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Volumn 227, Issue 8, 2012, Pages 2975-2981

Challenges and opportunities of metabolomics

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; PARACETAMOL; STABLE ISOTOPE;

EID: 84858730393     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.24002     Document Type: Short Survey
Times cited : (223)

References (87)
  • 1
    • 33947326873 scopus 로고    scopus 로고
    • Newborn screening: Current status
    • Arn PH. 2007. Newborn screening: Current status. Health Aff (Millwood) 26: 559-566.
    • (2007) Health Aff (Millwood) , vol.26 , pp. 559-566
    • Arn, P.H.1
  • 4
    • 78649411431 scopus 로고    scopus 로고
    • Metabolomics identifies novel Hnf1{alpha}-dependent physiological pathways in vivo
    • Bonzo JA, Patterson AD, Krausz KW, Gonzalez FJ. 2010. Metabolomics identifies novel Hnf1{alpha}-dependent physiological pathways in vivo. Mol Endocrinol 24: 2343-2355.
    • (2010) Mol Endocrinol , vol.24 , pp. 2343-2355
    • Bonzo, J.A.1    Patterson, A.D.2    Krausz, K.W.3    Gonzalez, F.J.4
  • 7
    • 60849139445 scopus 로고    scopus 로고
    • Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS)
    • Chan EC, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Keun HC. 2009. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res 8: 352-361.
    • (2009) J Proteome Res , vol.8 , pp. 352-361
    • Chan, E.C.1    Koh, P.K.2    Mal, M.3    Cheah, P.Y.4    Eu, K.W.5    Backshall, A.6    Cavill, R.7    Nicholson, J.K.8    Keun, H.C.9
  • 9
    • 34047250288 scopus 로고    scopus 로고
    • A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach
    • Chen C, Ma X, Malfatti MA, Krausz KW, Kimura S, Felton JS, Idle JR, Gonzalez FJ. 2007. A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach. Chem Res Toxicol 20: 531-542.
    • (2007) Chem Res Toxicol , vol.20 , pp. 531-542
    • Chen, C.1    Ma, X.2    Malfatti, M.A.3    Krausz, K.W.4    Kimura, S.5    Felton, J.S.6    Idle, J.R.7    Gonzalez, F.J.8
  • 10
    • 41949134860 scopus 로고    scopus 로고
    • Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice
    • Chen C, Krausz KW, Idle JR, Gonzalez FJ. 2008. Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. J Biol Chem 283: 4543-4559.
    • (2008) J Biol Chem , vol.283 , pp. 4543-4559
    • Chen, C.1    Krausz, K.W.2    Idle, J.R.3    Gonzalez, F.J.4
  • 11
    • 17144387912 scopus 로고    scopus 로고
    • Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy
    • Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS, Wu CL. 2005. Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res 65: 3030-3034.
    • (2005) Cancer Res , vol.65 , pp. 3030-3034
    • Cheng, L.L.1    Burns, M.A.2    Taylor, J.L.3    He, W.4    Halpern, E.F.5    McDougal, W.S.6    Wu, C.L.7
  • 12
    • 67650831245 scopus 로고    scopus 로고
    • Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity
    • Cheng J, Ma X, Krausz KW, Idle JR, Gonzalez FJ. 2009. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos 37: 1611-1621.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1611-1621
    • Cheng, J.1    Ma, X.2    Krausz, K.W.3    Idle, J.R.4    Gonzalez, F.J.5
  • 13
    • 77957236383 scopus 로고    scopus 로고
    • Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X receptor activation
    • Cheng J, Shah YM, Ma X, Pang X, Tanaka T, Kodama T, Krausz KW, Gonzalez FJ. 2010. Therapeutic role of rifaximin in inflammatory bowel disease: Clinical implication of human pregnane X receptor activation. J Pharmacol Exp Ther 335: 32-41.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 32-41
    • Cheng, J.1    Shah, Y.M.2    Ma, X.3    Pang, X.4    Tanaka, T.5    Kodama, T.6    Krausz, K.W.7    Gonzalez, F.J.8
  • 17
    • 70149096873 scopus 로고    scopus 로고
    • Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism
    • Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK. 2009. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proc Natl Acad Sci USA 106: 14728-14733.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14728-14733
    • Clayton, T.A.1    Baker, D.2    Lindon, J.C.3    Everett, J.R.4    Nicholson, J.K.5
  • 19
    • 79955461502 scopus 로고    scopus 로고
    • Comprehensive plasma thiol redox status determination for metabolomics
    • D'Agostino LA, Lam KP, Lee R, Britz-McKibbin P. 2011. Comprehensive plasma thiol redox status determination for metabolomics. J Proteome Res 10: 592-603.
