Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum

Archives of Toxicology

Volumn 87, Issue 11, 2013, Pages 1975-1987

  Fang, Zhong Ze ^a   Krausz, Kristopher W ^a   Tanaka, Naoki ^a   Li, Fei ^a   Qu, Aijuan ^a   Idle, Jeffrey R ^a   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Dichloroacetate; Metabolomics; PPAR ; Toxicity; Trichloroacetate; Trichloroethylene

Indexed keywords

DICHLOROACETIC ACID; ION; LYSOPHOSPHATIDYLCHOLINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; C57BL 6 MOUSE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DATA BASE; EXPOSURE; FATTY ACID METABOLISM; GENE EXPRESSION; LIVER HISTOLOGY; MALE; METABOLIC DISORDER; METABOLISM; METABOLOMICS; MOUSE; NONHUMAN; PHOSPHOLIPID METABOLISM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINE LEVEL;

MUS;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DICHLOROACETIC ACID; DRUG-INDUCED LIVER INJURY; FATTY ACIDS; HEPATOMEGALY; HOMEOSTASIS; MALE; METABOLISM; METABOLOMICS; MICE; MICE, INBRED C57BL; MULTIVARIATE ANALYSIS; PHOSPHOLIPIDS; POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRICHLOROACETIC ACID; TRICHLOROETHYLENE;

EID: 84885949173     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1053-1     Document Type: Article

References (40)

