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Volumn 2, Issue , 2012, Pages

A novel tumor suppressor network in squamous malignancies

Author keywords

[No Author keywords available]

Indexed keywords

MTOR PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P107; PROTEIN P53; PTEN PROTEIN, MOUSE; RBL1 PROTEIN, MOUSE; RETINOBLASTOMA PROTEIN; TARGET OF RAPAMYCIN KINASE;

EID: 84869155458     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep00828     Document Type: Article
Times cited : (11)

References (60)
  • 1
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 2
    • 0035063183 scopus 로고    scopus 로고
    • The Rb/E2F pathway and cancer
    • Nevins, J. R. The Rb/E2F pathway and cancer. Hum Mol Genet 10, 699-703 (2001). (Pubitemid 32331578)
    • (2001) Human Molecular Genetics , vol.10 , Issue.7 , pp. 699-703
    • Nevins, J.R.1
  • 3
    • 0026760426 scopus 로고
    • Requirement for a functional Rb-1 gene in murine development
    • Clarke, A. R. et al. Requirement for a functional Rb-1 gene in murine development. Nature 359, 328-330 (1992).
    • (1992) Nature , vol.359 , pp. 328-330
    • Clarke, A.R.1
  • 4
    • 0026702996 scopus 로고
    • Effects of an Rb mutation in themouse
    • Jacks, T. et al. Effects of an Rb mutation in themouse. Nature 359, 295-300 (1992).
    • (1992) Nature , vol.359 , pp. 295-300
    • Jacks, T.1
  • 5
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • Lee, E. Y. et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359, 288-294 (1992).
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1
  • 6
    • 3042813439 scopus 로고    scopus 로고
    • Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis
    • DOI 10.1242/dev.01148
    • Ruiz, S. et al. Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 131, 2737-2748 (2004). (Pubitemid 38877905)
    • (2004) Development , vol.131 , Issue.11 , pp. 2737-2748
    • Ruiz, S.1    Santos, M.2    Segrelles, C.3    Leis, H.4    Jorcano, J.L.5    Berns, A.6    Paramio, J.M.7    Vooijs, M.8
  • 9
    • 68549096090 scopus 로고    scopus 로고
    • Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation
    • Martinez-Cruz, A. B. et al. Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation. Anticancer research 29, 3035-3042 (2009).
    • (2009) Anticancer Research , vol.29 , pp. 3035-3042
    • Martinez-Cruz, A.B.1
  • 10
    • 84861701969 scopus 로고    scopus 로고
    • EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours
    • Bornachea, O. et al. EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours. Scientific reports 2, 434 (2012).
    • (2012) Scientific Reports , vol.2 , pp. 434
    • Bornachea, O.1
  • 11
    • 77954464575 scopus 로고    scopus 로고
    • Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy
    • Garcia-Escudero, R. et al. Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy. Molecular cancer 9, 193 (2010).
    • (2010) Molecular Cancer , vol.9 , pp. 193
    • Garcia-Escudero, R.1
  • 12
    • 84879413204 scopus 로고    scopus 로고
    • E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
    • doi: 10.1038/onc.2012.316
    • Costa, C. et al. E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis. Oncogene (2012) doi: 10.1038/onc.2012.316.
    • (2012) Oncogene
    • Costa, C.1
  • 15
    • 55949125166 scopus 로고    scopus 로고
    • Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage
    • Santos, M. et al. Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage. Mol Carcinog 47, 815-821 (2008).
    • (2008) Mol Carcinog , vol.47 , pp. 815-821
    • Santos, M.1
  • 16
    • 34547872766 scopus 로고    scopus 로고
    • The Rb family connects with the Tp53 family in skin carcinogenesis
    • DOI 10.1002/mc.20338
    • Lara, M. F. & Paramio, J. M. The Rb family connects with the Tp53 family in skin carcinogenesis. Mol Carcinog 46, 618-623 (2007). (Pubitemid 47255177)
    • (2007) Molecular Carcinogenesis , vol.46 , Issue.8 , pp. 618-623
    • Lara, M.F.1    Paramio, J.M.2
  • 18
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco, I. & Sawyers, C. L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2, 489-501 (2002). (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 19
    • 70349750265 scopus 로고    scopus 로고
    • PTEN new insights into its regulation and function in skin cancer
    • Ming, M. & He, Y. Y. PTEN: new insights into its regulation and function in skin cancer. The Journal of investigative dermatology 129, 2109-2112 (2009).