    • (2011) J Proteome Res , vol.10 , pp. 592-603
    • D'Agostino, L.A.1    Lam, K.P.2    Lee, R.3    Britz-McKibbin, P.4
  • 21
    • 42449122308 scopus 로고    scopus 로고
    • Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes
    • Dunn WB. 2008. Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes. Phys Biol 5: 011001.
    • (2008) Phys Biol , vol.5 , pp. 011001
    • Dunn, W.B.1
  • 23
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    • Fan TW, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, Miller DM. 2009b. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8: 41.
    • (2009) Mol Cancer , vol.8 , pp. 41
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5    Bousamra, M.6    Miller, D.M.7
  • 24
    • 78650732495 scopus 로고    scopus 로고
    • Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women
    • Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH. 2010. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS ONE 5: 1-10.
    • (2010) PLoS ONE , vol.5 , pp. 1-10
    • Fiehn, O.1    Garvey, W.T.2    Newman, J.W.3    Lok, K.H.4    Hoppel, C.L.5    Adams, S.H.6
  • 25
    • 0034634448 scopus 로고    scopus 로고
    • An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and Alpk: ApfCD mouse
    • Gavaghan CL, Holmes E, Lenz E, Wilson ID, Nicholson JK. 2000. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: Application to the C57BL10J and Alpk: ApfCD mouse. FEBS Lett 484: 169-174.
    • (2000) FEBS Lett , vol.484 , pp. 169-174
    • Gavaghan, C.L.1    Holmes, E.2    Lenz, E.3    Wilson, I.D.4    Nicholson, J.K.5
  • 26
    • 45949087351 scopus 로고    scopus 로고
    • Hydrophilic interaction and reversed-phase ultra-performance liquid chromatography TOF-MS for metabonomic analysis of Zucker rat urine
    • Gika HG, Theodoridis GA, Wilson ID. 2008. Hydrophilic interaction and reversed-phase ultra-performance liquid chromatography TOF-MS for metabonomic analysis of Zucker rat urine. J Sep Sci 31: 1598-1608.
    • (2008) J Sep Sci , vol.31 , pp. 1598-1608
    • Gika, H.G.1    Theodoridis, G.A.2    Wilson, I.D.3
  • 27
    • 0015030844 scopus 로고
    • The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat
    • Gingell R, Bridges JW, Williams RT. 1971. The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat. Xenobiotica 1: 143-156.
    • (1971) Xenobiotica , vol.1 , pp. 143-156
    • Gingell, R.1    Bridges, J.W.2    Williams, R.T.3
  • 28
    • 33745320763 scopus 로고    scopus 로고
    • A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse
    • Giri S, Idle JR, Chen C, Zabriskie TM, Krausz KW, Gonzalez FJ. 2006. A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse. Chem Res Toxicol 19: 818-827.
    • (2006) Chem Res Toxicol , vol.19 , pp. 818-827
    • Giri, S.1    Idle, J.R.2    Chen, C.3    Zabriskie, T.M.4    Krausz, K.W.5    Gonzalez, F.J.6
  • 29
    • 33845925755 scopus 로고    scopus 로고
    • The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases
    • Giri S, Krausz KW, Idle JR, Gonzalez FJ. 2007. The metabolomics of (+/-)-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases. Biochem Pharmacol 73: 561-573.
