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Volumn 36, Issue 2, 2001, Pages 165-178

5-HT6 receptor antagonists: Lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides

(6) Bös, Michael a Sleight, Andrew J b Godel, Thierry b Martin, James R b Riemer, Claus b Stadler, Heinz b

a BOEHRINGER INGELHEIM CANADA LTD (Canada)

b Preclinical Research (Switzerland)

Author keywords

Brain penetration; Lipophilicity; Passive avoidance paradigm; Serotonin; Sulfonamides

Indexed keywords

4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 4 AMINOBENZENESULFONAMIDE DERIVATIVE; BENZENE DERIVATIVE; BENZENESULFONAMIDE DERIVATIVE; BUFFER; HYDROCHLORIC ACID; INDOLE DERIVATIVE; OCTANOL; PYRIDINE DERIVATIVE; SCOPOLAMINE; SEROTONIN 6 ANTAGONIST; SEROTONIN ANTAGONIST; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMISTRY; CONTROLLED STUDY; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; NONHUMAN; PASSIVE AVOIDANCE; PH; RAT; REACTION ANALYSIS; RECEPTOR BINDING; TEMPERATURE;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; HUMANS; MEMORY DISORDERS; PROTEIN BINDING; PYRIMIDINES; RATS; RECEPTORS, SEROTONIN; SCOPOLAMINE; SEROTONIN ANTAGONISTS; SULFANILAMIDES;

EID: 0035246514 PISSN: 02235234 EISSN: None Source Type: Journal
DOI: 10.1016/S0223-5234(00)01209-5 Document Type: Article

Times cited : (52)

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