메뉴 건너뛰기




Volumn 110, Issue 50, 2013, Pages 20206-20211

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release

Author keywords

ATP secretion; Ectopic calcification; ENPP1; MRP6

Indexed keywords

ABC TRANSPORTER; ATP BINDING CASSETTE SUB FAMILY C MEMBER 6 PROTEIN; NUCLEOSIDE TRIPHOSPHATE; PYROPHOSPHATE; UNCLASSIFIED DRUG;

EID: 84890275902     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1319582110     Document Type: Article
Times cited : (208)

References (55)
  • 1
    • 0023744791 scopus 로고
    • Pseudoxanthoma elasticum
    • Neldner KH (1988) Pseudoxanthoma elasticum. Clin Dermatol 6(1):1-159.
    • (1988) Clin Dermatol , vol.6 , Issue.1 , pp. 1-159
    • Neldner, K.H.1
  • 2
    • 84878537533 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Progress in research toward treatment. Summary of the 2012 PXE international research meeting
    • Uitto J, Váradi A, Bercovitch L, Terry PF, Terry SF (2013) Pseudoxanthoma elasticum: Progress in research toward treatment. Summary of the 2012 PXE international research meeting. J Invest Dermatol 133(6):1444-1449.
    • (2013) J Invest Dermatol , vol.133 , Issue.6 , pp. 1444-1449
    • Uitto, J.1    Váradi, A.2    Bercovitch, L.3    Terry, P.F.4    Terry, S.F.5
  • 3
    • 76649133303 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Molecular genetics and putative pathomechanisms
    • Uitto J, Li Q, Jiang Q (2010) Pseudoxanthoma elasticum: Molecular genetics and putative pathomechanisms. J Invest Dermatol 130(3):661-670.
    • (2010) J Invest Dermatol , vol.130 , Issue.3 , pp. 661-670
    • Uitto, J.1    Li, Q.2    Jiang, Q.3
  • 4
    • 18844465976 scopus 로고    scopus 로고
    • Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum
    • Le Saux O, et al. (2000) Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet 25(2):223-227.
    • (2000) Nat Genet , vol.25 , Issue.2 , pp. 223-227
    • Le Saux, O.1
  • 5
    • 0034123093 scopus 로고    scopus 로고
    • Mutations in ABCC6 cause pseudoxanthoma elasticum
    • Bergen AA, et al. (2000) Mutations in ABCC6 cause pseudoxanthoma elasticum. Nat Genet 25(2):228-231.
    • (2000) Nat Genet , vol.25 , Issue.2 , pp. 228-231
    • Bergen, A.A.1
  • 6
    • 0034705145 scopus 로고    scopus 로고
    • Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
    • Ringpfeil F, Lebwohl MG, Christiano AM, Uitto J (2000) Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci USA 97(11):6001-6006.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.11 , pp. 6001-6006
    • Ringpfeil, F.1    Lebwohl, M.G.2    Christiano, A.M.3    Uitto, J.4
  • 7
    • 0033930195 scopus 로고    scopus 로고
    • Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum
    • Struk B, et al. (2000) Mutations of the gene encoding the transmembrane transporter protein ABC-C6 cause pseudoxanthoma elasticum. J Mol Med (Berl) 78(5):282-286.
    • (2000) J Mol Med (Berl) , vol.78 , Issue.5 , pp. 282-286
    • Struk, B.1
  • 8
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: Tthe multidrug resistance-associated proteins
    • Borst P, Evers R, Kool M, Wijnholds J (2000) A family of drug transporters: Tthe multidrug resistance-associated proteins. J Natl Cancer Inst 92(16):1295-1302.
    • (2000) J Natl Cancer Inst , vol.92 , Issue.16 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 9
    • 0032893268 scopus 로고    scopus 로고
    • Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
    • Kool M, van der Linden M, de Haas M, Baas F, Borst P (1999) Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res 59(1):175-182.
    • (1999) Cancer Res , vol.59 , Issue.1 , pp. 175-182
    • Kool, M.1    Van Der Linden, M.2    De Haas, M.3    Baas, F.4    Borst, P.5
  • 10
    • 0034007737 scopus 로고    scopus 로고
    • Transport function and hepatocellular localization of mrp6 in rat liver
    • Madon J, Hagenbuch B, Landmann L, Meier PJ, Stieger B (2000) Transport function and hepatocellular localization of mrp6 in rat liver. Mol Pharmacol 57(3):634-641.
