-
3
-
-
33751251394
-
Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin
-
Zinedine, A., Soriano, J. M., Molto, J. C., and Manes, J. (2007) Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin Food Chem. Toxicol. 45, 1-18
-
(2007)
Food Chem. Toxicol.
, vol.45
, pp. 1-18
-
-
Zinedine, A.1
Soriano, J.M.2
Molto, J.C.3
Manes, J.4
-
5
-
-
0039306168
-
Detoxication mechanisms in man
-
Williams, R. T. (1963) Detoxication mechanisms in man Clin. Pharmacol. Ther. 4, 234-254
-
(1963)
Clin. Pharmacol. Ther.
, vol.4
, pp. 234-254
-
-
Williams, R.T.1
-
6
-
-
0016721066
-
Metabolic activation and reactivity of chemical carcinogens
-
Miller, J. A. and Miller, E. C. (1975) Metabolic activation and reactivity of chemical carcinogens Mutat. Res. 33, 25-26
-
(1975)
Mutat. Res.
, vol.33
, pp. 25-26
-
-
Miller, J.A.1
Miller, E.C.2
-
7
-
-
77952351422
-
Clinical studies of excretion and localization of diethyl stilbestrol diphosphate labelled with radioactive phosphorus (P32)
-
Persky, L., Krohmer, J. S., and Storaasli, J. P. (1957) Clinical studies of excretion and localization of diethyl stilbestrol diphosphate labelled with radioactive phosphorus (P32) Surg. Forum 8, 610-613
-
(1957)
Surg. Forum
, vol.8
, pp. 610-613
-
-
Persky, L.1
Krohmer, J.S.2
Storaasli, J.P.3
-
8
-
-
0000957859
-
Chemotherapeutic action of a cyclic nitrogen mustard phosphamide ester (B 518-ASTA) in experimental tumours of the rat
-
Arnold, H., Bourseaux, F., and Brock, N. (1958) Chemotherapeutic action of a cyclic nitrogen mustard phosphamide ester (B 518-ASTA) in experimental tumours of the rat Nature 181, 931
-
(1958)
Nature
, vol.181
, pp. 931
-
-
Arnold, H.1
Bourseaux, F.2
Brock, N.3
-
9
-
-
0035107971
-
Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks
-
Holmes, E., Nicholson, J. K., and Tranter, G. (2001) Metabonomic characterization of genetic variations in toxicological and metabolic responses using probabilistic neural networks Chem. Res. Toxicol. 14, 182-191
-
(2001)
Chem. Res. Toxicol.
, vol.14
, pp. 182-191
-
-
Holmes, E.1
Nicholson, J.K.2
Tranter, G.3
-
10
-
-
0032694577
-
Metabonomics: Understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data
-
Nicholson, J. K., Lindon, J. C., and Holmes, E. (1999) Metabonomics: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 29, 1181-1189
-
(1999)
Xenobiotica
, vol.29
, pp. 1181-1189
-
-
Nicholson, J.K.1
Lindon, J.C.2
Holmes, E.3
-
11
-
-
41149162296
-
Metabolomics: A global biochemical approach to drug response and disease
-
Kaddurah-Daouk, R., Kristal, B. S., and Weinshilboum, R. M. (2008) Metabolomics: a global biochemical approach to drug response and disease Annu. Rev. Pharmacol. Toxicol. 48, 653-683
-
(2008)
Annu. Rev. Pharmacol. Toxicol.
, vol.48
, pp. 653-683
-
-
Kaddurah-Daouk, R.1
Kristal, B.S.2
Weinshilboum, R.M.3
-
12
-
-
33746065648
-
Understanding mouse models of disease through metabolomics
-
Griffin, J. L. (2006) Understanding mouse models of disease through metabolomics Curr. Opin. Chem. Biol. 10, 309-315
-
(2006)
Curr. Opin. Chem. Biol.
, vol.10
, pp. 309-315
-
-
Griffin, J.L.1
-
13
-
-
34548388291
-
LC-MS-based metabolomics in drug metabolism
-
Chen, C., Gonzalez, F. J., and Idle, J. R. (2007) LC-MS-based metabolomics in drug metabolism Drug Metab. Rev. 39, 581-597
-
(2007)
Drug Metab. Rev.
