메뉴 건너뛰기




Volumn 55, Issue 6, 2008, Pages 1015-1022

An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

Author keywords

5 Hyroxytryptamine6 receptor; Cognition; learning and memory; Morris water maze; Novel object discrimination; Serotonin

Indexed keywords

2 CHLORO N [3 [(1 METHYL 2 PYRROLIDINYL)METHYL] 1H INDOL 5YL]BENZENESULFONAMIDE; 4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; BGC 20761; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; PRX 07034; RO 4368554; SB 357134; SB 399885; SCOPOLAMINE; SEROTONIN 6 AGONIST; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG; WAY 181187;

EID: 53449090731     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.06.061     Document Type: Article
Times cited : (126)

References (86)
  • 1
    • 0002354695 scopus 로고    scopus 로고
    • 5-HT6 antisense oligonucleotide i.c.v. affects rat performance in the water maze and feeding
    • Bentley J., Sleight A.J., Marsden C.A., and Fone K.C.F. 5-HT6 antisense oligonucleotide i.c.v. affects rat performance in the water maze and feeding. Journal of Psychopharmacology 11 (1997) A64
    • (1997) Journal of Psychopharmacology , vol.11
    • Bentley, J.1    Sleight, A.J.2    Marsden, C.A.3    Fone, K.C.F.4
  • 4
    • 0034212645 scopus 로고    scopus 로고
    • Medial frontal cortex mediates perceptual attentional set shifting in the rat
    • Birrell J.M., and Brown V.J. Medial frontal cortex mediates perceptual attentional set shifting in the rat. Journal of Neuroscience 20 (2000) 4320-4324
    • (2000) Journal of Neuroscience , vol.20 , pp. 4320-4324
    • Birrell, J.M.1    Brown, V.J.2
  • 5
    • 33746277764 scopus 로고    scopus 로고
    • A null mutation of the serotonin 6 receptor alters acute responses to ethanol
    • Bonasera S.J., Chu H.M., Brennan T.J., and Tecott L.H. A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology 31 (2006) 1801-1813
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1801-1813
    • Bonasera, S.J.1    Chu, H.M.2    Brennan, T.J.3    Tecott, L.H.4
  • 6
    • 34250191571 scopus 로고    scopus 로고
    • Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors
    • Bonsi P., Cuomo D., Ding J., Sciamanna G., Ulrich S., Tscherter A., Bernardi G., Surmeier D.J., and Pisani A. Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Neuropsychopharmacology 32 (2007) 1840-1854
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1840-1854
    • Bonsi, P.1    Cuomo, D.2    Ding, J.3    Sciamanna, G.4    Ulrich, S.5    Tscherter, A.6    Bernardi, G.7    Surmeier, D.J.8    Pisani, A.9
  • 7
    • 0035246514 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
    • Bos M., Sleight A.J., Godel T., Martin J.R., Riemer C., and Stadler H. 5-HT6 receptor antagonists: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides. European Journal of Medicinal Chemistry 36 (2001) 165-178
    • (2001) European Journal of Medicinal Chemistry , vol.36 , pp. 165-178
    • Bos, M.1    Sleight, A.J.2    Godel, T.3    Martin, J.R.4    Riemer, C.5    Stadler, H.6
  • 9
    • 53449100734 scopus 로고    scopus 로고
    • Burnham, K.E., Baxter, M.G., Bainton, J., Southam, E., Dawson, L.A., Sharp, T., Bannerman, D.M., 2007. The 5-HT6 receptor agonist WAY181187 enhances extra-dimensional set-shifting in the rat. British Journal of Pharmacology pA2online.org/abstracts/Vol5Issue2abst027P.
    • Burnham, K.E., Baxter, M.G., Bainton, J., Southam, E., Dawson, L.A., Sharp, T., Bannerman, D.M., 2007. The 5-HT6 receptor agonist WAY181187 enhances extra-dimensional set-shifting in the rat. British Journal of Pharmacology pA2online.org/abstracts/Vol5Issue2abst027P.