    • (2007) Biochem Pharmacol , vol.73 , pp. 561-573
    • Giri, S.1    Krausz, K.W.2    Idle, J.R.3    Gonzalez, F.J.4
  • 30
    • 78650761774 scopus 로고    scopus 로고
    • Nanostructure-initiator mass spectrometry metabolite analysis and imaging
    • Greving MP, Patti GJ, Siuzdak G. 2011. Nanostructure-initiator mass spectrometry metabolite analysis and imaging. Anal Chem 83: 2-7.
    • (2011) Anal Chem , vol.83 , pp. 2-7
    • Greving, M.P.1    Patti, G.J.2    Siuzdak, G.3
  • 36
    • 46849112801 scopus 로고    scopus 로고
    • Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: Application to acyl glucuronide intramolecular transacylation reactions
    • Johnson CH, Athersuch TJ, Wilson ID, Iddon L, Meng X, Stachulski AV, Lindon JC, Nicholson JK. 2008. Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: Application to acyl glucuronide intramolecular transacylation reactions. Anal Chem 80: 4886-4895.
    • (2008) Anal Chem , vol.80 , pp. 4886-4895
    • Johnson, C.H.1    Athersuch, T.J.2    Wilson, I.D.3    Iddon, L.4    Meng, X.5    Stachulski, A.V.6    Lindon, J.C.7    Nicholson, J.K.8
  • 38
    • 79953314279 scopus 로고    scopus 로고
    • Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats
    • Johnson CH, Patterson AD, Krausz KW, Lanz C, Kang DW, Luecke H, Gonzalez FJ, Idle JR. 2011b. Radiation metabolomics. 4. UPLC-ESI-QTOFMS-based metabolomics for urinary biomarker discovery in gamma-irradiated rats. Radiat Res 175: 473-484.
    • (2011) Radiat Res , vol.175 , pp. 473-484
    • Johnson, C.H.1    Patterson, A.D.2    Krausz, K.W.3    Lanz, C.4    Kang, D.W.5    Luecke, H.6    Gonzalez, F.J.7    Idle, J.R.8
  • 39
    • 74749094140 scopus 로고    scopus 로고
    • Putative molecular signatures for the imaging of prostate cancer
    • Kassis AI, Yongliang YS, Adelstein J. 2010. Putative molecular signatures for the imaging of prostate cancer. Expert Rev Mol Diagn 10: 65-74.
    • (2010) Expert Rev Mol Diagn , vol.10 , pp. 65-74
    • Kassis, A.I.1    Yongliang, Y.S.2    Adelstein, J.3
  • 41
    • 37349113752 scopus 로고    scopus 로고
    • Medicinal importance of grapefruit juice and its interaction with various drugs
    • Kiani J, Imam SZ. 2007. Medicinal importance of grapefruit juice and its interaction with various drugs. Nutr J 6: 33.
    • (2007) Nutr J , vol.6 , pp. 33
    • Kiani, J.1    Imam, S.Z.2
  • 42
    • 72449186517 scopus 로고    scopus 로고
    • FiehnLib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
    • Kind T, Wohlgemuth G, Lee do Y, Lu Y, Palazoglu M, Shahbaz S, Fiehn O. 2009. FiehnLib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal Chem 81: 10038-10048.
    • (2009) Anal Chem , vol.81 , pp. 10038-10048
    • Kind, T.1    Wohlgemuth, G.2    Lee do, Y.3    Lu, Y.4    Palazoglu, M.5    Shahbaz, S.6    Fiehn, O.7
  • 43
    • 79957857701 scopus 로고    scopus 로고
    • Metabolic phenotyping for monitoring surgical patients
    • Kinross JM, Holmes E, Darzi AW, Nicholson JK. 2011. Metabolic phenotyping for monitoring surgical patients. Lancet 377: 1817-1819.
    • (2011) Lancet , vol.377 , pp. 1817-1819
    • Kinross, J.M.1    Holmes, E.2    Darzi, A.W.3    Nicholson, J.K.4
  • 46
    • 79952527112 scopus 로고    scopus 로고
    • Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer
    • Lane AN, Fan TW, Bousamra M, II, Higashi RM, Yan J, Miller DM. 2011. Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer. OMICS 15: 173-182.