, vol.39
, pp. 581-597
-
-
Chen, C.1
Gonzalez, F.J.2
Idle, J.R.3
-
14
-
-
4644262109
-
Metabonomics: Its potential as a tool in toxicology for safety assessment and data integration
-
Griffin, J. L. and Bollard, M. E. (2004) Metabonomics: its potential as a tool in toxicology for safety assessment and data integration Curr. Drug Metab. 5, 389-398
-
(2004)
Curr. Drug Metab.
, vol.5
, pp. 389-398
-
-
Griffin, J.L.1
Bollard, M.E.2
-
15
-
-
75649113424
-
Computational approaches to metabolomics
-
Wishart, D. S. (2010) Computational approaches to metabolomics Methods Mol. Biol. 593, 283-313
-
(2010)
Methods Mol. Biol.
, vol.593
, pp. 283-313
-
-
Wishart, D.S.1
-
16
-
-
33847369007
-
Chemometrics in metabonomics
-
Trygg, J., Holmes, E., and Lundstedt, T. (2007) Chemometrics in metabonomics J. Proteome Res. 6, 469-479
-
(2007)
J. Proteome Res.
, vol.6
, pp. 469-479
-
-
Trygg, J.1
Holmes, E.2
Lundstedt, T.3
-
17
-
-
63449106748
-
Generic dealkylation: A tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters
-
Mortishire-Smith, R. J., Castro-Perez, J. M., Yu, K., Shockcor, J. P., Goshawk, J., Hartshorn, M. J., and Hill, A. (2009) Generic dealkylation: a tool for increasing the hit-rate of metabolite rationalization, and automatic customization of mass defect filters Rapid Commun. Mass Spectrom. 23, 939-948
-
(2009)
Rapid Commun. Mass Spectrom.
, vol.23
, pp. 939-948
-
-
Mortishire-Smith, R.J.1
Castro-Perez, J.M.2
Yu, K.3
Shockcor, J.P.4
Goshawk, J.5
Hartshorn, M.J.6
Hill, A.7
-
18
-
-
25144438177
-
Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
-
Mortishire-Smith, R. J., OConnor, D., Castro-Perez, J. M., and Kirby, J. (2005) Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis Rapid Commun. Mass Spectrom. 19, 2659-2670
-
(2005)
Rapid Commun. Mass Spectrom.
, vol.19
, pp. 2659-2670
-
-
Mortishire-Smith, R.J.1
Oconnor, D.2
Castro-Perez, J.M.3
Kirby, J.4
-
19
-
-
77952379207
-
-
CAS The Latest CAS Registry Number and Substance Count, Chemical Abstracts Service, Columbus, OH
-
CAS (2009) The Latest CAS Registry Number and Substance Count, Chemical Abstracts Service, Columbus, OH.
-
(2009)
-
-
-
20
-
-
5444239783
-
Environmental and chemical carcinogenesis
-
Wogan, G. N., Hecht, S. S., Felton, J. S., Conney, A. H., and Loeb, L. A. (2004) Environmental and chemical carcinogenesis Semin. Cancer Biol. 14, 473-486
-
(2004)
Semin. Cancer Biol.
, vol.14
, pp. 473-486
-
-
Wogan, G.N.1
Hecht, S.S.2
Felton, J.S.3
Conney, A.H.4
Loeb, L.A.5
-
21
-
-
0345095459
-
Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids
-
Plumb, R. S., Stumpf, C. L., Granger, J. H., Castro-Perez, J., Haselden, J. N., and Dear, G. J. (2003) Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids Rapid Commun. Mass Spectrom. 17, 2632-2638
-
(2003)
Rapid Commun. Mass Spectrom.
