vol.34 , pp. 488-500
    • Da Silva Costa, V.1    Duchatelle, P.2    Boulouard, M.3    Dauphin, F.4
  • 7
    • 79955764929 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice
    • Da Silva Costa-Aze V, Dauphin F, Boulouard M (2011) Selective 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice. Behav Brain Res 222:134-140
    • (2011) Behav Brain Res , vol.222 , pp. 134-140
    • Da Silva Costa-Aze, V.1    Dauphin, F.2    Boulouard, M.3
  • 8
    • 0034098959 scopus 로고    scopus 로고
    • 6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate
    • Dawson LA, Nguyen HQ, Li P (2000) In vivo effects of the 5-HT(6) antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate. Br J Pharmacol 130:23-26 (Pubitemid 30248421)
    • (2000) British Journal of Pharmacology , vol.130 , Issue.1 , pp. 23-26
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 9
    • 0034782825 scopus 로고    scopus 로고
    • 6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
    • DOI 10.1016/S0893-133X(01)00265-2, PII S0893133X01002652
    • Dawson LA, Nguyen HQ, Li P (2001) The 5-HT(6) receptor antagonist SB-271046 selec- tively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 25:662-668 (Pubitemid 32995948)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.5 , pp. 662-668
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 11
    • 0025851708 scopus 로고
    • The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory
    • Decker MW, McGaugh JL (1991) The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7:151-168
    • (1991) Synapse , vol.7 , pp. 151-168
    • Decker, M.W.1    McGaugh, J.L.2
  • 12
    • 59449097789 scopus 로고    scopus 로고
    • Methylthioninium chloride reverses cognitive deficits induced by scopolamine: Comparison with rivastigmine
    • Deiana S, Harrington CR, Wischik CM, Riedel G (2009) Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine. Psychopharmacology (Berl) 202:53-65
    • (2009) Psychopharmacology (Berl) , vol.202 , pp. 53-65
    • Deiana, S.1    Harrington, C.R.2    Wischik, C.M.3    Riedel, G.4
  • 13
    • 0026660230 scopus 로고
    • A two-trial memory task with automated recording: Study in young and aged rats
    • Dellu F, Mayo W, Cherkaoui J, Le Moal M, Simon H (1992) A two-trial memory task with automated recording: study in young and aged rats. Brain Res 588:132-139
    • (1992) Brain Res , vol.588 , pp. 132-139
    • Dellu, F.1    Mayo, W.2    Cherkaoui, J.3    Le Moal, M.4    Simon, H.5
  • 14
    • 0034078621 scopus 로고    scopus 로고
    • Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice
    • DOI 10.1006/nlme.1999.3919
    • Dellu F, Contarino A, Simon H, Koob GF, Gold LH (2000) Genetic differences in response to novelty and spatial memory using a twotrial recognition task in mice. Neurobiol Learn Mem 73:31-48 (Pubitemid 30167117)
    • (2000) Neurobiology of Learning and Memory , vol.73 , Issue.1 , pp. 31-48
    • Dellu, F.1    Contarino, A.2    Simon, H.3    Koob, G.F.4    Gold, L.H.5
  • 15
    • 0000296289 scopus 로고
    • Spontaneous alternation behavior
    • Dember WN, Fowler H (1958) Spontaneous alternation behavior. Psychol Bull 55:412-428
    • (1958) Psychol Bull , vol.55 , pp. 412-428
    • Dember, W.N.1    Fowler, H.2
  • 16
    • 8844281576 scopus 로고    scopus 로고
    • An overview of the tasks used to test working memory in rodents
    • Dudchenko PA (2004) An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev 28:699-709
    • (2004) Neurosci Biobehav Rev , vol.28 , pp. 699-709
    • Dudchenko, P.A.1
  • 17