    • (2011) OMICS , vol.15 , pp. 173-182
    • Lane, A.N.1    Fan, T.W.2    Bousamra II, M.3    Higashi, R.M.4    Yan, J.5    Miller, D.M.6
  • 47
    • 70349310440 scopus 로고    scopus 로고
    • Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm
    • Lanz C, Patterson AD, Slavik J, Krausz KW, Ledermann M, Gonzalez FJ, Idle JR. 2009. Radiation metabolomics. 3. Biomarker discovery in the urine of gamma-irradiated rats using a simplified metabolomics protocol of gas chromatography-mass spectrometry combined with random forests machine learning algorithm. Radiat Res 172: 198-212.
    • (2009) Radiat Res , vol.172 , pp. 198-212
    • Lanz, C.1    Patterson, A.D.2    Slavik, J.3    Krausz, K.W.4    Ledermann, M.5    Gonzalez, F.J.6    Idle, J.R.7
  • 48
    • 77954693378 scopus 로고    scopus 로고
    • Metabolomic studies of radiation-induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation
    • Lee R, Britz-McKibbin P. 2010. Metabolomic studies of radiation-induced apoptosis of human leukocytes by capillary electrophoresis-mass spectrometry and flow cytometry: Adaptive cellular responses to ionizing radiation. Electrophoresis 31: 2328-2337.
    • (2010) Electrophoresis , vol.31 , pp. 2328-2337
    • Lee, R.1    Britz-McKibbin, P.2
  • 49
    • 74249119678 scopus 로고    scopus 로고
    • Obesity and the human microbiome
    • Ley RE. 2010. Obesity and the human microbiome. Curr Opin Gastroenterol 26: 5-11.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 5-11
    • Ley, R.E.1
  • 50
    • 77955660756 scopus 로고    scopus 로고
    • Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics
    • Li F, Patterson AD, Hofer CC, Krausz KW, Gonzalez FJ, Idle JR. 2010. Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol 80: 1063-1074.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1063-1074
    • Li, F.1    Patterson, A.D.2    Hofer, C.C.3    Krausz, K.W.4    Gonzalez, F.J.5    Idle, J.R.6
  • 51
    • 79952992201 scopus 로고    scopus 로고
    • A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics
    • Li F, Patterson AD, Hofer CC, Krausz KW, Gonzalez FJ, Idle JR. 2011. A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol 81: 1043-1053.
    • (2011) Biochem Pharmacol , vol.81 , pp. 1043-1053
    • Li, F.1    Patterson, A.D.2    Hofer, C.C.3    Krausz, K.W.4    Gonzalez, F.J.5    Idle, J.R.6
  • 53
    • 66649118903 scopus 로고    scopus 로고
    • Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics
    • Liu A, Patterson AD, Yang Z, Zhang X, Liu W, Qiu F, Sun H, Krausz KW, Idle JR, Gonzalez FJ, Dai R. 2009. Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics. Drug Metab Dispos 37: 1157-1163.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1157-1163
    • Liu, A.1    Patterson, A.D.2    Yang, Z.3    Zhang, X.4    Liu, W.5    Qiu, F.6    Sun, H.7    Krausz, K.W.8    Idle, J.R.9    Gonzalez, F.J.10    Dai, R.11
  • 54
    • 41549100628 scopus 로고    scopus 로고
    • A metabolomic perspective of melatonin metabolism in the mouse
    • Ma X, Chen C, Krausz KW, Idle JR, Gonzalez FJ. 2008a. A metabolomic perspective of melatonin metabolism in the mouse. Endocrinology 149: 1869-1879.
    • (2008) Endocrinology , vol.149 , pp. 1869-1879
    • Ma, X.1    Chen, C.2    Krausz, K.W.3    Idle, J.R.4    Gonzalez, F.J.5
  • 56
    • 77955463490 scopus 로고    scopus 로고
    • Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse
    • Manna SK, Patterson AD, Yang Q, Krausz KW, Li H, Idle JR, Fornace AJ, Jr., Gonzalez FJ. 2010. Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res 9: 4176-4188.
