Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor

Journal of Neurochemistry

Volumn 66, Issue 1, 1996, Pages 47-56

  Kohen, Ruth ^a,b   Metcalf, Mark A ^b   Khan, Naseem ^c   Druck, Teresa ^d   Huebner, Kay ^d   Lachowicz, Jean E ^e   Meltzer, Herbert Y ^c   Sibley, David R ^e   Roth, Bryan L ^c   Hamblin, Mark W ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Atypical antipsychotics; Chromosomal localization; Clozapine; G protein coupled receptors; Serotonin receptors

Indexed keywords

SEROTONIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN REGION; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; SEROTONIN RELEASE;

ANIMALIA;

EID: 13344275875     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66010047.x     Document Type: Article

References (32)

1. Abbott C. M., Blank R., Eppig J. T., Fiedorek F. T., Frankel W., Friedman J. M., Huppi K. E., Jackson I., Steel K., Mock B. A., Stoye J., and Seman R. W. (1993) Mouse chromosome 4. Mamm. Genome 4 (Suppl.), S58-S71.
2. Dβ receptor. Mol. Pharmacol. 41, 1-7.
3. Adham N., Ellerbrock B., Hartig P., Weinshank R. L., and Branchek T. (1993) Receptor reserve masks partial agonist activity of drugs in a cloned rat 5-hydroxytryptamine1B receptor expression system. Mol. Pharmacol. 43, 427-433.
4. Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
5. Bymaster F. P., Calligaro D. O., Falcone J. F., Marsh R. D., Moore N. A., Tye N. C., Seeman P., and Wong D. T. (1995) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology (in press).
6. 2 dopamine receptor in rat and bovine caudate nucleus. Nature 343, 266-269.
7. Cullen B. R. (1987) Use of eukaryotic expression technology in the functional analysis of cloned genes, in Guide to Molecular Cloning Techniques, Academic Press, San Diego. pp. 684-704.
8. 6 serotonin receptors may reflect psychoactive profile. Mol. Med. 1, 398-406.
9. Haluska F. G., Huebner K., Isobe M., Nishimura T., Croce C. M., and Vogt P. K. (1988) Localization of the human JUN protooncogene to chromosome region 1p31-32. Proc. Natl. Acad. Sci. USA 85, 2215-2218.
10. 1D-type serotonin receptor. Mol. Pharmacol. 40, 143-148.
11. 1D serotonin receptors in rat: structural and pharmacological comparison of the two cloned receptors. Mol. Cell. Neurosci. 3, 578-587.
12. 1D-like pharmacological specificity. Biochem. Biophys. Res. Commun. 184, 752-759.
13. Hoyer D., Clarke D. E., Fozard J. R., Hartig P. R., Martin G. R., Mylecharane E. J., Saxena P. R., and Humphrey P. P. A. (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46, 157-203.
14. Huebner K., Druck T., Croce C. M., and Thiesen H.-J. (1991) Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Am. J. Hum. Genet. 48, 726-740.
15. Humphrey P. P. A., Hartig P., and Hoyer D. (1993) A proposed new nomenclature for 5-HT receptors. Trends Pharmacol. Sci. 14, 233-236.
16. Libert F., Passage E., Parmentier M., Simons M.-J., Vassart G., and Mattei M.-G. (1991) Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor. Genomics 11, 225-227.
17. 5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol. Pharmacol. 43, 313-319.
18. Meltzer H. Y., Matsubara S., and Lee J.-C. (1989) Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2, and serotonin2 pKi values. J. Pharmacol. Exp. Ther. 251, 238-246.
19. 2 dopamine receptors produced by alternative RNA splicing. Nature 342, 926-929.
20. Monsma F. J. Jr., Shen Y., Ward R. P., Hamblin M. W., and Sibley D. R. (1993) Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Mol. Pharmacol. 43, 320-327.
21. Mount S. M. (1982) A catalogue of splice junction sequences. Nucleic Acids Res. 10, 459-472.
22. 2 receptor occupancy in clozapine treated patients demonstrated by PET. Psychopharmacology (Berlin) 110, 365-367.
23. 1C receptors. J. Pharmacol. Exp. Ther. 260, 1361-1365.
24. Roth B. L., Craigo S. C., Choudhary M. S., Uluer A., Monsma F. R. Jr., Shen Y., Meltzer H. Y., and Sibley D. R. (1994) Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther. 268, 1403-1410.
25. 6) receptor: molecular cloning, localization and stimulation of cAMP accumulation. Biochem. Biophys. Res. Commun. 193, 268-276.
26. Sambrook J., Fritsch E. F., and Maniatis T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
27. 6 receptor-like profile stimulating adenylyl cyclase activity in pig caudate membranes. Arch. Pharmacol. 350, 356-360.
28. A subtype. DNA 8, 683-689.
29. 3) as a target for neuroleptics. Nature 347, 146-151.
30. Takebe Y., Seiki M., Fujisawa J.-I., Hoy P., Yokota K., Arai K.-I., Yoshida M., and Arai N. (1988) SRα promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8, 466-472.
31. Ward R. P., Hamblin M. W., Lachowicz J. E., Hoffman B. J. D., Sibley D. R., and Dorsa D. M. (1995) Localization of serotonin subtype 6 receptor messenger RNA in the rat brain by in situ hybridization histochemistry. Neuroscience 64, 1105-1111.
32. Wilkie T. M., Chen Y., Gilbert D. J., Moore K. J., Yu L., Simon M. I., Copeland N. G., and Jenkins N. A. (1993) Identification, chromosomal localization and genome organization of mammalian G-protein coupled receptors. Genomics 18, 175-184.