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Volumn 33, Issue 8, 2012, Pages 1479-1486

The essential role of PIM kinases in sarcoma growth and bone invasion

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

EID: 84865333826     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs176     Document Type: Article
Times cited : (32)

References (62)
  • 1
    • 78650606450 scopus 로고    scopus 로고
    • For better or for worse: the role of Pim oncogenes in tumourigenesis
    • Nawijn, M.C. et al. (2011) For better or for worse: the role of Pim oncogenes in tumourigenesis. Nat. Rev. Cancer, 11, 23-34.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 23-34
    • Nawijn, M.C.1
  • 2
    • 26444448463 scopus 로고    scopus 로고
    • The survival kinases Akt and Pim as potential pharmacological targets
    • Amaravadi, R. et al. (2005) The survival kinases Akt and Pim as potential pharmacological targets. J. Clin. Invest., 115, 2618-2624.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2618-2624
    • Amaravadi, R.1
  • 3
    • 77953180976 scopus 로고    scopus 로고
    • PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers
    • Brault, L. et al. (2010) PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica, 95, 1004-1015.
    • (2010) Haematologica , vol.95 , pp. 1004-1015
    • Brault, L.1
  • 4
    • 0034708236 scopus 로고    scopus 로고
    • Developmental expression of pim kinases suggests functions also outside of the hematopoietic system
    • Eichmann, A. et al. (2000) Developmental expression of pim kinases suggests functions also outside of the hematopoietic system. Oncogene, 19, 1215-1224.
    • (2000) Oncogene , vol.19 , pp. 1215-1224
    • Eichmann, A.1
  • 5
    • 29344463277 scopus 로고    scopus 로고
    • Structure and substrate specificity of the Pim-1 kinase
    • Bullock, A.N. et al. (2005) Structure and substrate specificity of the Pim-1 kinase. J. Biol. Chem., 280, 41675-41682.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41675-41682
    • Bullock, A.N.1
  • 6
    • 79960411328 scopus 로고    scopus 로고
    • Roles of Pim-3, a novel survival kinase, in tumourigenesis
    • Mukaida, N. et al. (2011) Roles of Pim-3, a novel survival kinase, in tumourigenesis. Cancer Sci., 102, 1437-1442.
    • (2011) Cancer Sci , vol.102 , pp. 1437-1442
    • Mukaida, N.1
  • 7
    • 2942700011 scopus 로고    scopus 로고
    • Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors
    • Mikkers, H. et al. (2004) Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol. Cell Biol., 24, 6104-6115.
    • (2004) Mol. Cell Biol. , vol.24 , pp. 6104-6115
    • Mikkers, H.1
  • 8
    • 0024297307 scopus 로고
    • Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines
    • Dautry, F. et al. (1988) Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell lines. J. Biol. Chem., 263, 17615-17620.
    • (1988) J. Biol. Chem. , vol.263 , pp. 17615-17620
    • Dautry, F.1
  • 9
    • 0042626302 scopus 로고    scopus 로고
    • The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor
    • Fox, C.J. et al. (2003) The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor. Genes Dev., 17, 1841-1854.
    • (2003) Genes Dev , vol.17 , pp. 1841-1854
    • Fox, C.J.1
  • 10
    • 79953678390 scopus 로고    scopus 로고
    • The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells
    • Xu, D. et al. (2011) The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells. Carcinogenesis, 32, 488-495.
    • (2011) Carcinogenesis , vol.32 , pp. 488-495
    • Xu, D.1
  • 11
    • 0030829781 scopus 로고    scopus 로고
    • Pim-2 transgene induces lymphoid tumours, exhibiting potent synergy with c-myc
    • Allen, J.D. et al. (1997) Pim-2 transgene induces lymphoid tumours, exhibiting potent synergy with c-myc. Oncogene, 15, 1133-1141.
