The toxicity of 3-chloropropane-1,2-dipalmitate in Wistar rats and a metabonomics analysis of rat urine by ultra-performance liquid chromatography-mass spectrometry

Chemico-Biological Interactions

Volumn 206, Issue 2, 2013, Pages 337-345

  Li, Jianshuang ^a   Wang, Sen ^a   Wang, Maoqing ^a   Shi, Wenxiu ^a   Du, Xiaoyan ^a   Sun, Changhao ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

3 Chloropropane 1,2 dipalmitate; Metabonomics; Toxicity; UPLC MS

Indexed keywords

3 CHLOROPROPANE 1,2 DIPALMITATE; BIOLOGICAL MARKER; CREATININE; PALMITIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL CHEMISTRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; HISTOPATHOLOGY; KIDNEY TUBULE EPITHELIUM; LD 50; MASS SPECTROMETRY; METABOLISM; NEPHROTOXICITY; NONHUMAN; RAT; TOXICITY TESTING; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UREA NITROGEN BLOOD LEVEL; URINE;

3-CHLOROPROPANE-1,2-DIPALMITATE; 3-MCPD; 3-MONOCHLOROPROPANE-1,2-DIOL; 3-MPCD DIPALMITATE; ACID-HVP; ACID-HYDROLYZED VEGETABLE PROTEINS; ALANINE AMINOTRANSFERASE; ALT; ASPARTATE AMINOTRANSFERASE; AST; BASE PEAK INTENSITY; BLOOD UREA NITROGEN; BPI; BUN; CR; CREATININE; ELECTROSPRAY IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY; ESI-TOF-MS; HE; HEMATOXYLIN-EOSIN; IDO; INDOLAMINE-2,3-DIOXYGENASE; LD(50); MASS SPECTROMETRY; MEDIAN LETHAL DOSE; METABONOMICS; MS; PARTIAL LEAST SQUARES DISCRIMINANT ANALYSIS; PCA; PLS-DA; PRINCIPAL COMPONENT ANALYSIS; RETENTION TIME; RT; TDI; TOLERABLE DAILY INTAKE; TOXICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPLC; UPLC-MS; VARIABLE IMPORTANCE IN THE PROJECT; VIP;

ANIMALS; BLOOD UREA NITROGEN; BODY WEIGHT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CREATININE; DISCRIMINANT ANALYSIS; GLYCEROL; KIDNEY TUBULES; LEAST-SQUARES ANALYSIS; MALE; MASS SPECTROMETRY; METABOLOMICS; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 84886740231     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.10.004     Document Type: Article

References (30)

