The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3282-3285

  Vella, Peter ^a   Hussein, Waleed M ^a   Leung, Eleanor W W ^a   Clayton, Daniel ^a   Ollis, David L ^b   Mitić, Nataša ^c   Schenk, Gerhard ^a,c   McGeary, Ross P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Antibiotics resistance; Fragment based screening; Inhibition assays; Metallo lactamases; Molecular docking

Indexed keywords

CAPTOPRIL; CENTA; CEPHALOSPORIN; LEAD; METALLO BETA LACTAMASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL INFECTION; COLORIMETRY; COMPUTER MODEL; DRUG BINDING; DRUG IDENTIFICATION; DRUG INTERACTION; DRUG SCREENING; KLEBSIELLA PNEUMONIAE; NONHUMAN; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CEPHALOSPORINS; COLORIMETRY; ENZYME ACTIVATION; ENZYME INHIBITORS; KLEBSIELLA PNEUMONIAE; MOLECULAR STRUCTURE; PSEUDOMONAS AERUGINOSA; SMALL MOLECULE LIBRARIES;

BACTERIA (MICROORGANISMS); KLEBSIELLA PNEUMONIAE; PSEUDOMONAS AERUGINOSA;

EID: 79956140677     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.027     Document Type: Article

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