Metabonomic analysis reveals the CCl4-induced systems alterations for multiple rat organs

Journal of Proteome Research

Volumn 11, Issue 7, 2012, Pages 3848-3859

  Jiang, Limiao ^a,b   Huang, Jing ^a   Wang, Yulan ^a   Tang, Huiru ^a  

^a Wuhan National Laboratory for Optoelectronics   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

carbon tetrachloride; metabonomics; NMR; rat organs; systems toxicity

Indexed keywords

ADENOSINE; ALANINE; BETAINE; CARBON TETRACHLORIDE; CHOLINE; CREATINE; GLUCOSE; GLYCINE; GLYCOGEN; HISTIDINE; HYPOXANTHINE; ISOLEUCINE; LACTIC ACID; LEUCINE; LYSINE; METHIONINE; ORNITHINE; PHENYLALANINE; TAURINE; THREONINE; TRIMETHYLAMINE; TYROSINE; URACIL; URIDINE; VALINE;

ARTICLE; CATABOLISM; CHEMISTRY; CONTROLLED STUDY; FUNCTIONAL PROTEOMICS; GLYCOLYSIS; HISTOPATHOLOGY; KIDNEY; LUNG; METABONOMIC ANALYSIS; NONHUMAN; OSMOREGULATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SPLEEN;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BLOOD UREA NITROGEN; CARBON TETRACHLORIDE; CREATINE; KIDNEY; LIVER; LUNG; MALE; METABOLOME; METABOLOMICS; MULTIVARIATE ANALYSIS; NECROSIS; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; SPLEEN; TRIGLYCERIDES;

MAMMALIA; RATTUS;

EID: 84863628151     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr3003529     Document Type: Article

References (70)

