Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6336-6349

  Shi, Xiaolei ^a   Yao, Dan ^a   Chen, Chi ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; BIOCHEMICAL ANALYSIS; CHEMICAL COMPOSITIONS; CYTOSOLS; DOSE-DEPENDENT; ETHYL GLUCURONIDE; ETHYL SULFATE; HEPATIC STEATOSIS; HEPATOTOXICITY; IN-VITRO; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLOMES; METABOLOMIC ANALYSIS; METABOLOMICS; MOUSE MODELS; SMALL MOLECULES; STABLE-ISOTOPE LABELING; URINARY METABOLITES; WILD TYPES;

AMINO ACIDS; BIOCHEMISTRY; BIOMOLECULES; BIOSYNTHESIS; DEUTERIUM; MAMMALS; METABOLISM; METABOLITES; TISSUE; VOLATILE FATTY ACIDS;

ETHANOL;

ACETIC ACID; ACETYL COENZYME A; ALANINE AMINOTRANSFERASE; ALCOHOL; BIOLOGICAL MARKER; CYTOCHROME P450 2E1; ETHYL GLUCURONIDE; ETHYL SULFATE; N ACETYLTAURINE; N ACETYLTAURINE SYNTHASE; SULFATE; SYNTHETASE; TAURINE; TAURINE DERIVATIVE; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CELL FRACTIONATION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOSOL; DISEASE MODEL; ENZYME ACTIVITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; FATTY LIVER; HISTOPATHOLOGY; IN VITRO STUDY; INCUBATION TIME; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MALE; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS; WILD TYPE;

ACETATES; ALCOHOL DRINKING; ANIMALS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOCHROME P-450 CYP2E1; DISEASE MODELS, ANIMAL; ETHANOL; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; METABOLOMICS; MICE; MICE, 129 STRAIN; MICE, MUTANT STRAINS; TAURINE; TRITIUM;

MUS;

EID: 84863170205     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.312199     Document Type: Article

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