    • (2000) Mol Pharmacol , vol.57 , Issue.3 , pp. 634-641
    • Madon, J.1    Hagenbuch, B.2    Landmann, L.3    Meier, P.J.4    Stieger, B.5
  • 11
    • 0036231565 scopus 로고    scopus 로고
    • MRP6 (ABCC6) detection in normal human tissues and tumors
    • Scheffer GL, et al. (2002) MRP6 (ABCC6) detection in normal human tissues and tumors. Lab Invest 82(4):515-518.
    • (2002) Lab Invest , vol.82 , Issue.4 , pp. 515-518
    • Scheffer, G.L.1
  • 12
    • 80052827583 scopus 로고    scopus 로고
    • Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver
    • Le Saux O, et al. (2011) Expression and in vivo rescue of human ABCC6 disease-causing mutants in mouse liver. PLoS ONE 6(9):e24738.
    • (2011) PLoS ONE , vol.6 , Issue.9
    • Le Saux, O.1
  • 13
    • 84867634830 scopus 로고    scopus 로고
    • Abcc6 deficiency in the mouse leads to calcification of collagen fibers in Bruch's membrane
    • Gorgels TG, et al. (2012) Abcc6 deficiency in the mouse leads to calcification of collagen fibers in Bruch's membrane. Exp Eye Res 104:59-64.
    • (2012) Exp Eye Res , vol.104 , pp. 59-64
    • Gorgels, T.G.1
  • 14
    • 33847053974 scopus 로고    scopus 로고
    • Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: Systemic and local regulatory factors
    • Jiang Q, Li Q, Uitto J (2007) Aberrant mineralization of connective tissues in a mouse model of pseudoxanthoma elasticum: Systemic and local regulatory factors. J Invest Dermatol 127(6):1392-1402.
    • (2007) J Invest Dermatol , vol.127 , Issue.6 , pp. 1392-1402
    • Jiang, Q.1    Li, Q.2    Uitto, J.3
  • 15
    • 24344480438 scopus 로고    scopus 로고
    • Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues
    • Klement JF, et al. (2005) Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues. Mol Cell Biol 25(18):8299-8310.
    • (2005) Mol Cell Biol , vol.25 , Issue.18 , pp. 8299-8310
    • Klement, J.F.1
  • 16
    • 26444436944 scopus 로고    scopus 로고
    • Disruption of Abcc6 in the mouse: Novel insight in the pathogenesis of pseudoxanthoma elasticum
    • Gorgels TG, et al. (2005) Disruption of Abcc6 in the mouse: Novel insight in the pathogenesis of pseudoxanthoma elasticum. Hum Mol Genet 14(13):1763-1773.
    • (2005) Hum Mol Genet , vol.14 , Issue.13 , pp. 1763-1773
    • Gorgels, T.G.1
  • 18
    • 76649133470 scopus 로고    scopus 로고
    • -/- mice and their wild-type counterparts halts ectopic mineralization in a murine model of pseudoxanthoma elasticum
    • -/- mice and their wild-type counterparts halts ectopic mineralization in a murine model of pseudoxanthoma elasticum. Am J Pathol 176(4):1855- 1862.
    • (2010) Am J Pathol , vol.176 , Issue.4 , pp. 1855-1862
    • Jiang, Q.1
  • 19
    • 0036829109 scopus 로고    scopus 로고
    • Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6)
    • Belinsky MG, Chen ZS, Shchaveleva I, Zeng H, Kruh GD (2002) Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6). Cancer Res 62(21):6172-6177.
    • (2002) Cancer Res , vol.62 , Issue.21 , pp. 6172-6177
    • Belinsky, M.G.1    Chen, Z.S.2    Shchaveleva, I.3    Zeng, H.4    Kruh, G.D.5
  • 20
    • 0037053355 scopus 로고    scopus 로고
    • Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6)
    • Iliás A, et al. (2002) Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem 277(19):16860-16867.
    • (2002) J Biol Chem , vol.277 , Issue.19 , pp. 16860-16867
    • Iliás, A.1
  • 21
    • 45849111436 scopus 로고    scopus 로고
    • Does the absence of ABCC6 (multidrug resistance protein 6) in patients with pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery?
    • Borst P, van de Wetering K, Schlingemann R (2008) Does the absence of ABCC6 (multidrug resistance protein 6) in patients with pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery? Cell Cycle 7(11):1575-1579.
