-
1
-
-
7444244482
-
Modulatory influence of noscapine on the ethanol-altered hepatic biotransformation system enzymes, glutathione content and lipid peroxidation in vivo in rats
-
Aneja R, Katyal A, Chandra R (2004) Modulatory influence of noscapine on the ethanol-altered hepatic biotransformation system enzymes, glutathione content and lipid peroxidation in vivo in rats. Eur J Drug Metab Pharmacokinet 29:157-162 (Pubitemid 39447013)
-
(2004)
European Journal of Drug Metabolism and Pharmacokinetics
, vol.29
, Issue.3
, pp. 157-162
-
-
Aneja, R.1
Katyal, A.2
Chandra, R.3
-
2
-
-
34447645671
-
Uses of and exposure to trichloroethylene in US industry: A systematic literature review
-
Bakke B, Stewart PA, Waters MA (2007) Uses of and exposure to trichloroethylene in US industry: a systematic literature review. J Occup Environ Hyg 4:375-390
-
(2007)
J Occup Environ Hyg
, vol.4
, pp. 375-390
-
-
Bakke, B.1
Stewart, P.A.2
Waters, M.A.3
-
3
-
-
84893866868
-
Metabolomics reveals metabolite changes in acute pulmonary embolism
-
doi:10.1021/pr400872j
-
Bujak R, Garcia-Alvarez A, Ruperez FJ et al (2014) Metabolomics reveals metabolite changes in acute pulmonary embolism. J Proteome Res. doi:10.1021/pr400872j
-
(2014)
J Proteome Res
-
-
Bujak, R.1
Garcia-Alvarez, A.2
Ruperez, F.J.3
-
4
-
-
80053912889
-
Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy
-
Castro-Perez JM, Roddy TP, Shah V et al (2011) Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy. J Proteome Res 10:4683-4691
-
(2011)
J Proteome Res
, vol.10
, pp. 4683-4691
-
-
Castro-Perez, J.M.1
Roddy, T.P.2
Shah, V.3
-
5
-
-
34548388291
-
LC-MS-based metabolomics in drug metabolism
-
DOI 10.1080/03602530701497804, PII 781831943
-
Chen C, Gonzalez FJ, Idle JR (2007) LC-MS-based metabolomics in drug metabolism. Drug Metab Rev 39(2-3):581-597 (Pubitemid 47355739)
-
(2007)
Drug Metabolism Reviews
, vol.39
, Issue.2-3
, pp. 581-597
-
-
Chen, C.1
Gonzalez, F.J.2
Idle, J.R.3
-
6
-
-
41949134860
-
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice
-
Chen C, Krausz KW, Idle JR, Gonzalez FJ (2008a) Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem 283:4543-4559
-
(2008)
J Biol Chem
, vol.283
, pp. 4543-4559
-
-
Chen, C.1
Krausz, K.W.2
Idle, J.R.3
Gonzalez, F.J.4
-
7
-
-
38649128825
-
Metabolomics Reveals that Hepatic Stearoyl-CoA Desaturase 1 Downregulation Exacerbates Inflammation and Acute Colitis
-
DOI 10.1016/j.cmet.2007.12.003, PII S1550413107003762
-
Chen C, Shah YM, Morimura K et al (2008b) Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell Metab 7:135-147 (Pubitemid 351168558)
-
(2008)
Cell Metabolism
, vol.7
, Issue.2
, pp. 135-147
-
-
Chen, C.1
Shah, Y.M.2
Morimura, K.3
Krausz, K.W.4
Miyazaki, M.5
Richardson, T.A.6
Morgan, E.T.7
Ntambi, J.M.8
Idle, J.R.9
Gonzalez, F.J.10
-
8
-
-
84896449233
-
Metabolomic analysis reveals metabolic changes caused by bisphenol A in rats
-
doi:10.1093/toxsci/kfu016
-
Chen M, Zhou K, Chen X et al (2014) Metabolomic analysis reveals metabolic changes caused by bisphenol A in rats. Toxicol Sci. doi:10.1093/toxsci/kfu016
-
(2014)
Toxicol Sci
-
-
Chen, M.1
Zhou, K.2
Chen, X.3
-
9
-
-
77957236383
-
Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X Receptor activation
-
Cheng J, Shah YM, Ma XC et al (2010) Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X Receptor activation. J Pharmacol Exp Ther 335:32-41
