Influence of the 5-HT6 receptor on acetylcholine release in the cortex: Pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-ht6 receptor antagonist

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1273-1276

  Riemer, Claus ^a   Borroni, Edilio ^a   Levet Trafit, Bernard ^a   Martin, James R ^a   Poli, Sonia ^a   Porter, Richard H P ^a   Bös, Michael ^b  

^a Preclinical Research   (Switzerland)

^b BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 BROMO 6 PYRROLIDIN 1YLPYRIDINE 4 SULFONYL)PHENYLAMINE; PYRROLIDINE DERIVATIVE; SCOPOLAMINE; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; SULFONE DERIVATIVE; UNCLASSIFIED DRUG; 4 (2 BROMO 6 PYRROLIDIN 1 YLPYRIDINE 4 SULFONYL)PHENYLAMINE; 4-(2-BROMO-6-PYRROLIDIN-1-YLPYRIDINE-4-SULFONYL)PHENYLAMINE; ACETYLCHOLINE; PYRIDINE DERIVATIVE; SEROTONIN RECEPTOR; SULFONE;

ACETYLCHOLINE RELEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; FRONTAL CORTEX; HUMAN; HUMAN CELL; MEMORY DISORDER; MICRODIALYSIS; NEUROTRANSMISSION; NONHUMAN; PASSIVE AVOIDANCE; PHARMACOKINETICS; RAT; ANIMAL; AVOIDANCE BEHAVIOR; BIOAVAILABILITY; BLOOD BRAIN BARRIER; CELL LINE; CHEMISTRY; DRUG EFFECT; FRONTAL LOBE; HALF LIFE TIME; IN VITRO STUDY; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME; METABOLISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; SYNTHESIS; TISSUE DISTRIBUTION;

ACETYLCHOLINE; ADMINISTRATION, ORAL; ANIMALS; AVOIDANCE LEARNING; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CELL LINE; FRONTAL LOBE; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MICRODIALYSIS; MICROSOMES, LIVER; PYRIDINES; RATS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SULFONES; TISSUE DISTRIBUTION;

EID: 0037468873     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021085c     Document Type: Article

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