PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis

Journal of Biological Chemistry

Volumn 284, Issue 28, 2009, Pages 19018-19026

  Schade, Babette ^a   Rao, Trisha ^a   Dourdin, Nathalie ^a   Lesurf, Robert ^a,b   Hallett, Michael ^a,b   Cardiff, Robert D ^c   Muller, William J ^a,d  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NONE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS; NEGATIVE IMPEDANCE CONVERTERS; ONCOGENIC VIRUSES; TUMORS;

BIOLOGICAL IMPACTS; CRITICAL SIGNALING PATHWAYS; HUMAN BREAST CANCER; MAMMARY EPITHELIAL CELLS; MOLECULAR DETERMINANTS; PHOSPHATIDYLINOSITOL; SIGNALING PATHWAYS; THERAPEUTIC STRATEGY;

PATHOLOGY;

CRE RECOMBINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEFICIENCY; FEMALE; GENE AMPLIFICATION; GENE DISRUPTION; GENE INACTIVATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; METASTASIS; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

MOUSE MAMMARY TUMOR VIRUS; MUS; MUS MUSCULUS;

EID: 67650553421     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.018937     Document Type: Article

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