Recent advances in the discovery of metallo-β-lactamase inhibitors for β-lactam antibiotic-resistant reversing agents

Current Drug Targets

Volumn 15, Issue 7, 2014, Pages 689-702

  Guo, Zhenzhen ^a   Ma, Shutao ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Antibiotic; Inhibitor; Metallo lactamase; Resistant and zinc enzyme; lactam

Indexed keywords

2 PHENYL 4,5 DIHYDROTHIAZOLE 4 CARBOXYLIC ACID; 2,4 OXAZOLIDINEDICARBOXYLIC ACID; 2,4 PYRIDINEDICARBOXYLIC ACID; 2,5 BENZOPHENONE HYDROXAMIC ACID DERIVATIVE; 2,5 PYRROLIDINEDICARBOXYLIC ACID; 3 N BUTYL 1 PHENYLPYRAZOLE 5 CARBOXYLATE; 4 BUTYL 3 METHYLPHTHALIC ACID; 4 CHLOROMERCURIBENZOIC ACID; BENZOTHIENYLTHIOL DERIVATIVE; BETA LACTAM DERIVATIVE; BETA LACTAMASE INHIBITOR; CYCLOBUTANONE DERIVATIVE; LATAMOXEF; MALEIC ACID DERIVATIVE; MERCAPTOCARBOXYLATE INHIBITOR; MERCAPTOPHOSPHONATE; METALLO BETA LACTAMASE INHIBITOR; N CARBOBENZOXY D CYSTEINYL D PHENYLALANINE; PENICILLIN DERIVATIVE; SUCCINIC ACID; SULFIDE; SULFONE; THIOESTER; THIOMANDELATE; THIOMANDELIC ACID; THIOXO PIPERAZINEDIONE; TIDIACIC; TRANS 3,5 PYRROLIDINYLTHIOL DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; BACTERIAL PROTEIN; BETA LACTAMASE; ZINC;

ACINETOBACTER BAUMANNII; AEROMONAS; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; BACILLUS; BACTEROIDES FRAGILIS; BRADYRHIZOBIUM JAPONICUM; CAULOBACTER CRESCENTUS; CHAETOMIUM; CHRYSEOBACTERIUM INDOLOGENES; ELECTROSPRAY MASS SPECTROMETRY; ELIZABETHKINGIA MENINGOSEPTICA; ENTEROBACTER CLOACAE; ENZYME ACTIVITY; FLAVOBACTERIUM JOHNSONIAE; IC 50; KLEBSIELLA PNEUMONIAE; LEGIONELLA; MOLECULAR DOCKING; NONHUMAN; NUCLEOTIDE SEQUENCE; PSEUDOMONAS AERUGINOSA; REVIEW; SERRATIA MARCESCENS; SHEWANELLA; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME SPECIFICITY; ISOLATION AND PURIFICATION; METABOLISM; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; ZINC;

EID: 84904514434     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450115666140326094504     Document Type: Review

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