    • 42749091882 scopus 로고    scopus 로고
    • Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission
    • Eriksson TM, Madjid N, Elvander-Tottie E, Stiedl O, Svenningsson P, Ogren SO (2008) Blockade of 5-HT 1B receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission. Neuropharmacology 54:1041-1050
    • (2008) Neuropharmacology , vol.54 , pp. 1041-1050
    • Eriksson, T.M.1    Madjid, N.2    Elvander-Tottie, E.3    Stiedl, O.4    Svenningsson, P.5    Ogren, S.O.6
  • 18
    • 0032904156 scopus 로고    scopus 로고
    • Long-term memory in Alzheimer's disease
    • DOI 10.1016/S0959-4388(99)80034-8
    • Fleischman DA, Gabrieli J (1999) Long-term memory in Alzheimer's disease. Curr Opin Neurobiol 9:240-244 (Pubitemid 29201799)
    • (1999) Current Opinion in Neurobiology , vol.9 , Issue.2 , pp. 240-244
    • Fleischman, D.A.1    Gabrieli, J.2
  • 19
    • 0346057791 scopus 로고    scopus 로고
    • 6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats
    • DOI 10.1038/sj.npp.1300332
    • Foley AG, Murphy KJ, Hirst WD, Gallagher HC, Hagan JJ, Upton N, Walsh FS, Regan CM (2004) The 5-HT(6) receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 29:93-100 (Pubitemid 38068018)
    • (2004) Neuropsychopharmacology , vol.29 , Issue.1 , pp. 93-100
    • Foley, A.G.1    Murphy, K.J.2    Hirst, W.D.3    Gallagher, H.C.4    Hagan, J.J.5    Upton, N.6    Walsh, F.S.7    Regan, C.M.8
  • 22
    • 78649674046 scopus 로고    scopus 로고
    • Modes and models of forebrain cholinergic neuromodulation of cognition
    • Hasselmo ME, SarterM(2011) Modes and models of forebrain cholinergic neuromodulation of cognition. Neuropsychopharmacology 36:52-73
    • (2011) Neuropsychopharmacology , vol.36 , pp. 52-73
    • Hasselmo, M.E.1    Sarter, M.2
  • 23
    • 0347824360 scopus 로고    scopus 로고
    • Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling
    • DOI 10.1124/mol.64.6.1295
    • Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD (2003) Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Mol Pharmacol 64:1295-1308 (Pubitemid 37532219)
    • (2003) Molecular Pharmacology , vol.64 , Issue.6 , pp. 1295-1308
    • Hirst, W.D.1    Abrahamsen, B.2    Blaney, F.E.3    Calver, A.R.4    Aloj, L.5    Price, G.W.6    Medhurst, A.D.7
  • 25
    • 0014121199 scopus 로고
    • An improved one-trial passive avoidance learning situation
    • Jarvik ME, Kopp R (1967) An improved one-trial passive avoidance learning situation. Psychol Rep 21:221-224
    • (1967) Psychol Rep , vol.21 , pp. 221-224
    • Jarvik, M.E.1    Kopp, R.2
  • 26
    • 3042561627 scopus 로고    scopus 로고
    • 6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation - An effect sensitive to NMDA receptor antagonism
    • DOI 10.1016/j.neuropharm.2004.03.012, PII S0028390804000863
    • King MV, Sleight AJ, Woolley ML, Topham IA, Marsden CA, Fone KC (2004) 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation-an effect sensitive to NMDA receptor antagonism. Neuro-pharmacology 47:195-204 (Pubitemid 38824643)
    • (2004) Neuropharmacology , vol.47 , Issue.2 , pp. 195-204
    • King, M.V.1    Sleight, A.J.2    Woolley, M.L.3    Topham, I.A.4    Marsden, C.A.5    Fone, K.C.F.6
  • 27
    • 52949128037 scopus 로고    scopus 로고
    • A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning andmemory
    • KingMV,Marsden CA, Fone KC (2008) A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning andmemory. Trends Pharmacol Sci 29:482-492
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 482-492
    • King, M.V.1    Marsden, C.A.2    Fone, K.C.3