1. Weber, L. W. D.; Boll, M.; Stampfl, A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model Crit. Rev. Toxicol. 2003, 33 (2) 105-136 (Pubitemid 36432872)
2. Rechnagel, R. O.; Glende, E. A., Jr. Carbon tetrachloride hepatotoxicity: an example of lethal cleavage Crit. Rev. Toxicol. 1973, 2 (3) 263-297
3. Link, B.; Durk, H.; Thiel, D.; Frank, H. Binding of trichloromethyl radicals to lipids of the hepatic endoplasmic reticulum during tetrachloromethane metabolism Biochem. J. 1984, 223 (3) 577-586 (Pubitemid 15209050)
4. Recknagel, R. O.; Glende, E. A.; Dolak, J. A.; Waller, R. L. Mechanisms of carbon tetrachloride toxicity Pharmacol. Ther. 1989, 43 (1) 139-154 (Pubitemid 19200126)
5. Sanzgiri, U. Y.; Srivatsan, V.; Muralidhara, S.; Dallas, C. E.; Bruckner, J. V. Uptake, distribution, and elimination of carbon tetrachloride in rat tissues following inhalation and ingestion exposures Toxicol. Appl. Pharmacol. 1997, 143 (1) 120-129 (Pubitemid 27130615)
6. Sakaguchi, H.; Churg, J.; Dachs, S.; Mautner, W.; Grishman, E. Renal glomerular lesions after administration of carbon tetrachloride and ethionine Lab. Invest. 1964, 13 (11) 1418-1426
7. Gould, V. E.; Smuckler, E. A. Alveolar injury in acute carbon tetrachloride intoxication Arch. Intern. Med. 1971, 128 (1) 109-117
8. 4-induced hepatic cirrhosis Lab. Anim. 1991, 25 (1) 21-25
9. Abraham, P.; Wilfred, G.; Cathrine, S. P. Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication Clin. Chim. Acta 1999, 289 (1-2) 177-179 (Pubitemid 29505210)
10. Delaney, B.; Strom, S. C.; Collins, S.; Kaminski, N. E. Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-β1 Toxicol. Appl. Pharmacol. 1994, 126 (1) 98-107 (Pubitemid 24168873)
11. Ganie, S. A.; Haq, E.; Masood, A.; Zargar, M. A. Amelioration of carbon tetrachloride induced oxidative stress in kidney and lung tissues by ethanolic rhizome extract of Podophyllum hexandrum in Wistar rats J. Med. Plant Res. 2010, 4 (16) 1673-1677
12. Chen, W. J.; Chi, E. Y.; Smuckler, E. A. Carbon tetrachloride-induced changes in mixed function oxidases and microsomal cytochromes in the rat lung Lab. Invest. 1977, 36 (4) 388-394 (Pubitemid 8097892)
13. 4 on rat intestinal mucosa Biochim. Biophys. Acta 1968, 158 (3) 414-424
14. Nicholson, J. K.; Lindon, J. C.; Holmes, E. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 1999, 29 (11) 1181-1189
15. Tang, H. R.; Wang, Y. L. Metabonomics: a revolution in progress Prog. Biochem. Biophys. 2006, 33 (5) 401-417
16. 1H NMR spectroscopy as a result of metabonomic screening of humans Analyst 2004, 129 (3) 259-264 (Pubitemid 38333751)
17. 1H NMR spectroscopy in conjunction with multivariate data analysis J. Proteome Res. 2007, 6 (7) 2605-2614 (Pubitemid 47122355)
18. Ding, L. N.; Hao, F. H.; Shi, Z. M.; Wang, Y. L.; Zhang, H. X.; Tang, H. R.; Dai, J. Y. Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies J. Proteome Res. 2009, 8 (6) 2882-2891
19. Lindon, J. C.; Beckonert, O. P.; Holmes, E.; Nicholson, J. K. High-resolution magic angle spinning NMR spectroscopy: Application to biomedical studies Prog. Nucl. Magn. Reson. Spectrosc. 2009, 55 (2) 79-100
20. Zhang, L. M.; Ye, Y. F.; An, Y. P.; Tian, Y. A.; Wang, Y. L.; Tang, H. R. Systems responses of rats to aflatoxin B1 exposure revealed with metabonomic changes in multiple biological matrices J. Proteome Res. 2011, 10 (2) 614-623
21. Zhao, X. J.; Huang, C. Y.; Lei, H. H.; Nie, X.; Tang, H. R.; Wang, Y. L. Dynamic metabolic response of mice to acute mequindox exposure J. Proteome Res. 2011, 10 (11) 5183-5190
22. Garrod, S.; Bollard, M. E.; Nichollst, A. W.; Connor, S. C.; Connelly, J.; Nicholson, J. K.; Holmes, E. Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat Chem. Res. Toxicol. 2005, 18 (2) 115-122 (Pubitemid 40256228)
23. Zhang, H. X.; Ding, L. N.; Fang, X. M.; Shi, Z. M.; Zhang, Y. T.; Chen, H. B.; Yan, X. Z.; Dai, J. Y. Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies PLoS One 2011, 6 (6) e20862
24. Saric, J.; Li, J. V.; Utzinger, J.; Wang, Y. L.; Keiser, J.; Dirnhofer, S.; Beckonert, O.; Sharabiani, M. T. A.; Fonville, J. M.; Nicholson, J. K.; Holmes, E. Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain Mol. Syst. Biol. 2010, 6, 396
25. 1H NMR study of mice exposed to silica dust Toxicol. Mech. Methods 2008, 18 (5) 385-398 (Pubitemid 351883379)
26. Saric, J.; Li, J. V.; Wang, Y. L.; Keiser, J.; Veselkov, K.; Dirnhofer, S.; Yap, I. K. S.; Nicholson, J. K.; Holmes, E.; Utzinger, J. Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse J. Proteome Res. 2009, 8 (8) 3899-3911