    • (1997) Oncogene , vol.15 , pp. 1133-1141
    • Allen, J.D.1
  • 12
    • 0030265199 scopus 로고    scopus 로고
    • Complementation tagging of cooperating oncogenes in knockout mice
    • Allen, J.D. et al. (1996) Complementation tagging of cooperating oncogenes in knockout mice. Semin. Cancer Biol., 7, 299-306.
    • (1996) Semin. Cancer Biol. , vol.7 , pp. 299-306
    • Allen, J.D.1
  • 13
    • 0022522805 scopus 로고
    • The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases
    • Selten, G. et al. (1986) The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. Cell, 46, 603-611.
    • (1986) Cell , vol.46 , pp. 603-611
    • Selten, G.1
  • 14
    • 0022589844 scopus 로고
    • Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6
    • Cuypers, H.T. et al. (1986) Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6. Hum. Genet., 72, 262-265.
    • (1986) Hum. Genet. , vol.72 , pp. 262-265
    • Cuypers, H.T.1
  • 15
    • 0035754569 scopus 로고    scopus 로고
    • Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumourigenesis
    • Wang, Z. et al. (2001) Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumourigenesis. J. Vet. Sci., 2, 167-179.
    • (2001) J. Vet. Sci. , vol.2 , pp. 167-179
    • Wang, Z.1
  • 16
    • 53249137796 scopus 로고    scopus 로고
    • Potential roles for the PIM1 kinase in human cancer -a molecular and therapeutic appraisal
    • Shah, N. et al. (2008) Potential roles for the PIM1 kinase in human cancer -a molecular and therapeutic appraisal. Eur. J. Cancer, 44, 2144-2151.
    • (2008) Eur. J. Cancer , vol.44 , pp. 2144-2151
    • Shah, N.1
  • 17
    • 13444251304 scopus 로고    scopus 로고
    • The serine/threonine kinase Pim-1
    • Bachmann, M. et al. (2005) The serine/threonine kinase Pim-1. Int. J. Biochem. Cell Biol., 37, 726-730.
    • (2005) Int. J. Biochem. Cell Biol. , vol.37 , pp. 726-730
    • Bachmann, M.1
  • 18
    • 74549183449 scopus 로고    scopus 로고
    • PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications
    • Nga, M.E. et al. (2010) PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implications. Int. J. Exp. Pathol., 91, 34-43.
    • (2010) Int. J. Exp. Pathol. , vol.91 , pp. 34-43
    • Nga, M.E.1
  • 19
    • 70350218944 scopus 로고    scopus 로고
    • Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes
    • Mumenthaler, S.M. et al. (2009) Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. Mol. Cancer Ther., 8, 2882-2893.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2882-2893
    • Mumenthaler, S.M.1
  • 20
    • 67651113831 scopus 로고    scopus 로고
    • Pim-1 plays a pivotal role in hypoxia-induced chemoresistance
    • Chen, J. et al. (2009) Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene, 28, 2581-2592.
    • (2009) Oncogene , vol.28 , pp. 2581-2592
    • Chen, J.1
  • 21
    • 67649969176 scopus 로고    scopus 로고
    • Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumour formation
    • Chen, J. et al. (2009) Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumour formation. Am. J. Pathol., 175, 400-411.
    • (2009) Am. J. Pathol. , vol.175 , pp. 400-411
    • Chen, J.1
  • 22
    • 0024396220 scopus 로고
    • Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice
    • Breuer, M. et al. (1989) Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature, 340, 61-63.
    • (1989) Nature , vol.340 , pp. 61-63
    • Breuer, M.1
  • 23
    • 0024595556 scopus 로고
    • Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumours
    • van Lohuizen, M. et al. (1989) Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumours. Cell, 56, 673-682.
    • (1989) Cell , vol.56 , pp. 673-682
    • van Lohuizen, M.1
  • 25
    • 0033536203 scopus 로고    scopus 로고
    • The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway
    • Lilly, M. et al. (1999) The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway. Oncogene, 18, 4022-4031.