  • 11
    • 0034782825 scopus 로고    scopus 로고
    • The 5-HT6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus
    • Dawson L.A., Nguyen H.Q., and Li P. The 5-HT6 receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus. Neuropsychopharmacology 25 (2001) 662-668
    • (2001) Neuropsychopharmacology , vol.25 , pp. 662-668
    • Dawson, L.A.1    Nguyen, H.Q.2    Li, P.3
  • 12
    • 34250834292 scopus 로고    scopus 로고
    • Acute onset by 5-HT6-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression
    • De Foubert G., O'Neill M.J., and Zetterstrom T.S.C. Acute onset by 5-HT6-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression. Neuroscience 147 (2007) 778-785
    • (2007) Neuroscience , vol.147 , pp. 778-785
    • De Foubert, G.1    O'Neill, M.J.2    Zetterstrom, T.S.C.3
  • 15
    • 0346057791 scopus 로고    scopus 로고
    • The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats
    • Foley A.G., Murphy K.J., Hirst W.D., Gallagher H.C., Hagan J.J., Upton N., Walsh F.S., and Regan C.M. The 5-HT6 receptor antagonist SB-271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 29 (2004) 93-100
    • (2004) Neuropsychopharmacology , vol.29 , pp. 93-100
    • Foley, A.G.1    Murphy, K.J.2    Hirst, W.D.3    Gallagher, H.C.4    Hagan, J.J.5    Upton, N.6    Walsh, F.S.7    Regan, C.M.8
  • 16
    • 44149105604 scopus 로고    scopus 로고
    • The selective 5-HT(6) receptor antagonist SB-271046 and SB-399885 potentiate NCAM-PSA immunolabeling of dentate gyrus cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats
    • Foley A.G., Hirst W.D., Gallagher H.C., Barry C., Hagan J.J., Upton N., Walsh F.S., Hunter A.J., and Regan C.M. The selective 5-HT(6) receptor antagonist SB-271046 and SB-399885 potentiate NCAM-PSA immunolabeling of dentate gyrus cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54 (2008) 1166-1174
    • (2008) Neuropharmacology , vol.54 , pp. 1166-1174
    • Foley, A.G.1    Hirst, W.D.2    Gallagher, H.C.3    Barry, C.4    Hagan, J.J.5    Upton, N.6    Walsh, F.S.7    Hunter, A.J.8    Regan, C.M.9
  • 17
    • 45849149279 scopus 로고    scopus 로고
    • Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders
    • Fone K.C.F., and Porkess M.V. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neuroscience and Biobehavioral Reviews 32 (2008) 1087-1102
    • (2008) Neuroscience and Biobehavioral Reviews , vol.32 , pp. 1087-1102
    • Fone, K.C.F.1    Porkess, M.V.2
  • 18
    • 0029987475 scopus 로고    scopus 로고
    • Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats
    • Gerard C., El Mestikawy S., Lebrand C., Adrien J., Ruat M., Traiffort E., Hamon M., and Martres M.P. Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse 23 (1996) 164-173
    • (1996) Synapse , vol.23 , pp. 164-173
    • Gerard, C.1    El Mestikawy, S.2    Lebrand, C.3    Adrien, J.4    Ruat, M.5    Traiffort, E.6    Hamon, M.7    Martres, M.P.8
  • 21
    • 38549144692 scopus 로고    scopus 로고
    • Selective 5-HT6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders
    • Heal D.J., Smith S.L., Fisas A., Codony X., and Buschmann H. Selective 5-HT6 receptor ligands: Progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacology & Therapeutics 117 (2008) 207-231
    • (2008) Pharmacology & Therapeutics , vol.117 , pp. 207-231
    • Heal, D.J.1    Smith, S.L.2    Fisas, A.3    Codony, X.4    Buschmann, H.5
  • 22
    • 0347824360 scopus 로고    scopus 로고
    • Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling
    • Hirst W.D., Abrahamsen B., Blaney F.E., Calver A.R., Aloj L., Price G.W., and Medhurst A.D. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling. Molecular Pharmacology 64 (2003) 1295-1308
    • (2003) Molecular Pharmacology , vol.64 , pp. 1295-1308