27. Li, J. V.; Holmes, E.; Saric, J.; Keiser, J.; Dirnhofer, S.; Utzinger, J.; Wang, Y. L. Metabolic profiling of a Schistosoma mansoni infection in mouse tissues using magic angle spinning-nuclear magnetic resonance spectroscopy Int. J. Parasitol. 2009, 39 (5) 547-558
28. Nicholls, A. W.; Holmes, E.; Lindon, J. C.; Shockcor, J. P.; Farrant, R. D.; Haselden, J. N.; Damment, S. J. P.; Waterfield, C. J.; Nicholson, J. K. Metabonomic investigations into hydrazine toxicity in the rat Chem. Res. Toxicol. 2001, 14 (8) 975-987 (Pubitemid 32800153)
29. Waters, N. J.; Waterfield, C. J.; Farrant, R. D.; Holmes, E.; Nicholson, J. K. Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis J. Proteome Res. 2006, 5 (6) 1448-1459 (Pubitemid 43865813)
30. Yap, I. K. S.; Clayton, T. A.; Tang, H.; Everett, J. R.; Hanton, G.; Provost, J. P.; Le Net, J. L.; Charuel, C.; Lindon, J. C.; Nicholson, J. K. An integrated metabonomic approach to describe temporal metabolic disregulation induced in the rat by the model hepatotoxin allyl formate J. Proteome Res. 2006, 5 (10) 2675-2684 (Pubitemid 44595169)
31. Skordi, E.; Yap, I. K. S.; Claus, S. P.; Martin, F. P. J.; Cloarec, O.; Lindberg, J.; Schuppe-Koistinen, I.; Holmes, E.; Nicholson, J. K. Analysis of time-related metabolic fluctuations induced by ethionine in the rat J. Proteome Res. 2007, 6 (12) 4572-4581
32. Coen, M.; Want, E. J.; Clayton, T. A.; Rhode, C. M.; Hong, Y. S.; Keun, H. C.; Cantor, G. H.; Metz, A. L.; Robertson, D. G.; Reily, M. D.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. Mechanistic aspects and novel biomarkers of responder and non-responder phenotypes in galactosamine-induced hepatitis J. Proteome Res. 2009, 8 (11) 5175-5187
33. Coen, M.; Hong, Y. S.; Clayton, T. A.; Rohde, C. M.; Pearce, J. T.; Reily, M. D.; Robertson, D. G.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. The mechanism of galactosamine toxicity revisited; a metabonomic study J. Proteome Res. 2007, 6 (7) 2711-2719 (Pubitemid 47122366)
34. Robertson, D. G.; Reily, M. D.; Sigler, R. E.; Wells, D. F.; Paterson, D. A.; Braden, T. K. Metabonomics: evaluation of nuclear magnetic resonance (NMR) and pattern recognition technology for rapid in vivo screening of liver and kidney toxicants Toxicol. Sci. 2000, 57 (2) 326-337
35. Lin, Y. P.; Si, D. Y.; Zhang, Z. P.; Liu, C. X. An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine Toxicology 2009, 256 (3) 191-200
36. Wu, H. F.; Zhang, X. Y.; Li, X. J.; Li, Z. F.; Wu, Y. J.; Pei, F. K. Comparison of metabolic profiles from serum from hepatotoxin-treated rats by nuclear-magnetic-resonance-spectroscopy-based metabonomic analysis Anal. Biochem. 2005, 340 (1) 99-105
37. 4-induced acute liver failure using partial least square regression based on the GC/MS metabolic profiles of plasma in mice J. Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2008, 870 (2) 178-185
38. Xiao, C. N.; Hao, F. H.; Qin, X. R.; Wang, Y. L.; Tang, H. R. An optimized buffer system for NMR-based urinary metabonomics with effective pH control, chemical shift consistency and dilution minimization Analyst 2009, 134 (5) 916-925
39. Dai, H.; Xiao, C. N.; Liu, H. B.; Tang, H. R. Combined NMR and LC-MS analysis reveals the metabonomic changes in Salvia miltiorrhiza Bunge induced by water depletion J. Proteome Res. 2010, 9 (3) 1460-1475
40. Dai, H.; Xiao, C. N.; Liu, H. B.; Hao, F. H.; Tang, H. R. Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia miltiorrhiza Bunge J. Proteome Res. 2010, 9 (3) 1565-1578
41. Bax, A.; Griffey, R. H.; Hawkins, B. L. Correlation of proton and nitrogen-15 chemical shifts by multiple quantum NMR J. Magn. Reson. 1983, 55 (2) 301-315
42. Trygg, J.; Wold, S. Orthogonal projections to latent structures (O-PLS) J. Chemom. 2002, 16 (3) 119-128
43. Eriksson, L.; Trygg, J.; Wold, S. CV-ANOVA for significance testing of PLS and OPLS® models J. Chemom. 2008, 22 (11-12) 594-600
44. 1H NMR spectroscopic metabonomic studies Anal. Chem. 2005, 77 (2) 517-526 (Pubitemid 40116831)
45. Xu, J. Y.; Su, Y. Y.; Cheng, J. S.; Li, S. X.; Liu, R. L.; Li, W. X.; Xu, G. T.; Li, Q. N. Protective effects of fullerenol on carbon tetrachloride-induced acute hepatotoxicity and nephrotoxicity in rats Carbon 2010, 48 (5) 1388-1396
46. Muriel, P.; Alba, N.; Perez-Alvarez, V. M.; Shibayama, M.; Tsutsumi, V. K. Kupffer cells inhibition prevents hepatic lipid peroxidation and damage induced by carbon tetrachloride Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol. 2001, 130 (2) 219-226 (Pubitemid 32905300)