    • (1999) Oncogene , vol.18 , pp. 4022-4031
    • Lilly, M.1
  • 26
    • 0027301278 scopus 로고
    • Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells
    • Domen, J. et al. (1993) Impaired interleukin-3 response in Pim-1-deficient bone marrow-derived mast cells. Blood, 82, 1445-1452.
    • (1993) Blood , vol.82 , pp. 1445-1452
    • Domen, J.1
  • 27
    • 0242580961 scopus 로고    scopus 로고
    • The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
    • Yan, B. et al. (2003) The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J. Biol. Chem., 278, 45358-45367.
    • (2003) J. Biol. Chem. , vol.278 , pp. 45358-45367
    • Yan, B.1
  • 28
    • 9244243110 scopus 로고    scopus 로고
    • STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5
    • Paukku, K. et al. (2004) STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5. Cytokine Growth Factor Rev., 15, 435-455.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 435-455
    • Paukku, K.1
  • 29
    • 33744774483 scopus 로고    scopus 로고
    • Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity
    • Aho, T.L. et al. (2006) Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity. BMC Cell Biol., 7, 21.
    • (2006) BMC Cell Biol , vol.7 , pp. 21
    • Aho, T.L.1
  • 30
    • 0037121534 scopus 로고    scopus 로고
    • Phosphorylation of the cell cycle inhibitor p21Cip1/ WAF1 by Pim-1 kinase
    • Wang, Z. et al. (2002) Phosphorylation of the cell cycle inhibitor p21Cip1/ WAF1 by Pim-1 kinase. Biochim. Biophys. Acta, 1593, 45-55.
    • (2002) Biochim. Biophys. Acta , vol.1593 , pp. 45-55
    • Wang, Z.1
  • 31
    • 48549096958 scopus 로고    scopus 로고
    • Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
    • Morishita, D. et al. (2008) Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res., 68, 5076-5085.
    • (2008) Cancer Res , vol.68 , pp. 5076-5085
    • Morishita, D.1
  • 32
    • 0033603454 scopus 로고    scopus 로고
    • Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase Implications for the Pim-1-mediated activation of the c-Myc signaling pathway
    • Mochizuki, T. et al. (1999) Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway. J. Biol. Chem., 274, 18659-18666.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18659-18666
    • Mochizuki, T.1
  • 33
    • 0033959911 scopus 로고    scopus 로고
    • Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)
    • Koike, N. et al. (2000) Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1). FEBS Lett., 467, 17-21.
    • (2000) FEBS Lett , vol.467 , pp. 17-21
    • Koike, N.1
  • 34
    • 33846785197 scopus 로고    scopus 로고
    • Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus
    • Evans, K.E. et al. (2007) Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus. BMC Cell Biol., 8, 4.
    • (2007) BMC Cell Biol , vol.8 , pp. 4
    • Evans, K.E.1
  • 35
    • 0037083465 scopus 로고    scopus 로고
    • Cutting edge: transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase
    • Rainio, E.M. et al. (2002) Cutting edge: transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase. J. Immunol., 168, 1524-1527.
    • (2002) J. Immunol. , vol.168 , pp. 1524-1527
    • Rainio, E.M.1
  • 36
    • 0041292007 scopus 로고    scopus 로고
    • Pim-1 phosphorylates the DNA binding domain of c-Myb
    • Winn, L.M. et al. (2003) Pim-1 phosphorylates the DNA binding domain of c-Myb. Cell Cycle, 2, 258-262.
    • (2003) Cell Cycle , vol.2 , pp. 258-262
    • Winn, L.M.1
  • 37
    • 0035964820 scopus 로고    scopus 로고
    • Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus
    • Ishibashi, Y. et al. (2001) Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus. FEBS Lett., 506, 33-38.
    • (2001) FEBS Lett , vol.506 , pp. 33-38
    • Ishibashi, Y.1
  • 38
    • 0027501927 scopus 로고
    • In vivo analysis of Pim-1 deficiency
    • Laird, P.W. et al. (1993) In vivo analysis of Pim-1 deficiency. Nucleic Acids Res., 21, 4750-4755.
