N-arylsulfonyl hydrazones as inhibitors of IMP-1 metallo-β-lactamase

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 8, 2002, Pages 2450-2457

  Siemann, Stefan ^a   Evanoff, Darryl P ^a   Marrone, Laura ^a   Clarke, Anthony J ^a   Viswanatha, Thammaiah ^a   Dmitrienko, Gary I ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE INHIBITOR; HYDRAZONE DERIVATIVE; BETA LACTAMASE; BETA LACTAMASE IMP 1; BETA-LACTAMASE IMP-1; ENZYME INHIBITOR; SULFONAMIDE;

ARTICLE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; MOLECULAR MODEL; PREVALENCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; BACILLUS CEREUS; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; KINETICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS;

BACILLUS CEREUS; BETA-LACTAMASES; DRUG DESIGN; ENZYME INHIBITORS; HYDRAZONES; KINETICS; MODELS, MOLECULAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SUPPORT, NON-U.S. GOV'T;

EID: 0035991840     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.8.2450-2457.2002     Document Type: Article

References (44)

1. The structure of β-lactamases
2. The amino acid sequence of the zinc-requiring β-lactamase II from the bacterium Bacillus cereus 569
3. Convenient test for screening metallo-β-lactamase-producing gram-negative bacteria by using thiol compounds
4. The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent β-lactamase
5. Cysteinyl peptide inhibitors of Bacillus cereus zinc β-lactamase
6. Kinetic interaction of tazobactam with β-lactamases from all major structural classes
7. Crystal structure of the IMP-1 metallo β-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: Binding determinants of a potent, broad-spectrum inhibitor
8. A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors
9. Class B β-lactamases: The importance of being metallic
10. The determination of enzyme inhibitor constants
11. Standard numbering scheme for class B β-lactamases
12. Inhibition of the metallo-β-lactamase produced from Serratia marcescens by thiol compounds
13. Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-β-lectamase
14. Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives
15. Cloning and sequencing of the metallothioprotein β-lactamase 11 gene of Bacillus cereus 569/H in Escherichia coli
16. Penicillin resistance: The chemistry of β-lactamase inhibition
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Biochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-β-lactamase IMP-1 produced by Escherichia coli
19. IMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes
20. Cloning, nucleotide sequence, and expression of the Bacillus cereus 5/B/6 β-lactamase II structural gene
21. Carbapenemases: A problem in waiting?
22. The β-lactamase cycle: A tale of selective pressure and bacterial ingenuity
23. Identification of residues critical for metallo-β-lactamase function by codon randomization and selection
24. Thiomandelic acid, a broad spectrum inhibitor of zinc β-lactamases: Kinetic and spectroscopic studies
25. Carbapenem derivatives as potential inhibitors of various β-lactamases, including class B metallo-β-lactamases
26. In vitro antibacterial activity and mechanism of action of J-111,225, a novel β-methylcarbapenem, against transferable IMP-1 metallo-β-lactamase producers
27. Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate
28. The mechanism of catalysis and the inhibition of β-lactamases
29. 2+-β-lactamase. Role of the conserved cysteine in the catalytic mechanism
30. β-lactamase epidemiology and the utility of established and novel β-lactamase inhibitors
31. Inhibition of metallo-β-lactamase by a series of thiol ester derivatives of mercaptophenylacetic acid
32. Inhibition of metallo-β-lactamase by a series of mercaptoacetic acid thiol ester derivatives
33. Interaction between class B β-lactamases and suicide substrates of active-site serine β-lactamases
34. Interactions of cefotetan and the metallo-β-lactamases produced in Aeromonas spp. and in vitro activity
35. Carbapenem-hydrolyzing β-lactamases
36. Metal(II) binding ability of a novel N-protected amino acid. A solution-state investigation on binary and ternary complexes with 2,2′-bipyridine
37. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
38. Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase
39. Structure-activity relationships of biphenyl tetrazoles as metallo-β-lactamase inhibitors
40. Succinic acids as potent inhibitors of plasmid-borne IMP-1 metallo-β-lactamase
41. Trifluoromethyl alcohol and ketone inhibitors of metallo-β-lactamases
42. Hydroxamate inhibitors of Aeromonas hydrophila AE036 metallo-β-lactamase
43. Metallo-β-lactamase: Structure and mechanism
44. Transferable imipenem resistance in Pseudomonas aeruginosa