Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-β-lactamase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 17, 1999, Pages 2549-2554

  Greenlee, Mark L ^a   Laub, Joanne B ^a   Balkovec, James M ^a   Hammond, Milton L ^a   Hammond, Gail G ^a   Pompliano, David L ^a   Epstein Toney, Jeffrey H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYACID; ALANINE DERIVATIVE; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; RESIN; THIOACETIC ACID; THIODEPSIPEPTIDE; THIOESTER; THIOL; UNCLASSIFIED DRUG;

ARTICLE; BACTERICIDAL ACTIVITY; BACTEROIDES FRAGILIS; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

BACTERIAL PROTEINS; BETA-LACTAMASES; ENZYME INHIBITORS; ESTERS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 0033530093     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00425-4     Document Type: Article

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