    • (1993) Nucleic Acids Res , vol.21 , pp. 4750-4755
    • Laird, P.W.1
  • 39
    • 0027485674 scopus 로고
    • Analysis of Pim-1 function in mutant mice
    • Domen, J. et al. (1993) Analysis of Pim-1 function in mutant mice. Leukemia, 7 (suppl. 2), S108-112.
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 2
    • Domen, J.1
  • 40
    • 77957967569 scopus 로고    scopus 로고
    • Why target PIM1 for cancer diagnosis and treatment?
    • Magnuson, N.S. et al. (2010) Why target PIM1 for cancer diagnosis and treatment? Future Oncol., 6, 1461-1478.
    • (2010) Future Oncol , vol.6 , pp. 1461-1478
    • Magnuson, N.S.1
  • 41
    • 0034209908 scopus 로고    scopus 로고
    • Loss-of-function genetics in mammalian cells: the p53 tumour suppressor model
    • Carnero, A. et al. (2000) Loss-of-function genetics in mammalian cells: the p53 tumour suppressor model. Nucleic Acids Res., 28, 2234-2241.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2234-2241
    • Carnero, A.1
  • 42
    • 4043171390 scopus 로고    scopus 로고
    • Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation
    • Carnero, A. et al. (2004) Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation. Oncogene, 23, 6006-6011.
    • (2004) Oncogene , vol.23 , pp. 6006-6011
    • Carnero, A.1
  • 43
    • 35148842462 scopus 로고    scopus 로고
    • MAP17 enhances the malignant behavior of tumour cells through ROS increase
    • Guijarro, M.V. et al. (2007) MAP17 enhances the malignant behavior of tumour cells through ROS increase. Carcinogenesis, 28, 2096-2104.
    • (2007) Carcinogenesis , vol.28 , pp. 2096-2104
    • Guijarro, M.V.1
  • 44
    • 41149095149 scopus 로고    scopus 로고
    • Cellular senescence bypass screen identifies new putative tumour suppressor genes
    • Leal, J.F. et al. (2008) Cellular senescence bypass screen identifies new putative tumour suppressor genes. Oncogene, 27, 1961-1970.
    • (2008) Oncogene , vol.27 , pp. 1961-1970
    • Leal, J.F.1
  • 45
    • 78649629111 scopus 로고    scopus 로고
    • Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition
    • Blanco-Aparicio, C. et al. (2011) Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition. Cancer Lett., 300, 145-153.
    • (2011) Cancer Lett , vol.300 , pp. 145-153
    • Blanco-Aparicio, C.1
  • 46
    • 67649307131 scopus 로고    scopus 로고
    • Novel benzylidene-thiazolidine-2 4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells
    • Beharry, Z. et al. (2009) Novel benzylidene-thiazolidine-2, 4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol. Cancer Ther., 8, 1473-1483.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1473-1483
    • Beharry, Z.1
  • 47
    • 77951092205 scopus 로고    scopus 로고
    • Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver
    • Wu, Y. et al. (2010) Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver. Oncogene, 29, 2228-2237.
    • (2010) Oncogene , vol.29 , pp. 2228-2237
    • Wu, Y.1
  • 48
    • 77949452524 scopus 로고    scopus 로고
    • The PKB/AKT pathway in cancer
    • Carnero, A. (2010) The PKB/AKT pathway in cancer. Curr. Pharm. Des., 16, 34-44.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 34-44
    • Carnero, A.1
  • 49
    • 44649120132 scopus 로고    scopus 로고
    • Chemokine signaling via the CXCR2 receptor reinforces senescence
    • Acosta, J.C. et al. (2008) Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell, 133, 1006-1018.
    • (2008) Cell , vol.133 , pp. 1006-1018
    • Acosta, J.C.1
  • 50
    • 9144225473 scopus 로고    scopus 로고
    • The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint
    • Bachmann, M. et al. (2004) The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1): a novel role for Pim-1 at the G2/M cell cycle checkpoint. J. Biol. Chem., 279, 48319-48328.