, vol.17
, pp. 2632-2638
-
-
Plumb, R.S.1
Stumpf, C.L.2
Granger, J.H.3
Castro-Perez, J.4
Haselden, J.N.5
Dear, G.J.6
-
22
-
-
34248572197
-
MSE with mass defect filtering for in vitro and in vivo metabolite identification
-
Bateman, K. P., Castro-Perez, J., Wrona, M., Shockcor, J. P., Yu, K., Oballa, R., and Nicoll-Griffith, D. A. (2007) MSE with mass defect filtering for in vitro and in vivo metabolite identification Rapid Commun. Mass Spectrom. 21, 1485-1496
-
(2007)
Rapid Commun. Mass Spectrom.
, vol.21
, pp. 1485-1496
-
-
Bateman, K.P.1
Castro-Perez, J.2
Wrona, M.3
Shockcor, J.P.4
Yu, K.5
Oballa, R.6
Nicoll-Griffith, D.A.7
-
23
-
-
37649005083
-
High-temperature ultra-performance liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry applied to ibuprofen metabolites in human urine
-
Plumb, R. S., Rainville, P. D., Potts, W. B., 3rd, Castro-Perez, J. M., Johnson, K. A., and Wilson, I. D. (2007) High-temperature ultra-performance liquid chromatography coupled to hybrid quadrupole time-of-flight mass spectrometry applied to ibuprofen metabolites in human urine Rapid Commun. Mass Spectrom. 21, 4079-4085
-
(2007)
Rapid Commun. Mass Spectrom.
, vol.21
, pp. 4079-4085
-
-
Plumb, R.S.1
Rainville, P.D.2
Castro-Perez, J.M.3
Johnson, K.A.4
Wilson, I.D.5
-
24
-
-
67650726440
-
Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis
-
Sun, J., Von Tungeln, L. S., Hines, W., and Beger, R. D. (2009) Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis J. Chromatogr., B 877, 2557-2565
-
(2009)
J. Chromatogr., B
, vol.877
, pp. 2557-2565
-
-
Sun, J.1
Von Tungeln, L.S.2
Hines, W.3
Beger, R.D.4
-
25
-
-
66649118903
-
Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics
-
Liu, A., Patterson, A. D., Yang, Z., Zhang, X., Liu, W., Qiu, F., Sun, H., Krausz, K. W., Idle, J. R., Gonzalez, F. J., and Dai, R. (2009) Fenofibrate metabolism in the cynomolgus monkey using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry-based metabolomics Drug Metab. Dispos. 37, 1157-1163
-
(2009)
Drug Metab. Dispos.
, vol.37
, pp. 1157-1163
-
-
Liu, A.1
Patterson, A.D.2
Yang, Z.3
Zhang, X.4
Liu, W.5
Qiu, F.6
Sun, H.7
Krausz, K.W.8
Idle, J.R.9
Gonzalez, F.J.10
Dai, R.11
-
26
-
-
33846670459
-
Mutagenic potency of food-derived heterocyclic amines
-
Felton, J. S., Knize, M. G., Wu, R. W., Colvin, M. E., Hatch, F. T., and Malfatti, M. A. (2007) Mutagenic potency of food-derived heterocyclic amines Mutat. Res. 616, 90-94
-
(2007)
Mutat. Res.
, vol.616
, pp. 90-94
-
-
Felton, J.S.1
Knize, M.G.2
Wu, R.W.3
Colvin, M.E.4
Hatch, F.T.5
Malfatti, M.A.6
-
27
-
-
25444456926
-
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2
-
Cheung, C., Ma, X., Krausz, K. W., Kimura, S., Feigenbaum, L., Dalton, T. P., Nebert, D. W., Idle, J. R., and Gonzalez, F. J. (2005) Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2 Chem. Res. Toxicol. 18, 1471-1478
-
(2005)
Chem. Res. Toxicol.
, vol.18
, pp. 1471-1478
-
-
Cheung, C.1
Ma, X.2
Krausz, K.W.3
Kimura, S.4
Feigenbaum, L.5
Dalton, T.P.6
Nebert, D.W.7
Idle, J.R.8
Gonzalez, F.J.9
-
28
-
-
0037201551
-
An epidemiologic approach to studying heterocyclic amines
-
Sinha, R. (2002) An epidemiologic approach to studying heterocyclic amines Mutat. Res. 506-507, 197-204
-
(2002)
Mutat. Res.