    • Hirst, W.D.1    Abrahamsen, B.2    Blaney, F.E.3    Calver, A.R.4    Aloj, L.5    Price, G.W.6    Medhurst, A.D.7
  • 24
    • 33645880762 scopus 로고    scopus 로고
    • Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents
    • Holenz J., Pauwels P.J., Diaz J.L., Merce R., Codony X., and Buschmann H. Medicinal chemistry strategies to 5-HT6 receptor ligands as potential cognitive enhancers and antiobesity agents. Drug Discovery Today 11 (2006) 283-299
    • (2006) Drug Discovery Today , vol.11 , pp. 283-299
    • Holenz, J.1    Pauwels, P.J.2    Diaz, J.L.3    Merce, R.4    Codony, X.5    Buschmann, H.6
  • 26
    • 3042561627 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation-an effect sensitive to NMDA receptor antagonism
    • King M.V., Sleight A.J., Woolley M.L., Topham I.A., Marsden C.A., and Fone K.C.F. 5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation-an effect sensitive to NMDA receptor antagonism. Neuropharmacology 47 (2004) 195-204
    • (2004) Neuropharmacology , vol.47 , pp. 195-204
    • King, M.V.1    Sleight, A.J.2    Woolley, M.L.3    Topham, I.A.4    Marsden, C.A.5    Fone, K.C.F.6
  • 27
    • 53449094228 scopus 로고    scopus 로고
    • The selective 5-HT6 receptor antagonist Ro 04-6790 reverses age-related and chronic intermittent PCP-induced cognitive dysfunction in rats
    • King M.V., Sleight A.J., Fone K.C.F., and Marsden C.A. The selective 5-HT6 receptor antagonist Ro 04-6790 reverses age-related and chronic intermittent PCP-induced cognitive dysfunction in rats. Journal of Psychopharmacology 19 (2005) A12
    • (2005) Journal of Psychopharmacology , vol.19
    • King, M.V.1    Sleight, A.J.2    Fone, K.C.F.3    Marsden, C.A.4
  • 29
    • 59449085280 scopus 로고    scopus 로고
    • Influence of median or dorsal raphe 5,7-DHT lesions on 5-HT6 receptor antagonist activity in a novel object discrimination paradigm
    • King M.V., Spicer C.H., Sleight A.J., Fone K.C.F., and Marsden C.A. Influence of median or dorsal raphe 5,7-DHT lesions on 5-HT6 receptor antagonist activity in a novel object discrimination paradigm. Journal of Pharmacological Science 101 (2006) S97
    • (2006) Journal of Pharmacological Science , vol.101
    • King, M.V.1    Spicer, C.H.2    Sleight, A.J.3    Fone, K.C.F.4    Marsden, C.A.5
  • 30
    • 45949091503 scopus 로고    scopus 로고
    • The novel 5-HT6 receptor antagonist, PRX-07034, enhances memory and reduces food intake in a neurodvelopmental model of schizophrenia
    • King M.V., Fone K.C.F., Shacham S., and Gannon K.S. The novel 5-HT6 receptor antagonist, PRX-07034, enhances memory and reduces food intake in a neurodvelopmental model of schizophrenia. Journal of Psychopharmacology 21 (2007) A57
    • (2007) Journal of Psychopharmacology , vol.21
    • King, M.V.1    Fone, K.C.F.2    Shacham, S.3    Gannon, K.S.4
  • 34
    • 0346250850 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex
    • Lacroix L.P., Dawson L.A., Hagan J.J., and Heidbreder C.A. 5-HT6 receptor antagonist SB-271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex. Synapse 51 (2004) 158-164
    • (2004) Synapse , vol.51 , pp. 158-164
    • Lacroix, L.P.1    Dawson, L.A.2    Hagan, J.J.3    Heidbreder, C.A.4
  • 35
    • 0038107717 scopus 로고    scopus 로고
    • Effect of the 5-HT6 receptor antagonists Ro 04-6790 and Ro 65-7199 on latent inhibition and prepulse inhibition in the rat: comparison to clozapine
    • Leng A., Ouagazzal A., Feldon J., and Higgins G.A. Effect of the 5-HT6 receptor antagonists Ro 04-6790 and Ro 65-7199 on latent inhibition and prepulse inhibition in the rat: comparison to clozapine. Pharmacology Biochemistry and Behavior 75 (2003) 281-288
    • (2003) Pharmacology Biochemistry and Behavior , vol.75 , pp. 281-288
