Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the ppara -null mouse

Journal of Proteome Research

Volumn 9, Issue 8, 2010, Pages 4176-4188

  Manna, Soumen K ^a   Patterson, Andrew D ^a   Yang, Qian ^b   Krausz, Kristopher W ^a   Li, Henghong ^b   Idle, Jeffrey R ^c   Fornace Jr , Albert J ^b   Gonzalez, Frank J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

alcohol induced liver disease; biomarker; indole 3 lactic acid; metabolomics; multivariate data analysis; Ppara null mouse; PPARR; steatosis; UPLC ESI QTOF MS

Indexed keywords

2 HYDROXYPHENYLACETIC ACID; 4 HYDROXYPHENYLACETIC ACID; 4 HYDROXYPHENYLACETIC ACID SULFATE; ACETIC ACID; ADIPIC ACID; BIOLOGICAL MARKER; ETHYL BETA DEXTRO GLUCURONIDE; ETHYL SULFATE; GLUCURONIDE; INDOLEACETIC ACID; PIMELIC ACID; SULFATE; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MALE; MASS SPECTROMETRY; METABOLOMICS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; STRAIN DIFFERENCE; UNITED STATES; URINALYSIS; URINARY EXCRETION; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL MARKERS; INDOLES; LIVER DISEASES, ALCOHOLIC; MALE; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MICE; MICE, TRANSGENIC; MOLECULAR STRUCTURE; MULTIVARIATE ANALYSIS; PPAR ALPHA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPTOPHAN;

ANIMALIA; MUS;

EID: 77955463490     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100452b     Document Type: Article

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