Serum metabolomics study of polycystic ovary syndrome based on liquid chromatography-mass spectrometry

Journal of Proteome Research

Volumn 13, Issue 2, 2014, Pages 1101-1111

  Zhao, Xinjie ^a   Xu, Fang ^b   Qi, Bing ^c   Hao, Songli ^b   Li, Yanjie ^a   Li, Yan ^b   Zou, Lihong ^d   Lu, Caixia ^b   Xu, Guowang ^a   Hou, Lihui ^b  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

^c BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^d The First Affiliated Hospital of Herbin Medical University   (China)

Author keywords

biomarkers; LC MS; Metabolomics; polycystic ovary syndrome

Indexed keywords

ADULT; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; MASS SPECTROMETRY; METABOLOMICS; POLYCYSTIC OVARY SYNDROME; YOUNG ADULT;

EID: 84893851963     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr401130w     Document Type: Article

References (65)

1. Azziz, R.; Woods, K. S.; Reyna, R.; Key, T. J.; Knochenhauer, E. S.; Yildiz, B. O. The prevalence and features of the polycystic ovary syndrome in an unselected population J. Clin. Endocrinol. Metab. 2004, 89 (6) 2745-2749
2. Chen, X.; Yang, D.; Mo, Y.; Li, L.; Chen, Y.; Huang, Y. Prevalence of polycystic ovary syndrome in unselected women from southern China Eur. J. Obstet. Gynecol. Reprod. Biol. 2008, 139 (1) 59-64
3. Dunaif, A. Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis Endocr Rev. 1997, 18 (6) 774-800
4. Fauser, B.; Chang, J.; Azziz, R.; Legro, R.; Dewailly, D.; Franks, S.; Tarlatzis, R.; Fauser, B.; Balen, A.; Bouchard, P.; Dahlgren, E.; Devoto, L.; Diamanti, E.; Dunaif, A.; Filicori, M.; Homburg, R.; Ibanez, L.; Laven, J.; Magoffin, D.; Nestler, J.; Norman, R. J.; Pasquali, R.; Pugeat, M.; Strauss, J.; Tan, S.; Taylor, A.; Wild, R.; Wild, S.; Ehrmann, D.; Lobo, R.; Rotterdam, E.-A.-S. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum. Reprod. 2004, 19 (1) 41-47
5. Balen, A. Polycystic ovary syndrome and cancer Hum. Reprod. Update 2001, 7 (6) 522-525
6. Galazis, N.; Pang, Y.-L.; Galazi, M.; Haoula, Z.; Layfield, R.; Atiomo, W. Proteomic biomarkers of endometrial cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration Gynecol. Endocrinol. 2013, 29 (7) 638-644
7. Schildkraut, J. M.; Schwingl, P. J.; Bastos, E.; Evanoff, A.; Hughes, C. Epithelial ovarian cancer risk among women with polycystic ovary syndrome Obstet. Gynecol. 1996, 88 (4) 554-559
8. Waterworth, D. M.; Bennett, S. T.; Gharani, N.; McCarthy, M. I.; Hague, S.; Batty, S.; Conway, G. S.; White, D.; Todd, J. A.; Franks, S.; Williamson, R. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome Lancet 1997, 349 (9057) 986-990
9. Gharani, N.; Waterworth, D. M.; Batty, S.; White, D.; GillingSmith, C.; Conway, G. S.; McCarthy, M.; Franks, S.; Williamson, R. Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism Hum. Mol. Genet. 1997, 6 (3) 397-402
10. Diamanti-Kandarakis, E.; Kandarakis, H.; Legro, R. S. The role of genes and environment in the etiology of PCOS Endocrine 2006, 30 (1) 19-26
11. Huber-Buchholz, M. M.; Carey, D. G. P.; Norman, R. J. Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: Role of insulin sensitivity and luteinizing hormone J. Clin. Endocrinol. Metab. 1999, 84 (4) 1470-1474
12. Morales, A. J.; Laughlin, G. A.; Butzow, T.; Maheshwari, H.; Baumann, G.; Yen, S. S. C. Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: Common and distinct features J. Clin. Endocrinol. Metab. 1996, 81 (8) 2854-2864
13. Mohlig, M.; Spranger, J.; Osterhoff, M.; Ristow, M.; Pfeiffer, A. F. H.; Schill, T.; Schlosser, H. W.; Brabant, G.; Schofl, C. The polycystic ovary syndrome per se is not associated with increased chronic inflammation Eur. J. Endocrinol. 2004, 150 (4) 525-532