    • (2009) The Journal of Investigative Dermatology , vol.129 , pp. 2109-2112
    • Ming, M.1    He, Y.Y.2
  • 21
    • 0038348423 scopus 로고    scopus 로고
    • Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130
    • DOI 10.1242/dev.00453
    • Ruiz, S. et al. Abnormal epidermal differentiation and impaired epithelialmesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Development 130, 2341-2353 (2003). (Pubitemid 36722386)
    • (2003) Development , vol.130 , Issue.11 , pp. 2341-2353
    • Ruiz, S.1    Segrelles, C.2    Bravo, A.3    Santos, M.4    Perez, P.5    Leis, H.6    Jorcano, J.L.7    Paramio, J.M.8
  • 24
    • 33645285881 scopus 로고    scopus 로고
    • Is the loss of pRb essential for themouse skin carcinogenesis?
    • Ruiz, S., Santos, M. & Paramio, J. M. Is the loss of pRb essential for themouse skin carcinogenesis? Cell Cycle 5, 625-629 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 625-629
    • Ruiz, S.1    Santos, M.2    Paramio, J.M.3
  • 26
    • 81155137696 scopus 로고    scopus 로고
    • DeltaNp63alpha regulates keratinocyte proliferation by controlling PTEN expression and localization
    • Leonard, M. K. et al. DeltaNp63alpha regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell death and differentiation 18, 1924-1933 (2011).
    • (2011) Cell Death and Differentiation , vol.18 , pp. 1924-1933
    • Leonard, M.K.1
  • 28
    • 84864196455 scopus 로고    scopus 로고
    • A humanized mouse model of hpv-associated pathology driven by E7 expression
    • Buitrago-Perez, A. et al. A Humanized Mouse Model of HPV-Associated Pathology Driven by E7 Expression. PLoS One 7, e41743 (2012).
    • (2012) PLoS One , vol.7
    • Buitrago-Perez, A.1
  • 29
  • 30
    • 38149075312 scopus 로고    scopus 로고
    • Papillomavirus E6 and E7 proteins and their cellular targets
    • DOI 10.2741/2739
    • Wise-Draper, T. M. & Wells, S. I. Papillomavirus E6 and E7 proteins and their cellular targets. Front Biosci 13, 1003-1017 (2008). (Pubitemid 351594744)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.3 , pp. 1003-1017
    • Wise-Draper, T.M.1    Wells, S.I.2
  • 32
    • 84862777719 scopus 로고    scopus 로고
    • Distinct regulatory mechanisms and functions for p53-activated and p53-Repressed DNA damage response genes in embryonic stem cells
    • Li, M. et al.Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells. Molecular cell 46, 30-42 (2012).
    • (2012) Molecular Cell , vol.46 , pp. 30-42
    • Li, M.1
  • 34
    • 77951717316 scopus 로고    scopus 로고
    • Molecular target class is predictive of in vitro response profile
    • Greshock, J. et al. Molecular target class is predictive of in vitro response profile. Cancer Res 70, 3677-3686 (2010).
    • (2010) Cancer Res , vol.70 , pp. 3677-3686
    • Greshock, J.1
  • 35
    • 0030991235 scopus 로고    scopus 로고
    • The retinoblastoma protein: A master regulator of cell cycle, differentiation and apoptosis
    • Herwig, S. & Strauss, M. The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Biochem 246, 581-601 (1997). (Pubitemid 27252898)
    • (1997) European Journal of Biochemistry , vol.246 , Issue.3 , pp. 581-601
    • Herwig, S.1    Strauss, M.2
  • 36
    • 0030678627 scopus 로고    scopus 로고
    • Role of the retinoblastoma protein in the pathogenesis of human cancer
    • Sellers, W. R. & Kaelin, W. G., Jr. Role of the retinoblastoma protein in the pathogenesis of human cancer. J Clin Oncol 15, 3301-3312 (1997). (Pubitemid 27485848)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.11 , pp. 3301-3312
    • Sellers, W.R.1    Kaelin Jr., W.G.2
  • 37
    • 10044277901 scopus 로고    scopus 로고
    • Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130
    • DOI 10.1101/gad.322004
    • Dannenberg, J. H., Schuijff, L., Dekker, M., van der Valk, M. & Riele, H. T. Tissuespecific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev 18, 2952-2962 (2004). (Pubitemid 39602313)
    • (2004) Genes and Development , vol.18 , Issue.23 , pp. 2952-2962
    • Dannenberg, J.-H.1    Schuijff, L.2    Dekker, M.3    Van Der Valk, M.4    Te Riele, H.5
  • 39
    • 78049302116 scopus 로고    scopus 로고
    • P53 post-translational modification: Deregulated in tumorigenesis
    • Dai, C. & Gu, W. p53 post-translational modification: deregulated in tumorigenesis. Trends in molecular medicine 16, 528-536 (2010).