    • (2010) J Proteome Res , vol.9 , pp. 4176-4188
    • Manna, S.K.1    Patterson, A.D.2    Yang, Q.3    Krausz, K.W.4    Li, H.5    Idle, J.R.6    Fornace Jr., A.J.7    Gonzalez, F.J.8
  • 57
    • 80052465307 scopus 로고    scopus 로고
    • UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model
    • Manna SK, Patterson AD, Yang Q, Krausz KW, Idle JR, Fornace AJ, Gonzalez FJ. 2011. UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model. J Proteome Res 10: 4120-4133.
    • (2011) J Proteome Res , vol.10 , pp. 4120-4133
    • Manna, S.K.1    Patterson, A.D.2    Yang, Q.3    Krausz, K.W.4    Idle, J.R.5    Fornace, A.J.6    Gonzalez, F.J.7
  • 58
    • 0036389822 scopus 로고    scopus 로고
    • Principles and applications of comprehensive two-dimensional gas chromatography
    • Marriott P, Shellie R. 2002. Principles and applications of comprehensive two-dimensional gas chromatography. Trend Anal Chem 21: 573-583.
    • (2002) Trend Anal Chem , vol.21 , pp. 573-583
    • Marriott, P.1    Shellie, R.2
  • 60
    • 0023879753 scopus 로고
    • The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol. Studies in neomycin-pretreated and germ-free mice
    • Mikov M, Caldwell J, Dolphin CT, Smith RL. 1988. The role of intestinal microflora in the formation of the methylthio adduct metabolites of paracetamol. Studies in neomycin-pretreated and germ-free mice. Biochem Pharmacol 37: 1445-1449.
    • (1988) Biochem Pharmacol , vol.37 , pp. 1445-1449
    • Mikov, M.1    Caldwell, J.2    Dolphin, C.T.3    Smith, R.L.4
  • 62
    • 44649121995 scopus 로고    scopus 로고
    • Global systems biology and personalized healthcare solutions
    • Nicholson JK, Holmes E. 2006. Global systems biology and personalized healthcare solutions. Discov Med 6: 63-70.
    • (2006) Discov Med , vol.6 , pp. 63-70
    • Nicholson, J.K.1    Holmes, E.2
  • 63
    • 78650434645 scopus 로고    scopus 로고
    • Pharmacometabonomics as an effector for personalized medicine
    • Nicholson JK, Lindon JC, Wilson ID. 2011. Pharmacometabonomics as an effector for personalized medicine. Pharmacogenomics 12: 103-111.
    • (2011) Pharmacogenomics , vol.12 , pp. 103-111
    • Nicholson, J.K.1    Lindon, J.C.2    Wilson, I.D.3
  • 66
    • 78651366483 scopus 로고    scopus 로고
    • Pregnane X receptor-mediated induction of Cyp3a by black cohosh
    • Pang X, Cheng J, Krausz KW, Guo DA, Gonzalez FJ. 2011. Pregnane X receptor-mediated induction of Cyp3a by black cohosh. Xenobiotica 41: 112-123.
    • (2011) Xenobiotica , vol.41 , pp. 112-123
    • Pang, X.1    Cheng, J.2    Krausz, K.W.3    Guo, D.A.4    Gonzalez, F.J.5
  • 67
    • 38849104440 scopus 로고    scopus 로고
    • UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation
    • Patterson A, Li H, Eichler G, Krausz K, Weinstein J, Fornace AJ, Gonzalez F, Idle J. 2008. UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation. Anal Chem 80: 665-674.
    • (2008) Anal Chem , vol.80 , pp. 665-674
    • Patterson, A.1    Li, H.2    Eichler, G.3    Krausz, K.4    Weinstein, J.5    Fornace, A.J.6    Gonzalez, F.7    Idle, J.8
  • 73
    • 77953742534 scopus 로고    scopus 로고
    • Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: Contribution of hepatic and gut bacterial processes to the overall biotransformation
    • Sweeny DJ, Li W, Clough J, Bhamidipati S, Singh R, Park G, Baluom M, Grossbard E, Lau DT. 2010. Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: Contribution of hepatic and gut bacterial processes to the overall biotransformation. Drug Metab Dispos 38: 1166-1176.
