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Volumn 2, Issue , 2013, Pages

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CATALYTIC SUBUNIT ALPHA; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84885435958     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2013.38     Document Type: Article
Times cited : (46)

References (30)
  • 1
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC. PI3K pathway alterations in cancer: Variations on a theme. Oncogene 2008; 27: 5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 2
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: Navigating downstream. Cell 2007; 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 4
    • 70349741007 scopus 로고    scopus 로고
    • Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA
    • Kadota M, Sato M, Duncan B, Ooshima A, Yang HH, Diaz-Meyer N et al. Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA. Cancer Res 2009; 69: 7357-7365.
    • (2009) Cancer Res , vol.69 , pp. 7357-7365
    • Kadota, M.1    Sato, M.2    Duncan, B.3    Ooshima, A.4    Yang, H.H.5    Diaz-Meyer, N.6
  • 7
    • 27544515272 scopus 로고    scopus 로고
    • Somatic mutation and gain of copy number of PIK3CA in human breast cancer
    • Wu G, Xing M, Mambo E, Huang X, Liu J, Guo Z et al. Somatic mutation and gain of copy number of PIK3CA in human breast cancer. Breast Cancer Res 2005; 7: R609-R616.
    • (2005) Breast Cancer Res , vol.7 , pp. 609-616
    • Wu, G.1    Xing, M.2    Mambo, E.3    Huang, X.4    Liu, J.5    Guo, Z.6
  • 8
    • 84857184141 scopus 로고    scopus 로고
    • Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review)
    • Hafsi S, Pezzino FM, Candido S, Ligresti G, Spandidos DA, Soua Z et al. Gene alterations in the PI3K/PTEN/AKT pathway as a mechanism of drug-resistance (review). Int J Oncol 2012; 40: 639-644.
    • (2012) Int J Oncol , vol.40 , pp. 639-644
    • Hafsi, S.1    Pezzino, F.M.2    Candido, S.3    Ligresti, G.4    Spandidos, D.A.5    Soua, Z.6
  • 9
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5: 921-929.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 10
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader AG, Kang S, Vogt PK. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc Natl Acad Sci USA 2006; 103: 1475-1479.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 12
    • 29444449785 scopus 로고    scopus 로고
    • The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
    • Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci USA 2005; 102: 18443-18448.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18443-18448
    • Zhao, J.J.1    Liu, Z.2    Wang, L.3    Shin, E.4    Loda, M.F.5    Roberts, T.M.6
  • 13
    • 84878759104 scopus 로고    scopus 로고
    • Mouse models of PIK3CA mutations: One mutation initiates heterogeneous mammary tumors
    • Koren S, Bentires-Alj M. Mouse models of PIK3CA mutations: One mutation initiates heterogeneous mammary tumors. FEBS J 2013; 280: 2758-2765.
    • (2013) FEBS J , vol.280 , pp. 2758-2765
    • Koren, S.1    Bentires-Alj, M.2
  • 14
    • 40649096375 scopus 로고    scopus 로고
    • Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
    • Zhao L, Vogt PK. Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci USA 2008; 105: 2652-2657.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2652-2657
    • Zhao, L.1    Vogt, P.K.2
  • 15
    • 35948964043 scopus 로고    scopus 로고
    • Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas
    • Barbareschi M, Buttitta F, Felicioni L, Cotrupi S, Barassi F, Del Grammastro M et al. Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas. Clin Cancer Res 2007; 13: 6064-6069.
    • (2007) Clin Cancer Res , vol.13 , pp. 6064-6069
    • Barbareschi, M.1    Buttitta, F.2    Felicioni, L.3    Cotrupi, S.4    Barassi, F.5    Del Grammastro, M.6
  • 16
    • 84856774967 scopus 로고    scopus 로고
    • Initiating breast cancer by PIK3CA mutation
    • Miller TW. Initiating breast cancer by PIK3CA mutation. Breast Cancer Res 2012; 14: 301.
    • (2012) Breast Cancer Res , vol.14 , pp. 301
    • Miller, T.W.1
  • 17
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal LH, Holm K, Maurer M, Memeo L, Su T, Wang X et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005; 65: 2554-2559.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3    Memeo, L.4    Su, T.5    Wang, X.6
  • 18
  • 20
    • 40549113364 scopus 로고    scopus 로고
    • PIK3CA exonmutation is independently associated with a poor prognosis in breast cancer patients
    • Cancer Genome Atlas Network.
    • Lai YL, Mau BL, Cheng WH, Chen HM, Chiu HH, Tzen CY. PIK3CA exon mutation is independently associated with a poor prognosis in breast cancer patients. Ann Surg Oncol 2008; 15: 1064-1069. Cancer Genome Atlas Network.
