Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity

International Journal of Obesity

Volumn 32, Issue 4, 2008, Pages 639-647

  Taleux, N ^a,b   De Potter, I ^a   Deransart, C ^c   Lacraz, G ^b   Favier, R ^b   Leverve, X M ^b   Hue, L ^a   Guigas, B ^a,d  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b INSERM   (France)

^c GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adiponectin; AMPK; Food intake; Ghrelin; Hypothalamus; Leptin

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; ADENYLATE KINASE; ADIPONECTIN; CYTOKINE; ELONGATION FACTOR 2; GHRELIN; HORMONE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; NEUROPEPTIDE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FOOD DEPRIVATION; FOOD INTAKE; GENE EXPRESSION; HYPOPHAGIA; HYPOTHALAMUS; LEAN BODY WEIGHT; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; STARVATION;

ADIPONECTIN; ANIMALS; BLOTTING, WESTERN; DISEASE SUSCEPTIBILITY; EATING; ENZYME ACTIVATION; GHRELIN; HYPOTHALAMUS; LEPTIN; MALE; MULTIENZYME COMPLEXES; NEUROPEPTIDES; OBESITY; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, INBRED STRAINS; RATS, WISTAR; RNA, MESSENGER; SPECIES SPECIFICITY; STARVATION;

RATTUS; RATTUS NORVEGICUS;

EID: 42149139040     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803759     Document Type: Article

References (49)

1. Schwartz MW, Porte Jr D. Diabetes, obesity, and the brain. Science 2005; 307: 375-379.
2. Stanley S, Wynne K, McGowan B, Bloom S. Hormonal regulation of food intake. Physiol Rev 2005; 85: 1131-1158.
3. Leibowitz SF, Wortley KE. Hypothalamic control of energy balance: different peptides, different functions. Peptides 2004; 25: 473-504.
4. Wynne K, Stanley S, McGowan B, Bloom S. Appetite control. J Endocrinol 2005; 184: 291-318.
5. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428: 569-574.
6. Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR et al. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004; 279: 12005-12008.
7. Kim EK, Miller I, Aja S, Landree LE, Pinn M, McFadden J et al. C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase. J Biol Chem 2004; 279: 19970-19976.
8. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS et al. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 2004; 10: 727-733.
9. Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L et al. Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. J Physiol 2006; 574: 41-53.
10. Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase - development of the energy sensor concept. J Physiol 2006; 574: 7-15.
11. Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1: 15-25.
12. Kim MS, Lee KU. Role of hypothalamic 5′-AMP-activated protein kinase in the regulation of food intake and energy homeostasis. J Mol Med 2005; 83: 514-520.
13. Lee K, Li B, Xi X, Suh Y, Martin RJ. Role of neuronal energy status in the regulation of adenosine 5′-monophosphate-activated protein kinase, orexigenic neuropeptides expression, and feeding behavior. Endocrinology 2005; 146: 3-10.
14. Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H et al. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 2007; 6: 55-68.
15. Martin TL, Alquier T, Asakura K, Furukawa N, Preitner F, Kahn BB. Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle. J Biol Chem 2006; 281: 18933-18941.
16. Namkoong C, Kim MS, Jang PG, Han SM, Park HS, Koh EH et al. Enhanced hypothalamic AMP-activated protein kinase activity contributes to hyperphagia in diabetic rats. Diabetes 2005; 54: 63-68.
17. Bazin H. The Louvain (Lou) rats. In: Rat Hybridomas and Rat Monoclonal Antibodies. CRC Press: Cleveland, OH, 1990, pp 43-51.
18. Couturier K, Servais S, Koubi H, Sempore B, Sornay-Mayet MH, Cottet-Emard JM et al. Metabolic characteristics and body composition in a model of anti-obese rats (Lou/C). Obes Res 2002; 10: 188-195.
19. Couturier K, Servais S, Koubi H, Sempore B, Cottet-Emard JM, Guigas B et al. Metabolic and hormonal responses to exercise in the anti-obese Lou/C rats. Int J Obes Relat Metab Disord 2004; 28: 972-978.
20. Perrin D, Soulage C, Pequignot JM, Geloen A. Resistance to obesity in Lou/C rats prevents ageing-associated metabolic alterations. Diabetologia 2003; 46: 1489-1496.
21. Davies SP, Carling D, Hardie DG. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur J Biochem 1989; 186: 123-128.
22. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Academic Press: New York, 1991.
23. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
24. Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 2000; 346 (Part 3): 659-669.
25. Horman S, Browne G, Krause U, Patel J, Vertommen D, Bertrand L et al. Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol 2002; 12: 1419-1423.
26. Kappeler L, Zizzari P, Grouselle D, Epelbaum J, Bluet-Pajot MT. Plasma and hypothalamic peptide-hormone levels regulating somatotroph function and energy balance in fed and fasted states: a comparative study in four strains of rats. J Neuroendocrinol 2004; 16: 980-988.
27. McCowen KC, Chow JC, Smith RJ. Leptin signaling in the hypothalamus of normal rats in vivo. Endocrinology 1998; 139: 4442-4447.
28. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA et al. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 2002; 297: 240-243.
29. Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T et al. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 2003; 144: 1506-1512.
30. Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R et al. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci USA 2004; 101: 8227-8232.
31. Scarpace PJ, Matheny M, Shek EW. Impaired leptin signal transduction with age-related obesity. Neuropharmacology 2000; 39: 1872-1879.
32. Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 2001; 50: 2786-2791.
33. Sahu A. Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones. J Neuroendocrinol 2002; 14: 796-804.
34. Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93: 6231-6235.
35. Vaisse C, Halaas JL, Horvath CM, Darnell Jr JE, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996; 14: 95-97.
36. Baskin DG, Breininger JF, Schwartz MW. Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 1999; 48: 828-833.
37. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjoorbaek C et al. Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 2001; 107: 111-120.
38. Ahima RS, Kelly J, Elmquist JK, Flier JS. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology 1999; 140: 4923-4931.
39. Hu Z, Cha SH, Chohnan S, Lane MD. Hypothalamic malonyl-CoA as a mediator of feeding behavior. Proc Natl Acad Sci USA 2003; 100: 12624-12629.
40. Hu Z, Dai Y, Prentki M, Chohnan S, Lane MD. A role for hypothalamic malonyl-CoA in the control of food intake. J Biol Chem 2005; 280: 39681-39683.
41. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 2002; 51: 271-275.
42. Morgan K, Obici S, Rossetti L. Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J Biol Chem 2004; 279: 31139-31148.
43. He W, Lam TK, Obici S, Rossetti L. Molecular disruption of hypothalamic nutrient sensing induces obesity. Nat Neurosci 2006; 9: 227-233.
44. Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003; 144: 5179-5183.
45. Lam TK, Schwartz GJ, Rossetti L. Hypothalamic sensing of fatty acids. Nat Neurosci 2005; 8: 579-584.
46. Lane MD, Hu Z, Cha SH, Dai Y, Wolfgang M, Sidhaye A. Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. Biochem Soc Trans 2005; 33: 1063-1067.
47. Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G et al. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest 2004; 113: 414-424.
48. Cohen P, Ntambi JM, Friedman JM. Stearoyl-CoA desaturase-1 and the metabolic syndrome. Curr Drug Targets Immune Endocr Metabol Disord 2003; 3: 271-280.
49. Ntambi JM, Miyazaki M. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 2004; 43: 91-104.