  • 28
    • 77954086949 scopus 로고    scopus 로고
    • The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
    • Klinkenberg I, Blokland A (2010) The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev 34:1307-1350
    • (2010) Neurosci Biobehav Rev , vol.34 , pp. 1307-1350
    • Klinkenberg, I.1    Blokland, A.2
  • 29
    • 79960793767 scopus 로고    scopus 로고
    • A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment
    • Berl
    • Klinkenberg I, Blokland A (2011) A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment. Psychopharmacology (Berl) 215:549-566
    • (2011) Psychopharmacology , vol.215 , pp. 549-566
    • Klinkenberg, I.1    Blokland, A.2
  • 30
    • 0038303294 scopus 로고    scopus 로고
    • 4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse
    • DOI 10.1007/s00210-003-0743-2
    • Lelong V, Lhonneur L, Dauphin F, Boulouard M (2003) BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse. Naunyn Schmiedebergs Arch Pharmacol 367:621-628 (Pubitemid 36829461)
    • (2003) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.367 , Issue.6 , pp. 621-628
    • Lelong, V.1    Lhonneur, L.2    Dauphin, F.3    Boulouard, M.4
  • 31
    • 33749126079 scopus 로고    scopus 로고
    • Interactions of buprenorphine and dipotassium clorazepate on anxiety and memory functions in the mouse
    • DOI 10.1016/j.drugalcdep.2006.03.017, PII S0376871606001426
    • Lelong-Boulouard V, Quentin T, Moreaux F, Debruyne D, Boulouard M, Coquerel A (2006) Interactions of buprenorphine and dipotassium clorazepate on anxiety and memory functions in the mouse. Drug Alcohol Depend 85:103-113 (Pubitemid 44468139)
    • (2006) Drug and Alcohol Dependence , vol.85 , Issue.2 , pp. 103-113
    • Lelong-Boulouard, V.1    Quentin, T.2    Moreaux, F.3    Debruyne, D.4    Boulouard, M.5    Coquerel, A.6
  • 32
    • 27844475728 scopus 로고    scopus 로고
    • 6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat
    • DOI 10.1038/sj.npp.1300777, PII 1300777
    • Lieben CK, Blokland A, Sik A, Sung E, van Nieuwenhuizen P, Schreiber R (2005) The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology 30:2169-2179 (Pubitemid 41643968)
    • (2005) Neuropsychopharmacology , vol.30 , Issue.12 , pp. 2169-2179
    • Lieben, C.K.J.1    Blokland, A.2    Sik, A.3    Sung, E.4    Van Nieuwenhuizen, P.5    Schreiber, R.6
  • 33
    • 1842684429 scopus 로고    scopus 로고
    • Neuropsychology of cognitive ageing, minimal cognitive impairment, Alzheimer's disease, and vascular cognitive impairment
    • DOI 10.1016/j.ejphar.2004.02.046, PII S0014299904002031
    • Lindeboom J, Weinstein H (2004) Neuropsychology of cognitive ageing, minimal cognitive impairment, Alzheimer's disease, and vascular cognitive impairment. Eur J Pharmacol 490:83-86 (Pubitemid 38482162)
    • (2004) European Journal of Pharmacology , vol.490 , Issue.1-3 , pp. 83-86
    • Lindeboom, J.1    Weinstein, H.2
  • 34
    • 33748751956 scopus 로고    scopus 로고
    • 6 receptor-mediated acetylcholine release
    • DOI 10.1111/j.1460-9568.2006.05003.x
    • Marcos B, Gil-Bea FJ, Hirst WD, Garcia-Alloza M, Ramirez MJ (2006) Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. Eur J Neurosci 24:1299-1306 (Pubitemid 44401652)
    • (2006) European Journal of Neuroscience , vol.24 , Issue.5 , pp. 1299-1306
    • Marcos, B.1    Gil-Bea, F.J.2    Hirst, W.D.3    Garcia-Alloza, M.4    Ramirez, M.J.5
  • 35
    • 52949099850 scopus 로고    scopus 로고
    • Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat
    • Marcos B, Chuang TT, Gil-Bea FJ, Ramirez MJ (2008) Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat. Br J Pharmacol 155:434-440
    • (2008) Br J Pharmacol , vol.155 , pp. 434-440
    • Marcos, B.1    Chuang, T.T.2    Gil-Bea, F.J.3    Ramirez, M.J.4
  • 36
    • 0016737296 scopus 로고
    • Benzodiazepines: A comparison of their effects in mice on the magnitude of the palmar skin conductivity response and on pentylenetetrazole-induced seizures
    • Marcy R, Quermonne MA (1975) Benzodiazepines: a comparison of their effects in mice on the magnitude of the palmar skin conductivity response and on pentylenetetrazole-induced seizures. Experientia 31:954-955
    • (1975) Experientia , vol.31 , pp. 954-955
    • Marcy, R.1    Quermonne, M.A.2
  • 37
    • 0017281260 scopus 로고
    • Habituation to iterative photostimulation in the palmar skin conductance response of mice, its delay by psychoanaleptics
    • Marcy R, Quermonne MA, Nammathao B (1976) Habituation to iterative photostimulation in the palmar skin conductance response of mice, its delay by psychoanaleptics. Experientia 32:208-209
    • (1976) Experientia , vol.32 , pp. 208-209
    • Marcy, R.1    Quermonne, M.A.2    Nammathao, B.3
  • 38
    • 32144460821 scopus 로고    scopus 로고
    • 6 receptor-mediated mechanism
    • DOI 10.1016/j.neuropharm.2005.10.002, PII S0028390805003606
    • Mitchell ES, Hoplight BJ, Lear SP, Neumaier JF (2006) BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuo-spatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50:412-420 (Pubitemid 43209037)
    • (2006) Neuropharmacology , vol.50 , Issue.4 , pp. 412-420
    • Mitchell, E.S.1    Hoplight, B.J.2    Lear, S.P.3    Neumaier, J.F.4
  • 39
    • 0033040488 scopus 로고    scopus 로고
    • 6 receptors in rat nucleus accumbens by antisense oligonucleotides
    • DOI 10.1016/S0306-4522(99)00066-4, PII S0306452299000664
    • Otano A, Frechilla D, Cobreros A, Cruz-Orive LM, Insausti A, Insausti R, HamonM, Del Rio J (1999) Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine6 receptors in rat nucleus accumbens by antisense oligonucleotides. Neuroscience 92:1001-1009 (Pubitemid 29287545)
    • (1999) Neuroscience , vol.92 , Issue.3 , pp. 1001-1009
    • Otano, A.1    Frechilla, D.2    Cobreros, A.3    Cruz-Orive, L.M.4    Insausti, A.5    Insausti, R.6    Hamon, M.7    Del, R.J.8
  • 40
    • 22044457309 scopus 로고    scopus 로고
    • 6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task
    • DOI 10.1016/j.pbb.2005.05.005, PII S0091305705001693
    • Perez-Garcia G, Meneses A (2005) Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacol Biochem Behav 81:673-682 (Pubitemid 40966815)
    • (2005) Pharmacology Biochemistry and Behavior , vol.81 , Issue.3 , pp. 673-682
    • Perez-Garcia, G.1    Meneses, A.2
  • 41
    • 39149098130 scopus 로고    scopus 로고
    • The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801
    • Pitsikas N, Zisopoulou S, Pappas I, Sakellaridis N (2008) The selective 5-HT(6) receptor antagonist Ro 04-6790 attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801. Behav Brain Res 188:304-309
    • (2008) Behav Brain Res , vol.188 , pp. 304-309
    • Pitsikas, N.1    Zisopoulou, S.2    Pappas, I.3    Sakellaridis, N.4
  • 42
    • 51249171206 scopus 로고
    • Spontaneous alternation behavior in animals: A review
    • Richman CL, Dember WN, Kim P (1986) Spontaneous alternation behavior in animals: a review. Curr Psychol Res Rev 5:358-391
    • (1986) Curr Psychol Res Rev , vol.5 , pp. 358-391
    • Richman, C.L.1    Dember, W.N.2    Kim, P.3