, vol.506-507
, pp. 197-204
-
-
Sinha, R.1
-
29
-
-
34047250288
-
A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach
-
Chen, C., Ma, X., Malfatti, M. A., Krausz, K. W., Kimura, S., Felton, J. S., Idle, J. R., and Gonzalez, F. J. (2007) A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach Chem. Res. Toxicol. 20, 531-542
-
(2007)
Chem. Res. Toxicol.
, vol.20
, pp. 531-542
-
-
Chen, C.1
Ma, X.2
Malfatti, M.A.3
Krausz, K.W.4
Kimura, S.5
Felton, J.S.6
Idle, J.R.7
Gonzalez, F.J.8
-
30
-
-
77951235853
-
A comprehensive approach to the profiling of the cooked meat carcinogens, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine, and their metabolites in human urine
-
[online early access], DOI: 10.1021/tx900436m, published online Mar 1, 2010
-
Gu, D., McNaughton, L., Lemaster, D., Lake, B. G., Gooderham, N. J., Kadlubar, F. F., and Turesky, R. J. (2010) A comprehensive approach to the profiling of the cooked meat carcinogens, 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine. Chem. Res. Toxicol. [online early access], DOI: 10.1021/tx900436m, published online Mar 1, 2010.
-
(2010)
Chem. Res. Toxicol.
-
-
Gu, D.1
McNaughton, L.2
Lemaster, D.3
Lake, B.G.4
Gooderham, N.J.5
Kadlubar, F.F.6
Turesky, R.J.7
-
31
-
-
0036155884
-
Global epidemiology of areca nut usage
-
Gupta, P. C. and Warnakulasuriya, S. (2002) Global epidemiology of areca nut usage Addict. Biol. 7, 77-83
-
(2002)
Addict. Biol.
, vol.7
, pp. 77-83
-
-
Gupta, P.C.1
Warnakulasuriya, S.2
-
32
-
-
0036150996
-
Areca nut-abuse liability, dependence and public health
-
Winstock, A. (2002) Areca nut-abuse liability, dependence and public health Addict. Biol. 7, 133-138
-
(2002)
Addict. Biol.
, vol.7
, pp. 133-138
-
-
Winstock, A.1
-
34
-
-
33745320763
-
A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse
-
Giri, S., Idle, J. R., Chen, C., Zabriskie, T. M., Krausz, K. W., and Gonzalez, F. J. (2006) A metabolomic approach to the metabolism of the areca nut alkaloids arecoline and arecaidine in the mouse Chem. Res. Toxicol. 19, 818-827
-
(2006)
Chem. Res. Toxicol.
, vol.19
, pp. 818-827
-
-
Giri, S.1
Idle, J.R.2
Chen, C.3
Zabriskie, T.M.4
Krausz, K.W.5
Gonzalez, F.J.6
-
35
-
-
33845925755
-
The metabolomics of ()-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases
-
Giri, S., Krausz, K. W., Idle, J. R., and Gonzalez, F. J. (2007) The metabolomics of ()-arecoline 1-oxide in the mouse and its formation by human flavin-containing monooxygenases Biochem. Pharmacol. 73, 561-573
-
(2007)
Biochem. Pharmacol.
, vol.73
, pp. 561-573
-
-
Giri, S.1
Krausz, K.W.2
Idle, J.R.3
Gonzalez, F.J.4
-
36
-
-
77952820315
-
The role of mass spectrometry-based metabolomics in medical countermeasures against radiation
-
[online early access], DOI: 10.1002/mas.20272, published online Nov 4, 2009
-
Patterson, A. D., Lanz, C., Gonzalez, F. J., and Idle, J. R. (2009) The role of mass spectrometry-based metabolomics in medical countermeasures against radiation. Mass Spectrom. Rev. [online early access], DOI: 10.1002/mas.20272, published online Nov 4, 2009.
-
(2009)
Mass Spectrom. Rev.
