The 5-HT6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus

Neuropsychopharmacology

Volumn 25, Issue 5, 2001, Pages 662-668

  Dawson, Lee A ^a   Nguyen, Huy Q ^a   Li, Ping ^a  

^a Neuroscience Research   (United States)

Author keywords

5 HT6 receptor; Cognition; Dorsal hippocampus; Frontal cortex; Glutamate; Microdialysis; Nucleus accumbens; SB 271046; Striatum

Indexed keywords

5 CHLORO N (4 METHOXY 3 PIPERAZIN 1 YL PHENYL) 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; ATROPINE; DOPAMINE; GLUTAMIC ACID; NORADRENALIN; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DRUG SELECTIVITY; FRONTAL CORTEX; HIPPOCAMPUS; IN VIVO STUDY; MALE; MEMORY; MICRODIALYSIS; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

ANIMALS; ATROPINE; DOPAMINE; EXCITATORY AMINO ACIDS; EXTRACELLULAR SPACE; GLUTAMIC ACID; HIPPOCAMPUS; MALE; MICRODIALYSIS; MUSCARINIC ANTAGONISTS; NOREPINEPHRINE; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; SULFONAMIDES; SYNAPTIC TRANSMISSION; TETRODOTOXIN; THIOPHENES;

EID: 0034782825     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(01)00265-2     Document Type: Article

References (31)

1. Hippocampal synaptic plasticity and cognition
2. A review of central 5-HT receptors and their function
3. 6 receptor antagonist, Ro 04-6790, in rats
4. 6 receptors in nigro-striatal function in rodents
5. 6 receptor in the rat brain: A study using antisense oligonucleotides
6. Cognitive deficit in schizophrenia and its neurochemical basis
7. 6 receptor antagonist
8. The cerebral cortex and parafascicular thalamic nucleus facilitate in vivo acetylcholine release in the rat striatum through distinct glutamate receptor subtypes
9. 6 antagonist SB-271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5-HT, glutamate and aspartate
10. 1A receptor antagonists on fluoxetine-induced changes in serotonin in rat frontal cortex
11. Improved method for the measurement of glutamate and aspartate using capillary electrophoresis with laser induced fluorescence detection and its application to brain microdialysis
12. 6 receptor-like material in the rat central nervous system
13. 6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats
14. 7 mRNA expression in rat brain
15. In vivo monitoring of glutamate in the brain by microdialysis and capillary electrophoresis with laser-induced fluorescence detection
16. A pivotal role for glutamate in the pathogenesis of schizophrenia, and its cognitive dysfunction
17. The role of the anterior prefrontal cortex in human cognition
18. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
19. 6 antagonist SB-271046
20. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
21. 6 receptor antagonist
22. 6 receptor antagonist
23. 6) receptor: Molecular cloning, localization and stimulation of cAMP accumulation
24. M1 acetylcholine receptor stimulation increases the extracellular concentrations of glutamate and GABA in the medial prefrontal cortex
25. 6 receptors: Functional correlates and potential therapeutic indications
26. Cognitive function in schizophrenic patients
27. Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry
28. 6 receptors on GABAergic but not cholinergic neurones in the adult rat brain
29. 6 receptor subtype in the rat brain