1. J. Velisek, J. Davidek, J. Hajslova, V. Kubelka, G. Janicek, and B. Mankova Chlorohydrins in protein hydrolysates Z. Lebensm. Unters. F. A. 167 1978 241 244
2. W.S. Cho, B.S. Han, K.T. Nam, K. Park, M. Choi, S.H. Kim, J. Jeong, and D.D. Jang Carcinogenicity study of 3-monochloropropane-1,2-diol in Sprague-Dawley rats Food Chem. Toxicol. 46 2008 3172 3177
3. S. Robjohns, R. Marshall, M. Fellows, and G. Kowalczyk In vivo genotoxicity studies with 3-monochloropropan-1, 2-diol Mutagenesis 18 2003 401 404
4. SCF (Scientific Committee on Food), Opinion on 3-mono-chloro-propane-1,2- diol (3-MCPD), Updating the SCF opinion of 1994, European Commission, Brussels, 2001. Available from: < http://ec.europa.eu/food/fs/sc/scf/out91-en.pdf > (accessed March 2013).
5. C. Crews, P. Brereton, and A. Davies The effects of domestic cooking on the levels of 3-monochloropropanediol in foods Food Addit. Contam. 18 2001 271 280
6. C. Crews, P. Hough, P. Brereton, D. Harvey, R. MacArthur, and W. Matthews Survey of 3-monochloropropane-1,2-diol(3-MCPD) in selected food groups, 1999-2000 Food Addit. Contam. 19 2002 22 27
7. C.G. Hamlet, P.A. Sadd, C. Crews, J. Velíšek, and D.E. Baxter Occurrence of 3-chloro-propane-1,2-diol(3-MCPD) and related compounds in foods: a review Food Addit. Contam. 19 2002 619 631
8. C.G. Hamlet, P.A. Sadd, and D.A. Gray Generation of monochloropropanediols (MCPDs) in model dough systems. 2. Unleavened doughs J. Agric. Food Chem. 52 2004 2067 2072
9. C.M. Breitling-Utzmann, H. Köbler, D. Herbolzheimer, and A. Maier 3-MCPD: occurrence in bread crust and various food groups as well as formation in toast Deut. Lebensm. Rundsch. 99 2003 280 285
10. V. DiViNoVá, M. Dolezal, and J. Velisek Free and bound 3-chloropropane-1, 2-diol in coffee surrogates and malts Czech J. Food Sci. 25 2007 39 47
11. M. Doležal, M. Chaloupská, V. Divinová, B. Svejkovská, and J. Velišek Occurrence of 3-chloropropane-1, 2-diol and its esters in coffee Eur. Food Res. Technol. 221 2005 221 225
12. Z. Zelinková, B. Svejkovská, J. Velíšek, and M. Doležal Fatty acid esters of 3-chloropropane-1,2-diol in edible oils Food Addit. Contam. 23 2006 1290 1298
13. B. Svejkovska, M. Dolezal, and J. Velisek Formation and decomposition of 3-chloropropane-1,2-diol esters in models simulating processed foods Czech J. Food Sci. 24 2006 172 179
14. J.N. Cogburn, M.G. Donovan, and C.S. Schasteen A model of human small intestinal absorptive cells. 1. Transport barrier Pharm. Res. 8 1991 210 216
15. W. Seefelder, N. Varga, A. Studer, G. Williamson, F.P. Scanlan, and R.H. Stadler Esters of 3-chloro-1,2-propanediol(3-MCPD) in vegetable oils: significance in the formation of 3-MCPD Food Addit. Contam. 25 2008 391 400
16. Z. Zelinková, M. Doležal, and J. Velíšek 3-Chloropropane-1,2-diol fatty acid esters in potato products Czech J. Food Sci. 27 2009 S421 S424
17. Z. Zelinková, M. Doležal, and J. Velíšek Occurrence of 3-chloropropane-1,2-diol fatty acid esters in infant and baby foods Eur. Food Res. Technol. 228 2009 571 578
18. M. Liu, B.Y. Gao, F. Qin, P.P. Wu, H.M. Shi, W. Luo, A.N. Ma, Y.R. Jiang, X.B. Xu, and L.L. Yu Acute oral toxicity of 3-MCPD mono- and di-palmitic esters in Swiss mice and their cytotoxicity in NRK-52E rat kidney cells Food Chem. Toxicol. 50 2012 3785 3791
19. 50) calculations Biometrics 12 1956 311 322
20. L. Yetukuri, M. Katajamaa, G. Medina-Gomez, T. Seppänen-Laakso, A. Vidal-Puig, and M. Orešič Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis BMC Syst. Biol. 1 2007 1 12
21. R.J. Ericsson, and V.F. Baker Male antifertility compounds: biological properties of U-5897 and U-15,646 J. Reprod. Fertil. 21 1970 267 273
22. W.S. Cho, B.S. Han, H. Lee, C. Kim, K.T. Nam, K. Park, M. Choi, S.J. Kim, S.H. Kim, and J. Jeong Subchronic toxicity study of 3-monochloropropane-1,2- diol administered by drinking water to B6C3F1 mice Food Chem. Toxicol. 46 2008 1666 1673
23. N. Bakhiya, K. Abraham, R. Gürtler, K.E. Appel, and A. Lampen Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food Mol. Nutr. Food Res. 55 2011 509 521
24. B.S. Lynch, D.W. Bryant, G.J. Hook, E.R. Nestmann, and I.C. Munro Carcinogenicity of monochloro-1,2-propanediol(α-chlorohydrin,3-MCPD) Int. J. Toxicol. 17 1998 47 76
25. A.R. Jones, and L.A. Chantrill Oxidative metabolic activity of boar spermatozoa: a system for assessing anti-glycolytic activity of potential inhibitors in vitro Reprod. Fert. Develop. 1 1989 357 367
26. T. Niwa, and M. Ise Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis J. Lab. Clin. Med. 124 1994 96 104
27. J.P. Li, A. Meinhardt, M.E. Roehrich, D. Golshayan, J. Dudler, M. Pagnotta, M. Trucco, and G. Vassalli Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival Am. J. Physiol. Heart Circ. Physiol. 293 2007 H3415 H3423
28. J.M. Sauer, R.L. Smith, J. Bao, M.J. Kattnig, R.K. Kuester, T.D. McClure, M. Mayersohn, and I.G. Sipes Oral and topical absorption, disposition kinetics and the metabolic fate of trans-methyl styryl ketone in the male Fischer 344 rat Drug Metab. Dispos. 25 1997 732 739
29. F. Wada, and M. Usami Studies on fatty acid ω-oxidation antiketogenic effect and gluconeogenicity of dicarboxylic acids Biochim. Biophys. Acta Lipids Lipid Metab. 487 1977 261 268
30. M. Martinez, G.J. Cuskelly, J. Williamson, J.P. Toth, and J.F. Gregory Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine β-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration J. Nutr. 130 2000 1115 1123