1. Bakke B, Stewart PA, Waters MA (2007) Uses of and exposure to trichloroethylene in US industry: a systemic literature review. J Occup Environ Hyg 4(5):375-390
2. Bull RJ (2000) Mode of action of liver tumor induction by trichloroethylene and its metabolites, trichloroacetate and dichloroacetate. Environ Health Perspect 108(Suppl2):241-259
3. Bull RJ, Orner GA, Cheng RS, Stillwell L, Stauber AJ, Sasser LB, Lingohr MK, Thrall BD (2002) Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene. Toxicol Appl Pharmacol 182:55-65
4. Byers VS, Levin AS, Ozonoff DM, Baldwin RW (1988) Association between clinical symptoms and lymphocyte abnormalities in a population with chronic domestic exposure to industrial solvent contaminated domestic water supply and a high incidence of leukaemia. Cancer Immunol Immunother 27(1):77-81
5. Candura SM, Faustman EM (1991) Trichloroethylene: toxicology and health hazards. G Ital Med Lav 13(1-6):17-25
6. Corton JC (2008) Evaluation of the role of peroxisome proliferator-activated receptor α (PPARα) in mouse liver tumor induction by trichloroethylene and metabolites. Crit Rev Toxicol 38:857-875
7. Elcombe CR, Rose MS, Pratt IS (1985) Biochemical, histological, and ultrastructural changes in rat and mouse liver following the administration of trichloroethylene: possible relevance to species differences in hepatocarcinogenicity. Toxicol Appl Pharmacol 67:392-401
8. Evans MV, Chiu WA, Okino MS, Caldwell JC (2009) Development of an updated PBPK model for trichloroethylene and metabolites in mice, and its application to discern the role of oxidative metabolism in TCE-induced hepatomegaly. Toxicol Appl Pharmacol 236:329-340
9. Griffin JM, Gilbert KM, Lamps LW, Pumford NR (2000) CD4 + T cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL +/+ mice. Toxicol Sci 57:345-352
10. Hong WX, Yang L, Chen M, Yang X, Ren X, Fang S, Ye J, Huang H, Peng C, Zhou L, Huang X, Yang F, Wu D, Zhuang Z, Liu J (2012) Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Ia and two SET/TAF-Ia-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells. Toxicol Appl Pharmacol 263(2):259-272
11. Johnson CH, Gonzalez FJ (2011) Challenges and opportunities of metabolomics. J Cell Physiol 227(8):2975-2981
12. Keshava N, Caldwell JC (2006) Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity. Environ Health Perspect 114(9):1464-1470
13. Kim D, Ghanayem BI (2006) Comparative metabolism and disposition of trichloroethylene in Cyp2e1-/- and wild-type mice. Drug Metab Dispos 34(12):2020-2027
14. Kind T, Fiehn O (2007) Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics 8:105
15. Larson JL, Bull RJ (1992) Metabolism and lipoperoxidative activity of trichloroethylene and dichloroacetate in rats and mice. Toxicol Appl Pharmacol 115:268-277
16. Laughter AR, Dunn CS, Swanson CL, Howroyd P (2004) Role of the peroxisome proliferator-activated receptor a (PPARa) in responses to trichloroethylene and metabolites, trichloroacetate and dichloroacetate in mouse liver. Toxicology 203:83-98
17. Lee JW, Yamamoto T, Uchikata T, Matsubara A, Fukusaki E, Bamba T (2011) Development of a polar lipid profiling method by supercritical fluid chromatography/mass spectrometry. J Sep Sci 34:3553-3560
18. Li F, Patterson AD, Höfer CC, Krausz KW, Gonzalez FJ, Idle JR (2011a) A comprehensive understanding of thioTEPA metabolism in the mouse using UPLC-ESI-QTOFMS-based metabolomics. Biochem Pharmacol 81:1043-1053
19. Li S, Liu H, Jin Y, Lin S, Cai Z, Jiang Y (2011b) Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. J Chromatogr B 879:2369-2375
20. Li F, Patterson AD, Krausz KW, Tanaka N, Gonzalez FJ (2012) Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis. J Lipid Res 53(8):1625-1635
21. Liu J, Huang H, Xing X, Xi R, Zhuang Z, Yuan J, Yang F, Zhao J (2007) Comparative proteomic analysis on human L-02 liver cells treated with varying concentrations of trichloroethylene. Toxicol Ind Health 23(2):91-101
22. Maronpot RR, Anna CH, Devereux TR, Lucier GW, Butterworth BE, Anderson MW (1995) Considerations concerning the murine hepatocarcinogenicity of selected chlorinated hydrocarbons. Prog Clin Biol Res 391:305-323
23. Matsubara T, Tanaka N, Patterson AD, Cho JY, Krausz KW, Gonzalez FJ (2011) Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice. Hepatology 53(4):1282-1293
24. Merdink JL, Gonzalez-Leon A, Bull RJ, Schultz IR (1998) The extent of dichloroacetate formation from trichloroethylene, chloral hydrate, trichloroacetate, and trichloroethanol in B6C3F1 mice. Toxicol Sci 45:33-41
25. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W (2006) International union of pharmacology. LXI peroxisome proliferator-activated receptors. Pharmacol Rev 58(4):726-741
26. Nakajima T, Kamijo Y, Usuda N, Liang Y, Fukushima Y, Kametani K, Gonzalez FJ, Aoyama T (2000) Sex-dependent regulation of hepatic peroxisome proliferation in mice by trichloroethylene via peroxisome proliferator-activated receptor α (PPARα). Carcinogenesis 21(4):677-682
27. Park SK, Nam SW, Ryu JC, Ham JH, Lee MY (2010) Proteomic analysis of rat liver proteins differentially induced by trichloroethylene. Biochip J 4(1):57-62
28. Patterson AD, Slanar O, Krausz KW, Li F, Höfer CC, Perlík F, Gonzalez FJ, Idle JR (2009) Human urinary metabolomic profile of PPARa induced fatty acid β-oxidation. J Proteome Res 8:4293-4300
29. Pesch B, Haerting J, Ranft U, Klimpel A, Oelschlägel B, Schill W (2000) Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany, MURC Study Group. Multicenter urothelial and renal cancer study. Int J Epidemiol 29(6):1014-1024
30. Ramdhan DH, Kamijima M, Yamada N, Ito Y, Yanagiba Y, Nakamura D, Okamura A, Ichihara G, Aoyama T, Gonzalez FJ, Nakajima T (2008) Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1. Toxicol Appl Pharmacol 231(3):300-307
31. Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T (2010) Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARα-humanized mice. Environ Health Perspect 118(11):1557-1563
32. Tan Y, Yin P, Tang L, Xing W, Huang Q, Cao D, Zhao X, Wang W, Lu X, Xu Z, Wang H, Xu G (2012) Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients: potential biomarkers effective for small hepatocellular carcinoma diagnosis. Mol Cell Proteomics 11(2): DOI: 10.1074/mcp.M111.010694
33. Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T (2008) PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J Clin Invest 118:683-694
34. Tanaka N, Matsubara T, Krausz KW, Patterson AD, Gonzalez FJ (2012) Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. Hepatology 56(1):118-129
35. Templin MV, Parker JC, Bull RJ (1993) Relative formation of dichloroacetate and trichloroacetate from trichloroethylene in male B6C3F1 mice. Toxicol Appl Pharmacol 123:1-8
36. Templin MV, Stevens DK, Stenner RD, Bonate PL, Tuman D, Bull RJ (1995) Factors affecting species differences in the kinetics of metabolites of trichloroethylene. J Tocicol Environ Health 44:435-447
37. Viant MR, Bundy JG, Pincetich CA, de Ropp JS, Tjeerdema RS (2005) NMR-derived developmental metabolic trajectories: an approach for visualizing the toxic actions of trichloroethylene during embryogenesis. Metabolomics 1(2):149-158
38. Wartenberg D, Reyner D, Scott CS (2000) Trichloroethylene and cancer: epidemiologic evidence. Environ Health Perspect 108(Suppl. 2):161-176
39. Zhen Y, Krausz KW, Chen C, Idle JR, Gonzalez FJ (2007) Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor a expression and activation. Mol Endocrinol 21(9):2136-2151
40. Zhou YC, Waxman DJ (1998) Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environ Health Perspect 106(Suppl 4):983-988