-
(2010)
J Pharmacol Exp Ther
, vol.335
, pp. 32-41
-
-
Cheng, J.1
Shah, Y.M.2
Ma, X.C.3
-
10
-
-
84866606730
-
Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice
-
Cheng J, Krausz KW, Tanaka N, Gonzalez FJ (2012) Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci 129:456-468
-
(2012)
Toxicol Sci
, vol.129
, pp. 456-468
-
-
Cheng, J.1
Krausz, K.W.2
Tanaka, N.3
Gonzalez, F.J.4
-
11
-
-
84871835693
-
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid
-
Cheng J, Krausz KW, Li F, Ma XC, Gonzalez FJ (2013) CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid. Toxicol Appl Pharm 266:245-253
-
(2013)
Toxicol Appl Pharm
, vol.266
, pp. 245-253
-
-
Cheng, J.1
Krausz, K.W.2
Li, F.3
Ma, X.C.4
Gonzalez, F.J.5
-
12
-
-
84894765975
-
Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in vitamin D receptor intestine-deficient mice
-
Cheng J, Fang ZZ, Kim JH, Krausz KW, Tanaka N, Chiang JY, Gonzalez FJ (2014) Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in vitamin D receptor intestine-deficient mice. J Lipid Res 55:455-465
-
(2014)
J Lipid Res
, vol.55
, pp. 455-465
-
-
Cheng, J.1
Fang, Z.Z.2
Kim, J.H.3
Krausz, K.W.4
Tanaka, N.5
Chiang, J.Y.6
Gonzalez, F.J.7
-
13
-
-
84890597306
-
Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease
-
Dumas ME, Kinross J, Nicholson JK (2014) Metabolic phenotyping and systems biology approaches to understanding metabolic syndrome and fatty liver disease. Gastroenterology 146:46-62
-
(2014)
Gastroenterology
, vol.146
, pp. 46-62
-
-
Dumas, M.E.1
Kinross, J.2
Nicholson, J.K.3
-
14
-
-
84861223878
-
The biological interpretation of metabolomic data can be misled by the extraction method used
-
Duportet X, Aggio RBM, Carneiro S, Villas-Boas SG (2012) The biological interpretation of metabolomic data can be misled by the extraction method used. Metabolomics 8:410-421
-
(2012)
Metabolomics
, vol.8
, pp. 410-421
-
-
Duportet, X.1
Aggio, R.B.M.2
Carneiro, S.3
Villas-Boas, S.G.4
-
15
-
-
62249210251
-
Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: Implications in metabolites in safety testing
-
Espina R, Yu LN, Wang JY et al (2009) Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing. Chem Res Toxicol 22:299-310
-
(2009)
Chem Res Toxicol
, vol.22
, pp. 299-310
-
-
Espina, R.1
Yu, L.N.2
Wang, J.Y.3
-
16
-
-
84893854125
-
Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health
-
doi:10.1021/pr4007624
-
Evans CR, Karnovsky A, Kovach MA, Standiford TJ, Burant CF, Stringer KA (2013) Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health. J Proteome Res. doi:10.1021/pr4007624
-
(2013)
J Proteome Res
-
-
Evans, C.R.1
Karnovsky, A.2
Kovach, M.A.3
Standiford, T.J.4
Burant, C.F.5
Stringer, K.A.6
-
17
-
-
75149152466
-
Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction
-
Fang ZZ, Zhang YY, Ge GB, Huo H, Liang SC, Yang L (2010) Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. Br J Clin Pharmacol 69:193-199
-
(2010)
Br J Clin Pharmacol
, vol.69
, pp. 193-199
-
-
Fang, Z.Z.1
Zhang, Y.Y.2
Ge, G.B.3
Huo, H.4
Liang, S.C.5
Yang, L.6
-
18
-
-
84867824844
-
Metabolic map and bioactivation of the anti-tumour drug noscapine
-
Fang ZZ, Krausz KW, Li F, Cheng J, Tanaka N, Gonzalez FJ (2012) Metabolic map and bioactivation of the anti-tumour drug noscapine. Br J Pharmacol 167:1271-1286
-
(2012)
Br J Pharmacol