-
-
Patterson, A.D.1
Lanz, C.2
Gonzalez, F.J.3
Idle, J.R.4
-
37
-
-
51449101022
-
Thirty four years since the discovery of gastrointestinal melatonin
-
Bubenik, G. A. (2008) Thirty four years since the discovery of gastrointestinal melatonin J. Physiol. Pharmacol. 59 (Suppl. 2) 33-51
-
(2008)
J. Physiol. Pharmacol.
, vol.59
, Issue.SUPPL. 2
, pp. 33-51
-
-
Bubenik, G.A.1
-
38
-
-
41549100628
-
A metabolomic perspective of melatonin metabolism in the mouse
-
Ma, X., Chen, C., Krausz, K. W., Idle, J. R., and Gonzalez, F. J. (2008) A metabolomic perspective of melatonin metabolism in the mouse Endocrinology 149, 1869-1879
-
(2008)
Endocrinology
, vol.149
, pp. 1869-1879
-
-
Ma, X.1
Chen, C.2
Krausz, K.W.3
Idle, J.R.4
Gonzalez, F.J.5
-
39
-
-
33645449734
-
Urinary metabolites and antioxidant products of exogenous melatonin in the mouse
-
Ma, X., Idle, J. R., Krausz, K. W., Tan, D. X., Ceraulo, L., and Gonzalez, F. J. (2006) Urinary metabolites and antioxidant products of exogenous melatonin in the mouse J. Pineal Res. 40, 343-349
-
(2006)
J. Pineal Res.
, vol.40
, pp. 343-349
-
-
Ma, X.1
Idle, J.R.2
Krausz, K.W.3
Tan, D.X.4
Ceraulo, L.5
Gonzalez, F.J.6
-
40
-
-
67349240411
-
Circulating melatonin and the risk of breast and endometrial cancer in women
-
Viswanathan, A. N. and Schernhammer, E. S. (2009) Circulating melatonin and the risk of breast and endometrial cancer in women Cancer Lett. 281, 1-7
-
(2009)
Cancer Lett.
, vol.281
, pp. 1-7
-
-
Viswanathan, A.N.1
Schernhammer, E.S.2
-
41
-
-
57149103123
-
Melatonin and the immune system in aging
-
Cardinali, D. P., Esquifino, A. I., Srinivasan, V., and Pandi-Perumal, S. R. (2008) Melatonin and the immune system in aging Neuroimmunomodulation 15, 272-278
-
(2008)
Neuroimmunomodulation
, vol.15
, pp. 272-278
-
-
Cardinali, D.P.1
Esquifino, A.I.2
Srinivasan, V.3
Pandi-Perumal, S.R.4
-
42
-
-
52649111722
-
Therapeutic actions of melatonin in cancer: Possible mechanisms
-
Srinivasan, V., Spence, D. W., Pandi-Perumal, S. R., Trakht, I., and Cardinali, D. P. (2008) Therapeutic actions of melatonin in cancer: possible mechanisms Integr. Cancer Ther. 7, 189-203
-
(2008)
Integr. Cancer Ther.
, vol.7
, pp. 189-203
-
-
Srinivasan, V.1
Spence, D.W.2
Pandi-Perumal, S.R.3
Trakht, I.4
Cardinali, D.P.5
-
43
-
-
4644356675
-
Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle
-
Sakano, K., Oikawa, S., Hiraku, Y., and Kawanishi, S. (2004) Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle Biochem. Pharmacol. 68, 1869-1878
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 1869-1878
-
-
Sakano, K.1
Oikawa, S.2
Hiraku, Y.3
Kawanishi, S.4
-
44
-
-
21044436893
-
6-Hydroxymelatonin protects against quinolinic-acid-induced oxidative neurotoxicity in the rat hippocampus
-
Maharaj, D. S., Maharaj, H., Antunes, E. M., Maree, D. M., Nyokong, T., Glass, B. D., and Daya, S. (2005) 6-Hydroxymelatonin protects against quinolinic-acid-induced oxidative neurotoxicity in the rat hippocampus J. Pharm. Pharmacol. 57, 877-881
-
(2005)