  • 43
    • 0037468873 scopus 로고    scopus 로고
    • 6 receptor antagonist
    • DOI 10.1021/jm021085c
    • Riemer C, Borroni E, Levet-Trafit B, Martin JR, Poli S, Porter RH, Bos M (2003) Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4- sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. J Med Chem 46:1273-1276 (Pubitemid 36428233)
    • (2003) Journal of Medicinal Chemistry , vol.46 , Issue.7 , pp. 1273-1276
    • Riemer, C.1    Borroni, E.2    Levet-Trafit, B.3    Martin, J.R.4    Poli, S.5    Porter, R.H.P.6    Bos, M.7
  • 44
    • 0034740154 scopus 로고    scopus 로고
    • 6 receptor antagonists enhance retention of a water maze task in the rat
    • DOI 10.1007/s002130100840
    • Rogers DC, Hagan JJ (2001) 5-HT6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology (Berl) 158:114-119 (Pubitemid 33020829)
    • (2001) Psychopharmacology , vol.158 , Issue.2 , pp. 114-119
    • Rogers, D.C.1    Hagan, J.J.2
  • 45
    • 0023685961 scopus 로고
    • Scopolamine amnesia of passive avoidance: A deficit of information acquisition
    • Rush DK (1988) Scopolamine amnesia of passive avoidance: a deficit of information acquisition. Behav Neural Biol 50:255-274
    • (1988) Behav Neural Biol , vol.50 , pp. 255-274
    • Rush, D.K.1
  • 46
    • 33750445930 scopus 로고    scopus 로고
    • The significance of the cholinergic system in the brain during aging and in Alzheimer's disease
    • DOI 10.1007/s00702-006-0579-2, 100 Years of Alzheimer's Disease
    • Schliebs R, Arendt T (2006) The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J Neural Transm 113:1625-1644 (Pubitemid 44657659)
    • (2006) Journal of Neural Transmission , vol.113 , Issue.11 , pp. 1625-1644
    • Schliebs, R.1    Arendt, T.2
  • 48
    • 0036201186 scopus 로고    scopus 로고
    • Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat
    • DOI 10.1016/S0893-133X(01)00400-6, PII S0893133X01004006
    • Shirazi-Southall S, Rodriguez DE, Nomikos GG (2002) Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology 26:583-594 (Pubitemid 34260977)
    • (2002) Neuropsychopharmacology , vol.26 , Issue.5 , pp. 583-594
    • Shirazi-Southall, S.1    Rodriguez, D.E.2    Nomikos, G.G.3
  • 50
    • 0028924167 scopus 로고
    • The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour
    • Steckler T, Sahgal A (1995) The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour. Behav Brain Res 67:165-199
    • (1995) Behav Brain Res , vol.67 , pp. 165-199
    • Steckler, T.1    Sahgal, A.2
  • 51
    • 0031913748 scopus 로고    scopus 로고
    • Recognition memory in rats - II. Neuroanatomical substrates
    • DOI 10.1016/S0301-0082(97)00061-0, PII S0301008297000610
    • Steckler T, Drinkenburg WH, Sahgal A, Aggleton JP (1998) Recognition memory in rats-II. Neuroanatomical substrates. Prog Neurobiol 54:313-332 (Pubitemid 28112649)
    • (1998) Progress in Neurobiology , vol.54 , Issue.3 , pp. 313-332
    • Steckler, T.1    Drinkenburg, W.H.I.M.2    Sahgal, A.3    Aggleton, J.P.4
  • 54
    • 38749096623 scopus 로고    scopus 로고
    • The reduction in electric footshocks perception interferes with the amnesic effect of scopolamine
    • Torquet N, Hagues J, Costentin J (2008) The reduction in electric footshocks perception interferes with the amnesic effect of scopolamine. Behav Brain Res 188:238-240
    • (2008) Behav Brain Res , vol.188 , pp. 238-240
    • Torquet, N.1    Hagues, J.2    Costentin, J.3
  • 55
    • 0035968558 scopus 로고    scopus 로고
    • Episodic memory and common sense: How far apart?