    • (2008) Ann Surg Oncol , vol.15 , pp. 1064-1069
    • Lai, Y.L.1    Mau, B.L.2    Cheng, W.H.3    Chen, H.M.4    Chiu, H.H.5    Tzen, C.Y.6
  • 21
    • 84877028141 scopus 로고    scopus 로고
    • Comprehensive molecular portraits of human breast tumours
    • Comprehensive molecular portraits of human breast tumours. Nature 2012; 490: 61-70.
    • (2012) Nature , vol.490 , pp. 61-70
  • 22
    • 79959860167 scopus 로고    scopus 로고
    • Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors
    • Meyer DS, Brinkhaus H, Muller U, Muller M, Cardiff RD, Bentires-Alj M. Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors. Cancer Res 2011; 71: 4344-4351.
    • (2011) Cancer Res , vol.71 , pp. 4344-4351
    • Meyer, D.S.1    Brinkhaus, H.2    Muller, U.3    Muller, M.4    Cardiff, R.D.5    Bentires-Alj, M.6
  • 23
    • 79953297489 scopus 로고    scopus 로고
    • Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation
    • Adams JR, Xu K, Liu JC, Agamez NM, Loch AJ, Wong RG et al. Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation. Cancer Res 2011; 71: 2706-2717.
    • (2011) Cancer Res , vol.71 , pp. 2706-2717
    • Adams, J.R.1    Xu, K.2    Liu, J.C.3    Agamez, N.M.4    Loch, A.J.5    Wong, R.G.6
  • 24
    • 80052490834 scopus 로고    scopus 로고
    • Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms
    • Liu P, Cheng H, Santiago S, Raeder M, Zhang F, Isabella A et al. Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med 2011; 17: 1116-1120.
    • (2011) Nat Med , vol.17 , pp. 1116-1120
    • Liu, P.1    Cheng, H.2    Santiago, S.3    Raeder, M.4    Zhang, F.5    Isabella, A.6
  • 25
    • 84861634733 scopus 로고    scopus 로고
    • Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERalpha-positive tumors
    • Tikoo A, Roh V, Montgomery KG, Ivetac I, Waring P, Pelzer R et al. Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERalpha-positive tumors. PLoS One 2012; 7: E36924.
    • (2012) PLoS One , vol.7
    • Tikoo, A.1    Roh, V.2    Montgomery, K.G.3    Ivetac, I.4    Waring, P.5    Pelzer, R.6
  • 26
    • 70349230969 scopus 로고    scopus 로고
    • Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice
    • Tchorz JS, Kinter J, Muller M, Tornillo L, Heim MH, Bettler B. Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology 2009; 50: 871-879.
    • (2009) Hepatology , vol.50 , pp. 871-879
    • Tchorz, J.S.1    Kinter, J.2    Muller, M.3    Tornillo, L.4    Heim, M.H.5    Bettler, B.6
  • 27
    • 0036321924 scopus 로고    scopus 로고
    • Targeting mammary epithelial cells using a bacterial artificial chromosome
    • Wintermantel TM, Mayer AK, Schutz G, Greiner EF. Targeting mammary epithelial cells using a bacterial artificial chromosome. Genesis 2002; 33: 125-130.
    • (2002) Genesis , vol.33 , pp. 125-130
    • Wintermantel, T.M.1    Mayer, A.K.2    Schutz, G.3    Greiner, E.F.4
  • 28
    • 13244273440 scopus 로고    scopus 로고
    • Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression
    • Boulanger CA, Wagner KU, Smith GH. Parity-induced mouse mammary epithelial cells are pluripotent, self-renewing and sensitive to TGF-beta1 expression. Oncogene 2005; 24: 552-560.
    • (2005) Oncogene , vol.24 , pp. 552-560
    • Boulanger, C.A.1    Wagner, K.U.2    Smith, G.H.3
  • 29
    • 34547960767 scopus 로고    scopus 로고
    • Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation
    • Booth BW, Boulanger CA, Smith GH. Alveolar progenitor cells develop in mouse mammary glands independent of pregnancy and lactation. J Cell Physiol 2007; 212: 729-736.
    • (2007) J Cell Physiol , vol.212 , pp. 729-736
    • Booth, B.W.1    Boulanger, C.A.2    Smith, G.H.3
  • 30
    • 79954994412 scopus 로고    scopus 로고
    • Functional characterization of stem cell activity in the mouse mammary gland
    • Bruno RD, Smith GH. Functional characterization of stem cell activity in the mouse mammary gland. Stem Cell Rev 2011; 7: 238-247.
    • (2011) Stem Cell Rev , vol.7 , pp. 238-247
    • Bruno, R.D.1    Smith, G.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.