14. Kelly, C. C. J.; Lyall, H.; Petrie, J. R.; Gould, G. W.; Connell, J. M. C.; Sattar, N. Low grade chronic inflammation in women with polycystic ovarian syndrome J. Clin. Endocrinol. Metab. 2001, 86 (6) 2453-2455
15. Sabuncu, T.; Vural, H.; Harma, M. Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease Clin. Biochem. 2001, 34 (5) 407-413
16. Karadeniz, M.; Erdogan, M.; Tamsel, S.; Zengi, A.; Alper, G. E.; Caglayan, O.; Saygili, F.; Yilmaz, C. Oxidative stress markers in young patients with polycystic ovary syndrome, the relationship between insulin resistances Exp. Clin. Endocrinol. Diabetes 2008, 116 (4) 231-235
17. Sreekumar, A.; Poisson, L. M.; Rajendiran, T. M.; Khan, A. P.; Cao, Q.; Yu, J.; Laxman, B.; Mehra, R.; Lonigro, R. J.; Li, Y.; Nyati, M. K.; Ahsan, A.; Kalyana-Sundaram, S.; Han, B.; Cao, X.; Byun, J.; Omenn, G. S.; Ghosh, D.; Pennathur, S.; Alexander, D. C.; Berger, A.; Shuster, J. R.; Wei, J. T.; Varambally, S.; Beecher, C.; Chinnaiyan, A. M. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression Nature 2009, 457 (7231) 910-914
18. Brindle, J. T.; Antti, H.; Holmes, E.; Tranter, G.; Nicholson, J. K.; Bethell, H. W. L.; Clarke, S.; Schofield, P. M.; McKilligin, E.; Mosedale, D. E.; Grainger, D. J. Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using H-1-NMR-based metabonomics Nat. Med. 2002, 8 (12) 1439-1444
19. Chen, J.; Zhang, X.; Cao, R.; Lu, X.; Zhao, S.; Fekete, A.; Huang, Q.; Schmitt-Kopplin, P.; Wang, Y.; Xu, Z.; Wan, X.; Wu, X.; Zhao, N.; Xu, C.; Xu, G. Serum 27-nor-5 beta-Cholestane-3,7,12,24,25 pentol glucuronide discovered by metabolomics as potential diagnostic biomarker for epithelium ovarian cancer J. Proteome Res. 2011, 10 (5) 2625-2632
20. Zhao, X.; Fritsche, J.; Wang, J.; Chen, J.; Rittig, K.; Schmitt-Kopplin, P.; Fritsche, A.; Haering, H.-U.; Schleicher, E. D.; Xu, G.; Lehmann, R. Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits Metabolomics 2010, 6 (3) 362-374
21. Huang, Q.; Yin, P.; Wang, J.; Chen, J.; Kong, H.; Lu, X.; Xu, G. Method for liver tissue metabolic profiling study and its application in type 2 diabetic rats based on ultra performance liquid chromatography-mass spectrometry J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2011, 879 (13-14) 961-967
22. Chaudhury, K.; Babu, K. N.; Joshi, V. M.; Srivastava, S.; Chakravarty, B. N. NMR-based metabolomics reveals differently expressed metabolites in follicular fluid of pcos women: potential biomarkers for good quality oocyte? Hum. Reprod. 2011, 26, I232-I232
23. Zhao, Y.; Fu, L.; Li, R.; Wang, L.-N.; Yang, Y.; Liu, N.-N.; Zhang, C.-M.; Wang, Y.; Liu, P.; Tu, B.-B.; Zhang, X.; Qiao, J. Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis BMC Med. 2012, 10
24. Atiomo, W.; Daykin, C. A. Metabolomic biomarkers in women with polycystic ovary syndrome: a pilot study Mol. Hum. Reprod. 2012, 18 (11) 546-553
25. Sun, L.; Hu, W.; Liu, Q.; Hao, Q.; Sun, B.; Zhang, Q.; Mao, S.; Qiao, J.; Yan, X. Metabonomics reveals plasma metabolic changes and inflammatory marker in polycystic ovary syndrome patients J. Proteome Res. 2012, 11 (5) 2937-2946
26. Lu, X.; Zhao, X.; Bai, C.; Zhao, C.; Lu, G.; Xu, G. LC-MS-based metabonomics analysis J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2008, 866 (1-2) 64-76
27. Theodoridis, G.; Gika, H. G.; Wilson, I. D. LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics TrAC, Trends Anal. Chem. 2008, 27 (3) 251-260
28. Weng, X.; Liu, Y.; Ma, J.; Wang, W.; Yang, G.; Caballero, B. Use of body mass index to identify obesity-related metabolic disorders in the Chinese population Eur. J. Clin. Nutr. 2006, 60 (8) 931-937
29. Bijlsma, S.; Bobeldijk, L.; Verheij, E. R.; Ramaker, R.; Kochhar, S.; Macdonald, I. A.; van Ommen, B.; Smilde, A. K. Large-scale human metabolomics studies: A strategy for data (pre-) processing and validation Anal. Chem. 2006, 78 (2) 567-574