J. Pharm. Pharmacol.
, vol.57
, pp. 877-881
-
-
Maharaj, D.S.1
Maharaj, H.2
Antunes, E.M.3
Maree, D.M.4
Nyokong, T.5
Glass, B.D.6
Daya, S.7
-
45
-
-
33644839704
-
Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity
-
Maharaj, D. S., Maharaj, H., Daya, S., and Glass, B. D. (2006) Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity J. Neurochem. 96, 78-81
-
(2006)
J. Neurochem.
, vol.96
, pp. 78-81
-
-
Maharaj, D.S.1
Maharaj, H.2
Daya, S.3
Glass, B.D.4
-
46
-
-
0015944572
-
In vitro and in vivo formation of two new metabolites of melatonin
-
Hirata, F., Hayaishi, O., Tokuyama, T., and Seno, S. (1974) In vitro and in vivo formation of two new metabolites of melatonin J. Biol. Chem. 249, 1311-1313
-
(1974)
J. Biol. Chem.
, vol.249
, pp. 1311-1313
-
-
Hirata, F.1
Hayaishi, O.2
Tokuyama, T.3
Seno, S.4
-
47
-
-
0029792884
-
Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer
-
Akama, T., Shida, Y., Sugaya, T., Ishida, H., Gomi, K., and Kasai, M. (1996) Novel 5-aminoflavone derivatives as specific antitumor agents in breast cancer J. Med. Chem. 39, 3461-3469
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3461-3469
-
-
Akama, T.1
Shida, Y.2
Sugaya, T.3
Ishida, H.4
Gomi, K.5
Kasai, M.6
-
48
-
-
0034640186
-
Identification of the principal circulating metabolite of a synthetic 5,4′-diaminoflavone (NSC 686288), an antitumor agent, in the rat
-
Phillips, L. R., Bramhall, C., Buckley, J., Wolfe, T., House, T. L., and Stinson, S. F. (2000) Identification of the principal circulating metabolite of a synthetic 5,4′-diaminoflavone (NSC 686288), an antitumor agent, in the rat J. Chromatogr., B 741, 205-211
-
(2000)
J. Chromatogr., B
, vol.741
, pp. 205-211
-
-
Phillips, L.R.1
Bramhall, C.2
Buckley, J.3
Wolfe, T.4
House, T.L.5
Stinson, S.F.6
-
49
-
-
0036085571
-
Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2
-
Kuffel, M. J., Schroeder, J. C., Pobst, L. J., Naylor, S., Reid, J. M., Kaufmann, S. H., and Ames, M. M. (2002) Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2 Mol. Pharmacol. 62, 143-153
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 143-153
-
-
Kuffel, M.J.1
Schroeder, J.C.2
Pobst, L.J.3
Naylor, S.4
Reid, J.M.5
Kaufmann, S.H.6
Ames, M.M.7
-
50
-
-
33747584882
-
Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone)
-
Chen, C., Meng, L., Ma, X., Krausz, K. W., Pommier, Y., Idle, J. R., and Gonzalez, F. J. (2006) Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone) J. Pharmacol. Exp. Ther. 318, 1330-1342
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.318
, pp. 1330-1342
-
-
Chen, C.1
Meng, L.2
Ma, X.3
Krausz, K.W.4
Pommier, Y.5
Idle, J.R.6
Gonzalez, F.J.7
-
51
-
-
33747610305
-
Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX
-
Meng, L. H., Shankavaram, U., Chen, C., Agama, K., Fu, H. Q., Gonzalez, F. J., Weinstein, J., and Pommier, Y. (2006) Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX Cancer Res. 66, 9656-9664
-
(2006)
Cancer Res.
