Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

PLoS Genetics

Volumn 8, Issue 11, 2012, Pages

  Menezes, Luis F ^a   Zhou, Fang ^a   Patterson, Andrew D ^b   Piontek, Klaus B ^c   Krausz, Kristopher W ^b   Gonzalez, Frank J ^b   Germino, Gregory G ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; MICRORNA; POLYCYSTIN 1;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE INACTIVATION; GENE REGULATORY NETWORK; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HEPATOCYTE NUCLEAR FACTOR 4ALPHA GENE; HETEROZYGOTE; KIDNEY CYST; KIDNEY DEVELOPMENT; KIDNEY POLYCYSTIC DISEASE; METABOLITE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYCYSTIN 1 GENE; PREDICTION; TRANSCRIPTOMICS; WILD TYPE;

ALLELES; ANIMALS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; MICE; MUTATION; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; PROTEIN KINASE C;

ANIMALIA; MUS;

EID: 84870707829     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003053     Document Type: Article

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