30. Owens, S.; Litaker, M.; Allison, J.; Riggs, S.; Ferguson, M.; Gutin, B. Prediction of visceral adipose tissue from simple anthropometric measurements in youths with obesity Obes. Res. 1999, 7 (1) 16-22
31. Carroll, J.; Saxena, R.; Welt, C. K. Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome J. Clin. Endocrinol. Metab. 2012, 25 (5-6) 459-466
32. Gika, H. G.; Theodoridis, G. A.; Wingate, J. E.; Wilson, I. D. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine J. Proteome Res. 2007, 6 (8) 3291-3303
33. Chen, J.; Zhao, X.; Fritsche, J.; Yin, P.; Schmitt-Kopplin, P.; Wang, W.; Lu, X.; Haring, H. U.; Schleicher, E. D.; Lehmann, R.; Xu, G. Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information Anal. Chem. 2008, 80 (4) 1280-1289
34. Delarue, J.; Magnan, C. Free fatty acids and insulin resistance Curr. Opin. Clin. Nutr. Metab. Care 2007, 10 (2) 142-148
35. Wilding, J. P. H. The importance of free fatty acids in the development of Type 2 diabetes Diabetes Med. 2007, 24 (9) 934-945
36. Attie, A. D.; Krauss, R. M.; Gray-Keller, M. P.; Brownlie, A.; Miyazaki, M.; Kastelein, J. J.; Lusis, A. J.; Stalenhoef, A. F. H.; Stoehr, J. P.; Hayden, M. R.; Ntambi, J. M. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia J. Lipid Res. 2002, 43 (11) 1899-1907
37. Ntambi, J. M. The regulation of stearoyl-CoA desaturase (SCD) Prog. Lipid Res. 1995, 34 (2) 139-150
38. Ntambi, J. M. Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol J. Lipid Res. 1999, 40 (9) 1549-1558
39. Dobrzyn, A.; Ntambi, J. M. The role of stearoyl-CoA desaturase in body weight regulation Trends Cardiovasc. Med. 2004, 14 (2) 77-81
40. Ntambi, J. M.; Miyazaki, M.; Stoehr, J. P.; Lan, H.; Kendziorski, C. M.; Yandell, B. S.; Song, Y.; Cohen, P.; Friedman, J. M.; Attie, A. D. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity Proc. Natl. Acad. Sci. U.S.A. 2002, 99 (17) 11482-11486
41. Hsieh, S. L.; Chang, H. T.; Wu, C. H.; Kuo, C. M. Cloning, tissue distribution and hormonal regulation of stearoyl-CoA desaturase in tilapia, Oreochromis mossambicus Aquaculture 2004, 230 (1-4) 527-546
42. Marks, K. A.; Kitson, A. P.; Shaw, B.; Mutch, D. M.; Stark, K. D. Stearoyl-CoA desaturase 1, elongase 6 and their fatty acid products and precursors are altered in ovariectomized rats with 17β-estradiol and progesterone treatment Prostaglandins, Leukotrienes Essent. Fatty Acids 2013, 89-96
43. Brown, J. M.; Chung, S.; Sawyer, J. K.; Degirolamo, C.; Alger, H. M.; Nguyen, T. M.; Zhu, X.; Duong, M.-N.; Brown, A. L.; Lord, C.; Shah, R.; Davis, M. A.; Kelley, K.; Wilson, M. D.; Madenspacher, J.; Fessler, M. B.; Parks, J. S.; Rudel, L. L. Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis Arterioscler., Thromb., Vasc. Biol. 2010, 30 (1) 24-U63
44. Mar-Heyming, R.; Miyazaki, M.; Weissglas-Volkov, D.; Kolaitis, N. A.; Sadaat, N.; Plaisier, C.; Pajukanta, P.; Cantor, R. M.; de Bruin, T. W. A.; Ntambi, J. M.; Lusis, A. J. Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia Arterioscler., Thromb., Vasc. Biol. 2008, 28 (6) 1193-1199
45. Harizi, H.; Corcuff, J.-B.; Gualde, N. Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology Trends Mol. Med. 2008, 14 (10) 461-469
46. Iwase, M.; Sonoki, K.; Sasaki, N.; Ohdo, S.; Higuchi, S.; Hattori, H.; Iida, M. Lysophosphatidylcholine contents in plasma LDL in patients with type 2 diabetes mellitus: Relation with lipoprotein-associated phospholipase A(2) and effects of simvastatin treatment Atherosclerosis 2008, 196 (2) 931-936
47. Perez-Chacon, G.; Astudillo, A. M.; Ruiperez, V.; Balboa, M. A.; Balsinde, J. Signaling role for lysophosphatidylcholine acyltransferase 3 in receptor-regulated arachidonic acid reacylation reactions in human monocytes J. Immunol. 2010, 184 (2) 1071-1078