    • (2008) Cell Cycle , vol.7 , Issue.11 , pp. 1575-1579
    • Borst, P.1    Van De Wetering, K.2    Schlingemann, R.3
  • 22
    • 79955164527 scopus 로고    scopus 로고
    • Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum
    • Markello TC, et al. (2011) Vascular pathology of medial arterial calcifications in NT5E deficiency: Implications for the role of adenosine in pseudoxanthoma elasticum. Mol Genet Metab 103(1):44-50.
    • (2011) Mol Genet Metab , vol.103 , Issue.1 , pp. 44-50
    • Markello, T.C.1
  • 23
    • 82355180873 scopus 로고    scopus 로고
    • ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum
    • Fülöp K, et al. (2011) ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: Relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun 415(3):468-471.
    • (2011) Biochem Biophys Res Commun , vol.415 , Issue.3 , pp. 468-471
    • Fülöp, K.1
  • 24
    • 82455164303 scopus 로고    scopus 로고
    • ABCC6 does not transport adenosine: Relevance to pathomechanism of pseudoxanthoma elasticum
    • author reply 422
    • Szabó Z, Váradi A, Li Q, Uitto J (2011) ABCC6 does not transport adenosine: Relevance to pathomechanism of pseudoxanthoma elasticum. Mol Genet Metab 104(3):421, author reply 422.
    • (2011) Mol Genet Metab , vol.104 , Issue.3 , pp. 421
    • Szabó, Z.1    Váradi, A.2    Li, Q.3    Uitto, J.4
  • 25
    • 84861915827 scopus 로고    scopus 로고
    • XCMS Online: A Web-based platform to process untargeted metabolomic data
    • Tautenhahn R, Patti GJ, Rinehart D, Siuzdak G (2012) XCMS Online: A Web-based platform to process untargeted metabolomic data. Anal Chem 84(11):5035-5039.
    • (2012) Anal Chem , vol.84 , Issue.11 , pp. 5035-5039
    • Tautenhahn, R.1    Patti, G.J.2    Rinehart, D.3    Siuzdak, G.4
  • 26
    • 84876560030 scopus 로고    scopus 로고
    • MetaboLights-an open-access general-purpose repository for metabolomics studies and associated meta-data
    • Haug K, et al. (2013) MetaboLights-an open-access general-purpose repository for metabolomics studies and associated meta-data. Nucleic Acids Res 41(Database issue): D781-D786.
    • (2013) Nucleic Acids Res , vol.41 , Issue.DATABASE ISSUE
    • Haug, K.1
  • 27
    • 25144473903 scopus 로고    scopus 로고
    • NPP-type ectophosphodiesterases: Unity in diversity
    • Stefan C, Jansen S, Bollen M (2005) NPP-type ectophosphodiesterases: Unity in diversity. Trends Biochem Sci 30(10):542-550.
    • (2005) Trends Biochem Sci , vol.30 , Issue.10 , pp. 542-550
    • Stefan, C.1    Jansen, S.2    Bollen, M.3
  • 29
    • 0015802623 scopus 로고
    • Identification of inorganic pyrophosphate in human platelets and its release on stimulation with thrombin
    • Silcox DC, Jacobelli S, McCarty DJ (1973) Identification of inorganic pyrophosphate in human platelets and its release on stimulation with thrombin. J Clin Invest 52(7):1595-1600.
    • (1973) J Clin Invest , vol.52 , Issue.7 , pp. 1595-1600
    • Silcox, D.C.1    Jacobelli, S.2    McCarty, D.J.3
  • 30
    • 84861532159 scopus 로고    scopus 로고
    • Vesicular and conductive mechanisms of nucleotide release
    • Lazarowski ER (2012) Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal 8(3):359-373.
    • (2012) Purinergic Signal , vol.8 , Issue.3 , pp. 359-373
    • Lazarowski, E.R.1
  • 31
    • 0030845302 scopus 로고    scopus 로고
    • Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume
    • Roman RM, et al. (1997) Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume. J Biol Chem 272(35):21970-21976.
    • (1997) J Biol Chem , vol.272 , Issue.35 , pp. 21970-21976
    • Roman, R.M.1
  • 32
    • 0027937589 scopus 로고
    • The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel
    • Reisin IL, et al. (1994) The cystic fibrosis transmembrane conductance regulator is a dual ATP and chloride channel. J Biol Chem 269(32):20584-20591.
    • (1994) J Biol Chem , vol.269 , Issue.32 , pp. 20584-20591
    • Reisin, I.L.1
  • 33
    • 0042166167 scopus 로고    scopus 로고
    • Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification
    • Rutsch F, et al. (2003) Mutations in ENPP1 are associated with "idiopathic" infantile arterial calcification. Nat Genet 34(4):379-381.