, vol.167
, pp. 1271-1286
-
-
Fang, Z.Z.1
Krausz, K.W.2
Li, F.3
Cheng, J.4
Tanaka, N.5
Gonzalez, F.J.6
-
19
-
-
84885949173
-
Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
-
Fang ZZ, Krausz KW, Tanaka N et al (2013) Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum. Arch Toxicol 87:1975-1987
-
(2013)
Arch Toxicol
, vol.87
, pp. 1975-1987
-
-
Fang, Z.Z.1
Krausz, K.W.2
Tanaka, N.3
-
20
-
-
84905041987
-
In vivo application of the pure aryl hydrocarbon receptor antagonist GNF-351 is limited to the gastrointestinal track
-
Fang ZZ, Krausz KW, Nagaoka K et al (2014) In vivo application of the pure aryl hydrocarbon receptor antagonist GNF-351 is limited to the gastrointestinal track. Br J Pharmacol 171:1735-1746
-
(2014)
Br J Pharmacol
, vol.171
, pp. 1735-1746
-
-
Fang, Z.Z.1
Krausz, K.W.2
Nagaoka, K.3
-
21
-
-
84899867980
-
Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of Cd toxicity
-
Go YM, Roede JR, Orr M, Liang Y, Jones DP (2014) Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of Cd toxicity. Toxicol Sci 171:1735-1746
-
(2014)
Toxicol Sci
, vol.171
, pp. 1735-1746
-
-
Go, Y.M.1
Roede, J.R.2
Orr, M.3
Liang, Y.4
Jones, D.P.5
-
22
-
-
84901639526
-
Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease
-
doi:10.1016/j.jprot.2014.01.014
-
Gonzalez-Dominguez R, Garcia-Barrera T, Gomez-Ariza JL (2014) Combination of metabolomic and phospholipid-profiling approaches for the study of Alzheimer's disease. J Proteomics. doi:10.1016/j.jprot.2014.01.014
-
(2014)
J Proteomics
-
-
Gonzalez-Dominguez, R.1
Garcia-Barrera, T.2
Gomez-Ariza, J.L.3
-
23
-
-
84887122660
-
Loss of estrogen-related receptor a promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances
-
Hong EJ, Levasseur MP, Dufour CR, Perry MC, Giguere V (2013) Loss of estrogen-related receptor a promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances. Proc Natl Acad Sci USA 110:17975-17980
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 17975-17980
-
-
Hong, E.J.1
Levasseur, M.P.2
Dufour, C.R.3
Perry, M.C.4
Giguere, V.5
-
24
-
-
84890275902
-
ABC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release
-
Jansen RS, Kucukosmanoglu A, de Haas M et al (2013) ABC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci USA 110:20206-20211
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 20206-20211
-
-
Jansen, R.S.1
Kucukosmanoglu, A.2
De Haas, M.3
-
25
-
-
84863628151
-
Metabonomic analysis reveals the Cl4-Induced systems alterations for multiple rat organs
-
Jiang LM, Huang J, Wang YL, Tang HR (2012) Metabonomic analysis reveals the Cl4-Induced systems alterations for multiple rat organs. J Proteome Res 11:3848-3859
-
(2012)
J Proteome Res
, vol.11
, pp. 3848-3859
-
-
Jiang, L.M.1
Huang, J.2
Wang, Y.L.3
Tang, H.R.4
-
26
-
-
84858730393
-
Challenges and opportunities of metabolomics
-
Johnson CH, Gonzalez FJ (2012) Challenges and opportunities of metabolomics. J Cell Phys 227:2975-2981
-
(2012)
J Cell Phys
, vol.227
, pp. 2975-2981
-
-
Johnson, C.H.1
Gonzalez, F.J.2
-
28
-
-
84866613381
-
Novel metabolites and roles for alpha-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics
-
Johnson CH, Slanar O, Krausz KW et al (2012b) Novel metabolites and roles for alpha-tocopherol in humans and mice discovered by mass spectrometry-based metabolomics. Am J Clin Nutr 96:818-830
-
(2012)
Am J Clin Nutr