48. Yea, K.; Kim, J.; Yoon, J. H.; Kwon, T.; Kim, J. H.; Lee, B. D.; Lee, H.-J.; Lee, S. J.; Kim, J.-I.; Lee, T. G.; Baek, M.-C.; Park, H. S.; Park, K. S.; Ohba, M.; Suh, P.-G.; Ryu, S. H. Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes J. Biol. Chem. 2009, 284 (49) 33833-33840
49. Barber, M. N.; Risis, S.; Yang, C.; Meikle, P. J.; Staples, M.; Febbraio, M. A.; Bruce, C. R. Plasma Lysophosphatidylcholine Levels Are Reduced in Obesity and Type 2 Diabetes PLoS One 2012, 7 (7) e41456
50. Ezzili, C.; Otrubova, K.; Boger, D. L. Fatty acid amide signaling molecules Bioorg. Med. Chem. Lett. 2010, 20 (20) 5959-5968
51. Scherma, M.; Medalie, J.; Fratta, W.; Vadivel, S. K.; Makriyannis, A.; Piomelli, D.; Mikics, E.; Haller, J.; Yasar, S.; Tanda, G.; Goldberg, S. R. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition Neuropharmacology 2008, 54 (1) 129-140
52. Herrera-Solis, A.; Guzman Vasquez, K.; Prospero-Garcia, O. Acute and subchronic administration of anandamide or oleamide increases REM sleep in rats Pharmacol., Biochem. Behav. 2010, 95 (1) 106-112
53. Sudhahar, V.; Shaw, S.; Imig, J. D. Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries Eur. J. Pharmacol. 2009, 607 (1-3) 143-150
54. Lambert, D. M.; Vandevoorde, S.; Jonsson, K. O.; Fowler, C. J. The palmitoylethanolamide family: A new class of anti-inflammatory agents? Curr. Med. Chem. 2002, 9 (6) 663-674
55. Hoareau, L.; Buyse, M.; Festy, F.; Ravanan, P.; Gonthier, M.-P.; Matias, I.; Petrosino, S.; Tallet, F.; d'Hellencourt, C. L.; Cesari, M.; Di Marzo, V.; Roche, R. Anti-inflammatory effect of palmitoylethanolamide on human adipocytes Obesity 2009, 17 (3) 431-438
56. Matias, I.; Gonthier, M. P.; Petrosino, S.; Docimo, L.; Capasso, R.; Hoareau, L.; Monteleone, P.; Roche, R.; Izzo, A. A.; Di Marzo, V. Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells Br. J. Pharmacol. 2007, 152 (5) 676-690
57. Legro, R. S.; Kunselman, A. R.; Demers, L.; Wang, S. C.; Bentley-Lewis, R.; Dunaif, A. Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome J. Clin. Endocrinol. Metab. 2002, 87 (5) 2134-2138
58. Kauffman, R. P.; Baker, V. M.; DiMarino, P.; Castracane, V. D. Hyperinsulinemia and circulating dehydroepiandrosterone sulfate in white and Mexican American women with polycystic ovary syndrome Fertil. Steril. 2006, 85 (4) 1010-1016
59. Brennan, K.; Huang, A.; Azziz, R. Dehydroepiandrosterone sulfate and insulin resistance in patients with polycystic ovary syndrome Fertil. Steril. 2009, 91 (5) 1848-1852
60. Schleicher, E. D.; Wagner, E.; Nerlich, A. G. Increased accumulation of the glycoxidation product N -epsilon(carboxymethyl)lysine in human tissues in diabetes and aging J. Clin. Invest. 1997, 99 (3) 457-468
61. Rohlfing, C. L.; Little, R. R.; Wiedmeyer, H. M.; England, J. D.; Madsen, R.; Harris, M. I.; Flegal, K. M.; Eberhardt, M. S.; Goldstein, D. E. Use of GHb (HbA(1c)) in screening for undiagnosed diabetes in che US population Diabetes Care 2000, 23 (2) 187-191
62. Singh, R.; Barden, A.; Mori, T.; Beilin, L. Advanced glycation end-products: a review Diabetologia 2001, 44 (2) 129-146
63. Goh, S.-Y.; Cooper, M. E. The role of advanced glycation end products in progression and complications of diabetes J. Clin. Endocrinol. Metab. 2008, 93 (4) 1143-1152
64. Diamanti-Kandarakis, E.; Piperi, C.; Kalofoutis, A.; Creatsas, G. Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome Clin. Endocrinol. 2005, 62 (1) 37-43
65. Diamanti-Kandarakis, E.; Katsikis, I.; Piperi, C.; Kandaraki, E.; Piouka, A.; Papavassiliou, A. G.; Panidis, D. Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS) Clin. Endocrinol. 2008, 69 (4) 634-641