Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2

Journal of Microbiology and Biotechnology

Volumn 18, Issue 6, 2008, Pages 1197-1202

  Han, Chul ^a   Nam, Min Kyung ^b   Park, Hyo Jin ^a,b   Seong, Young Mo ^a,b   Kang, Seongman ^a   Rhim, Hyangshuk ^b  

^a Korea University   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; ER stress; HtrA2; Tunicamycin

Indexed keywords

ECDYSONE; SERINE PROTEINASE OMI; TUNICAMYCIN; MITOCHONDRIAL PROTEIN; SERINE PROTEINASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL FRACTIONATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MITOCHONDRION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; UPREGULATION; BIOSYNTHESIS; CELL LINE; CYTOSOL; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; METABOLISM; STRESS;

MAMMALIA;

APOPTOSIS; CELL LINE; CYTOSOL; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; SERINE ENDOPEPTIDASES; STRESS; TUNICAMYCIN; UP-REGULATION;

EID: 53149088265     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Bertolotti, A., Y. Zhang, L. M. Hendershot, H. P. Harding, and D. Ron. 2000. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat. Cell Biol. 2: 326-332.
2. Boya, P., I. Cohen, N. Zamzami, H. L. Vieira, and G. Kroemer. 2002. Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization. Cell Death Differ. 9: 465-467.
3. Danial, N. N. and S. J. Korsmeyer. 2004. Cell death: Critical control points. Cell 116: 205-219.
4. de Bruin, E. C., D. Meersma, J. de Wilde, I. den Otter, E. M. Schipper, J. P. Medema, and L. T. Peltenburg. 2003. A serine protease is involved in the initiation of DNA damage-induced apoptosis. Cell Death Differ. 10: 1204-1212.
5. Egger, L., J. Schneider, C. Rheme, M. Tapernoux, J. Hacki, and C. Borner. 2003. Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ. 10: 1188-1203.
6. Faccio, L., C. Fusco, A. Chen, S. Martinotti, J. V. Bonventre, and A. S. Zervos. 2000. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. J. Biol. Chem. 275: 2581-2588.
7. Garrido, C., L. Galluzzi, M. Brunet, P. E. Puig, C. Didelot, and G. Kroemer. 2006. Mechanisms of cytochrome c release from mitochondria. Cell Death Differ. 13: 1423-1433.
8. Gorlach, A., P. Klappa, and T. Kietzmann. 2006. The endoplasmic reticulum: Folding, calcium homeostasis, signaling, and redox control. Antioxid. Redox Signal. 8: 1391-1418.
9. Gray, C. W., R. V. Ward, E. Karran, S. Turconi, A. Rowles, D. Viglienghi, et al. 2000. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur. J. Biochem. 267: 5699-5710.
10. Hacki, J., L. Egger, L. Monney, S. Conus, T. Rosse, I. Fellay, and C. Borner. 2000. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 19: 2286-2295.
11. Hegde, R., S. M. Srinivasula, Z. Zhang, R. Wassell, R. Mukattash, L. Cilenti, et al. 2002. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 277: 432-438.
12. Hori, O., F. Ichinoda, T. Tamatani, A. Yamaguchi, N. Sato, K. Ozawa, et al. 2002. Transmission of cell stress from endoplasmic reticulum to mitochondria: Enhanced expression of Lon protease. J. Cell Biol. 157: 1151-1160.
13. Jin, S., M. Kalkum, M. Overholtzer, A. Stoffel, B. T. Chait, and A. J. Levine. 2003. CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes Dev. 17: 359-367.
14. Jones, J. M., P. Datta, S. M. Srinivasula, W. Ji, S. Gupta, Z. Zhang, et al. 2003. Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice. Nature 425: 721-727.
15. Kaufman, R. J. 1999. Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev. 13: 1211-1233.
16. Kaufman, R. J. 2002. Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110: 1389-1398.
17. Kobayashi, T., H. Sawa, J. Morikawa, S. Ueno, N. Katayama, W. Zhang, and H. Shiku. 2002. Bax-induction alone is sufficient to activate apoptosis cascade in wild-type Bax-bearing K562 cells, and the initiation of apoptosis requires simultaneous caspase activation. Int. J. Oncol. 20: 723-728.
18. Lindholm, D., H. Wootz, and L. Korhonen. 2006. ER stress and neurodegenerative diseases. Cell Death Differ. 13: 385-392.
19. Ma, K., K. M. Vattem, and R. C. Wek. 2002. Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. J. Biol. Chem. 277: 18728-18735.
20. Martins, L. M., I. Iaccarino, T. Tenev, S. Gschmeissner, N. F. Totty, N. R. Lemoine, et al. 2002. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. 277: 439-444.
