AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 9, 2014, Pages 1844-1854

  Li, Hongliang ^a   Min, Qing ^a   Ouyang, Changhan ^a   Lee, Jiyeon ^a   He, Chaoyong ^a   Zou, Ming Hui ^a   Xie, Zhonglin ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

AMPK; ER stress; Lipid accumulation; MTORC1; SREBP

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE DERIVATIVE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 2ALPHA; LIPID; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PALMITIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TUBERIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; MOUSE; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMPK; ER STRESS; LIPID ACCUMULATION; MTORC1; SREBP;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOTTING, WESTERN; CHOLESTEROL; DIET, HIGH-FAT; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HEP G2 CELLS; HUMANS; HYPERINSULINISM; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MULTIPROTEIN COMPLEXES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SWEETENING AGENTS; TOR SERINE-THREONINE KINASES; TRIGLYCERIDES;

EID: 84904514591     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.07.002     Document Type: Article

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