    • Tulving E (2001) Episodic memory and common sense: how far apart? Philos Trans R Soc Lond B Biol Sci 356:1505-1515
    • (2001) Philos Trans R Soc Lond B Biol Sci , vol.356 , pp. 1505-1515
    • Tulving, E.1
  • 56
    • 38349117506 scopus 로고    scopus 로고
    • The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: The impact of benzodiazepine receptors
    • Wesolowska A (2008) The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors. Eur J Pharmacol 580:355-360
    • (2008) Eur J Pharmacol , vol.580 , pp. 355-360
    • Wesolowska, A.1
  • 57
    • 77957983253 scopus 로고    scopus 로고
    • Potential role of the 5-HT6 receptor in depression and anxiety; an overview of preclinical data
    • Wesolowska A (2010) Potential role of the 5-HT6 receptor in depression and anxiety; an overview of preclinical data. Pharmacol Rep 62:564-577
    • (2010) Pharmacol Rep , vol.62 , pp. 564-577
    • Wesolowska, A.1
  • 58
    • 34047183030 scopus 로고    scopus 로고
    • 6 receptor antagonist SB-399885 in animal models of anxiety and depression
    • DOI 10.1016/j.neuropharm.2007.01.007, PII S0028390807000111
    • Wesolowska A, Nikiforuk A (2007) Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52:1274-1283 (Pubitemid 46527703)
    • (2007) Neuropharmacology , vol.52 , Issue.5 , pp. 1274-1283
    • Wesolowska, A.1    Nikiforuk, A.2
  • 59
    • 34548383532 scopus 로고    scopus 로고
    • Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats
    • DOI 10.1097/FBP.0b013e3282d28f9c, PII 0000887720070900000011
    • Wesolowska A, Nikiforuk A, Stachowicz K (2007) Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats. Behav Pharmacol 18:439-446 (Pubitemid 47356370)
    • (2007) Behavioural Pharmacology , vol.18 , Issue.5-6 , pp. 439-446
    • Wesolowska, A.1    Nikiforuk, A.2    Stachowicz, K.3
  • 60
    • 0034742606 scopus 로고    scopus 로고
    • 6 receptors in retention of spatial learning in the Morris water maze
    • DOI 10.1016/S0028-3908(01)00056-9, PII S0028390801000569
    • Woolley ML, Bentley JC, Sleight AJ, Marsden CA, Fone KC (2001) A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 41:210-219 (Pubitemid 32728092)
    • (2001) Neuropharmacology , vol.41 , Issue.2 , pp. 210-219
    • Woolley, M.L.1    Bentley, J.C.2    Sleight, A.J.3    Marsden, C.A.4    Fone, K.C.F.5
  • 61
    • 0346973946 scopus 로고    scopus 로고
    • 6 receptor antagonist, Ro 04-6790
    • DOI 10.1007/s00213-003-1552-5
    • Woolley ML, Marsden CA, Sleight AJ, Fone KC (2003) Reversal of a cholinergic-induced deficit in a rodentmodel of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psycho-pharmacology (Berl) 170:358-367 (Pubitemid 38010507)
    • (2003) Psychopharmacology , vol.170 , Issue.4 , pp. 358-367
    • Woolley, M.L.1    Marsden, C.A.2    Sleight, A.J.3    Fone, K.C.F.4
  • 62
    • 34249931450 scopus 로고    scopus 로고
    • Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples
    • DOI 10.1016/j.jpba.2007.02.024, PII S0731708507001392, Hyphenated Techniques in Pharmaceutical and Biomedical Analysis 2006
    • Zhang MY, Hughes ZA, Kerns EH, Lin Q, Beyer CE (2007) Development of a liquid chromatography/tandem mass spectrometrymethod for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples. J Pharm Biomed Anal 44:586-593 (Pubitemid 46880097)
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.44 , Issue.2 , pp. 586-593
    • Zhang, M.-Y.1    Hughes, Z.A.2    Kerns, E.H.3    Lin, Q.4    Beyer, C.E.5


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