    • Leng, A.1    Ouagazzal, A.2    Feldon, J.3    Higgins, G.A.4
  • 36
    • 27844475728 scopus 로고    scopus 로고
    • The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat
    • Lieben C.K.J., Blokland A., Sik A., Sung E., van Nieuwenhuizen P., and Schreiber R. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology 30 (2005) 2169-2179
    • (2005) Neuropsychopharmacology , vol.30 , pp. 2169-2179
    • Lieben, C.K.J.1    Blokland, A.2    Sik, A.3    Sung, E.4    van Nieuwenhuizen, P.5    Schreiber, R.6
  • 38
    • 38149054026 scopus 로고    scopus 로고
    • Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex
    • Loiseau F., Dekeyne A., and Millan M.J. Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. Psychopharmacology 196 (2008) 93-104
    • (2008) Psychopharmacology , vol.196 , pp. 93-104
    • Loiseau, F.1    Dekeyne, A.2    Millan, M.J.3
  • 40
    • 33748751956 scopus 로고    scopus 로고
    • Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release
    • Marcos B., Gil-Bea F.J., Hirst W.D., Garcia-Alloza M., and Ramirez M.J. Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release. European Journal of Neuroscience 24 (2006) 1299-1306
    • (2006) European Journal of Neuroscience , vol.24 , pp. 1299-1306
    • Marcos, B.1    Gil-Bea, F.J.2    Hirst, W.D.3    Garcia-Alloza, M.4    Ramirez, M.J.5
  • 41
    • 0028837690 scopus 로고
    • Agonist-induced desensitisation of 5-HT6 serotonin receptor-coupled adenylyl cyclase in stably transfected HEK-293 cells
    • Max S.I., Monsma F.J., and Sibley D.R. Agonist-induced desensitisation of 5-HT6 serotonin receptor-coupled adenylyl cyclase in stably transfected HEK-293 cells. Journal of Serotonin Research 2 (1995) 101-116
    • (1995) Journal of Serotonin Research , vol.2 , pp. 101-116
    • Max, S.I.1    Monsma, F.J.2    Sibley, D.R.3
  • 42
    • 0035825243 scopus 로고    scopus 로고
    • Effects of the 5-HT6 receptor antagonist Ro 04-6790 on learning consolidation
    • Meneses A. Effects of the 5-HT6 receptor antagonist Ro 04-6790 on learning consolidation. Behavioural Brain Research 118 (2001) 107-110
    • (2001) Behavioural Brain Research , vol.118 , pp. 107-110
    • Meneses, A.1
  • 43
    • 33846994072 scopus 로고    scopus 로고
    • Memory consolidation and amnesia modify 5-HT6 receptors expression in rat brain: An autoradiographic study
    • Meneses A., Manuel-Apolinar L., Castillo C., and Castillo E. Memory consolidation and amnesia modify 5-HT6 receptors expression in rat brain: An autoradiographic study. Behavioural Brain Research 178 (2007) 53-61
    • (2007) Behavioural Brain Research , vol.178 , pp. 53-61
    • Meneses, A.1    Manuel-Apolinar, L.2    Castillo, C.3    Castillo, E.4
  • 44
    • 33645230435 scopus 로고    scopus 로고
    • Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: Focus on novel therapeutic strategies
    • Millan M.J. Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: Focus on novel therapeutic strategies. Therapie 60 (2005) 441-460
    • (2005) Therapie , vol.60 , pp. 441-460
    • Millan, M.J.1
  • 45
    • 1542313953 scopus 로고    scopus 로고
    • Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study
    • Minabe Y., Shirayama Y., Hashimoto K., Routledge C., Hagan J.J., and Ashby C.R. Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse 52 (2004) 20-28
    • (2004) Synapse , vol.52 , pp. 20-28
    • Minabe, Y.1    Shirayama, Y.2    Hashimoto, K.3    Routledge, C.4    Hagan, J.J.5    Ashby, C.R.6
  • 46
    • 28044437798 scopus 로고    scopus 로고
    • 5-HT6 receptors: a novel target for cognitive enhancement
    • Mitchell E.S., and Neumaier J.F. 5-HT6 receptors: a novel target for cognitive enhancement. Pharmacology & Therapeutics 108 (2005) 320-333
    • (2005) Pharmacology & Therapeutics , vol.108 , pp. 320-333