47. Holecek, M.; Skalska, H.; Mraz, J. Plasma amino acid levels after carbon tetrachloride induced acute liver damage. A dose-response and time-response study in rats Amino Acids 1999, 16 (1) 1-11 (Pubitemid 29086140)
48. Lee, K. J.; Choi, J. H.; Kim, H. G.; Han, E. H.; Hwang, Y. P.; Lee, Y. C.; Chung, Y. C.; Jeong, H. G. Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice Food Chem. Toxicol. 2008, 46 (5) 1778-1785
49. Tang, H. R.; Wang, Y. L.; Nicholson, J. K.; Lindon, J. C. Use of relaxation-edited one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy to improve detection of small metabolites in blood plasma Anal. Biochem. 2004, 325 (2) 260-272 (Pubitemid 38134363)
50. Fan, W. M. T. Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures Prog. Nucl. Magn. Reson. Spectrosc. 1996, 28 (2) 161-219
51. Ahmad, F. F.; Cowan, D. L.; Sun, A. Y. Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil Life Sci. 1987, 41 (22) 2469-2475 (Pubitemid 18020209)
52. Guo, T. L.; McCay, J. A.; Brown, R. D.; Musgrove, D. L.; Germolec, D. R.; Butterworth, L.; Munson, A. E.; White, K. L. Carbon tetrachloride is immunosuppressive and decreases host resistance to Listeria monocytogenes and Streptococcus pneumoniae in female B6C3F1 mice Toxicology 2000, 154 (1-3) 85-101
53. Khan, M. R.; Rizvi, W.; Khan, G. N.; Khan, R. A.; Shaheen, S. Carbon tetrachloride-induced nephrotoxicity in rats: Protective role of Digera muricata J. Ethnopharmacol. 2009, 122 (1) 91-99
54. Eden, E.; Harrison, D. D.; Linnane, A. W. Studies in carbon tetrachloride poisoning. 2. The effect on creatine metabolism Aust. J. Exp. Biol. Med. Sci. 1954, 32 (3) 341-346
55. Cawthorne, M. A.; Palmer, E. D.; Bunyan, J.; Green, J. In vivo effects of carbon tetrachloride and chloroform on liver and kidney glucose-6-phosphatase in mice Biochem. Pharmacol. 1971, 20 (2) 494-496
56. Sein, K. T.; Chu, N. Liver and kidney glucose-6-phosphatase levels in carbon tetrachloride- and DDT-administered mice Enzyme 1979, 24 (1) 72-74 (Pubitemid 9104728)
57. 4-induced toxicity in rats Toxicology 2008, 248 (1) 59-65
58. Yoshiji, O.; Mutsumi, K.-N.; Yoichiro, I.; Teruaki, K. Contribution of xanthine oxidase-derived oxygen free radicals to the development of carbon tetrachloride-induced acute liver injury in rats J. Clin. Biochem. Nutr. 2003, 33 (3) 83-93
59. Huxtable, R. J. Physiological actions of taurine Physiol. Rev. 1992, 72 (1) 101-163
60. 1H NMR study of renal trimethylamine responses to dehydration and acute volume loading in man Proc. Natl. Acad. Sci. U.S.A. 1991, 88 (14) 6053-6057 (Pubitemid 21914884)
61. Boyd, M. R.; Statham, C. N.; Longo, N. S. The pulmonary Clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride J. Pharmacol. Exp. Ther. 1980, 212 (1) 109-114 (Pubitemid 10063395)
62. Boyd, M. R. Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation Crit. Rev. Toxicol. 1980, 7 (2) 103-176
63. Candelario-Jalil, E.; Mohammed-Al-Dalain, S.; Fernandez, O. S. L.; Menendez, S.; Perez-Davison, G.; Merino, N.; Sam, S.; Ajamieh, H. H. Oxidative preconditioning affords protection against carbon tetrachloride-induced glycogen depletion and oxidative stress in rats J. Appl. Toxicol. 2001, 21 (4) 297-301 (Pubitemid 32755701)
64. Hickenbottom, R. S.; Hornbrook, K. R. Effects of carbon tetrachloride on metabolism of liver glycogen in rat J. Pharmacol. Exp. Ther. 1971, 178 (2) 383-394
65. Banks, M. A.; Porter, D. W.; Martin, W. G.; Castranova, V. Ozone-induced lipid peroxidation and membrane leakage in isolated rat alveolar macrophages: protective effects of taurine J. Nutr. Biochem. 1991, 2 (6) 308-313
66. Bhavsar, T. M.; Cantor, J. O.; Patel, S. N.; Lau-Cam, C. A. Attenuating effect of taurine on lipopolysaccharide-induced acute lung injury in hamsters Pharmacol. Res. 2009, 60 (5) 418-428
67. Villela, G. G.; Mitidieri, E. Rat liver xanthine oxidase in carbon tetrachloride poisoning Nature 1955, 175 (4448) 208-209
68. Lu, Z.; Nie, G.; Belton, P. S.; Tang, H. R.; Zhao, B. L. Structure-activity relationship analysis of antioxidant ability and neuroprotective effects of gallic acid derivatives Neurochem. Int. 2006, 48, 263-274 (Pubitemid 43177148)
69. Tang, H. R.; Covington, A. D.; Hancock, R. A. Structure-activity relationships in the hydrophobic interactions of polyphenols with cellulose and collagen Biopolymers 2003, 70, 403-413 (Pubitemid 37411793)
70. Chen, C.; Tang, H. R.; Sutcliffe, L.; Belton, P. S. Green tea polyphenols react with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radicals in the bilayer of liposomes: direct evidence from ESR studies J. Agric. Food Chem. 2000, 48, 5710-5714