Loss of estrogen-related receptor - Promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 44, 2013, Pages 17975-17980

  Hong, Eui Ju ^a   Levasseur, Marie Pier ^a,b   Dufour, Catherine R ^a   Perry, Marie Claude ^a,b   Giguére, Vincent ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b Biochemistry Department   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DIETHYLNITROSAMINE; ESTROGEN RELATED RECEPTOR ALPHA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; ENERGY YIELD; GENE ACTIVATION; INFLAMMATORY DISEASE; KUPFFER CELL; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER INJURY; LIVER NECROSIS; METABOLIC DISORDER; METABOLOMICS; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

LIVER CANCER; NUCLEAR RECEPTOR;

ANIMALS; BLOTTING, WESTERN; CARCINOGENESIS; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CHROMATOGRAPHY, LIQUID; DIETHYLNITROSAMINE; DNA PRIMERS; HEPATOCYTES; I-KAPPA B PROTEINS; IMMUNOHISTOCHEMISTRY; KUPFFER CELLS; LIVER NEOPLASMS; METABOLOMICS; MICE; MICE, KNOCKOUT; NECROSIS; NF-KAPPA B; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; TANDEM MASS SPECTROMETRY;

EID: 84887122660     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315319110     Document Type: Article

References (43)

1. El-Serag HB (2012) Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142(6):1264-1273.e1.
2. Bosch FX, Ribes J, Díaz M, Cléries R (2004) Primary liver cancer: Worldwide incidence and trends. Gastroenterology 127(5, Suppl 1):S5-S16.
3. Fox JG, et al. (2010) Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 59(1):88-97.
4. Verna L, Whysner J, Williams GM (1996) N-nitrosodiethylamine mechanistic data and risk assessment: Bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther 71(1-2):57-81.
5. Maeda S, Kamata H, Luo JL, Leffert H, Karin M (2005) IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121(7):977-990.
6. Giguére V (2008) Transcriptional control of energy homeostasis by the estrogenrelated receptors. Endocr Rev 29(6):677-696.
7. Charest-Marcotte A, et al. (2010) The homeobox protein Prox1 is a negative modulator of ERR/PGC-1 bioenergetic functions. Genes Dev 24(6):537-542.
8. Deblois G, et al. (2009) Genome-wide identification of direct target genes implicates estrogen-related receptor as a determinant of breast cancer heterogeneity. Cancer Res 69(15):6149-6157.
9. Dufour CR, et al. (2011) Genomic convergence among ERR, PROX1, and BMAL1 in the control of metabolic clock outputs. PLoS Genet 7(6):e1002143.
10. Dufour CR, et al. (2007) Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and . Cell Metab 5(5):345-356.
11. Chaveroux C, et al. (2013) Molecular and genetic crosstalks between mTOR and ERR are key determinants of rapamycin-induced nonalcoholic fatty liver. Cell Metab 17(4): 586-598.
12. Deblois G, Giguére V (2011) Functional and physiological genomics of estrogenrelated receptors (ERRs) in health and disease. Biochim Biophys Acta 1812(8):1032-1040.
13. Sonoda J, et al. (2007) Nuclear receptor ERR and coactivator PGC-1 are effectors of IFN-β-induced host defense. Genes Dev 21(15):1909-1920.
14. Eichner LJ, et al. (2010) miR-378 mediates metabolic shift in breast cancer cells via the PGC-1/ERR transcriptional pathway. Cell Metab 12(4):352-361.
15. Deblois G, et al. (2010) Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1 promotes mammary gland tumorigenesis. Cancer Res 70(24):10277-10287.
16. Chang CY, et al. (2011) The metabolic regulator ERR, a downstream target of HER2/ IGF-1R, as a therapeutic target in breast cancer. Cancer Cell 20(4):500-510.
17. Deblois G, Giguére V (2013) Oestrogen-related receptors in breast cancer: Control of cellular metabolism and beyond. Nat Rev Cancer 13(1):27-36.
18. Sánchez-Alcázar JA, et al. (1997) Tumor necrosis factor-alpha increases ATP content in metabolically inhibited L929 cells preceding cell death. J Biol Chem 272(48): 30167-30177.
19. Zong WX, Thompson CB (2006) Necrotic death as a cell fate. Genes Dev 20(1):1-15.
20. Scaffidi P, Misteli T, Bianchi ME (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418(6894):191-195.
21. Patch RJ, et al. (2011) Identification of diaryl ether-based ligands for estrogen-related receptor as potential antidiabetic agents. J Med Chem 54(3):788-808.
22. Chandel NS, et al. (1998) Mitochondrial reactive oxygen species trigger hypoxiainduced transcription. Proc Natl Acad Sci USA 95(20):11715-11720.
23. Barish GD, et al. (2010) Bcl-6 and NF-kappaB cistromes mediate opposing regulation of the innate immune response. Genes Dev 24(24):2760-2765.
24. Basak S, et al. (2007) A fourth IkappaB protein within the NF-kappaB signaling module. Cell 128(2):369-381.
25. Fox JG, Wang TC (2007) Inflammation, atrophy, and gastric cancer. J Clin Invest 117(1): 60-69.
26. Grivennikov SI, Greten FR, Karin M (2010) Immunity, inflammation, and cancer. Cell 140(6):883-899.
27. Charles KA, et al. (2009) The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans. J Clin Invest 119(10):3011-3023.
28. De Marzo AM, et al. (2007) Inflammation in prostate carcinogenesis. Nat Rev Cancer 7(4):256-269.
29. Terzic J, Grivennikov S, Karin E, Karin M (2010) Inflammation and colon cancer. Gastroenterology 138(6):2101-2114.e5.
30. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115(5):1111-1119.
31. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444(7121): 860-867.
32. Deblois G, St-Pierre J, Giguere V (2013) The PGC-1/ERR signaling axis in cancer. Oncogene 32(30):3483-3490.
33. Sakurai T, et al. (2008) Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14(2):156-165.
34. Huss JM, et al. (2007) The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell Metab 6(1):25-37.
35. Vakkila J, Lotze MT (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4(8):641-648.
36. Karin M, Greten FR (2005) NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5(10):749-759.
37. Cressman DE, et al. (1996) Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 274(5291):1379-1383.
38. Kovalovich K, et al. (2001) Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem 276(28):26605-26613.
39. Hong F, et al. (2002) Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: Involvement of induction of Bcl-2 and Bcl-x(L) proteins. Oncogene 21(1):32-43.
40. Pikarsky E, et al. (2004) NF-kappaB functions as a tumour promoter in inflammationassociated cancer. Nature 431(7007):461-466.
41. Kamata H, et al. (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120(5): 649-661.
42. Taub R (2004) Liver regeneration: From myth to mechanism. Nat Rev Mol Cell Biol 5(10):836-847.
43. Luo J, et al. (2003) Reduced fat mass in mice lacking orphan nuclear receptor estrogen- related receptor ?. Mol Cell Biol 23(22):7947-7956.