, vol.66
, pp. 9656-9664
-
-
Meng, L.H.1
Shankavaram, U.2
Chen, C.3
Agama, K.4
Fu, H.Q.5
Gonzalez, F.J.6
Weinstein, J.7
Pommier, Y.8
-
52
-
-
42449092509
-
Cytokeratin-RNA cross-linking mediated by the antitumor aminoflavone, 5-amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one
-
Meng, L. H., Meng, Z., Miao, Z. H., Veenstra, T. D., and Pommier, Y. (2008) Cytokeratin-RNA cross-linking mediated by the antitumor aminoflavone, 5-amino-2,3-fluorophenyl-6,8-difluoro-7-methyl-4H-1-benzopyran-4-one J. Pharmacol. Exp. Ther. 325, 674--680
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.325
, pp. 674-680
-
-
Meng, L.H.1
Meng, Z.2
Miao, Z.H.3
Veenstra, T.D.4
Pommier, Y.5
-
53
-
-
65249156513
-
Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma
-
Wiegand, R., Wu, J., Sha, X., LoRusso, P., Heath, E., and Li, J. (2009) Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate aminoflavone (NSC 686288) in human plasma J. Chromatogr., B 877, 1460-1464
-
(2009)
J. Chromatogr., B
, vol.877
, pp. 1460-1464
-
-
Wiegand, R.1
Wu, J.2
Sha, X.3
Lorusso, P.4
Heath, E.5
Li, J.6
-
54
-
-
0043069547
-
Opinion: Understanding global systems biology: Metabonomics and the continuum of metabolism
-
Nicholson, J. K. and Wilson, I. D. (2003) Opinion: understanding global systems biology: metabonomics and the continuum of metabolism Nat. Rev. Drug Discovery 2, 668-676
-
(2003)
Nat. Rev. Drug Discovery
, vol.2
, pp. 668-676
-
-
Nicholson, J.K.1
Wilson, I.D.2
-
55
-
-
70349908127
-
Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation
-
Patterson, A. D., Slanar, O., Krausz, K. W., Li, F., Hofer, C. C., Perlik, F., Gonzalez, F. J., and Idle, J. R. (2009) Human urinary metabolomic profile of PPARalpha induced fatty acid beta-oxidation J. Proteome Res. 8, 4293-4300
-
(2009)
J. Proteome Res.
, vol.8
, pp. 4293-4300
-
-
Patterson, A.D.1
Slanar, O.2
Krausz, K.W.3
Li, F.4
Hofer, C.C.5
Perlik, F.6
Gonzalez, F.J.7
Idle, J.R.8
-
56
-
-
75549091977
-
SMPDB: The small molecule pathway database
-
Frolkis, A., Knox, C., Lim, E., Jewison, T., Law, V., Hau, D. D., Liu, P., Gautam, B., Ly, S., Guo, A. C., Xia, J., Liang, Y., Shrivastava, S., and Wishart, D. S. (2010) SMPDB: The Small Molecule Pathway Database Nucleic Acids Res. 38, D480-D487
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Frolkis, A.1
Knox, C.2
Lim, E.3
Jewison, T.4
Law, V.5
Hau, D.D.6
Liu, P.7
Gautam, B.8
Ly, S.9
Guo, A.C.10
Xia, J.11
Liang, Y.12
Shrivastava, S.13
Wishart, D.S.14
-
57
-
-
75549085747
-
T3DB: A comprehensively annotated database of common toxins and their targets
-
Lim, E., Pon, A., Djoumbou, Y., Knox, C., Shrivastava, S., Guo, A. C., Neveu, V., and Wishart, D. S. (2010) T3DB: a comprehensively annotated database of common toxins and their targets Nucleic Acids Res. 38, D781-D786
-
(2010)
Nucleic Acids Res.
, vol.38
-
-
Lim, E.1
Pon, A.2
Djoumbou, Y.3
Knox, C.4
Shrivastava, S.5
Guo, A.C.6
Neveu, V.7
Wishart, D.S.8
-
58
-
-
63049090930
-
Exploring human metabolites using the human metabolome database
-
Forsythe, I. J. and Wishart, D. S. (2009) Exploring human metabolites using the human metabolome database Curr. Protoc. Bioinf. Chapter14 (Unit14) 18
-
(2009)
Curr. Protoc. Bioinf.