, vol.96
, pp. 818-830
-
-
Johnson, C.H.1
Slanar, O.2
Krausz, K.W.3
-
29
-
-
84867894831
-
Implication of intestinal VDR deficiency in inflammatory bowel disease
-
Kim JH, Yamaori S, Tanabe T et al (2013) Implication of intestinal VDR deficiency in inflammatory bowel disease. Bba-Gen Subj 1830:2118-2128
-
(2013)
Bba-Gen Subj
, vol.1830
, pp. 2118-2128
-
-
Kim, J.H.1
Yamaori, S.2
Tanabe, T.3
-
30
-
-
79952527112
-
Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to non-small cell lung cancer
-
Lane AN, Fan TWM, Bousamra M, Higashi RM, Yan J, Miller DM (2011) Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to non-small cell lung cancer. OMICS 15:173-182
-
(2011)
OMICS
, vol.15
, pp. 173-182
-
-
Lane, A.N.1
Fan, T.W.M.2
Bousamra, M.3
Higashi, R.M.4
Yan, J.5
Miller, D.M.6
-
31
-
-
84864046667
-
Serum amino acid profiles and their alterations in colorectal cancer
-
Leichtle AB, Nuoffer JM, Ceglarek U et al (2012) Serum amino acid profiles and their alterations in colorectal cancer. Metabolomics 8:643-653
-
(2012)
Metabolomics
, vol.8
, pp. 643-653
-
-
Leichtle, A.B.1
Nuoffer, J.M.2
Ceglarek, U.3
-
32
-
-
84855221918
-
Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine
-
Li F, Miao Y, Zhang LR, Neuenswander SA, Douglas JT, Ma XC (2011) Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine. Drug Metab Pharmacok 26:569-576
-
(2011)
Drug Metab Pharmacok
, vol.26
, pp. 569-576
-
-
Li, F.1
Miao, Y.2
Zhang, L.R.3
Neuenswander, S.A.4
Douglas, J.T.5
Ma, X.C.6
-
33
-
-
84859105093
-
Metabolomics reveals the metabolic map of procainamide in humans and mice
-
Li F, Patterson AD, Krausz KW et al (2012) Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol 83:1435-1444
-
(2012)
Biochem Pharmacol
, vol.83
, pp. 1435-1444
-
-
Li, F.1
Patterson, A.D.2
Krausz, K.W.3
-
34
-
-
84887960056
-
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
-
Li F, Jiang CT, Krausz KW et al (2013a) Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun 4:2384
-
(2013)
Nat Commun
, vol.4
, pp. 2384
-
-
Li, F.1
Jiang, C.T.2
Krausz, K.W.3
-
35
-
-
84878451935
-
Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy
-
Li F, Lu J, Cheng J et al (2013b) Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med 19:418-420
-
(2013)
Nat Med
, vol.19
, pp. 418-420
-
-
Li, F.1
Lu, J.2
Cheng, J.3
-
36
-
-
84874597916
-
Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: A study expanding tempol pharmacology
-
Li F, Pang XY, Krausz KW et al (2013c) Stable isotope- and mass spectrometry-based metabolomics as tools in drug metabolism: a study expanding tempol pharmacology. J Proteome Res 12:1369-1376
-
(2013)
J Proteome Res
, vol.12
, pp. 1369-1376
-
-
Li, F.1
Pang, X.Y.2
Krausz, K.W.3
-
37
-
-
84881092517
-
Metabolomics reveals that tumor xenografts induce liver dysfunction
-
Li F, Patterson AD, Krausz KW et al (2013d) Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol Cell Proteomics 12:2126-2135
-
(2013)
Mol Cell Proteomics
, vol.12
, pp. 2126-2135
-
-
Li, F.1
Patterson, A.D.2
Krausz, K.W.3
-
38
-
-
84886740231
-
The toxicity of 3-chloropropane-1,2-dipalmitate in Wistar rats and a metabonomics analysis of rat urine by ultra-performance liquid chromatography-mass spectrometry
-
Li JS, Wang S, Wang MQ, Shi WX, Du XY, Sun CH (2013e) The toxicity of 3-chloropropane-1,2-dipalmitate in Wistar rats and a metabonomics analysis of rat urine by ultra-performance liquid chromatography-mass spectrometry. Chem-Biol Interact 206:337-345
