Adaptations in 5-HT receptor expression and function: Implications for treatment of cognitive impairment in aging

Journal of Neuroscience Research

Volumn 87, Issue 12, 2009, Pages 2803-2811

  Mitchell, Ellen S ^a,b   McDevitt, Ross A ^a   Neumaier, John F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

5 HT1A; 5 HT1B; 5 HT6; Dementia; Ki 67; Object recognition; PCNA; Social discrimination; Tryptophan hydroxylase 2

Indexed keywords

CYCLINE; KI 67 ANTIGEN; MESSENGER RNA; RO 4368554; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FOREBRAIN; LEARNING; MALE; MEMORY; MENTAL PERFORMANCE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RAT; SOCIAL DISCRIMINATION; TREATMENT DURATION; VISUAL MEMORY;

AGING; ANIMALS; BRAIN; COGNITION DISORDERS; INDOLES; KI-67 ANTIGEN; MALE; MEMORY DISORDERS; NEURONAL PLASTICITY; PIPERAZINES; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, INBRED F344; RATS, LONG-EVANS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; RNA, MESSENGER; SEROTONIN; SEROTONIN ANTAGONISTS; TRYPTOPHAN HYDROXYLASE;

EID: 70449467081     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22100     Document Type: Article

References (41)

1. Alvarez-Alvareza M, Galdos L, Fernandez-Martinez M, Gomez-Busto F, Garcia-Centeno V, Arias-Arias C, Sanchez-Salazar C, Rodriguez-Martinez AB, Zarranz JJ, de Pancorbo MM. 2003. 5-Hydroxytryptamine 6 receptor (5-HT6) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque country. Neurosci Lett 339:85-87. (Pubitemid 36263226)
2. Azmitia EC. 2001. Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56:413-424.
3. Baker KB, Kim JJ. 2002. Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats. Learn Mem 9:58-65. (Pubitemid 34507492)
4. 6 receptor antagonist. Soc Neurosci 844:5.
5. Buhot HC, Martin S, Segu L. 2000. Role of serotonin in memory impairment. Ann Med 32:210-221.
6. 1B receptor gene deletion on the age-related decline in spatial learning abilities in mice. Behav Brain Res 142:135-142.
7. 1B, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei. J Comp Neurol 498:611-623.
8. 1B receptors in old mice. Psychopharmacology 153:443-449.
9. 6 receptor binding sites in schizophrenia and following antipsychotic drug administration: autoradiographic studies with [I-125]SB-258585. Synapse 45:191-199.
10. 6 receptors in the nucleus accumbens blocks the rewarding but not psychomotor activating properties of cocaine. Biol Psychiatry 63:207-213.
11. Foley AG, Murphy KJ, Hirst WD, Gallagher HC, Hagan JJ, Upton N, Walsh FS, Regan CM. 2004. The 5-HT6 receptor antagonist SB- 271046 reverses scopolamine-disrupted consolidation of a passive avoidance task and ameliorates spatial task deficits in aged rats. Neuropsychopharmacology 29:93-100. (Pubitemid 38068018)
12. 6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats. Neuropharmacology 54:1166-1174.
13. 6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology 29:410-416.
14. 6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats. Synapse 23:164-173.
15. 6 receptor-like material in the rat central nervous system. Brain Res 746:207-219.
16. Hiroi R, McDevitt RA, Neumaier JF. 2006. Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Biol Psychiatry 60:288-295. (Pubitemid 44093439)
17. Kan R, Wang BB, Zhang CF, Yang Z, Ji S, Lu ZP, Zheng CG, Jin F, Wang L. 2004. Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese. Neurosci Lett 372:27-29. (Pubitemid 39505222)
18. Kee N, Sivalingam S, Boonstra R, Wojtowicz JM. 2002. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. J Neurosci Methods 115:97-105. (Pubitemid 34202283)
19. 6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop. Brain Res Mol Brain Res 90:110-117.
20. Lieben CKJ, Blokland A, Sik A, Sung E, van Nieuwenhuizen P, Schreiber R. 2005. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology 30:2169-2179. (Pubitemid 41643968)
21. Limke TL, Cai JL, Miura T, Rao MS, Mattson MP. 2003. Distinguishing features of progenitor cells in the late embryonic and adult hippocampus. Dev Neurosci 25:257-272. (Pubitemid 37100218)
22. 6 receptors in the prefrontal cortex of Alzheimer and normal aging patients. BMC Neurosci 7:36.
23. 6 receptor-mediated acetylcholine release. Eur J Neurosci 24:1299-1306.
24. Mattson MP, Maudsley S, Martin B. 2004. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27:589-594. (Pubitemid 39221394)
25. 6 receptors in memory formation. Drug News Perspect 14:396-400.
26. 6 receptors: a novel target for cognitive enhancement. Pharmacol Ther 108:320-333.
27. Mitchell ES, Hoplight BJ, Lear SP, Neumaier JF. 2006. BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacol 50:412-420.
28. 6 receptors in the rat dorsomedial striatum impairs instrumental learning. Neuropsychopharmacology 32:1520-1530.
29. Monsma FJ Jr, Shen Y, Ward RP, Hamblin MW, Sibley DR. 1993. Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol Pharmacol 43:320-327. (Pubitemid 23081986)
30. 1B receptor mRNA levels in rat brain. Brain Res Mol Brain Res 722:50-58.
31. 1B receptor mRNA in rat hippocampus. Brain Res Mol Brain Res 82:65-73.
32. Orlacchio A, Kawarai T, Paciotti E, Stefani A, Orlacchio A, Sorbi S, St. George-Hyslop PH, Bernardi G. 2002. Association study of the 5-hydroxytryptamine( 6) receptor gene in Alzheimer's disease. Neurosci Lett 325:13-16. (Pubitemid 34521969)
33. Paxinos G, Watson C. 2003. The rat brain in stereotaxic coordinates, 5th ed. San Diego: Academic Press.
34. Plassat JL, Amlaiky N, Hen R. 1993. Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase. Mol Pharmacol 44:229-236. (Pubitemid 23252224)
35. 6 receptor on acetylcholine release in the cortex: Pharmacological characterization of 4-(2-bromo-6-pyrrolidin- 1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5- HT6 receptor antagonist. J Med Chem 46:1273-1276.
36. 6 receptor antagonists enhance retention of a water maze task in the rat. Psychopharmacology 158:114-119.
37. 1B-receptor knockout mice. Brain Res Bull 70:81-93.
38. Turturro A, Witt WW, Lewis S, Hass BS, Lipman RD, Hart RW. 1999. Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J Gerontol Biol 54:B492-B501. (Pubitemid 30017610)
39. Vanluijtelaar MGPA, Tonnaer JADM, Steinbusch HWM. 1992. Aging of the serotonergic system in the rat forebrain - an immunocytochemical and neurochemical study. Neurobiol Aging 13:201-215.
40. Walther DJ, Bader M. 2003. A unique central tryptophan hydroxylase isoform. Biochem Pharmacol 66:1673-1680. (Pubitemid 37249312)
41. 6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 41:210-219.