    • (2003) Nat Genet , vol.34 , Issue.4 , pp. 379-381
    • Rutsch, F.1
  • 34
    • 75149190148 scopus 로고    scopus 로고
    • An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy
    • Le Boulanger G, et al. (2010) An unusual severe vascular case of pseudoxanthoma elasticum presenting as generalized arterial calcification of infancy. Am J Med Genet A 152A(1):118-123.
    • (2010) Am J Med Genet A , vol.152 A , Issue.1 , pp. 118-123
    • Le Boulanger, G.1
  • 35
    • 84855860969 scopus 로고    scopus 로고
    • Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6
    • Nitschke Y, et al. (2012) Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. Am J Hum Genet 90(1):25-39.
    • (2012) Am J Hum Genet , vol.90 , Issue.1 , pp. 25-39
    • Nitschke, Y.1
  • 36
    • 79551565257 scopus 로고    scopus 로고
    • NT5E mutations and arterial calcifications
    • St Hilaire C, et al. (2011) NT5E mutations and arterial calcifications. N Engl J Med 364(5):432-442.
    • (2011) N Engl J Med , vol.364 , Issue.5 , pp. 432-442
    • St Hilaire, C.1
  • 37
    • 80052153431 scopus 로고    scopus 로고
    • Genetics in arterial calcification: Pieces of a puzzle and cogs in a wheel
    • Rutsch F, Nitschke Y, Terkeltaub R (2011) Genetics in arterial calcification: Pieces of a puzzle and cogs in a wheel. Circ Res 109(5):578-592.
    • (2011) Circ Res , vol.109 , Issue.5 , pp. 578-592
    • Rutsch, F.1    Nitschke, Y.2    Terkeltaub, R.3
  • 38
    • 84868278414 scopus 로고    scopus 로고
    • Genetics in arterial calcification: Lessons learned from rare diseases
    • Nitschke Y, Rutsch F (2012) Genetics in arterial calcification: Lessons learned from rare diseases. Trends Cardiovasc Med 22(6):145-149.
    • (2012) Trends Cardiovasc Med , vol.22 , Issue.6 , pp. 145-149
    • Nitschke, Y.1    Rutsch, F.2
  • 39
    • 1642313676 scopus 로고    scopus 로고
    • Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: An integrated model of the pathogenesis of mineralization disorders
    • Harmey D, et al. (2004) Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: An integrated model of the pathogenesis of mineralization disorders. Am J Pathol 164(4):1199-1209.
    • (2004) Am J Pathol , vol.164 , Issue.4 , pp. 1199-1209
    • Harmey, D.1
  • 40
    • 84862215360 scopus 로고    scopus 로고
    • Magnesium reduces carotid intima-media thickness in a mouse model of pseudoxanthoma elasticum: A novel treatment biomarker
    • Kupetsky-Rincon EA, Li Q, Uitto J (2012) Magnesium reduces carotid intima-media thickness in a mouse model of pseudoxanthoma elasticum: A novel treatment biomarker. Clin Transl Sci 5(3):259-264.
    • (2012) Clin Transl Sci , vol.5 , Issue.3 , pp. 259-264
    • Kupetsky-Rincon, E.A.1    Li, Q.2    Uitto, J.3
  • 41
    • 0017746196 scopus 로고
    • Pyrophosphate levels and magnesium oxide therapy in osteogenesis imperfecta
    • Granda JL, Falvo KA, Bullough PG (1977) Pyrophosphate levels and magnesium oxide therapy in osteogenesis imperfecta. Clin Orthop Relat Res (126):228-231.
    • (1977) Clin Orthop Relat Res , Issue.126 , pp. 228-231
    • Granda, J.L.1    Falvo, K.A.2    Bullough, P.G.3
  • 42
    • 31844441584 scopus 로고    scopus 로고
    • Role of serum fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum
    • Hendig D, et al. (2006) Role of serum fetuin-A, a major inhibitor of systemic calcification, in pseudoxanthoma elasticum. Clin Chem 52(2):227-234.
    • (2006) Clin Chem , vol.52 , Issue.2 , pp. 227-234
    • Hendig, D.1
  • 43
    • 0347717867 scopus 로고    scopus 로고
    • Serum levels of the fetuinmineral complex correlate with artery calcification in the rat
    • Price PA, Williamson MK, Nguyen TM, Than TN (2004) Serum levels of the fetuinmineral complex correlate with artery calcification in the rat. J Biol Chem 279(3):1594-1600.