    • Mitchell, E.S.1    Neumaier, J.F.2
  • 47
    • 36148938722 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine
    • Mitchell E.S., and Neumaier J.F. 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine. Pharmacology Biochemistry and Behavior 88 (2008) 291-298
    • (2008) Pharmacology Biochemistry and Behavior , vol.88 , pp. 291-298
    • Mitchell, E.S.1    Neumaier, J.F.2
  • 48
    • 32144460821 scopus 로고    scopus 로고
    • BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism
    • Mitchell E.S., Hoplight B.J., Lear S.P., and Neumaier J.F. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 50 (2006) 412-420
    • (2006) Neuropharmacology , vol.50 , pp. 412-420
    • Mitchell, E.S.1    Hoplight, B.J.2    Lear, S.P.3    Neumaier, J.F.4
  • 49
    • 34250379176 scopus 로고    scopus 로고
    • Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning
    • Mitchell E.S., Sexton T., and Neumaier J.F. Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning. Neuropsychopharmacology 32 (2007) 1520-1530
    • (2007) Neuropsychopharmacology , vol.32 , pp. 1520-1530
    • Mitchell, E.S.1    Sexton, T.2    Neumaier, J.F.3
  • 50
    • 0027481384 scopus 로고
    • Cloning and Expression of a Novel Serotonin Receptor with High-Affinity for Tricyclic Psychotropic-Drugs
    • Monsma F.J., Shen Y., Ward R.P., Hamblin M.W., and Sibley D.R. Cloning and Expression of a Novel Serotonin Receptor with High-Affinity for Tricyclic Psychotropic-Drugs. Molecular Pharmacology 43 (1993) 320-327
    • (1993) Molecular Pharmacology , vol.43 , pp. 320-327
    • Monsma, F.J.1    Shen, Y.2    Ward, R.P.3    Hamblin, M.W.4    Sibley, D.R.5
  • 51
    • 33751343194 scopus 로고    scopus 로고
    • ECNP Consensus Meeting. Negative, depressive and cognitive symptoms of schizophrenia. Nice, 2004
    • Montgomery S.A., and van Zwieten-Boot B.J. ECNP Consensus Meeting. Negative, depressive and cognitive symptoms of schizophrenia. Nice, 2004. European Neuropsychopharmacology 17 (2007) 70-77
    • (2007) European Neuropsychopharmacology , vol.17 , pp. 70-77
    • Montgomery, S.A.1    van Zwieten-Boot, B.J.2
  • 53
    • 0033040488 scopus 로고    scopus 로고
    • Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine(6) receptors in rat nucleus accumbens by antisense oligonucleotides
    • Otano A., Frechilla D., Cobreros A., Cruz-Orive L.M., Insausti A., Insausti R., Hamon M., and Del Rio J. Anxiogenic-like effects and reduced stereological counting of immunolabelled 5-hydroxytryptamine(6) receptors in rat nucleus accumbens by antisense oligonucleotides. Neuroscience 92 (1999) 1001-1009
    • (1999) Neuroscience , vol.92 , pp. 1001-1009
    • Otano, A.1    Frechilla, D.2    Cobreros, A.3    Cruz-Orive, L.M.4    Insausti, A.5    Insausti, R.6    Hamon, M.7    Del Rio, J.8
  • 54
    • 53449098602 scopus 로고    scopus 로고
    • Memory enhancing properties of E-6801, a 5-HT6 receptor ligand with agonist properties, in the novel object discrimination test
    • Pauwels P., Slotten H., Fone K., Merce R., Buschmann H., and Codony X. Memory enhancing properties of E-6801, a 5-HT6 receptor ligand with agonist properties, in the novel object discrimination test. Acta Pharmacologica Sinica 27 (2006) 76
    • (2006) Acta Pharmacologica Sinica , vol.27 , pp. 76
    • Pauwels, P.1    Slotten, H.2    Fone, K.3    Merce, R.4    Buschmann, H.5    Codony, X.6
  • 55
    • 22044457309 scopus 로고    scopus 로고
    • Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task
    • Perez-Garcia G., and Meneses A. Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task. Pharmacology Biochemistry and Behavior 81 (2005) 673-682
    • (2005) Pharmacology Biochemistry and Behavior , vol.81 , pp. 673-682
    • Perez-Garcia, G.1    Meneses, A.2
  • 56
