Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling

Molecular Pharmacology

Volumn 64, Issue 6, 2003, Pages 1295-1308

  Hirst, Warren D ^a   Abrahamsen, Bjarke ^a   Blaney, Frank E ^a   Calver, Andrew R ^a   Aloj, Lucia ^a   Price, Gary W ^a   Medhurst, Andrew D ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; AMINO ACID; AMITRIPTYLINE; ASPARAGINE; BRL 34849; BRL 34969; CLOZAPINE; LYSERGIDE; MEMBRANE PROTEIN; MESSENGER RNA; METITEPINE; MIANSERIN; MUTANT PROTEIN; PHENYLALANINE; RADIOLIGAND; RECEPTOR PROTEIN; RO 046790; SB 214111; SB 258510; SB 258585; SB 357134; SERINE; SEROTONIN; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; SULFONAMIDE; SUMATRIPTAN; TYROSINE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN; CASE REPORT; CENTRAL NERVOUS SYSTEM; CLONING; COGNITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; MALE; MOLECULAR MODEL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RECEPTOR OCCUPANCY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

AGED; ANIMALS; CELL LINE; CENTRAL NERVOUS SYSTEM; HUMANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPECIES SPECIFICITY;

EID: 0347824360     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.6.1295     Document Type: Article

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