Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

Chemical Research in Toxicology

Volumn 26, Issue 7, 2013, Pages 1088-1096

  Patterson, Andrew D ^a   Carlson, Bradley A ^a   Li, Fei ^a   Bonzo, Jessica A ^a   Yoo, Min Hyuk ^a   Krausz, Kristopher W ^a   Conrad, Marcus ^b   Chen, Chi ^c   Gonzalez, Frank J ^a   Hatfield, Dolph L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; PARACETAMOL; THIOREDOXIN REDUCTASE 1; TRANSCRIPTION FACTOR NRF2; NFE2L2 PROTEIN, MOUSE; TXNRD1 PROTEIN, MOUSE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; RECEPTOR UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DEFICIENCY; DRUG-INDUCED LIVER INJURY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; TOXICITY; TRANSGENIC MOUSE;

ACETAMINOPHEN; ANIMALS; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-E2-RELATED FACTOR 2; THIOREDOXIN REDUCTASE 1;

EID: 84880322948     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx4001013     Document Type: Article

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