Integrated analysis of transcriptomics and metabonomics profiles in aflatoxin B1-induced hepatotoxicity in rat

Food and Chemical Toxicology

Volumn 55, Issue , 2013, Pages 444-455

  Lu, Xiaoyan ^a   Hu, Bin ^a   Shao, Li ^a   Tian, Yu ^a   Jin, Tingting ^a   Jin, Yachao ^a   Ji, Shen ^b   Fan, Xiaohui ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE FOR FOOD AND DRUG CONTROL   (China)

Author keywords

Acute hepatotoxicity; Aflatoxin B1; Integrated analysis; Metabonomics; Potential biomarkers; Transcriptomics

Indexed keywords

AFLATOXIN B1; BIOLOGICAL MARKER; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN G1; FATTY ACID SYNTHASE; GLUTATHIONE TRANSFERASE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN BAX; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATP BINDING CASSETTE SUBFAMILY B MEMBER 1B GENE; BAX GENE; CONTROLLED STUDY; CYCLIN D1 GENE; CYCLIN DEPENDENT KINASE INHIBITOR 1A GENE; CYCLIN G1 GENE; FATTY ACID SYNTHASE GENE; GENE ACTIVATION; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLUTATHIONE TRANSFERASE YC2 GENE; LIPID METABOLISM; LIVER PARENCHYMA; LIVER TOXICITY; LONG TERM EXPOSURE; MALE; MARKER GENE; METABOLITE; METABOLOMICS; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE GENE; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; UPREGULATION;

AFLATOXIN B1; ANIMALS; BASE SEQUENCE; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; LIVER; MALE; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED F344; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

EID: 84874441993     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.01.020     Document Type: Article

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