    • (2010) Trends in Molecular Medicine , vol.16 , pp. 528-536
    • Dai, C.1    Gu, W.2
  • 41
    • 84863986224 scopus 로고    scopus 로고
    • Protein methylation: A new mechanism of p53 tumor suppressor regulation
    • Scoumanne, A. & Chen, X. Protein methylation: a new mechanism of p53 tumor suppressor regulation. Histol Histopathol 23, 1143-1149 (2008).
    • (2008) Histol Histopathol , vol.23 , pp. 1143-1149
    • Scoumanne, A.1    Chen, X.2
  • 42
    • 59149092491 scopus 로고    scopus 로고
    • Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma
    • Moral, M. et al. Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Res 69, 1099-1108 (2009).
    • (2009) Cancer Res , vol.69 , pp. 1099-1108
    • Moral, M.1
  • 43
    • 84857725551 scopus 로고    scopus 로고
    • Pocket proteins suppress head and neck cancer
    • Shin, M. K., Pitot, H. C. & Lambert, P. F. Pocket proteins suppress head and neck cancer. Cancer Res 72, 1280-1289 (2012).
    • (2012) Cancer Res , vol.72 , pp. 1280-1289
    • Shin, M.K.1    Pitot, H.C.2    Lambert, P.F.3
  • 44
    • 48149083805 scopus 로고    scopus 로고
    • Gene expression profiling as a tool for basic analysis and clinical application of human cancer
    • Garcia-Escudero, R. & Paramio, J. M. Gene expression profiling as a tool for basic analysis and clinical application of human cancer. Mol Carcinog 47, 573-579 (2008).
    • (2008) Mol Carcinog , vol.47 , pp. 573-579
    • Garcia-Escudero, R.1    Paramio, J.M.2
  • 45
    • 33745241083 scopus 로고    scopus 로고
    • Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein
    • DOI 10.1158/0008-5472.CAN-06-0499
    • Menges, C. W., Baglia, L. A., Lapoint, R. &McCance, D. J. Human papillomavirus type 16 E7 up-regulates AKT activity through the retinoblastoma protein. Cancer Res 66, 5555-5559 (2006). (Pubitemid 43927104)
    • (2006) Cancer Research , vol.66 , Issue.11 , pp. 5555-5559
    • Menges, C.W.1    Baglia, L.A.2    Lapoint, R.3    McCance, D.J.4
  • 47
    • 54449101189 scopus 로고    scopus 로고
    • Akt pathway as a target for therapeutic intervention in HNSCC
    • Moral, M. & Paramio, J.M. Akt pathway as a target for therapeutic intervention in HNSCC. Histol Histopathol 23, 1269-1278 (2008).
    • (2008) Histol Histopathol , vol.23 , pp. 1269-1278
    • Moral, M.1    Paramio, J.M.2
  • 50
    • 67349108318 scopus 로고    scopus 로고
    • Dysregulated molecular networks in head and neck carcinogenesis
    • Molinolo, A. A. et al. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45, 324-334 (2009).
    • (2009) Oral Oncol , vol.45 , pp. 324-334
    • Molinolo, A.A.1
  • 51
    • 66249095194 scopus 로고    scopus 로고
    • Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model
    • Raimondi, A. R., Molinolo, A. & Gutkind, J. S. Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res 69, 4159-4166 (2009).
    • (2009) Cancer Res , vol.69 , pp. 4159-4166
    • Raimondi, A.R.1    Molinolo, A.2    Gutkind, J.S.3
  • 52
    • 0033539945 scopus 로고    scopus 로고
    • PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein
    • Paramio, J.M., Navarro, M., Segrelles, C., Gomez-Casero, E.&Jorcano, J. L. PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene 18, 7462-7468 (1999). (Pubitemid 30035047)
    • (1999) Oncogene , vol.18 , Issue.52 , pp. 7462-7468
    • Paramio, J.M.1    Navarro, M.2    Segrelles, C.3    Gomez-Casero, E.4    Jorcano, J.L.5
  • 55
    • 33846011470 scopus 로고    scopus 로고
    • A five-gene signature and clinical outcome in non-small-cell lung cancer
    • Chen, H. Y. et al. A five-gene signature and clinical outcome in non-small-cell lung cancer. N Engl J Med 356, 11-20 (2007).
    • (2007) N Engl J Med , vol.356 , pp. 11-20
    • Chen, H.Y.1
  • 56
    • 0038005018 scopus 로고    scopus 로고
    • DAVID: Database for annotation, visualization, and integrated discovery
    • Dennis, G., Jr. et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4, P3 (2003).
    • (2003) Genome Biol , vol.4
    • Dennis Jr., G.1
  • 60
    • 33847246805 scopus 로고    scopus 로고
    • Oncomine 3.0: Genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles
    • Rhodes, D. R. et al. Oncomine 3.0: genes, pathways, and networks in a collection of 18, 000 cancer gene expression profiles. Neoplasia 9, 166-180 (2007).
    • (2007) Neoplasia , vol.9 , pp. 166-180
    • Rhodes, D.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.