-
(2013)
Chem-Biol Interact
, vol.206
, pp. 337-345
-
-
Li, J.S.1
Wang, S.2
Wang, M.Q.3
Shi, W.X.4
Du, X.Y.5
Sun, C.H.6
-
39
-
-
84891794649
-
CPY3A4-mediated α-hydroxyaldehyde formation in saquinavir metabolism
-
Li F, Lu J, Ma XC (2014a) CPY3A4-mediated α-hydroxyaldehyde formation in saquinavir metabolism. Drug Metab Dispos 42:213-220
-
(2014)
Drug Metab Dispos
, vol.42
, pp. 213-220
-
-
Li, F.1
Lu, J.2
Ma, X.C.3
-
40
-
-
84897540192
-
Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis
-
doi:10.1039/c3mb70386j
-
Li M, Li H, Jiang P, Liu X, Xu D, Wang F (2014b) Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis. Mol BioSyst. doi:10.1039/ c3mb70386j
-
(2014)
Mol BioSyst
-
-
Li, M.1
Li, H.2
Jiang, P.3
Liu, X.4
Xu, D.5
Wang, F.6
-
41
-
-
84897116245
-
Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity
-
doi:10.1007/s00204-013-1188-0
-
Liu A, Krausz KW, Fang ZZ, Brocker C, Qu A, Gonzalez FJ (2014) Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity. Arch Toxicol. doi:10.1007/s00204-013-1188-0
-
(2014)
Arch Toxicol
-
-
Liu, A.1
Krausz, K.W.2
Fang, Z.Z.3
Brocker, C.4
Qu, A.5
Gonzalez, F.J.6
-
42
-
-
84874441993
-
Integrated analysis of transcriptomics and metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat
-
Lu XY, Hu B, Shao L et al (2013) Integrated analysis of transcriptomics and metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat. Food Chem Toxicol 55:444-455
-
(2013)
Food Chem Toxicol
, vol.55
, pp. 444-455
-
-
Lu, X.Y.1
Hu, B.2
Shao, L.3
-
44
-
-
77955463490
-
Identification of non-invasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse
-
Manna SK, Patterson AD, Yang QA et al (2010) Identification of non-invasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res 9:4176-4188
-
(2010)
J Proteome Res
, vol.9
, pp. 4176-4188
-
-
Manna, S.K.1
Patterson, A.D.2
Yang, Q.A.3
-
45
-
-
84899462458
-
Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans
-
doi:10.1053/j.gastro.2014.01.017
-
Manna SK, Tanaka N, Krausz KW et al (2014) Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology. doi:10.1053/j.gastro.2014.01.017
-
(2014)
Gastroenterology
-
-
Manna, S.K.1
Tanaka, N.2
Krausz, K.W.3
-
46
-
-
84871452509
-
Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis
-
Matsubara T, Tanaka N, Krausz KW et al (2012) Metabolomics identifies an inflammatory cascade involved in dioxin- and diet-induced steatohepatitis. Cell Metab 16(5):634-644
-
(2012)
Cell Metab
, vol.16
, Issue.5
, pp. 634-644
-
-
Matsubara, T.1
Tanaka, N.2
Krausz, K.W.3
-
47
-
-
84883189700
-
Metabolomic signatures of aggressive prostate cancer
-
McDunn JE, Li Z, Adam KP et al (2013) Metabolomic signatures of aggressive prostate cancer. Prostate 73(14):1547-1560
-
(2013)
Prostate
, vol.73
, Issue.14
, pp. 1547-1560
-
-
McDunn, J.E.1
Li, Z.2
Adam, K.P.3
-
48
-
-
84870707829
-
Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease Modifier
-
Menezes LF, Zhou F, Patterson AD et al (2012) Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease Modifier. PLoS Genet 8:e1003053
-
(2012)
PLoS Genet
, vol.8
-
-
Menezes, L.F.1
Zhou, F.2
Patterson, A.D.3
-
49
-
-
53549106345
-
Application of stable isotope-labeled compounds in metabolism and in metabolism-mediated toxicity studies