    • (2010) Drug Metab Dispos , vol.38 , pp. 1166-1176
    • Sweeny, D.J.1    Li, W.2    Clough, J.3    Bhamidipati, S.4    Singh, R.5    Park, G.6    Baluom, M.7    Grossbard, E.8    Lau, D.T.9
  • 76
    • 67949095917 scopus 로고    scopus 로고
    • Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice
    • Tyburski JB, Patterson AD, Krausz KW, Slavik J, Fornace AJ, Jr., Gonzalez FJ, Idle JR. 2009. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiat Res 172: 42-57.
    • (2009) Radiat Res , vol.172 , pp. 42-57
    • Tyburski, J.B.1    Patterson, A.D.2    Krausz, K.W.3    Slavik, J.4    Fornace Jr., A.J.5    Gonzalez, F.J.6    Idle, J.R.7
  • 77
    • 84860437096 scopus 로고    scopus 로고
    • Analytical methods from the perspective of method standardization
    • Neilsen J, Jewett MC, editors. Berlin: Springer
    • Villas-Boas SG, Koulman A, Lane GA. 2010. Analytical methods from the perspective of method standardization. In: Neilsen J, Jewett MC, editors. Metabolomics: A powerful tool in systems biology. Berlin: Springer. pp 11-52.
    • (2010) Metabolomics: A powerful tool in systems biology , pp. 11-52
    • Villas-Boas, S.G.1    Koulman, A.2    Lane, G.A.3
  • 80
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. 1956. On the origin of cancer cells. Science 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 81
    • 36649020263 scopus 로고    scopus 로고
    • Metabolomics identifies perturbations in human disorders of propionate metabolism
    • Wikoff WR, Gangoiti JA, Barshop BA, Siuzdak G. 2007. Metabolomics identifies perturbations in human disorders of propionate metabolism. Clin Chem 53: 2169-2176.
    • (2007) Clin Chem , vol.53 , pp. 2169-2176
    • Wikoff, W.R.1    Gangoiti, J.A.2    Barshop, B.A.3    Siuzdak, G.4
  • 82
    • 67650595188 scopus 로고    scopus 로고
    • The role of gut microbiota in drug response
    • Wilson ID, Nicholson JK. 2009. The role of gut microbiota in drug response. Curr Pharm Design 15: 1519-1523.
    • (2009) Curr Pharm Design , vol.15 , pp. 1519-1523
    • Wilson, I.D.1    Nicholson, J.K.2
  • 83
    • 17444404226 scopus 로고    scopus 로고
    • High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies
    • Wilson ID, Nicholson JK, Castro-Perez J, Granger JH, Johnson KA, Smith BW, Plumb RS. 2005. High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies. J Proteome Res 4: 591-598.
    • (2005) J Proteome Res , vol.4 , pp. 591-598
    • Wilson, I.D.1    Nicholson, J.K.2    Castro-Perez, J.3    Granger, J.H.4    Johnson, K.A.5    Smith, B.W.6    Plumb, R.S.7
  • 85
    • 80051682403 scopus 로고    scopus 로고
    • Advances in metabolite identification
    • Wishart DS. 2011. Advances in metabolite identification. Bioanalysis 3: 1769-1782.
    • (2011) Bioanalysis , vol.3 , pp. 1769-1782
    • Wishart, D.S.1
  • 87
    • 34548356352 scopus 로고    scopus 로고
    • Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation
    • Zhen Y, Krausz KW, Chen C, Idle JR, Gonzalez FJ. 2007. Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor alpha expression and activation. Mol Endocrinol 21: 2136-2151.
    • (2007) Mol Endocrinol , vol.21 , pp. 2136-2151
    • Zhen, Y.1    Krausz, K.W.2    Chen, C.3    Idle, J.R.4    Gonzalez, F.J.5


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