Inhibition of metallo-β-lactamases by a series of thiol ester derivatives of mercaptophenylacetic acid

FEMS Microbiology Letters

Volumn 157, Issue 1, 1997, Pages 171-175

  Payne, David J ^a   Bateson, John H ^a   Gasson, Brian C ^a   Khushi, Teresa ^a   Proctor, David ^a   Pearson, Stewart C ^a   Reid, Robert ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Lactamase; Mercaptophenylacetic acid; Metalloenzyme; Thiolester

Indexed keywords

BETA LACTAMASE; METALLOPROTEIN; THIOESTER;

ARTICLE; BACILLUS CEREUS; BACTEROIDES FRAGILIS; CALORIMETRY; ENZYME INHIBITION; ENZYME ISOLATION; IN VITRO STUDY; PRIORITY JOURNAL; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE ACTIVITY RELATION;

BACILLUS CEREUS; BETA-LACTAMASES; BINDING SITES; ESTERS; METALLOPROTEINS; SUBSTRATE SPECIFICITY; SULFHYDRYL COMPOUNDS; ZINC;

BACILLUS CEREUS; BACTEROIDES FRAGILIS; POSIBACTERIA; STENOTROPHOMONAS MALTOPHILIA;

EID: 0031416125     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00472-2     Document Type: Article

References (11)

1. Perez, A.N., Bonet, I.G., Robledo, E.H., Abascal, R.S. and Plous, C.V. (1996) Metallo-β-lactamases in Acinetobacter calcoaceticus. Med. Sci. Res. 24, 315-317.
2. Rasmussen, B. and Bush, K. (1997) Carbapenem-hydrolyzing β-lactamases. Antimicrob. Agents Chemother. 41, 223-232.
3. Yamaguchi, H., Nukaga, M. and Sawai, T. (1994) Klebseilla pneumoniae RDK4 metallo-β-lactamase. EMBL Database, Accession Number D29636.
4. Payne, D.J., Bateson, J.H., Gasson, B.C., Proctor, D., Khushi, T., Farmer, T.H., Tolson, D., Bell, D., Skett, P.W., Marshall, A.C., Reid, R., Ghosez, L., Combret, Y. and Marchand-Brynaert, J. (1997) Inhibition of metallo-β-lactamases by a series of mercaptoacetic acid thiol ester derivatives. Antimicrob. Agents Chemother. 41, 135-140.
5. Felici, A., Amicosante, G., Oratore, A., Strom, R., Ledent, P., Joris, B., Fanuel, L. and Frère, J-M. (1993) An overview of the kinetic parameters of Class B β-lactamases. Biochem. J. 291, 151-155.
6. Khushi, T., Payne, D.J., Fosberry, A. and Reading, C. (1995) Production of metal dependent β-lactamases by clinical strains of B. fragilis isolated before 1987. J. Antimicrob. Chemother. 37, 345-350.
7. Damblon, C., Zhaio, C.-H, Jamin, M., Ledent, P., Dubus, A., Vanhove, M., Raquet, X., Christaens, L. and Frere, J.M. (1995) Breakdown of the stereospecificity of DD-peptidases and β-lactamases with thiolester substrates. Biochem. J. 309, 431-436.
8. Payne, D.J., Cramp, R., Winstanley, D. and Knowles, D. (1994) Comparative activities of clavulanic acid, sulbactam, and tazobactam against clinically important β-lactamases. Antimicrob. Agents Chemother. 38, 767-772.
9. Carfi, A., Pares, S., Duée, E., Galleni, M., Duez, C., Frère, J.M. and Dideburg, O. (1995) The 3-D structure of a zinc metallo β-lactamase from Bacillus cereus reveals a new type of protein fold. EMBO J. 14, 4914-4921.
10. Concha, N.O., Rasmussen, B.A., Bush, K. and Hertzberg, O. (1996) Crystal structure of the wide-spectrum binuclear zinc β-lactamase from Bacteroides fragilis. Structure 4, 823-836.
11. Fabiane, S.M., Sohi, M., Wan, T., Payne, D.J., Bateson, J.H., Mitchell, T. and Sutton, B.J. (1996) Crystal structure of a metallo-β-lactamase II form B.cereus at 2.5 A. International Union of Crystallography, XVII Congress and General Assembly, August 8-17, Seattle, WA, USA.