-
Mutlib AE (2008) Application of stable isotope-labeled compounds in metabolism and in metabolism-mediated toxicity studies. Chem Res Toxicol 21:1672-1689
-
(2008)
Chem Res Toxicol
, vol.21
, pp. 1672-1689
-
-
Mutlib, A.E.1
-
51
-
-
79957581759
-
Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus
-
Patterson AD, Bonzo JA, Li F et al (2011a) Metabolomics reveals attenuation of the SLC6A20 kidney transporter in nonhuman primate and mouse models of type 2 diabetes mellitus. J Biol Chem 286(22):19511-19522
-
(2011)
J Biol Chem
, vol.286
, Issue.22
, pp. 19511-19522
-
-
Patterson, A.D.1
Bonzo, J.A.2
Li, F.3
-
52
-
-
80155205757
-
Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling
-
Patterson AD, Maurhofer O, Beyoglu D et al (2011b) Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer Res 71:6590-6600
-
(2011)
Cancer Res
, vol.71
, pp. 6590-6600
-
-
Patterson, A.D.1
Maurhofer, O.2
Beyoglu, D.3
-
53
-
-
84863522631
-
Peroxisome proliferator-activated receptor α induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity
-
Patterson AD, Shah YM, Matsubara T, Krausz KW, Gonzalez FJ (2012) Peroxisome proliferator-activated receptor α induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity. Hepatology 56:281-290
-
(2012)
Hepatology
, vol.56
, pp. 281-290
-
-
Patterson, A.D.1
Shah, Y.M.2
Matsubara, T.3
Krausz, K.W.4
Gonzalez, F.J.5
-
54
-
-
84880322948
-
Disruption of thioredoxin reductase 1 protects Mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity
-
Patterson AD, Carlson BA, Li F et al (2013) Disruption of thioredoxin reductase 1 protects Mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. Chem Res Toxicol 26:1088-1096
-
(2013)
Chem Res Toxicol
, vol.26
, pp. 1088-1096
-
-
Patterson, A.D.1
Carlson, B.A.2
Li, F.3
-
55
-
-
0345095459
-
Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids
-
Plumb RS, Stumpf CL, Granger JH, Castro-Perez J, Haselden JN, Dear GJ (2003) Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids. Rapid Commun Mass Spectrom 17:2632-2638 (Pubitemid 37498776)
-
(2003)
Rapid Communications in Mass Spectrometry
, vol.17
, Issue.23
, pp. 2632-2638
-
-
Plumb, R.S.1
Stumpf, C.L.2
Granger, J.H.3
Castro-Perez, J.4
Haselden, J.N.5
Dear, G.J.6
-
56
-
-
77949822339
-
Urinary metabonomic study on colorectal cancer
-
Qiu YP, Cai GX, Su MM et al (2010) Urinary metabonomic study on colorectal cancer. J Proteome Res 9:1627-1634
-
(2010)
J Proteome Res
, vol.9
, pp. 1627-1634
-
-
Qiu, Y.P.1
Cai, G.X.2
Su, M.M.3
-
57
-
-
84892835565
-
Metabolomics signature improves the prediction of cardiovascular events in elderly subjects
-
Rizza S, Copetti M, Rossi C et al (2014) Metabolomics signature improves the prediction of cardiovascular events in elderly subjects. Atherosclerosis 232:260-264
-
(2014)
Atherosclerosis
, vol.232
, pp. 260-264
-
-
Rizza, S.1
Copetti, M.2
Rossi, C.3
-
58
-
-
20544466649
-
Metabonomics in toxicology: A review
-
Robertson DG (2005) Metabonomics in toxicology: a review. Toxicol Sci 85:809-822
-
(2005)
Toxicol Sci
, vol.85
, pp. 809-822
-
-
Robertson, D.G.1
-
59
-
-
84890432985
-
p53 status determines the role of autophagy in pancreatic tumour development
-
Rosenfeldt MT, O'Prey J, Morton JP et al (2013) p53 status determines the role of autophagy in pancreatic tumour development. Nature 504:296-300
-
(2013)
Nature
, vol.504