, vol.14
, Issue.UNIT14
, pp. 18
-
-
Forsythe, I.J.1
Wishart, D.S.2
-
59
-
-
58149202163
-
HMDB: A knowledgebase for the human metabolome
-
Wishart, D. S., Knox, C., Guo, A. C., Eisner, R., Young, N., Gautam, B., Hau, D. D., Psychogios, N., Dong, E., Bouatra, S., Mandal, R., Sinelnikov, I., Xia, J., Jia, L., Cruz, J. A., Lim, E., Sobsey, C. A., Shrivastava, S., Huang, P., Liu, P., Fang, L., Peng, J., Fradette, R., Cheng, D., Tzur, D., Clements, M., Lewis, A., De Souza, A., Zuniga, A., Dawe, M., Xiong, Y., Clive, D., Greiner, R., Nazyrova, A., Shaykhutdinov, R., Li, L., Vogel, H. J., and Forsythe, I. (2009) HMDB: a knowledgebase for the human metabolome Nucleic Acids Res. 37, D603-D610
-
(2009)
Nucleic Acids Res.
, vol.37
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Eisner, R.4
Young, N.5
Gautam, B.6
Hau, D.D.7
Psychogios, N.8
Dong, E.9
Bouatra, S.10
Mandal, R.11
Sinelnikov, I.12
Xia, J.13
Jia, L.14
Cruz, J.A.15
Lim, E.16
Sobsey, C.A.17
Shrivastava, S.18
Huang, P.19
Liu, P.20
Fang, L.21
Peng, J.22
Fradette, R.23
Cheng, D.24
Tzur, D.25
Clements, M.26
Lewis, A.27
De Souza, A.28
Zuniga, A.29
Dawe, M.30
Xiong, Y.31
Clive, D.32
Greiner, R.33
Nazyrova, A.34
Shaykhutdinov, R.35
Li, L.36
Vogel, H.J.37
Forsythe, I.38
more..
-
60
-
-
33846088138
-
HMDB: The human metabolome database
-
Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., Fung, C., Nikolai, L., Lewis, M., Coutouly, M. A., Forsythe, I., Tang, P., Shrivastava, S., Jeroncic, K., Stothard, P., Amegbey, G., Block, D., Hau, D. D., Wagner, J., Miniaci, J., Clements, M., Gebremedhin, M., Guo, N., Zhang, Y., Duggan, G. E., Macinnis, G. D., Weljie, A. M., Dowlatabadi, R., Bamforth, F., Clive, D., Greiner, R., Li, L., Marrie, T., Sykes, B. D., Vogel, H. J., and Querengesser, L. (2007) HMDB: the Human Metabolome Database Nucleic Acids Res. 35, D521-D526
-
(2007)
Nucleic Acids Res.
, vol.35
-
-
Wishart, D.S.1
Tzur, D.2
Knox, C.3
Eisner, R.4
Guo, A.C.5
Young, N.6
Cheng, D.7
Jewell, K.8
Arndt, D.9
Sawhney, S.10
Fung, C.11
Nikolai, L.12
Lewis, M.13
Coutouly, M.A.14
Forsythe, I.15
Tang, P.16
Shrivastava, S.17
Jeroncic, K.18
Stothard, P.19
Amegbey, G.20
Block, D.21
Hau, D.D.22
Wagner, J.23
Miniaci, J.24
Clements, M.25
Gebremedhin, M.26
Guo, N.27
Zhang, Y.28
Duggan, G.E.29
MacInnis, G.D.30
Weljie, A.M.31
Dowlatabadi, R.32
Bamforth, F.33
Clive, D.34
Greiner, R.35
Li, L.36
Marrie, T.37
Sykes, B.D.38
Vogel, H.J.39
Querengesser, L.40
more..
-
61
-
-
44949233606
-
Analysis of the adult human plasma metabolome
-
Lawton, K. A., Berger, A., Mitchell, M., Milgram, K. E., Evans, A. M., Guo, L., Hanson, R. W., Kalhan, S. C., Ryals, J. A., and Milburn, M. V. (2008) Analysis of the adult human plasma metabolome Pharmacogenomics 9, 383-397
-
(2008)
Pharmacogenomics
, vol.9
, pp. 383-397
-
-
Lawton, K.A.1
Berger, A.2
Mitchell, M.3
Milgram, K.E.4
Evans, A.M.5
Guo, L.6
Hanson, R.W.7
Kalhan, S.C.8
Ryals, J.A.9
Milburn, M.V.10
|