    • (2004) J. Biol. Chem. , vol.279 , pp. 48319-48328
    • Bachmann, M.1
  • 51
    • 34548670994 scopus 로고    scopus 로고
    • Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells
    • Zhang, Y. et al. (2007) Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Mol. Cancer Res., 5, 909-922.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 909-922
    • Zhang, Y.1
  • 52
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco, I. et al. (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer, 2, 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1
  • 53
    • 78449292337 scopus 로고    scopus 로고
    • Regulation of GSK3 isoforms by phosphatases PP1 and PP2A
    • Hernandez, F. et al. (2010) Regulation of GSK3 isoforms by phosphatases PP1 and PP2A. Mol. Cell Biochem., 344, 211-215.
    • (2010) Mol. Cell Biochem. , vol.344 , pp. 211-215
    • Hernandez, F.1
  • 54
    • 0036122349 scopus 로고    scopus 로고
    • Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A
    • Mora, A. et al. (2002) Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. Cell Signal., 14, 557-562.
    • (2002) Cell Signal , vol.14 , pp. 557-562
    • Mora, A.1
  • 55
    • 0036170771 scopus 로고    scopus 로고
    • Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta
    • Ivaska, J. et al. (2002) Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Mol. Cell Biol., 22, 1352-1359.
    • (2002) Mol. Cell Biol. , vol.22 , pp. 1352-1359
    • Ivaska, J.1
  • 56
    • 24144458232 scopus 로고    scopus 로고
    • Pim family kinases enhance tumour growth of prostate cancer cells
    • Chen, W.W. et al. (2005) Pim family kinases enhance tumour growth of prostate cancer cells. Mol. Cancer Res., 3, 443-451.
    • (2005) Mol. Cancer Res. , vol.3 , pp. 443-451
    • Chen, W.W.1
  • 57
    • 77957905244 scopus 로고    scopus 로고
    • Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion
    • Santio, N.M. et al. (2010) Pim-selective inhibitor DHPCC-9 reveals Pim kinases as potent stimulators of cancer cell migration and invasion. Mol. Cancer, 9, 279.
    • (2010) Mol. Cancer , vol.9 , pp. 279
    • Santio, N.M.1
  • 58
    • 65549111109 scopus 로고    scopus 로고
    • Pim-3 is expressed in endothelial cells and promotes vascular tube formation
    • Zhang, P. et al. (2009) Pim-3 is expressed in endothelial cells and promotes vascular tube formation. J. Cell Physiol., 220, 82-90.
    • (2009) J. Cell Physiol. , vol.220 , pp. 82-90
    • Zhang, P.1
  • 59
    • 69549086437 scopus 로고    scopus 로고
    • Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
    • Grundler, R. et al. (2009) Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J. Exp. Med., 206, 1957-1970.
    • (2009) J. Exp. Med. , vol.206 , pp. 1957-1970
    • Grundler, R.1
  • 60
    • 70350514636 scopus 로고    scopus 로고
    • NFAT proteins: emerging roles in cancer progression
    • Mancini, M. et al. (2009) NFAT proteins: emerging roles in cancer progression. Nat. Rev. Cancer, 9, 810-820.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 810-820
    • Mancini, M.1
  • 61
    • 33646489986 scopus 로고    scopus 로고
    • Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase
    • Qian, K.C. et al. (2005) Expression, purification, crystallization and preliminary crystallographic analysis of human Pim-1 kinase. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 61, 96-99.
    • (2005) Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. , vol.61 , pp. 96-99
    • Qian, K.C.1
  • 62
    • 34547132324 scopus 로고    scopus 로고
    • Structural analysis identifies imidazo[1 2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity
    • Pogacic, V. et al. (2007) Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. Cancer Res., 67, 6916-6924.
    • (2007) Cancer Res , vol.67 , pp. 6916-6924
    • Pogacic, V.1


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