, pp. 296-300
-
-
Rosenfeldt, M.T.1
O'Prey, J.2
Morton, J.P.3
-
60
-
-
0034464747
-
Genomics and inflammatory bowel disease
-
DOI 10.1097/00001574-200007000-00002
-
Schreiber S, Hampe J (2000) Genomics and inflammatory bowel disease. Curr Opin Gastroenterol 16:297-305 (Pubitemid 32260398)
-
(2000)
Current Opinion in Gastroenterology
, vol.16
, Issue.4
, pp. 297-305
-
-
Schreiber, S.1
Hampe, J.2
-
61
-
-
0344959399
-
Noscapine hydrochloride disrupts the mitotic spindle in mammalian cells and induces aneuploidy as well as polyploidy in cultured human lymphocytes
-
DOI 10.1093/mutage/14.1.51
-
Schuler M, Muehlbauer P, Guzzie P, Eastmond DA (1999) Noscapine hydrochloride disrupts the mitotic spindle in mammalian cells and induces aneuploidy as well as polyploidy in cultured human lymphocytes. Mutagenesis 14:51-56 (Pubitemid 29048240)
-
(1999)
Mutagenesis
, vol.14
, Issue.1
, pp. 51-56
-
-
Schuler, M.1
Muehlbauer, P.2
Guzzie, P.3
Eastmond, D.A.4
-
62
-
-
84891677915
-
Plasma metabolomic profiles in breast cancer patients and healthy controls: By race and tumor receptor subtypes
-
Shen J, Yan L, Liu S, Ambrosone CB, Zhao H (2013) Plasma metabolomic profiles in breast cancer patients and healthy controls: by race and tumor receptor subtypes. Transl Oncol 6:757-765
-
(2013)
Transl Oncol
, vol.6
, pp. 757-765
-
-
Shen, J.1
Yan, L.2
Liu, S.3
Ambrosone, C.B.4
Zhao, H.5
-
63
-
-
84863170205
-
Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis
-
Shi XL, Yao D, Chen C (2012) Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. J Biol Chem 287:6336-6349
-
(2012)
J Biol Chem
, vol.287
, pp. 6336-6349
-
-
Shi, X.L.1
Yao, D.2
Chen, C.3
-
64
-
-
79959509068
-
Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism
-
Smith KJ, Murray IA, Tanos R et al (2011) Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. J Pharmacol Exp Ther 338:318-327
-
(2011)
J Pharmacol Exp Ther
, vol.338
, pp. 318-327
-
-
Smith, K.J.1
Murray, I.A.2
Tanos, R.3
-
65
-
-
84895879554
-
Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease
-
Suh JH, Kanathezhath B, Shenvi S et al (2014) Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease. PLoS ONE 9(2):e88868
-
(2014)
PLoS ONE
, vol.9
, Issue.2
-
-
Suh, J.H.1
Kanathezhath, B.2
Shenvi, S.3
-
66
-
-
84863502669
-
Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
-
Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ (2012) Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 56:118-129
-
(2012)
Hepatology
, vol.56
, pp. 118-129
-
-
Tanaka, N.1
Matsubara, T.2
Krausz, K.W.3
Patterson, A.D.4
Gonzalez, F.J.5
-
67
-
-
84898612132
-
Metabolomics coupled with multivariate data and pathway analysis on potential biomarkers in gastric ulcer and intervention effects of Corydalis yanhusuo Alkaloid
-
Tianjiao L, Shuai W, Xiansheng M et al (2014) Metabolomics coupled with multivariate data and pathway analysis on potential biomarkers in gastric ulcer and intervention effects of Corydalis yanhusuo Alkaloid. PLoS ONE 9:e82499
-
(2014)
PLoS ONE
, vol.9
-
-
Tianjiao, L.1
Shuai, W.2
Xiansheng, M.3
-
68
-
-
0019775140
-
Metabolic fate of noscapine. III. Further studies on identification and determination of the metabolites
-
Tsunoda N, Yoshimura H (1981) Metabolic-fate of noscapine 3 further-studies on identification and determination of the metabolites. Xenobiotica 11:23-32 (Pubitemid 12249864)