    • 0036119234 scopus 로고    scopus 로고
    • Effects of the 5-HT6 receptor antagonist, SB-271046, in animal models for schizophrenia
    • Pouzet B., Didriksen M., and Arnt J. Effects of the 5-HT6 receptor antagonist, SB-271046, in animal models for schizophrenia. Pharmacology Biochemistry and Behavior 71 (2002) 635-643
    • (2002) Pharmacology Biochemistry and Behavior , vol.71 , pp. 635-643
    • Pouzet, B.1    Didriksen, M.2    Arnt, J.3
  • 58
    • 0037468873 scopus 로고    scopus 로고
    • Influence of the 5-HT6 receptor on acetylcholine release in the cortex: Pharmacological characterization of 4-(2-bromo-6- pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist
    • Riemer C., Borroni E., Levet-Trafit B., Martin J.R., Poli S., Porter R.H.P., and Bos M. Influence of the 5-HT6 receptor on acetylcholine release in the cortex: Pharmacological characterization of 4-(2-bromo-6- pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist. Journal of Medicinal Chemistry 46 (2003) 1273-1276
    • (2003) Journal of Medicinal Chemistry , vol.46 , pp. 1273-1276
    • Riemer, C.1    Borroni, E.2    Levet-Trafit, B.3    Martin, J.R.4    Poli, S.5    Porter, R.H.P.6    Bos, M.7
  • 59
    • 0037177441 scopus 로고    scopus 로고
    • The distribution of 5-HT6 receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT6 receptor antagonist I-125 SB-258585
    • Roberts J.C., Reavill C., East S.Z., Harrison P.J., Patel S., Routledge C., and Leslie R.A. The distribution of 5-HT6 receptors in rat brain: an autoradiographic binding study using the radiolabelled 5-HT6 receptor antagonist I-125 SB-258585. Brain Research 934 (2002) 49-57
    • (2002) Brain Research , vol.934 , pp. 49-57
    • Roberts, J.C.1    Reavill, C.2    East, S.Z.3    Harrison, P.J.4    Patel, S.5    Routledge, C.6    Leslie, R.A.7
  • 60
    • 0034740154 scopus 로고    scopus 로고
    • 5-HT6 receptor antagonists enhance retention of a water maze task in the rat
    • Rogers D.C., and Hagan J.J. 5-HT6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology 158 (2001) 114-119
    • (2001) Psychopharmacology , vol.158 , pp. 114-119
    • Rogers, D.C.1    Hagan, J.J.2
  • 65
    • 0036597204 scopus 로고    scopus 로고
    • Memories are made of this (perhaps): a review of serotonin 5-HT6 receptor ligands and their biological functions
    • Russell M.G.N., and Dias R. Memories are made of this (perhaps): a review of serotonin 5-HT6 receptor ligands and their biological functions. Current Topics in Medicinal Chemistry 2 (2002) 643-654
    • (2002) Current Topics in Medicinal Chemistry , vol.2 , pp. 643-654
    • Russell, M.G.N.1    Dias, R.2
  • 70
    • 0345735825 scopus 로고    scopus 로고
    • Why mice are neither miniature humans nor small rats: A cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants
    • Setola V., and Roth B.L. Why mice are neither miniature humans nor small rats: A cautionary tale involving 5-hydroxytryptamine-6 serotonin receptor species variants. Molecular Pharmacology 64 (2003) 1277-1278
    • (2003) Molecular Pharmacology , vol.64 , pp. 1277-1278
    • Setola, V.1    Roth, B.L.2
  • 71
    • 53449085049 scopus 로고    scopus 로고
    • Shacham, S., Heal, D.J., Cheetham, S.C., Jackson, H.C., Mendelez, R., Rutkowski, J.V., Orbach, P., Gannon, K.S., 2006. PRX-07034, a potent and selective 5-HT6 receptor antagonist, reduces food intake and body weight in dietary-induced obese (DIO) rats. Society for Neuroscience Abstracts P62.10.
    • Shacham, S., Heal, D.J., Cheetham, S.C., Jackson, H.C., Mendelez, R., Rutkowski, J.V., Orbach, P., Gannon, K.S., 2006. PRX-07034, a potent and selective 5-HT6 receptor antagonist, reduces food intake and body weight in dietary-induced obese (DIO) rats. Society for Neuroscience Abstracts P62.10.