    • (2004) J Biol Chem , vol.279 , Issue.3 , pp. 1594-1600
    • Price, P.A.1    Williamson, M.K.2    Nguyen, T.M.3    Than, T.N.4
  • 44
    • 84875216385 scopus 로고    scopus 로고
    • Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls
    • Boraldi F, et al. (2013) Matrix gla protein and alkaline phosphatase are differently modulated in human dermal fibroblasts from PXE patients and controls. J Invest Dermatol 133(4):946-954.
    • (2013) J Invest Dermatol , vol.133 , Issue.4 , pp. 946-954
    • Boraldi, F.1
  • 46
    • 80755129249 scopus 로고    scopus 로고
    • Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals
    • O' Young J, et al. (2011) Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals. J Am Chem Soc 133(45):18406-18412.
    • (2011) J Am Chem Soc , vol.133 , Issue.45 , pp. 18406-18412
    • O'Young, J.1
  • 48
    • 79960322874 scopus 로고    scopus 로고
    • Daily peritoneal administration of sodium pyrophosphate in a dialysis solution prevents the development of vascular calcification in a mouse model of uraemia
    • Riser BL, et al. (2011) Daily peritoneal administration of sodium pyrophosphate in a dialysis solution prevents the development of vascular calcification in a mouse model of uraemia. Nephrol Dial Transplant 26(10):3349-3357.
    • (2011) Nephrol Dial Transplant , vol.26 , Issue.10 , pp. 3349-3357
    • Riser, B.L.1
  • 49
    • 33645102836 scopus 로고    scopus 로고
    • Idiopathic infantile arterial calcification: Two case reports, a review of the literature and a role for cardiac transplantation
    • Glatz AC, Pawel BR, Hsu DT, Weinberg P, Chrisant MR (2006) Idiopathic infantile arterial calcification: Two case reports, a review of the literature and a role for cardiac transplantation. Pediatr Transplant 10(2):225-233.
    • (2006) Pediatr Transplant , vol.10 , Issue.2 , pp. 225-233
    • Glatz, A.C.1    Pawel, B.R.2    Hsu, D.T.3    Weinberg, P.4    Chrisant, M.R.5
  • 50
    • 68149120891 scopus 로고    scopus 로고
    • Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy
    • GACI Study Group
    • Rutsch F, et al.; GACI Study Group (2008) Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Circ Cardiovasc Genet 1(2):133-140.
    • (2008) Circ Cardiovasc Genet , vol.1 , Issue.2 , pp. 133-140
    • Rutsch, F.1
  • 51
    • 84860321632 scopus 로고    scopus 로고
    • Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene
    • Li Q, Schumacher W, Jablonski D, Siegel D, Uitto J (2012) Cutaneous features of pseudoxanthoma elasticum in a patient with generalized arterial calcification of infancy due to a homozygous missense mutation in the ENPP1 gene. Br J Dermatol 166(5):1107-1111.
    • (2012) Br J Dermatol , vol.166 , Issue.5 , pp. 1107-1111
    • Li, Q.1    Schumacher, W.2    Jablonski, D.3    Siegel, D.4    Uitto, J.5
  • 52
    • 80755139715 scopus 로고    scopus 로고
    • Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum
    • Gorgels TG, et al. (2011) Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum. J Mol Med (Berl) 89(11):1125-1135.
    • (2011) J Mol Med (Berl) , vol.89 , Issue.11 , pp. 1125-1135
    • Gorgels, T.G.1
  • 53
    • 33645289143 scopus 로고    scopus 로고
    • The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells
    • Huitema LF, et al. (2006) The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells. Calcif Tissue Int 78(3):171-177.
    • (2006) Calcif Tissue Int , vol.78 , Issue.3 , pp. 171-177
    • Huitema, L.F.1
  • 54
    • 0038752694 scopus 로고    scopus 로고
    • Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5
    • Reid G, et al. (2003) Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Mol Pharmacol 63(5):1094-1103.
    • (2003) Mol Pharmacol , vol.63 , Issue.5 , pp. 1094-1103
    • Reid, G.1
  • 55
    • 34547223597 scopus 로고    scopus 로고
    • Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides
    • van de Wetering K, et al. (2007) Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides. Mol Pharmacol 72(2):387-394.
    • (2007) Mol Pharmacol , vol.72 , Issue.2 , pp. 387-394
    • Van De Wetering, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.