-
(1981)
Xenobiotica
, vol.11
, Issue.1
, pp. 23-32
-
-
Tsunoda, N.1
Yoshimura, H.2
-
69
-
-
79951931440
-
Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR
-
Walker GS, Ryder TF, Sharma R, Smith EB, Freund A (2011) Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR. Drug Metab Dispos 39:433-440
-
(2011)
Drug Metab Dispos
, vol.39
, pp. 433-440
-
-
Walker, G.S.1
Ryder, T.F.2
Sharma, R.3
Smith, E.B.4
Freund, A.5
-
70
-
-
84885031125
-
2-Aminoadipic acid is a biomarker for diabetes risk
-
Wang TJ, Ngo D, Psychogios N et al (2013) 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest 123:4309-4317
-
(2013)
J Clin Invest
, vol.123
, pp. 4309-4317
-
-
Wang, T.J.1
Ngo, D.2
Psychogios, N.3
-
71
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
DOI 10.1038/nature06005, PII NATURE06005
-
Xavier RJ, Podolsky DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448:427-434 (Pubitemid 47123518)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
72
-
-
84871598157
-
Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling
-
Yao D, Shi XL, Wang L, Gosnell BA, Chen C (2013) Characterization of differential cocaine metabolism in mouse and rat through metabolomics-guided metabolite profiling. Drug Metab Dispos 41:79-88
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 79-88
-
-
Yao, D.1
Shi, X.L.2
Wang, L.3
Gosnell, B.A.4
Chen, C.5
-
73
-
-
84876950001
-
Preanalytical aspects and sample quality assessment in metabolomics studies of human blood
-
Yin PY, Peter A, Franken H et al (2013) Preanalytical aspects and sample quality assessment in metabolomics studies of human blood. Clin Chem 59:833-845
-
(2013)
Clin Chem
, vol.59
, pp. 833-845
-
-
Yin, P.Y.1
Peter, A.2
Franken, H.3
-
74
-
-
84863788678
-
Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice
-
Zhang YY, Li F, Patterson AD et al (2012) Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. J Biol Chem 287:24784-24794
-
(2012)
J Biol Chem
, vol.287
, pp. 24784-24794
-
-
Zhang, Y.Y.1
Li, F.2
Patterson, A.D.3
-
75
-
-
84888619257
-
Characterization of inhibition kinetics of (S)-warfarin hydroxylation by noscapine: Implications in warfarin therapy
-
Zhang N, Seguin RP, Kunze KL, Zhang YY, Jeong H (2013a) Characterization of inhibition kinetics of (S)-warfarin hydroxylation by noscapine: implications in warfarin therapy. Drug Metab Dispos 41:2114-2123
-
(2013)
Drug Metab Dispos
, vol.41
, pp. 2114-2123
-
-
Zhang, N.1
Seguin, R.P.2
Kunze, K.L.3
Zhang, Y.Y.4
Jeong, H.5
-
76
-
-
84893829206
-
Global and targeted metabolomics reveal that bupleurotoxin, a toxic type of polyacetylene, induces cerebral lesion by inhibiting GABA receptor in mice
-
doi:10.1021/pr400968c
-
Zhang Z, Lu C, Liu X et al (2013b) Global and targeted metabolomics reveal that bupleurotoxin, a toxic type of polyacetylene, induces cerebral lesion by inhibiting GABA receptor in mice. J Proteome Res. doi:10.1021/ pr400968c
-
(2013)
J Proteome Res
-
-
Zhang, Z.1
Lu, C.2
Liu, X.3
-
77
-
-
84893851963
-
Serum metabolomics study of polycystic ovary syndrome based on liquid chromatography-mass spectrometry
-
Zhao X, Xu F, Qi B et al (2014) Serum metabolomics study of polycystic ovary syndrome based on liquid chromatography-mass spectrometry. J Proteome Res 13:1101-1111
-
(2014)
J Proteome Res
, vol.13
, pp. 1101-1111
-
-
Zhao, X.1
Xu, F.2
Qi, B.3
|