21. Martins, L. M., A. Morrison, K. Klupsch, V. Fedele, N. Moisoi, P. Teismann, et al. 2004. Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice. Mol. Cell. Biol. 24: 9848-9862.
22. Nakagawa, T., H. Zhu, N. Morishima, E. Li, J. Xu, B. A. Yankner, and J. Yuan. 2000. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103.
23. Newmeyer, D. D. and S. Ferguson-Miller. 2003. Mitochondria: Releasing power for life and unleashing the machineries of death. Cell 112: 481-490.
24. No, D., T. P. Yao, and R. M. Evans. 1996. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA 93: 3346-3351.
25. Park, J. H., D. H. Cho, C. W. Yun, J. W. Soh, Y. M. Jee, S. I. Park, I. Jo, and J. H. Nam. 2006. Role of protein kinase C δ in an early stage of coxsackievirus-B3-induced apoptosis in HeLa cells. J. Microbiol. Biotechnol. 16: 550-555.
26. Park, S. E., M. J. Lee, M. H. Yang, K. Y. Ahn, S. I. Jang, Y. J. Suh, H. Myung, J. C. You, and J. H. Park. 2007. Expression profiles and pathway analysis in HEK 293 T cells overexpressing HIV-1 Tat and nucleocapsid using cDNA microarray. J. Microbiol. Biotechnol. 17: 154-161.
27. Puthalakath, H., L. A. O'Reilly, P. Gunn, L. Lee, P. N. Kelly, N. D. Huntington, et al. 2007. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 129: 1337-1349.
28. Rao, R. V. and D. E. Bredesen. 2004. Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr. Opin. Cell Biol. 16: 653-662.
29. Rideout, H. J., E. Zang, M. Yeasmin, R. Gordon, O. Jabado, D. S. Park, and L. Stefanis. 2001. Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction. Neuroscience 107: 339-352.
30. Ruddock, L. W. and M. Molinari. 2006. N-Glycan processing in ER quality control. J. Cell Sci. 119: 4373-4380.
31. Saelens, X., N. Festjens, L. Vande Walle, M. van Gurp, G. van Loo, and P. Vandenabeele. 2004. Toxic proteins released from mitochondria in cell death. Oncogene 23: 2861-2874.
32. Seong, Y. M., J. Y. Choi, H. J. Park, K. J. Kim, S. G. Ahn, G. H. Seong, I. K. Kim, S. Kang, and H. Rhim. 2004. Autocatalytic processing of HtrA2/ Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP. J. Biol. Chem. 279: 37588-37596.
33. Shen, J., X. Chen, L. Hendershot, and R. Prywes. 2002. ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev. Cell 3: 99-111.
34. Sidrauski, C., R. Chapman, and P. Walter. 1998. The unfolded protein response: An intracellular signalling pathway with many surprising features. Trends Cell Biol. 8: 245-249.
35. Strauss, K. M., L. M. Martins, H. Plun-Favreau, F. P. Marx, S. Kautzmann, D. Berg, et al. 2005. Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease. Hum. Mol. Genet. 14: 2099-2111.
36. Suzuki, Y., Y. Imai, H. Nakayama, K. Takahashi, K. Takio, and R. Takahashi. 2001. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 8: 613-621.
37. Suzuki, Y., K. Takahashi-Niki, T. Akagi, T. Hashikawa, and R. Takahashi. 2004. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ. 11: 208-216.
38. Urano, F., A. Bertolotti, and D. Ron. 2000. IRE1 and efferent signaling from the endoplasmic reticulum. J. Cell Sci. 21: 3697-3702.
39. Uren, R. T., G. Dewson, C. Bonzon, T. Lithgow, D. D. Newmeyer, and R. M. Kluck. 2005. Mitochondrial release of pro-apoptotic proteins: Electrostatic interactions can hold cytochrome c but not Smac/ DIABLO to mitochondrial membranes. J. Biol. Chem. 280: 2266-2274.
40. van Loo, G., M. van Gurp, B. Depuydt, S. M. Srinivasula, I. Rodriguez, E. S. Alnemri, et al. 2002. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ. 9: 20-26.
41. Verhagen, A. M., J. Silke, P. G. Ekert, M. Pakusch, H. Kaufmann, L. M. Connolly, et al. 2002. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277: 445-454.
42. Wolf, B. B. and D. R. Green. 2002. Apoptosis: Letting slip the dogs of war. Curr. Biol. 12: 177-179.
43. Yamaguchi, H., K. Bhalla, and H. G. Wang. 2003. Bax plays a pivotal role in thapsigargin-induced apoptosis of human colon cancer HCT116 cells by controlling Smac/Diablo and Omi/HtrA2 release from mitochondria. Cancer Res. 63: 1483-1489.
44. Yun, J., H.-Y. Chung, S.-J. Kim, H.-S. Cho, and J.-W. Oh. 2006. Purification and characterization of the functional catalytic domain of PKR-like endoplasmic reticulum kinase expressed in Escherichia coli. J. Microbiol. Biotechnol. 16: 1453-1458.
45. Zhao, L. and S. L. Ackerman. 2006. Endoplasmic reticulum stress in health and disease. Curr. Opin. Cell Biol. 18: 444-452.