Chloroquine enhances cobalt chloride-induced leukemic cell differentiation via the suppression of autophagy at the late phase

Biochemical and Biophysical Research Communications

Volumn 430, Issue 3, 2013, Pages 926-932

  Yan, Zhao Wen ^a   Hou, Jia Kai ^b   He, Wei ^a   Fan, Li ^a   Huang, Ying ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

Acute myeloid leukemia; Autophagy; Chloroquine; Cobalt chloride; Differentiation; HIF 1

Indexed keywords

CHLOROQUINE; COBALT CHLORIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DIFFERENTIATION; GROWTH DISORDER; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL;

AUTOPHAGY; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHLOROQUINE; COBALT; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKEMIA, MYELOID, ACUTE; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; PHAGOSOMES;

EID: 84872498059     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.12.052     Document Type: Article

References (40)

1. Estey E., Dohner H. Acute myeloid leukaemia. Lancet 2006, 368:1894-1907.
2. Wang Z.Y., Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008, 111:2505-2515.
3. Liu C.X., Zhou H.C., Yin Q.Q., Wu Y.L., Chen G.Q. Targeting peroxiredoxins against leukemia. Exp. Cell Res. 2013, 319:170-176.
4. Ablain J., de The H. Revisiting the differentiation paradigm in acute promyelocytic leukemia. Blood 2011, 117:5795-5802.
5. Huang Y., Du K.M., Xue Z.H., et al. Cobalt chloride and low oxygen tension trigger differentiation of acute myeloid leukemic cells: possible mediation of HIF-1α. Leukemia 2003, 17:2065-2073.
6. Jiang Y., Xue Z.H., Shen W.Z., et al. Desferrioxamine induces leukemic cell differentiation potentially by HIF-1α that augments transcriptional activity of CCAAT/enhancer-binding protein-α. Leukemia 2005, 19:1239-1247.
7. Kim J.S., Cho E.W., Chung H.W., Kim I.G. Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology 2006, 223:36-45.
8. Liu W., Guo M., Xu Y.B., et al. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood 2006, 107:698-707.
9. Zhang J., Song L.P., Huang Y., et al. Accumulation of HIF-1 α protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica 2008, 93:1480-1487.
10. Song L.P., Zhang J., Wu S.F., et al. Hypoxia-inducible factor-1α-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene 2008, 27:519-527.
11. Peng Z.G., Zhou M.Y., Huang Y., et al. Physical and functional interaction of Runt-related protein 1 with HIF-1α. Oncogene 2008, 27:839-847.
12. Zhang J., Chen G.Q. Hypoxia-HIF-1α-C/EBPα/Runx1 signaling in leukemic cell differentiation. Pathophysiology 2009, 16:297-303.
13. Janardhan H.P. The HIF-1α-C/EBPα axis. Sci. Signal. 2008, 1:jc2.
14. Mizushima N., Levine B. Autophagy in mammalian development and differentiation. Nat. Cell Biol. 2010, 12:823-830.
15. Levine B., Klionsky D.J. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 2004, 6:463-477.
16. Mizushima N., Levine B., Cuervo A.M., Klionsky D.J. Autophagy fights disease through cellular self-digestion. Nature 2008, 451:1069-1075.
17. Huang Y., Hou J.K., Chen T.T., et al. PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy 2011, 7:1132-1144.
18. Robert G., Ben Sahra I., Puissant A., et al. Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. PLoS One 2009, 4:e7889.
19. Han W., Sun J., Feng L., et al. Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells. PLoS One 2011, 6:e28491.
20. Wang Z., Cao L., Kang R., et al. Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein. Autophagy 2011, 7:401-411.
21. Wang J., Lian H., Zhao Y., et al. Vitamin D3 induces autophagy of human myeloid leukemia cells. J. Biol. Chem. 2008, 283:25596-25605.
22. Solomon V.R., Lee H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur. J. Pharmacol. 2009, 625:220-233.
23. Zhu J., Shi X.G., Chu H.Y., et al. Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4. Leukemia 1995, 9:302-309.
24. Mizushima N., Yoshimori T., Levine B. Methods in mammalian autophagy research. Cell 2010, 140:313-326.
25. Munafo D.B., Colombo M.I. A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation. J. Cell Sci. 2001, 114:3619-3629.
26. Kihara A., Kabeya Y., Ohsumi Y., Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2001, 2:330-335.
27. Puissant A., Fenouille N., Auberger P. When autophagy meets cancer through p62/SQSTM1. Am. J. Cancer Res. 2012, 2:397-413.
28. Johansen T., Lamark T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7:279-296.
29. Yan H., Peng Z.G., Wu Y.L., et al. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica 2005, 90:1607-1616.
30. Stegmaier K., Ross K.N., Colavito S.A., et al. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nat. Genet. 2004, 36:257-263.
31. Huynh K.K., Eskelinen E.L., Scott C.C., et al. LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J. 2007, 26:313-324.
32. Eskelinen E.L. Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. Mol. Aspects Med. 2006, 27:495-502.
33. Sasaki R., Furukawa Y., Okada K., et al. Chloroquine induces basophilic differentiation of HL-60 cells. Leukemia 1997, 11(Suppl 3):478-479.
34. Iyamu E., Perdew H., Woods G. Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway. Biochem. Pharmacol. 2009, 77:1021-1028.
35. Scarlatti F., Maffei R., Beau I., et al. Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ. 2008, 15:1318-1329.
36. Tian S., Lin J., Jun Zhou J., et al. Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18. Autophagy 2010, 6:1032-1041.
37. Mazure N.M., Pouyssegur J. Hypoxia-induced autophagy: cell death or cell survival?. Curr. Opin. Cell Biol. 2010, 22:177-180.
38. Bartlett B.J., Isakson P., Lewerenz J., et al. P62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy 2011, 7:572-583.
39. Pursiheimo J.P., Rantanen K., Heikkinen P.T., et al. Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62. Oncogene 2009, 28:334-344.
40. Korolchuk V.I., Mansilla A., Menzies F.M., Rubinsztein D.C. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol. Cell 2009, 33:517-527.