  • 72
    • 13344293715 scopus 로고    scopus 로고
    • Effects of altered 5-ht(6) expression in the rat: Functional studies using antisense oligonucleotides
    • Sleight A.J., Monsma F.J., Borroni E., Austin R.H., and Bourson A. Effects of altered 5-ht(6) expression in the rat: Functional studies using antisense oligonucleotides. Behavioural Brain Research 73 (1996) 245-248
    • (1996) Behavioural Brain Research , vol.73 , pp. 245-248
    • Sleight, A.J.1    Monsma, F.J.2    Borroni, E.3    Austin, R.H.4    Bourson, A.5
  • 76
    • 33645230634 scopus 로고    scopus 로고
    • A comparison of multiple 5-HT receptors in two tasks measuring impulsivity
    • Talpos J.C., Wilkinson L.S., and Robbins T.W. A comparison of multiple 5-HT receptors in two tasks measuring impulsivity. Journal of Psychopharmacology 20 (2006) 47-58
    • (2006) Journal of Psychopharmacology , vol.20 , pp. 47-58
    • Talpos, J.C.1    Wilkinson, L.S.2    Robbins, T.W.3
  • 77
    • 0030018405 scopus 로고    scopus 로고
    • Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum
    • Ward R.P., and Dorsa D.M. Colocalization of serotonin receptor subtypes 5-HT2A, 5-HT2C, and 5-HT6 with neuropeptides in rat striatum. Journal of Comparative Neurology 370 (1996) 405-414
    • (1996) Journal of Comparative Neurology , vol.370 , pp. 405-414
    • Ward, R.P.1    Dorsa, D.M.2
  • 78
    • 34047183030 scopus 로고    scopus 로고
    • Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression
    • Wesolowska A., and Nikiforuk A. Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression. Neuropharmacology 52 (2007) 1274-1283
    • (2007) Neuropharmacology , vol.52 , pp. 1274-1283
    • Wesolowska, A.1    Nikiforuk, A.2
  • 79
    • 21244448316 scopus 로고    scopus 로고
    • A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia
    • Woodward N.D., Purdon S.E., Meltzer H.Y., and Zald D.H. A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. International Journal of Neuropsychopharmacology 8 (2005) 457-472
    • (2005) International Journal of Neuropsychopharmacology , vol.8 , pp. 457-472
    • Woodward, N.D.1    Purdon, S.E.2    Meltzer, H.Y.3    Zald, D.H.4
  • 80
    • 0034742606 scopus 로고    scopus 로고
    • A role for 5-ht(6) receptors in retention of spatial learning in the Morris water maze
    • Woolley M.L., Bentley J.C., Sleight A.J., Marsden C.A., and Fone K.C.F. A role for 5-ht(6) receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 41 (2001) 210-219
    • (2001) Neuropharmacology , vol.41 , pp. 210-219
    • Woolley, M.L.1    Bentley, J.C.2    Sleight, A.J.3    Marsden, C.A.4    Fone, K.C.F.5
  • 82
    • 0346973946 scopus 로고    scopus 로고
    • Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790
    • Woolley M.L., Marsden C.A., Sleight A.J., and Fone K.C.F. Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790. Psychopharmacology 170 (2003) 358-367
    • (2003) Psychopharmacology , vol.170 , pp. 358-367
    • Woolley, M.L.1    Marsden, C.A.2    Sleight, A.J.3    Fone, K.C.F.4
  • 83
    • 33748268092 scopus 로고    scopus 로고
    • Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques
    • Yang G.B., Qiu C.L., Zhao H., Liu Q., and Shao Y.M. Expression of mRNA for multiple serotonin (5-HT) receptor types/subtypes by the peripheral blood mononuclear cells of rhesus macaques. Journal of Neuroimmunology 178 (2006) 24-29
    • (2006) Journal of Neuroimmunology , vol.178 , pp. 24-29
    • Yang, G.B.1    Qiu, C.L.2    Zhao, H.3    Liu, Q.4    Shao, Y.M.5
  • 84
    • 0031128218 scopus 로고    scopus 로고
    • Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus
    • Yau J.L.W., Noble J., Widdowson J., and Seckl J.R. Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus. Molecular Brain Research 45 (1997) 182-186
    • (1997) Molecular Brain Research , vol.45 , pp. 182-186
    • Yau, J.L.W.1    Noble, J.2    Widdowson, J.3    Seckl, J.R.4
  • 85
    • 0032571283 scopus 로고    scopus 로고
    • Central distribution and function of 5-HT6 receptor subtype in the rat brain
    • Yoshioka M., Matsumoto M., Togashi H., Mori K., and Saito H. Central distribution and function of 5-HT6 receptor subtype in the rat brain. Life Sciences 62 (1998) 1473-1477
    • (1998) Life Sciences , vol.62 , pp. 1473-1477
    • Yoshioka, M.1    Matsumoto, M.2    Togashi, H.3    Mori, K.4    Saito, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.